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Volumn 57, Issue 12, 2008, Pages 1445-1453

Helicobacter pylori virulence and the diversity of gastric cancer in Asia

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CAGA PROTEIN; CAGPAI PROTEIN; UNCLASSIFIED DRUG;

EID: 57749200155     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.2008/003160-0     Document Type: Review
Times cited : (52)

References (97)
  • 1
    • 30744476220 scopus 로고    scopus 로고
    • Association between cag-pathogenicity island in Helicobacter pylori isolates from peptic ulcer, gastric carcinoma, and non-ulcer dyspepsia subjects with histological changes
    • Ali, M., Khan, A. A., Tiwari, S. K., Ahmed, N., Rao, L. V. & Habibullah, C. M. (2005). Association between cag-pathogenicity island in Helicobacter pylori isolates from peptic ulcer, gastric carcinoma, and non-ulcer dyspepsia subjects with histological changes. World J Gastroenterol 11, 6815-6822.
    • (2005) World J Gastroenterol , vol.11 , pp. 6815-6822
    • Ali, M.1    Khan, A.A.2    Tiwari, S.K.3    Ahmed, N.4    Rao, L.V.5    Habibullah, C.M.6
  • 2
    • 0038780624 scopus 로고    scopus 로고
    • Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA
    • Amieva, M. R., Vogelmann, R., Covacci, A., Tompkins, L. S., Nelson, W. J. & Falkow, S. (2003). Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA. Science 300, 1430-1434.
    • (2003) Science , vol.300 , pp. 1430-1434
    • Amieva, M.R.1    Vogelmann, R.2    Covacci, A.3    Tompkins, L.S.4    Nelson, W.J.5    Falkow, S.6
  • 3
    • 4143096988 scopus 로고    scopus 로고
    • Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori
    • Argent, R. H., Kidd, M., Owen, R. J., Thomas, R. J., Limb, M. C. & Atherton, J. C. (2004). Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori. Gastroenterology 127, 514-523.
    • (2004) Gastroenterology , vol.127 , pp. 514-523
    • Argent, R.H.1    Kidd, M.2    Owen, R.J.3    Thomas, R.J.4    Limb, M.C.5    Atherton, J.C.6
  • 4
    • 0029059733 scopus 로고
    • Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration
    • Atherton, J. C., Cao, P., Peek, R. M., Jr, Tummuru, M. K., Blaser, M. J. & Cover, T. L. (1995). Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem 270, 17771-17777.
    • (1995) J Biol Chem , vol.270 , pp. 17771-17777
    • Atherton, J.C.1    Cao, P.2    Peek Jr, R.M.3    Tummuru, M.K.4    Blaser, M.J.5    Cover, T.L.6
  • 5
    • 0031032033 scopus 로고    scopus 로고
    • Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori
    • Atherton, J. C., Peek, R. M., Jr, Tham, K. T., Cover, T. L. & Blaser, M. J. (1997). Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology 112, 92-99.
    • (1997) Gastroenterology , vol.112 , pp. 92-99
    • Atherton, J.C.1    Peek Jr, R.M.2    Tham, K.T.3    Cover, T.L.4    Blaser, M.J.5
  • 6
    • 12144291018 scopus 로고    scopus 로고
    • Association between diversity in the Src homology 2 domain - containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer
    • Azuma, T., Yamazaki, S., Yamakawa, A., Ohtani, M., Muramatsu, A., Suto, H., Ito, Y., Dojo, M., Yamazaki, Y. & other authors (2004). Association between diversity in the Src homology 2 domain - containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer. J Infect Dis 189, 820-827.
    • (2004) J Infect Dis , vol.189 , pp. 820-827
    • Azuma, T.1    Yamazaki, S.2    Yamakawa, A.3    Ohtani, M.4    Muramatsu, A.5    Suto, H.6    Ito, Y.7    Dojo, M.8    Yamazaki, Y.9
  • 7
    • 33645865541 scopus 로고    scopus 로고
    • Type IV secretion systems and their effectors in bacterial pathogenesis
    • Backert, S. & Meyer, T. F. (2006). Type IV secretion systems and their effectors in bacterial pathogenesis. Curr Opin Microbiol 9, 207-217.
    • (2006) Curr Opin Microbiol , vol.9 , pp. 207-217
    • Backert, S.1    Meyer, T.F.2
  • 9
    • 0035162820 scopus 로고    scopus 로고
    • Phosphorylation of tyrosine 972 of the Helicobacter pylori CagA protein is essential for induction of a scattering phenotype in gastric epithelial cells
    • Backert, S., Moese, S., Selbach, M., Brinkmann, V. & Meyer, T. F. (2001). Phosphorylation of tyrosine 972 of the Helicobacter pylori CagA protein is essential for induction of a scattering phenotype in gastric epithelial cells. Mol Microbiol 42, 631-644.
    • (2001) Mol Microbiol , vol.42 , pp. 631-644
    • Backert, S.1    Moese, S.2    Selbach, M.3    Brinkmann, V.4    Meyer, T.F.5
  • 10
    • 28044437976 scopus 로고    scopus 로고
    • Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells
    • Bagnoli, F., Buti, L., Tompkins, L., Covacci, A. & Amieva, M. R. (2005). Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells. Proc Natl Acad Sci U S A 102, 16339-16344.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 16339-16344
    • Bagnoli, F.1    Buti, L.2    Tompkins, L.3    Covacci, A.4    Amieva, M.R.5
  • 11
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow?
    • Balkwill, F. & Mantovani, A. (2001). Inflammation and cancer: back to Virchow? Lancet 357, 539-545.
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 13
    • 21544441173 scopus 로고    scopus 로고
    • NFkB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein
    • Brandt, S., Kwok, T., Hartig, R., Konig, W. & Backert, S. (2005). NFkB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein. Proc Natl Acad Sci U S A 102, 9300-9305.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 9300-9305
    • Brandt, S.1    Kwok, T.2    Hartig, R.3    Konig, W.4    Backert, S.5
  • 14
    • 0942279638 scopus 로고    scopus 로고
    • Is Helicobacter pylori infection a necessary condition for noncardia gastric cancer?
    • Brenner, H., Arndt, V., Stegmaier, C., Ziegler, H. & Rothenbacher, D. (2004). Is Helicobacter pylori infection a necessary condition for noncardia gastric cancer? Am J Epidemiol 159, 252-258.
    • (2004) Am J Epidemiol , vol.159 , pp. 252-258
    • Brenner, H.1    Arndt, V.2    Stegmaier, C.3    Ziegler, H.4    Rothenbacher, D.5
  • 17
    • 0037300006 scopus 로고    scopus 로고
    • Chaudhuri, S., Chowdhury, A., Datta, S., Mukhopadhyay, A. K., Chattopadhya, S., Saha, D. R., Dhali, G., Santra, A., Nair, G. B. & other authors (2003). Anti-Helicobacter pylori therapy in India: differences in eradication efficiency associated with particular alleles of vacuolating cytotoxin (vacA) gene. J Gastroenterol Hepatol 18, 190-195.
    • Chaudhuri, S., Chowdhury, A., Datta, S., Mukhopadhyay, A. K., Chattopadhya, S., Saha, D. R., Dhali, G., Santra, A., Nair, G. B. & other authors (2003). Anti-Helicobacter pylori therapy in India: differences in eradication efficiency associated with particular alleles of vacuolating cytotoxin (vacA) gene. J Gastroenterol Hepatol 18, 190-195.
  • 18
    • 0032438571 scopus 로고    scopus 로고
    • Cheng, A. M., Saxton, T. M., Sakai, R., Kulkarni, S., Mbamalu, G., Vogel, W., Tortorice, C. G., Cardiff, R. D., Cross, J. C. & other authors (1998). Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cell 95, 793-803.
    • Cheng, A. M., Saxton, T. M., Sakai, R., Kulkarni, S., Mbamalu, G., Vogel, W., Tortorice, C. G., Cardiff, R. D., Cross, J. C. & other authors (1998). Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cell 95, 793-803.
  • 19
    • 33947609115 scopus 로고    scopus 로고
    • Analysis of the 39 variable region of the cagA gene of Helicobacter pylori isolated in Koreans
    • Choi, K. D., Kim, N., Lee, D. H., Kim, J. M., Kim, J. S., Jung, H. C. & Song, I. S. (2007). Analysis of the 39 variable region of the cagA gene of Helicobacter pylori isolated in Koreans. Dig Dis Sci 52, 960-966.
    • (2007) Dig Dis Sci , vol.52 , pp. 960-966
    • Choi, K.D.1    Kim, N.2    Lee, D.H.3    Kim, J.M.4    Kim, J.S.5    Jung, H.C.6    Song, I.S.7
  • 21
    • 0037732638 scopus 로고    scopus 로고
    • Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response
    • Churin, Y., Al-Ghoul, L., Kepp, O., Meyer, T. F., Birchmeier, W. & Naumann, M. (2003). Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response. J Cell Biol 161, 249-255.
    • (2003) J Cell Biol , vol.161 , pp. 249-255
    • Churin, Y.1    Al-Ghoul, L.2    Kepp, O.3    Meyer, T.F.4    Birchmeier, W.5    Naumann, M.6
  • 22
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens, L. M. & Werb, Z. (2002). Inflammation and cancer. Nature 420, 860-867.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 25
    • 0037162397 scopus 로고    scopus 로고
    • SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities
    • De Souza, D., Fabri, L. J., Nash, A., Hilton, D. J., Nicola, N. A. & Baca, M. (2002). SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities. Biochemistry 41, 9229-9236.
    • (2002) Biochemistry , vol.41 , pp. 9229-9236
    • De Souza, D.1    Fabri, L.J.2    Nash, A.3    Hilton, D.J.4    Nicola, N.A.5    Baca, M.6
  • 26
    • 0034793043 scopus 로고    scopus 로고
    • Helicobacter pylori in gastric cancer established by CagA immunoblot as a marker of past infection
    • Ekstrom, A. M., Held, M., Hansson, L. E., Engstrand, L. & Nyren, O. (2001). Helicobacter pylori in gastric cancer established by CagA immunoblot as a marker of past infection. Gastroenterology 121, 784-791.
    • (2001) Gastroenterology , vol.121 , pp. 784-791
    • Ekstrom, A.M.1    Held, M.2    Hansson, L.E.3    Engstrand, L.4    Nyren, O.5
  • 27
    • 4944245876 scopus 로고    scopus 로고
    • Phosphorylation-independent effects of CagA during interaction between Helicobacter pylori and T84 polarized monolayers
    • El-Etr, S. H., Mueller, A., Tompkins, L. S., Falkow, S. & Merrell, D. S. (2004). Phosphorylation-independent effects of CagA during interaction between Helicobacter pylori and T84 polarized monolayers. J Infect Dis 190, 1516-1523.
    • (2004) J Infect Dis , vol.190 , pp. 1516-1523
    • El-Etr, S.H.1    Mueller, A.2    Tompkins, L.S.3    Falkow, S.4    Merrell, D.S.5
  • 28
    • 33750553565 scopus 로고    scopus 로고
    • Prevalence of Helicobacter pylori vacA, cagA, cagE, iceA, babA2 genotypes and correlation with clinical outcome in Turkish patients with dyspepsia
    • Erzin, Y., Koksal, V., Altun, S., Dobrucali, A., Aslan, M., Erdamar, S., Dirican, A. & Kocazeybek, B. (2006). Prevalence of Helicobacter pylori vacA, cagA, cagE, iceA, babA2 genotypes and correlation with clinical outcome in Turkish patients with dyspepsia. Helicobacter 11, 574-580.
    • (2006) Helicobacter , vol.11 , pp. 574-580
    • Erzin, Y.1    Koksal, V.2    Altun, S.3    Dobrucali, A.4    Aslan, M.5    Erdamar, S.6    Dirican, A.7    Kocazeybek, B.8
  • 30
    • 0035725211 scopus 로고    scopus 로고
    • Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: Essential genes for CagA translocation in host cells and induction of interleukin-8
    • Fischer, W., Puls, J., Buhrdorf, R., Gebert, B., Odenbreit, S. & Haas, R. (2001). Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin-8. Mol Microbiol 42, 1337-1348.
    • (2001) Mol Microbiol , vol.42 , pp. 1337-1348
    • Fischer, W.1    Puls, J.2    Buhrdorf, R.3    Gebert, B.4    Odenbreit, S.5    Haas, R.6
  • 31
    • 33847740988 scopus 로고    scopus 로고
    • Wnt/b-catenin signaling in cancer stemness and malignant behavior
    • Fodde, R. & Brabletz, T. (2007). Wnt/b-catenin signaling in cancer stemness and malignant behavior. Curr Opin Cell Biol 19, 150-158.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 150-158
    • Fodde, R.1    Brabletz, T.2
  • 32
    • 0025871037 scopus 로고
    • Association between infection with Helicobacter pylori and risk of gastric cancer: Evidence from a prospective investigation
    • Forman, D., Newell, D. G., Fullerton, F., Yarnell, J. W., Stacey, A. R., Wald, N. & Sitas, F. (1991). Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. BMJ 302, 1302-1305.
    • (1991) BMJ , vol.302 , pp. 1302-1305
    • Forman, D.1    Newell, D.G.2    Fullerton, F.3    Yarnell, J.W.4    Stacey, A.R.5    Wald, N.6    Sitas, F.7
  • 33
    • 23044463653 scopus 로고    scopus 로고
    • Franco, A. T., Israel, D. A., Washington, M. K., Krishna, U., Fox, J. G., Rogers, A. B., Neish, A. S., Collier-Hyams, L., Perez-Perez, G. I. & other authors (2005). Activation of b-catenin by carcinogenic Helicobacter pylori. Proc Natl Acad Sci U S A 102, 10646-10651.
    • Franco, A. T., Israel, D. A., Washington, M. K., Krishna, U., Fox, J. G., Rogers, A. B., Neish, A. S., Collier-Hyams, L., Perez-Perez, G. I. & other authors (2005). Activation of b-catenin by carcinogenic Helicobacter pylori. Proc Natl Acad Sci U S A 102, 10646-10651.
  • 34
    • 33846940534 scopus 로고    scopus 로고
    • East Asian-type Helicobacter pylori cytotoxin-associated gene A protein has a more significant effect on growth of rat gastric mucosal cells than the Western type
    • Fu, H. Y., Asahi, K., Hayashi, Y., Eguchi, H., Murata, H., Tsujii, M., Tsuji, S., Azuma, T. & Kawano, S. (2007). East Asian-type Helicobacter pylori cytotoxin-associated gene A protein has a more significant effect on growth of rat gastric mucosal cells than the Western type. J Gastroenterol Hepatol 22, 355-362.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 355-362
    • Fu, H.Y.1    Asahi, K.2    Hayashi, Y.3    Eguchi, H.4    Murata, H.5    Tsujii, M.6    Tsuji, S.7    Azuma, T.8    Kawano, S.9
  • 35
    • 0037069444 scopus 로고    scopus 로고
    • East Asian genotypes of Helicobacter pylori strains in Amerindians provide evidence for its ancient human carriage
    • Ghose, C., Perez-Perez, G. I., Dominguez-Bello, M. G., Pride, D. T., Bravi, C. M. & Blaser, M. J. (2002). East Asian genotypes of Helicobacter pylori strains in Amerindians provide evidence for its ancient human carriage. Proc Natl Acad Sci U S A 99, 15107-15111.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 15107-15111
    • Ghose, C.1    Perez-Perez, G.I.2    Dominguez-Bello, M.G.3    Pride, D.T.4    Bravi, C.M.5    Blaser, M.J.6
  • 36
    • 0037069449 scopus 로고    scopus 로고
    • cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection
    • Guillemin, K., Salama, N. R., Tompkins, L. S. & Falkow, S. (2002). cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection. Proc Natl Acad Sci U S A 99, 15136-15141.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 15136-15141
    • Guillemin, K.1    Salama, N.R.2    Tompkins, L.S.3    Falkow, S.4
  • 37
    • 4544334936 scopus 로고    scopus 로고
    • Oncogenic mechanisms of the Helicobacter pylori CagA protein
    • Hatakeyama, M. (2004). Oncogenic mechanisms of the Helicobacter pylori CagA protein. Nat Rev Cancer 4, 688-694.
    • (2004) Nat Rev Cancer , vol.4 , pp. 688-694
    • Hatakeyama, M.1
  • 38
    • 33747497716 scopus 로고    scopus 로고
    • Helicobacter pylori CagA - a bacterial intruder conspiring gastric carcinogenesis
    • Hatakeyama, M. (2006). Helicobacter pylori CagA - a bacterial intruder conspiring gastric carcinogenesis. Int J Cancer 119, 1217-1223.
    • (2006) Int J Cancer , vol.119 , pp. 1217-1223
    • Hatakeyama, M.1
  • 39
    • 0037195107 scopus 로고    scopus 로고
    • Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites
    • Higashi, H., Tsutsumi, R., Fujita, A., Yamazaki, S., Asaka, M., Azuma, T. & Hatakeyama, M. (2002a). Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites. Proc Natl Acad Sci U S A 99, 14428-14433.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 14428-14433
    • Higashi, H.1    Tsutsumi, R.2    Fujita, A.3    Yamazaki, S.4    Asaka, M.5    Azuma, T.6    Hatakeyama, M.7
  • 40
    • 0037169076 scopus 로고    scopus 로고
    • SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein
    • Higashi, H., Tsutsumi, R., Muto, S., Sugiyama, T., Azuma, T., Asaka, M. & Hatakeyama, M. (2002b). SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science 295, 683-686.
    • (2002) Science , vol.295 , pp. 683-686
    • Higashi, H.1    Tsutsumi, R.2    Muto, S.3    Sugiyama, T.4    Azuma, T.5    Asaka, M.6    Hatakeyama, M.7
  • 41
    • 2342429370 scopus 로고    scopus 로고
    • Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation
    • Higashi, H., Nakaya, A., Tsutsumi, R., Yokoyama, K., Fujii, Y., Ishikawa, S., Higuchi, M., Takahashi, A., Kurashima, Y. & other authors (2004). Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation. J Biol Chem 279, 17205-17216.
    • (2004) J Biol Chem , vol.279 , pp. 17205-17216
    • Higashi, H.1    Nakaya, A.2    Tsutsumi, R.3    Yokoyama, K.4    Fujii, Y.5    Ishikawa, S.6    Higuchi, M.7    Takahashi, A.8    Kurashima, Y.9
  • 43
    • 33847367723 scopus 로고    scopus 로고
    • Wnt signalling: Variety at the core
    • Hoppler, S. & Kavanagh, C. L. (2007). Wnt signalling: variety at the core. J Cell Sci 120, 385-393.
    • (2007) J Cell Sci , vol.120 , pp. 385-393
    • Hoppler, S.1    Kavanagh, C.L.2
  • 44
    • 0344197110 scopus 로고    scopus 로고
    • Meta-analysis of the relationship between cagA seropositivity and gastric cancer
    • Huang, J. Q., Zheng, G. F., Sumanac, K., Irvine, E. J. & Hunt, R. H. (2003). Meta-analysis of the relationship between cagA seropositivity and gastric cancer. Gastroenterology 125, 1636-1644.
    • (2003) Gastroenterology , vol.125 , pp. 1636-1644
    • Huang, J.Q.1    Zheng, G.F.2    Sumanac, K.3    Irvine, E.J.4    Hunt, R.H.5
  • 46
    • 0036228744 scopus 로고    scopus 로고
    • Intercellular adhesion, signalling and the cytoskeleton
    • Jamora, C. & Fuchs, E. (2002). Intercellular adhesion, signalling and the cytoskeleton. Nat Cell Biol 4, E101-E108.
    • (2002) Nat Cell Biol , vol.4
    • Jamora, C.1    Fuchs, E.2
  • 47
    • 40449133706 scopus 로고    scopus 로고
    • Genotyping of the cagA gene of Helicobacter pylori on immunohistochemistry with East Asian CagA-specific antibody
    • Kanada, R., Uchida, T., Tsukamoto, Y., Nguyen, L. T., Hijiya, N., Matsuura, K., Kodama, M., Okimoto, T., Murakami, K. & other authors (2008). Genotyping of the cagA gene of Helicobacter pylori on immunohistochemistry with East Asian CagA-specific antibody. Pathol Int 58, 218-225.
    • (2008) Pathol Int , vol.58 , pp. 218-225
    • Kanada, R.1    Uchida, T.2    Tsukamoto, Y.3    Nguyen, L.T.4    Hijiya, N.5    Matsuura, K.6    Kodama, M.7    Okimoto, T.8    Murakami, K.9
  • 48
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-κB in cancer development and progression
    • Karin, M. (2006). Nuclear factor-κB in cancer development and progression. Nature 441, 431-436.
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 49
    • 8644252623 scopus 로고    scopus 로고
    • The cag pathogenicity island of Helicobacter pylori is disrupted in the majority of patient isolates from different human populations
    • Kauser, F., Khan, A. A., Hussain, M. A., Carroll, I. M., Ahmad, N., Tiwari, S., Shouche, Y., Das, B., Alam, M. & other authors (2004). The cag pathogenicity island of Helicobacter pylori is disrupted in the majority of patient isolates from different human populations. J Clin Microbiol 42, 5302-5308.
    • (2004) J Clin Microbiol , vol.42 , pp. 5302-5308
    • Kauser, F.1    Khan, A.A.2    Hussain, M.A.3    Carroll, I.M.4    Ahmad, N.5    Tiwari, S.6    Shouche, Y.7    Das, B.8    Alam, M.9
  • 50
    • 12944277033 scopus 로고    scopus 로고
    • Kersulyte, D., Mukhopadhyay, A. K., Velapatino, B., Su, W., Pan, Z., Garcia, C., Hernandez, V., Valdez, Y., Mistry, R. S. & other authors (2000). Differences in genotypes of Helicobacter pylori from different human populations. J Bacteriol 182, 3210-3218.
    • Kersulyte, D., Mukhopadhyay, A. K., Velapatino, B., Su, W., Pan, Z., Garcia, C., Hernandez, V., Valdez, Y., Mistry, R. S. & other authors (2000). Differences in genotypes of Helicobacter pylori from different human populations. J Bacteriol 182, 3210-3218.
  • 51
    • 0032831452 scopus 로고    scopus 로고
    • Heterogeneity in the Helicobacter pylori vacA and cagA genes: Association with gastroduodenal disease in South Africa?
    • Kidd, M., Lastovica, A. J., Atherton, J. C. & Louw, J. A. (1999). Heterogeneity in the Helicobacter pylori vacA and cagA genes: association with gastroduodenal disease in South Africa? Gut 45, 499-502.
    • (1999) Gut , vol.45 , pp. 499-502
    • Kidd, M.1    Lastovica, A.J.2    Atherton, J.C.3    Louw, J.A.4
  • 52
    • 38349019459 scopus 로고    scopus 로고
    • Deregulation of β-catenin signal by Helicobacter pylori CagA requires the CagA-multimerization sequence
    • Kurashima, Y., Murata-Kamiya, N., Kikuchi, K., Higashi, H., Azuma, T., Kondo, S. & Hatakeyama, M. (2008). Deregulation of β-catenin signal by Helicobacter pylori CagA requires the CagA-multimerization sequence. Int J Cancer 122, 823-831.
    • (2008) Int J Cancer , vol.122 , pp. 823-831
    • Kurashima, Y.1    Murata-Kamiya, N.2    Kikuchi, K.3    Higashi, H.4    Azuma, T.5    Kondo, S.6    Hatakeyama, M.7
  • 53
    • 0033018042 scopus 로고    scopus 로고
    • Structure of cag pathogenicity island in Japanese Helicobacter pylori isolates
    • Maeda, S., Yoshida, H., Ikenoue, T., Ogura, K., Kanai, F., Kato, N., Shiratori, Y. & Omata, M. (1999). Structure of cag pathogenicity island in Japanese Helicobacter pylori isolates. Gut 44, 336-341.
    • (1999) Gut , vol.44 , pp. 336-341
    • Maeda, S.1    Yoshida, H.2    Ikenoue, T.3    Ogura, K.4    Kanai, F.5    Kato, N.6    Shiratori, Y.7    Omata, M.8
  • 54
    • 34147180434 scopus 로고    scopus 로고
    • Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium
    • Matsumoto, Y., Marusawa, H., Kinoshita, K., Endo, Y., Kou, T., Morisawa, T., Azuma, T., Okazaki, I. M., Honjo, T. & other authors (2007). Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat Med 13, 470-476.
    • (2007) Nat Med , vol.13 , pp. 470-476
    • Matsumoto, Y.1    Marusawa, H.2    Kinoshita, K.3    Endo, Y.4    Kou, T.5    Morisawa, T.6    Azuma, T.7    Okazaki, I.M.8    Honjo, T.9
  • 56
    • 0036809776 scopus 로고    scopus 로고
    • Grb2 is a key mediator of Helicobacter pylori CagA protein activities
    • Mimuro, H., Suzuki, T., Tanaka, J., Asahi, M., Haas, R. & Sasakawa, C. (2002). Grb2 is a key mediator of Helicobacter pylori CagA protein activities. Mol Cell 10, 745-755.
    • (2002) Mol Cell , vol.10 , pp. 745-755
    • Mimuro, H.1    Suzuki, T.2    Tanaka, J.3    Asahi, M.4    Haas, R.5    Sasakawa, C.6
  • 57
    • 0036245306 scopus 로고    scopus 로고
    • Miwa, H., Go, M. F. & Sato, N. (2002). H. pylori and gastric cancer: the Asian enigma. Am J Gastroenterol 97, 1106-1112.
    • Miwa, H., Go, M. F. & Sato, N. (2002). H. pylori and gastric cancer: the Asian enigma. Am J Gastroenterol 97, 1106-1112.
  • 58
    • 34047245107 scopus 로고    scopus 로고
    • The Helicobacter pylori CagA protein disrupts matrix adhesion of gastric epithelial cells by dephosphorylation of vinculin
    • Moese, S., Selbach, M., Brinkmann, V., Karlas, A., Haimovich, B., Backert, S. & Meyer, T. F. (2007). The Helicobacter pylori CagA protein disrupts matrix adhesion of gastric epithelial cells by dephosphorylation of vinculin. Cell Microbiol 9, 1148-1161.
    • (2007) Cell Microbiol , vol.9 , pp. 1148-1161
    • Moese, S.1    Selbach, M.2    Brinkmann, V.3    Karlas, A.4    Haimovich, B.5    Backert, S.6    Meyer, T.F.7
  • 59
    • 12944316453 scopus 로고    scopus 로고
    • Mukhopadhyay, A. K., Kersulyte, D., Jeong, J. Y., Datta, S., Ito, Y., Chowdhury, A., Chowdhury, S., Santra, A., Bhattacharya, S. K. & other authors (2000). Distinctiveness of genotypes of Helicobacter pylori in Calcutta, India. J Bacteriol 182, 3219-3227.
    • Mukhopadhyay, A. K., Kersulyte, D., Jeong, J. Y., Datta, S., Ito, Y., Chowdhury, A., Chowdhury, S., Santra, A., Bhattacharya, S. K. & other authors (2000). Distinctiveness of genotypes of Helicobacter pylori in Calcutta, India. J Bacteriol 182, 3219-3227.
  • 60
    • 34447519946 scopus 로고    scopus 로고
    • Helicobacter pylori CagA interacts with E-cadherin and deregulates the b-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells
    • Murata-Kamiya, N., Kurashima, Y., Teishikata, Y., Yamahashi, Y., Saito, Y., Higashi, H., Aburatani, H., Akiyama, T., Peek, R. M., Jr & other authors (2007). Helicobacter pylori CagA interacts with E-cadherin and deregulates the b-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells. Oncogene 26, 4617-4626.
    • (2007) Oncogene , vol.26 , pp. 4617-4626
    • Murata-Kamiya, N.1    Kurashima, Y.2    Teishikata, Y.3    Yamahashi, Y.4    Saito, Y.5    Higashi, H.6    Aburatani, H.7    Akiyama, T.8    Peek Jr, R.M.9
  • 61
    • 33646016600 scopus 로고    scopus 로고
    • Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA
    • Naito, M., Yamazaki, T., Tsutsumi, R., Higashi, H., Onoe, K., Yamazaki, S., Azuma, T. & Hatakeyama, M. (2006). Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA. Gastroenterology 130, 1181-1190.
    • (2006) Gastroenterology , vol.130 , pp. 1181-1190
    • Naito, M.1    Yamazaki, T.2    Tsutsumi, R.3    Higashi, H.4    Onoe, K.5    Yamazaki, S.6    Azuma, T.7    Hatakeyama, M.8
  • 62
    • 0038771965 scopus 로고    scopus 로고
    • The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
    • Neel, B. G., Gu, H. & Pao, L. (2003). The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends Biochem Sci 28, 284-293.
    • (2003) Trends Biochem Sci , vol.28 , pp. 284-293
    • Neel, B.G.1    Gu, H.2    Pao, L.3
  • 63
    • 0242286536 scopus 로고    scopus 로고
    • Correlation between cag pathogenicity island composition and Helicobacter pylori-associated gastroduodenal disease
    • Nilsson, C., Sillen, A., Eriksson, L., Strand, M. L., Enroth, H., Normark, S., Falk, P. & Engstrand, L. (2003). Correlation between cag pathogenicity island composition and Helicobacter pylori-associated gastroduodenal disease. Infect Immun 71, 6573-6581.
    • (2003) Infect Immun , vol.71 , pp. 6573-6581
    • Nilsson, C.1    Sillen, A.2    Eriksson, L.3    Strand, M.L.4    Enroth, H.5    Normark, S.6    Falk, P.7    Engstrand, L.8
  • 64
    • 17344379177 scopus 로고    scopus 로고
    • Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion
    • Odenbreit, S., Puls, J., Sedlmaier, B., Gerland, E., Fischer, W. & Haas, R. (2000). Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science 287, 1497-1500.
    • (2000) Science , vol.287 , pp. 1497-1500
    • Odenbreit, S.1    Puls, J.2    Sedlmaier, B.3    Gerland, E.4    Fischer, W.5    Haas, R.6
  • 66
    • 0035467993 scopus 로고    scopus 로고
    • Global cancer statistics in the year 2000
    • Parkin, D. M. (2001). Global cancer statistics in the year 2000. Lancet Oncol 2, 533-543.
    • (2001) Lancet Oncol , vol.2 , pp. 533-543
    • Parkin, D.M.1
  • 67
    • 4444244978 scopus 로고    scopus 로고
    • International variation
    • Parkin, D. M. (2004). International variation. Oncogene 23, 6329-6340.
    • (2004) Oncogene , vol.23 , pp. 6329-6340
    • Parkin, D.M.1
  • 68
    • 33646413672 scopus 로고    scopus 로고
    • The global health burden of infection-associated cancers in the year 2002
    • Parkin, D. M. (2006). The global health burden of infection-associated cancers in the year 2002. Int J Cancer 118, 3030-3044.
    • (2006) Int J Cancer , vol.118 , pp. 3030-3044
    • Parkin, D.M.1
  • 70
    • 0037509990 scopus 로고    scopus 로고
    • Focal adhesion kinase: The first ten years
    • Parsons, J. T. (2003). Focal adhesion kinase: the first ten years. J Cell Sci 116, 1409-1416.
    • (2003) J Cell Sci , vol.116 , pp. 1409-1416
    • Parsons, J.T.1
  • 71
    • 33745697763 scopus 로고    scopus 로고
    • Targeting the c-Met signaling pathway in cancer
    • Peruzzi, B. & Bottaro, D. P. (2006). Targeting the c-Met signaling pathway in cancer. Clin Cancer Res 12, 3657-3660.
    • (2006) Clin Cancer Res , vol.12 , pp. 3657-3660
    • Peruzzi, B.1    Bottaro, D.P.2
  • 72
    • 33845943988 scopus 로고    scopus 로고
    • Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cells
    • Ren, S., Higashi, H., Lu, H., Azuma, T. & Hatakeyama, M. (2006). Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cells. J Biol Chem 281, 32344-32352.
    • (2006) J Biol Chem , vol.281 , pp. 32344-32352
    • Ren, S.1    Higashi, H.2    Lu, H.3    Azuma, T.4    Hatakeyama, M.5
  • 74
    • 19044366273 scopus 로고    scopus 로고
    • Helicobacter pylori Cag-type IV secretion system facilitates corpus colonization to induce precancerous conditions in Mongolian gerbils
    • Rieder, G., Merchant, J. L. & Haas, R. (2005). Helicobacter pylori Cag-type IV secretion system facilitates corpus colonization to induce precancerous conditions in Mongolian gerbils. Gastroenterology 128, 1229-1242.
    • (2005) Gastroenterology , vol.128 , pp. 1229-1242
    • Rieder, G.1    Merchant, J.L.2    Haas, R.3
  • 76
    • 34249657932 scopus 로고    scopus 로고
    • A preliminary study on the genetic profile of cag pathogenicity-island and other virulent gene loci of Helicobacter pylori strains from Turkey
    • Salih, B. A., Abasiyanik, M. F. & Ahmed, N. (2007). A preliminary study on the genetic profile of cag pathogenicity-island and other virulent gene loci of Helicobacter pylori strains from Turkey. Infect Genet Evol 7, 509-512.
    • (2007) Infect Genet Evol , vol.7 , pp. 509-512
    • Salih, B.A.1    Abasiyanik, M.F.2    Ahmed, N.3
  • 77
    • 6944256527 scopus 로고    scopus 로고
    • Analysis of Helicobacter pylori genotypes and correlation with clinical outcome in Turkey
    • Saribasak, H., Salih, B. A., Yamaoka, Y. & Sander, E. (2004). Analysis of Helicobacter pylori genotypes and correlation with clinical outcome in Turkey. J Clin Microbiol 42, 1648-1651.
    • (2004) J Clin Microbiol , vol.42 , pp. 1648-1651
    • Saribasak, H.1    Salih, B.A.2    Yamaoka, Y.3    Sander, E.4
  • 78
    • 33747887088 scopus 로고    scopus 로고
    • Relationship between the diversity of the cagA gene ofHelicobacter pylori and gastric cancer in Okinawa, Japan
    • Satomi, S., Yamakawa, A., Matsunaga, S., Masaki, R., Inagaki, T., Okuda, T., Suto, H., Ito, Y., Yamazaki, Y. & other authors (2006). Relationship between the diversity of the cagA gene ofHelicobacter pylori and gastric cancer in Okinawa, Japan. J Gastroenterol 41, 668-673.
    • (2006) J Gastroenterol , vol.41 , pp. 668-673
    • Satomi, S.1    Yamakawa, A.2    Matsunaga, S.3    Masaki, R.4    Inagaki, T.5    Okuda, T.6    Suto, H.7    Ito, Y.8    Yamazaki, Y.9
  • 79
    • 0033456273 scopus 로고    scopus 로고
    • Altered states: Involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori
    • Segal, E. D., Cha, J., Lo, J., Falkow, S. & Tompkins, L. S. (1999). Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori. Proc Natl Acad Sci U S A 96, 14559-14564.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 14559-14564
    • Segal, E.D.1    Cha, J.2    Lo, J.3    Falkow, S.4    Tompkins, L.S.5
  • 80
    • 0036510363 scopus 로고    scopus 로고
    • Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo
    • Selbach, M., Moese, S., Hauck, C. R., Meyer, T. F. & Backert, S. (2002). Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo. J Biol Chem 277, 6775-6778.
    • (2002) J Biol Chem , vol.277 , pp. 6775-6778
    • Selbach, M.1    Moese, S.2    Hauck, C.R.3    Meyer, T.F.4    Backert, S.5
  • 81
    • 0037415684 scopus 로고    scopus 로고
    • The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation
    • Selbach, M., Moese, S., Hurwitz, R., Hauck, C. R., Meyer, T. F. & Backert, S. (2003). The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation. EMBO J 22, 515-528.
    • (2003) EMBO J , vol.22 , pp. 515-528
    • Selbach, M.1    Moese, S.2    Hurwitz, R.3    Hauck, C.R.4    Meyer, T.F.5    Backert, S.6
  • 82
    • 5644225534 scopus 로고    scopus 로고
    • The Helicobacter pylori CagA protein induces tyrosine dephosphorylation of ezrin
    • Selbach, M., Moese, S., Backert, S., Jungblut, P. R. & Meyer, T. F. (2004). The Helicobacter pylori CagA protein induces tyrosine dephosphorylation of ezrin. Proteomics 4, 2961-2968.
    • (2004) Proteomics , vol.4 , pp. 2961-2968
    • Selbach, M.1    Moese, S.2    Backert, S.3    Jungblut, P.R.4    Meyer, T.F.5
  • 83
    • 33645504595 scopus 로고    scopus 로고
    • Causal role of Helicobacter pylori infection in gastric cancer: An Asian enigma
    • Singh, K. & Ghoshal, U. C. (2006). Causal role of Helicobacter pylori infection in gastric cancer: an Asian enigma. World J Gastroenterol 12, 1346-1351.
    • (2006) World J Gastroenterol , vol.12 , pp. 1346-1351
    • Singh, K.1    Ghoshal, U.C.2
  • 84
    • 0033953359 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation
    • Stein, M., Rappuoli, R. & Covacci, A. (2000). Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation. Proc Natl Acad Sci U S A 97, 1263-1268.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 1263-1268
    • Stein, M.1    Rappuoli, R.2    Covacci, A.3
  • 85
    • 0036227053 scopus 로고    scopus 로고
    • c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs
    • Stein, M., Bagnoli, F., Halenbeck, R., Rappuoli, R., Fantl, W. J. & Covacci, A. (2002). c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs. Mol Microbiol 43, 971-980.
    • (2002) Mol Microbiol , vol.43 , pp. 971-980
    • Stein, M.1    Bagnoli, F.2    Halenbeck, R.3    Rappuoli, R.4    Fantl, W.J.5    Covacci, A.6
  • 87
    • 0344837816 scopus 로고    scopus 로고
    • β-Catenin expression in intramucosal neoplastic lesions of the stomach. Comparative analysis of adenoma/dysplasia, adenocarcinoma and signet-ring cell carcinoma
    • Tsukashita, S., Kushima, R., Bamba, M., Nakamura, E., Mukaisho, K., Sugihara, H. & Hattori, T. (2003). β-Catenin expression in intramucosal neoplastic lesions of the stomach. Comparative analysis of adenoma/dysplasia, adenocarcinoma and signet-ring cell carcinoma. Oncology 64, 251-258.
    • (2003) Oncology , vol.64 , pp. 251-258
    • Tsukashita, S.1    Kushima, R.2    Bamba, M.3    Nakamura, E.4    Mukaisho, K.5    Sugihara, H.6    Hattori, T.7
  • 88
    • 0037423309 scopus 로고    scopus 로고
    • Attenuation of Helicobacter pylori CagA SHP-2 signaling by interaction between CagA and C-terminal Src kinase
    • Tsutsumi, R., Higashi, H., Higuchi, M., Okada, M. & Hatakeyama, M. (2003). Attenuation of Helicobacter pylori CagA SHP-2 signaling by interaction between CagA and C-terminal Src kinase. J Biol Chem 278, 3664-3670.
    • (2003) J Biol Chem , vol.278 , pp. 3664-3670
    • Tsutsumi, R.1    Higashi, H.2    Higuchi, M.3    Okada, M.4    Hatakeyama, M.5
  • 89
    • 33645214468 scopus 로고    scopus 로고
    • Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA
    • Tsutsumi, R., Takahashi, A., Azuma, T., Higashi, H. & Hatakeyama, M. (2006). Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA. Mol Cell Biol 26, 261-276.
    • (2006) Mol Cell Biol , vol.26 , pp. 261-276
    • Tsutsumi, R.1    Takahashi, A.2    Azuma, T.3    Higashi, H.4    Hatakeyama, M.5
  • 90
    • 34147192061 scopus 로고    scopus 로고
    • Immunohistochemical diagnosis of the cagA-gene genotype of Helicobacter pylori with anti-East Asian CagA-specific antibody
    • Uchida, T., Kanada, R., Tsukamoto, Y., Hijiya, N., Matsuura, K., Yano, S., Yokoyama, S., Kishida, T., Kodama, M. & other authors (2007). Immunohistochemical diagnosis of the cagA-gene genotype of Helicobacter pylori with anti-East Asian CagA-specific antibody. Cancer Sci 98, 521-528.
    • (2007) Cancer Sci , vol.98 , pp. 521-528
    • Uchida, T.1    Kanada, R.2    Tsukamoto, Y.3    Hijiya, N.4    Matsuura, K.5    Yano, S.6    Yokoyama, S.7    Kishida, T.8    Kodama, M.9
  • 92
    • 9244245293 scopus 로고    scopus 로고
    • Viala, J., Chaput, C., Boneca, I. G., Cardona, A., Girardin, S. E., Moran, A. P., Athman, R., Memet, S., Huerre, M. R. & other authors (2004). Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol 5, 1166-1174.
    • Viala, J., Chaput, C., Boneca, I. G., Cardona, A., Girardin, S. E., Moran, A. P., Athman, R., Memet, S., Huerre, M. R. & other authors (2004). Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol 5, 1166-1174.
  • 93
    • 4644359818 scopus 로고    scopus 로고
    • Molecular epidemiology and outcome of Helicobacter pylori infection in Thailand: A cultural cross roads
    • Vilaichone, R. K., Mahachai, V., Tumwasorn, S., Wu, J. Y., Graham, D. Y. & Yamaoka, Y. (2004). Molecular epidemiology and outcome of Helicobacter pylori infection in Thailand: a cultural cross roads. Helicobacter 9, 453-459.
    • (2004) Helicobacter , vol.9 , pp. 453-459
    • Vilaichone, R.K.1    Mahachai, V.2    Tumwasorn, S.3    Wu, J.Y.4    Graham, D.Y.5    Yamaoka, Y.6
  • 94
    • 9844229885 scopus 로고    scopus 로고
    • Induction of various cytokines and development of severe mucosal inflammation by cagA gene positive Helicobacter pylori strains
    • Yamaoka, Y., Kita, M., Kodama, T., Sawai, N., Kashima, K. & Imanishi, J. (1997). Induction of various cytokines and development of severe mucosal inflammation by cagA gene positive Helicobacter pylori strains. Gut 41, 442-451.
    • (1997) Gut , vol.41 , pp. 442-451
    • Yamaoka, Y.1    Kita, M.2    Kodama, T.3    Sawai, N.4    Kashima, K.5    Imanishi, J.6
  • 95
    • 0037165666 scopus 로고    scopus 로고
    • Yamaoka, Y., Orito, E., Mizokami, M., Gutierrez, O., Saitou, N., Kodama, T., Osato, M. S., Kim, J. G., Ramirez, F. C. & other authors (2002). Helicobacter pylori in North and South America before Columbus. FEBS Lett 517, 180-184.
    • Yamaoka, Y., Orito, E., Mizokami, M., Gutierrez, O., Saitou, N., Kodama, T., Osato, M. S., Kim, J. G., Ramirez, F. C. & other authors (2002). Helicobacter pylori in North and South America before Columbus. FEBS Lett 517, 180-184.
  • 96
    • 1542509782 scopus 로고    scopus 로고
    • cagA genotype and variants in Chinese Helicobacter pylori strains and relationship to gastroduodenal diseases
    • Zhou, J., Zhang, J., Xu, C. & He, L. (2004a). cagA genotype and variants in Chinese Helicobacter pylori strains and relationship to gastroduodenal diseases. J Med Microbiol 53, 231-235.
    • (2004) J Med Microbiol , vol.53 , pp. 231-235
    • Zhou, J.1    Zhang, J.2    Xu, C.3    He, L.4


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