The stability and aggregation of ovine prion protein associated with classical and atypical scrapie correlates with the ease of unwinding of helix-2

Biochemical Journal

Volumn 409, Issue 2, 2008, Pages 367-375

  Fitzmaurice, Tim J ^a   Burke, David F ^a   Hopkins, Lee ^a   Yang, Sujeong ^a   Yu, Shuiliang ^b   Sy, Man Sun ^b   Thackray, Alana M ^a   Bujdoso, Raymond ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Conformational stability; Polymorphism; Prion related protein (PrP); Protease; Transmissible spongiform encephalopathies

Indexed keywords

CONFORMATIONAL STABILITY; POLYMORPHISMS; SUSCEPTIBILITY; TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES;

AGGLOMERATION; CORRELATION METHODS; DISEASES; GENES;

PROTEINS;

ALANYLALANYLARGININE; ALANYLHISTIDYLGLUTAMINE; ALANYLLEUCYLARGINYLGLUTAMINE; ALANYLPHENYLALANYLARGINYLGLUTAMINE; AMINO ACID DERIVATIVE; COPPER ION; MONOCLONAL ANTIBODY; PRION PROTEIN; PROTEINASE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VALYLARGINYLGLUTAMINE;

ALLELE; ARTICLE; CHEMICAL ANALYSIS; CONFORMATIONAL TRANSITION; CORRELATION ANALYSIS; DISEASE PREDISPOSITION; GENETIC VARIABILITY; MOLECULAR DYNAMICS; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN POLYMORPHISM; PROTEIN STABILITY; SCRAPIE;

ALLELES; ANIMALS; ANTIBODIES, MONOCLONAL; COPPER; GENOTYPE; MODELS, MOLECULAR; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PRPSC PROTEINS; RECOMBINANT PROTEINS; SHEEP; VARIATION (GENETICS);

OVIS; OVIS ARIES;

EID: 38749113941     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20071122     Document Type: Article

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