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Volumn 4, Issue 9, 2004, Pages 688-694

Oncogenic mechanisms of the Helicobacter pylori CagA protein

Author keywords

[No Author keywords available]

Indexed keywords

CAGA PROTEIN; PROTEIN TYROSINE PHOSPHATASE SHP 2; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; CAGA PROTEIN, HELICOBACTER PYLORI; PROTEIN TYROSINE PHOSPHATASE; SIGNAL PEPTIDE; SRC HOMOLOGY 2 (SH2) DOMAIN CONTAINING PHOSPHATASES; SRC HOMOLOGY-2 (SH2) DOMAIN-CONTAINING PHOSPHATASES;

EID: 4544334936     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc1433     Document Type: Review
Times cited : (639)

References (48)
  • 1
    • 0035856021 scopus 로고    scopus 로고
    • Helicobacter pylori infection and the development of gastric cancer
    • Uemura, N. et al. Helicobacter pylori infection and the development of gastric cancer. N. Engl. J. Med. 345, 784-789 (2001). Provides compelling epidemiological evidence for the role of H. pylori in the development of gastric carcinoma.
    • (2001) N. Engl. J. Med. , vol.345 , pp. 784-789
    • Uemura, N.1
  • 2
    • 9144220789 scopus 로고    scopus 로고
    • Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: A randomized controlled trial
    • Wong, B. C. et al. Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. JAMA 291, 187-194 (2004).
    • (2004) JAMA , vol.291 , pp. 187-194
    • Wong, B.C.1
  • 3
    • 0025101087 scopus 로고
    • Characterization of and human serologic response to proteins in Helicobacter pylori broth culture supematants with vacuolizing cytotoxin activity
    • Cover, T. L. et al. Characterization of and human serologic response to proteins in Helicobacter pylori broth culture supematants with vacuolizing cytotoxin activity. Infect. Immun. 58, 603-610 (1990).
    • (1990) Infect. Immun. , vol.58 , pp. 603-610
    • Cover, T.L.1
  • 4
    • 0025807183 scopus 로고
    • Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology
    • Crabtree, J. E. et al. Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology. Lancet 338, 332-335 (1991).
    • (1991) Lancet , vol.338 , pp. 332-335
    • Crabtree, J.E.1
  • 5
    • 0027173990 scopus 로고
    • Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer
    • Covacci, A. et al. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc. Natl Acad. Sci. USA 90, 5791-6795 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 5791-6795
    • Covacci, A.1
  • 6
    • 0027230726 scopus 로고
    • Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: Evidence of linkage to cytotoxin production
    • Tummuru, M. K., Cover, T. L. & Blaser, M. J. Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production. Infect. Immun. 61, 1799-1809 (1993).
    • (1993) Infect. Immun. , vol.61 , pp. 1799-1809
    • Tummuru, M.K.1    Cover, T.L.2    Blaser, M.J.3
  • 7
    • 0029963677 scopus 로고    scopus 로고
    • cag, a pathogenecity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors
    • Censini, S. et al. cag, a pathogenecity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc. Natl Acad. Sci. USA 93, 14648-14653 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 14648-14653
    • Censini, S.1
  • 9
    • 0029043658 scopus 로고
    • Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach
    • Blaser, M. J. et al. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res, 55, 2111-2115 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 2111-2115
    • Blaser, M.J.1
  • 10
    • 0030975595 scopus 로고    scopus 로고
    • Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection
    • Personnel, J., Friedman, G. D., Orentreich, N. & Vogelman, H. Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut 40, 297-301 (1997).
    • (1997) Gut , vol.40 , pp. 297-301
    • Personnel, J.1    Friedman, G.D.2    Orentreich, N.3    Vogelman, H.4
  • 11
    • 0033456273 scopus 로고    scopus 로고
    • Altered states: Involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori
    • Segal, E. D., Cha, J., Lo, J., Falkow, S. & Tompkins, L. S. Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori. Proc. Natl Acad. Sci. USA 96, 14559-14564 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 14559-14564
    • Segal, E.D.1    Cha, J.2    Lo, J.3    Falkow, S.4    Tompkins, L.S.5
  • 12
    • 0034695875 scopus 로고    scopus 로고
    • Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells
    • Asahi, M. et al. Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells. J. Exp. Med. 191, 593-602 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 593-602
    • Asahi, M.1
  • 13
    • 0033953359 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation
    • Stein, M., Rappuoli, R. & Covacci, A. Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation. Proc. Natl Acad. Sci. USA 97, 1263-1268 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 1263-1268
    • Stein, M.1    Rappuoli, R.2    Covacci, A.3
  • 14
    • 17344379177 scopus 로고    scopus 로고
    • Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion
    • Odenbreit, S. et al. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science 287, 1497-1500 (2000).
    • (2000) Science , vol.287 , pp. 1497-1500
    • Odenbreit, S.1
  • 15
    • 0035725211 scopus 로고    scopus 로고
    • Systematic mutagenesis of the Helicobacter pylori Gag pathogenicity island: Essential genes for CagA translocation in host cells and induction of interleukin-8
    • Fischer, W. et al. Systematic mutagenesis of the Helicobacter pylori Gag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin-8. Mol. Microbiol. 42, 1337-1348 (2001).
    • (2001) Mol. Microbiol. , vol.42 , pp. 1337-1348
    • Fischer, W.1
  • 16
    • 0036227053 scopus 로고    scopus 로고
    • c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs
    • Stein, M. et al. c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs. Mol. Microbiol. 43, 971-980 (2002).
    • (2002) Mol. Microbiol. , vol.43 , pp. 971-980
    • Stein, M.1
  • 17
    • 0036510363 scopus 로고    scopus 로고
    • Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo
    • Selbach, M., Moese, S., Hauck, C. R., Meyer, T. F. & Backert, S. Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo. J. Biol. Chem. 277, 6775-6778 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 6775-6778
    • Selbach, M.1    Moese, S.2    Hauck, C.R.3    Meyer, T.F.4    Backert, S.5
  • 18
    • 0037169076 scopus 로고    scopus 로고
    • SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein
    • Higashi, H. et al. SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science 295, 683-686 (2002). The first demonstration that tyrosine-phosphotylated CagA specifically binds and activates SHP2 phosphatase in gastric epithelial cells.
    • (2002) Science , vol.295 , pp. 683-686
    • Higashi, H.1
  • 19
    • 0037195107 scopus 로고    scopus 로고
    • Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites
    • Higashi, H. et al. Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites. Proc. Natl Acad. Sci. USA 99, 14428-14433 (2002). Provides evidence that East-Asian CagA is biologically more active than Western CagA.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 14428-14433
    • Higashi, H.1
  • 20
    • 0035162820 scopus 로고    scopus 로고
    • Phosphorylation of tyrosine 972 of the Helicobacter pylori CagA protein is essential for induction of a scattering phenotype in gastric epithelial cells
    • Backert, S., Moese, S., Selbach, M., Brinkmann, V. & Meyer, T. F. Phosphorylation of tyrosine 972 of the Helicobacter pylori CagA protein is essential for induction of a scattering phenotype in gastric epithelial cells. Mol. Microbiol. 42, 631-644 (2001).
    • (2001) Mol. Microbiol. , vol.42 , pp. 631-644
    • Backert, S.1    Moese, S.2    Selbach, M.3    Brinkmann, V.4    Meyer, T.F.5
  • 21
    • 0028047349 scopus 로고
    • Phosphotyrosine phosphatases with SH2 domains: Regulators of signal transduction
    • Feng, G. S. & Pawson, T. Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction. Trends Genet. 10, 54-58 (1994).
    • (1994) Trends Genet. , vol.10 , pp. 54-58
    • Feng, G.S.1    Pawson, T.2
  • 22
    • 0032548830 scopus 로고    scopus 로고
    • Crystal structure of the tyrosine phosphatase SHP-2
    • Hof, P., Pluskey, S., Dhe-Paganon, S., Eok, M. J. & Shoelson, S. E. Crystal structure of the tyrosine phosphatase SHP-2. Cell 92, 441-450 (1998).
    • (1998) Cell , vol.92 , pp. 441-450
    • Hof, P.1    Pluskey, S.2    Dhe-Paganon, S.3    Eok, M.J.4    Shoelson, S.E.5
  • 24
    • 3543036342 scopus 로고    scopus 로고
    • Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion
    • Yu, I. H., Qu, C. K., Henegariu, O., Lu, X. & Feng, G. S. Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion. J. Biol. Chem. 273, 21125-21131 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 21125-21131
    • Yu, I.H.1    Qu, C.K.2    Henegariu, O.3    Lu, X.4    Feng, G.S.5
  • 25
    • 0039441744 scopus 로고    scopus 로고
    • Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility
    • Manes, S. et al. Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility. Mol. Cell. Biol. 19, 3125-3135 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 3125-3135
    • Manes, S.1
  • 26
    • 0033761488 scopus 로고    scopus 로고
    • The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase
    • Maroun, C. R., Naujokas, M. A., Holgado-Madruga, M., Wong, A. J. & Park, M. The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase. Mol. Cell. Biol. 20, 8513-8525 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 8513-8525
    • Maroun, C.R.1    Naujokas, M.A.2    Holgado-Madruga, M.3    Wong, A.J.4    Park, M.5
  • 27
    • 18344385476 scopus 로고    scopus 로고
    • Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome
    • Tartaglia, M. et al. Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Nature Genet. 29, 465-468 (2001).
    • (2001) Nature Genet. , vol.29 , pp. 465-468
    • Tartaglia, M.1
  • 28
    • 0038278866 scopus 로고    scopus 로고
    • Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia
    • Tartaglia, M. et al. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nature Genet. 34, 148-150 (2003).
    • (2003) Nature Genet. , vol.34 , pp. 148-150
    • Tartaglia, M.1
  • 29
    • 12144286410 scopus 로고    scopus 로고
    • Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis
    • Loh, M. L. et al. Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis. Blood 103, 2325-2331 (2004). References 28 and 29 demonstrate gain-of-function mutations in SHP2 in human leukaemias.
    • (2004) Blood , vol.103 , pp. 2325-2331
    • Loh, M.L.1
  • 30
    • 2342429370 scopus 로고    scopus 로고
    • Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation
    • Higashi, H. et al. Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation. J. Biol. Chem. 279, 17205-17216 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 17205-17216
    • Higashi, H.1
  • 31
    • 3042545272 scopus 로고    scopus 로고
    • Conditional gene silencing utilizing the lac repressor reveals a role of SHP-2 in cagA-positive Helicobacter pylori pathogenicity
    • Higuchi, M., Tsutsumi, R., Higashi, H. & Hatakeyama, M. Conditional gene silencing utilizing the lac repressor reveals a role of SHP-2 in cagA-positive Helicobacter pylori pathogenicity. Cancer Sci. 95, 442-447 (2004).
    • (2004) Cancer Sci. , vol.95 , pp. 442-447
    • Higuchi, M.1    Tsutsumi, R.2    Higashi, H.3    Hatakeyama, M.4
  • 32
    • 0037423309 scopus 로고    scopus 로고
    • Attenuation of Helicobacter pylori CagA-SHP-2 signaling by interaction between CagA and C-temninal Src kinase
    • Tsutsumi, R., Higashi, H., Higuchi, M., Okada, M. & Hatakeyama, M. Attenuation of Helicobacter pylori CagA-SHP-2 signaling by interaction between CagA and C-temninal Src kinase. J. Biol. Chem. 278, 3664-3670 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 3664-3670
    • Tsutsumi, R.1    Higashi, H.2    Higuchi, M.3    Okada, M.4    Hatakeyama, M.5
  • 33
    • 0037415684 scopus 로고    scopus 로고
    • The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation
    • Selbach, M. et al. The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation. EMBO J. 22, 515-528 (2003).
    • (2003) EMBO J. , vol.22 , pp. 515-528
    • Selbach, M.1
  • 34
    • 0032803236 scopus 로고    scopus 로고
    • Suppression of Ras-induced apoptosis by the Rac GTPase
    • Joneson, T. & Bar-Sagi, D. Suppression of Ras-induced apoptosis by the Rac GTPase. Mol. Cell. Biol. 19, 5892-5901 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 5892-5901
    • Joneson, T.1    Bar-Sagi, D.2
  • 36
    • 0037439278 scopus 로고    scopus 로고
    • The CagA protein of Helicobacter pylori translocated into epithelial cells and binds to SHP-2 in human gastric mucosa
    • Yamazaki, S. et al. The CagA protein of Helicobacter pylori translocated into epithelial cells and binds to SHP-2 in human gastric mucosa. J. Infect. Dis. 187, 334-337 (2003).
    • (2003) J. Infect. Dis. , vol.187 , pp. 334-337
    • Yamazaki, S.1
  • 37
    • 0030005551 scopus 로고    scopus 로고
    • The risk of stomach cancer in patients with gastric or duodenal ulcer disease
    • Hansson, L. E. et al. The risk of stomach cancer in patients with gastric or duodenal ulcer disease. N. Engl. J. Med. 335, 242-249 (1996).
    • (1996) N. Engl. J. Med. , vol.335 , pp. 242-249
    • Hansson, L.E.1
  • 38
    • 0036605498 scopus 로고    scopus 로고
    • Relation between Helicobacter pylori cagA status and risk of peptic ulcer disease
    • Nomura, A. M., Perez-Perez, G. I., Lee, J., Stemmermann, G. & Blaser, M. J. Relation between Helicobacter pylori cagA status and risk of peptic ulcer disease. Am. J. Epidemiol. 155, 1054-1059 (2002).
    • (2002) Am. J. Epidemiol. , vol.155 , pp. 1054-1059
    • Nomura, A.M.1    Perez-Perez, G.I.2    Lee, J.3    Stemmermann, G.4    Blaser, M.J.5
  • 39
    • 0037622073 scopus 로고    scopus 로고
    • Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms
    • El-Omar, E. M. et al. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology 124, 1193-1201 (2003).
    • (2003) Gastroenterology , vol.124 , pp. 1193-1201
    • El-Omar, E.M.1
  • 40
    • 0037162397 scopus 로고    scopus 로고
    • SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities
    • De Souza, D. et al. SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities. Biochemistry 41, 9229-9236 (2002).
    • (2002) Biochemistry , vol.41 , pp. 9229-9236
    • De Souza, D.1
  • 41
    • 12144291018 scopus 로고    scopus 로고
    • Association between diversity in the Src homology 2 domain-containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer
    • Azuma, T. et al. Association between diversity in the Src homology 2 domain-containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer. J. Infect. Dis. 189, 820-827 (2004).
    • (2004) J. Infect. Dis. , vol.189 , pp. 820-827
    • Azuma, T.1
  • 42
    • 0032815340 scopus 로고    scopus 로고
    • Relationship between the cagA 3′ repeat region of Helicobacter pylori, gastric histology, and susceptibility to low pH
    • Yamaoka Y. et al. Relationship between the cagA 3′ repeat region of Helicobacter pylori, gastric histology, and susceptibility to low pH. Gastroenterology 117, 342-349 (1999).
    • (1999) Gastroenterology , vol.117 , pp. 342-349
    • Yamaoka, Y.1
  • 43
    • 9144249648 scopus 로고    scopus 로고
    • Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130
    • Judd, L. M. et al. Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130. Gastroenterology 126, 196-207 (2004). Reports the development of a mouse model of gastric carcinoma by expressing the interleukin-6 receptor gp130 that lacks the SHP2 binding site.
    • (2004) Gastroenterology , vol.126 , pp. 196-207
    • Judd, L.M.1
  • 44
    • 0036809776 scopus 로고    scopus 로고
    • Grb2 is a key mediator of Helicobacter pylori CagA protein activities
    • Mimuro, H. et al. Grb2 is a key mediator of Helicobacter pylori CagA protein activities. Mol. Cell 10, 745-55 (2002).
    • (2002) Mol. Cell , vol.10 , pp. 745-755
    • Mimuro, H.1
  • 45
    • 0037732638 scopus 로고    scopus 로고
    • Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response
    • Churin, Y. et al. Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response. J. Cell Biol. 161, 249-255 (2003).
    • (2003) J. Cell Biol. , vol.161 , pp. 249-255
    • Churin, Y.1
  • 46
    • 0038780624 scopus 로고    scopus 로고
    • Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA
    • Amieva, M. R. et al. Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA. Science 300, 1430-1434 (2003).
    • (2003) Science , vol.300 , pp. 1430-1434
    • Amieva, M.R.1
  • 47
    • 0034842129 scopus 로고    scopus 로고
    • Enteropathogenic E. Coli Tir binds Nck to initiate actin pedestal formation in host cells
    • Gruenheid, S. et al. Enteropathogenic E. Coli Tir binds Nck to initiate actin pedestal formation in host cells. Nature Cell Biol. 3, 856-859 (2001).
    • (2001) Nature Cell Biol. , vol.3 , pp. 856-859
    • Gruenheid, S.1
  • 48
    • 1542318323 scopus 로고    scopus 로고
    • Helicobacter pylori infection and gastric atrophy: Risk of adenocarcinoma and squamous-cell carcinoma of the esophagus and adenocarcinoma of the gastric cardia
    • Ye, W. et al. Helicobacter pylori infection and gastric atrophy: risk of adenocarcinoma and squamous-cell carcinoma of the esophagus and adenocarcinoma of the gastric cardia. J. Natl Cancer Inst. 96, 388-396 (2004).
    • (2004) J. Natl. Cancer Inst. , vol.96 , pp. 388-396
    • Ye, W.1


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