Identification of a conserved N-capping box important for the structural autonomy of the prion α3-helix: The disease associated D202N mutation destabilizes the helical conformation

International Journal of Immunopathology and Pharmacology

Volumn 18, Issue 1, 2005, Pages 95-112

  Gallo, M ^a   Paludi, D ^b   Cicero, D O ^a   Chiovitti, K ^c   Millo, E ^d   Salis, A ^e   Damonte, G ^e   Corsaro, A ^f   Thellung, S ^f   Schettini, G ^f   Melino, S ^a   Florio, T ^f,g   Paci, M ^a   Aceto, Antonio ^c  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF TERAMO   (Italy)

^c UNIVERSITY OF CHIETI   (Italy)

^d G GASLINI INSTITUTE   (Italy)

^e c/o Ctr Excellence Biomed Res ^*  (Italy)

^f UNIVERSITY OF GENOA   (Italy)

^g UNIVERSITY OF GENOA   (Italy)

Author keywords

Circular dichroism; D202N pathological mutations; N capping box; NMR; Prion protein; 3 helix

Indexed keywords

PRION PROTEIN;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; HYDROGEN BOND; MUTATION; NUCLEAR OVERHAUSER EFFECT; NUCLEOTIDE SEQUENCE; PRION DISEASE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTON NUCLEAR MAGNETIC RESONANCE; SEQUENCE ANALYSIS;

EID: 20044381672     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463200501800111     Document Type: Article

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