The determinants of stability in the human prion protein: Insights into folding and misfolding from the analysis of the change in the stabilization energy distribution in different conditions

Proteins: Structure, Function and Genetics

Volumn 62, Issue 3, 2006, Pages 698-707

  Colacino, Stefano ^a,b,c   Tiana, Guido ^a,b   Broglia, Ricardo A ^a,b,d   Colombo, Giorgio ^c  

^a UNIVERSITY OF MILAN   (Italy)

^b INFN SEZIONE DI MILANO   (Italy)

^c CNR   (Italy)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Conformational changes; Human prion protein; Misfolding; Molecular dynamics

Indexed keywords

PRION PROTEIN;

ARTICLE; BETA SHEET; ENERGY TRANSFER; MOLECULAR DYNAMICS; MUTATION; NUCLEAR MAGNETIC RESONANCE; PH; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; TEMPERATURE DEPENDENCE;

COMPUTER SIMULATION; DRUG STABILITY; HUMANS; LYSINE; MODELS, MOLECULAR; PRIONS; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PRPC PROTEINS; PRPSC PROTEINS; THERMODYNAMICS;

EID: 31944435727     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.20804     Document Type: Article

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