Immunoglobulin diversity, B-cell and antibody repertoire development in large farm animals

OIE Revue Scientifique et Technique

Volumn 17, Issue 1, 1998, Pages 43-70

  Butler, J E ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

B cells; Cattle; Genetics; Horses; Nomenclature; Passive immunity; Repertoire development; Swine

Indexed keywords

ANIMALIA; BOS TAURUS; BOVIDAE; BOVINAE; EQUIDAE; EQUUS CABALLUS; MAMMALIA; OVIS ARIES; PRIMATES; RODENTIA; SUS SCROFA;

IMMUNOGLOBULIN;

ANIMAL; ANTIBODY PRODUCTION; B LYMPHOCYTE; BIOSYNTHESIS; BOVIDS; CATTLE; CHEMISTRY; CYTOLOGY; DOMESTIC ANIMAL; GENE REARRANGEMENT; GENETIC VARIABILITY; GENETICS; HORSE; IMMUNOLOGY; NOMENCLATURE; PASSIVE IMMUNIZATION; PHYSIOLOGY; REVIEW; SWINE;

ANIMALS; ANIMALS, DOMESTIC; ANTIBODY FORMATION; B-LYMPHOCYTES; CATTLE; GENE REARRANGEMENT, B-LYMPHOCYTE; HORSES; IMMUNITY, MATERNALLY-ACQUIRED; IMMUNOGLOBULINS; RUMINANTS; SWINE; TERMINOLOGY; VARIATION (GENETICS);

EID: 0032038391     PISSN: 02531933     EISSN: None     Source Type: Journal    
DOI: 10.20506/rst.17.1.1096     Document Type: Article

References (167)

1. Allen W.D. & Porter P. (1975). - Localisation of immunoglobulins in intestinal mucosa and the production of secretory antibodies in response to intraluminal administration of bacterial antigens in the preruminant calf. Clin. expl Immunol., 21, 407-418.
2. Appleyard G.D. & Wilkie B.N. (1998). - Porcine CD5 gene and gene product identified on the basis of inter-species conserved cytoplasmic domain sequences. Vet. Immunol. Immunopathol. (in press).
3. Aruffo A., Farrington M., Hollenbaugh D., Li X., Milatovich A., Nonoyama S., Bajorath J., Gromaire L.S., Stenkamp R., Neubauer M., Roberts R.L., Noele R.J., Ledbetter J.A., Francke U. & Ochs H.D. (1993). - The CD40 ligand, gp39, is defective in activated T-cells from patients with x-linked hyper-IgM syndrome. Cell, 72, 291-300.
4. Avrameas S. (1991). - Natural autoantibodies: from horror autotoxicus to gnothis seauton. Immunol. Today, 12, 154.
5. Bastida-Corceura F., Butler J.E. & Corbeil L.B. (1998). - The heterogeneity of bovine IgG2. X. Differential complement activation of bovine IgG2a A1 and A2 allotypes (submitted for publication).
6. Bendelac A. & Fearon D.T. (1997). - Innate pathways that control acquired immunity. Curr. Opin. Immunol., 9, 1-3.
7. Bennell M.A. & Watson D.L. (1979). - Immunological parameters in the intestinal lymph of pigs including changes during experimentally induced diarrhea. Res. vet. Sci., 3, 284-288.
8. H family and long CDR3 in the variable region of cattle Ig heavy chains. Int. Immunol., 9, 198-199.
9. Beyer M., Jentsch W., Schliemann R. & Wittenburg H. (1986). - Milchleistung von Sauen. Tierzucht, 40, 324-326.
10. Blanchi A.T.J., Zwart R.J., Jeurissen S.H.M. & Moonen-Leusen H.W.M. (1992). - Development of the B-and T-cell compartments in porcine lymphoid organs from birth to adult life: an immunohistological approach. Vet. Immunol. Immunopathol., 33, 201-222.
11. Blanchi A.T.J., Butler J.E., Hoorfar J. Howard C. & Lind P. (1996). - Workshop summary: immunoglobulins and Fc receptors. Vet. Immunol. Immunopathol., 54, 24-31.
12. Blakeslee D., Butler J.E. & Stone W.H. (1971). - Serum antigens of cattle. II. Immunogenetics of two immunoglobulin allotypes. J. Immunol., 107, 227-235.
13. Bohl E.H. & Saif L.J. (1975). - Passive immunity in transmissible gastroenteritis of swine: immunoglobulin characteristics of antibodies in milk after inoculating virus by different routes. Infect. Immun., 11, 23-32.
14. Bokhout B.A., van Asten-Noordijk J.J.L. & Stok W. (1986). -Porcine IgG. Isolation of two IgG-subclasses and anti-IgG class-and subclass-specific antibodies. Molec. Immunol., 23, 675-683.
15. Bos N.A., Komura H., Meeuwsen C.G., De Visser H., Hazenberg M.P., Wostman B.S., Pleasants J.R., Benner R. & Marcus D.M. (1989). - Serum immunoglobulin levels and naturally occurring antibodies against carbohydrate antigens in germ-free BALB/c mice fed chemically defined ultrafiltered diet. Eur. J. Immunol., 19, 2335-2339.
16. Bourne F.J. (1969). - IgA immunoglobulin from porcine serum. Biochem. biophys. Res. Commu., 36, 138-145.
17. Bourne F.J. & Curtis J. (1973). - The transfer of immunoglobulins IgG, IgA and IgM from serum to colostrum and milk in the sow. Immunology, 24, 57-162.
18. Bourne F.J., Curtis J. & Wah L.S. (1973). - Urinary immunoglobulins in the adult pig. Immunology, 24, 1-12.
19. Brandon M.R., Watson D.L. & Lascelles A.K. (1971). - The mechanism of transfer of immunoglobulins into mammary secretion of cows. Aust. J. expl Biol med. Sci., 49, 613-623.
20. Brown P.J. & Bourne F.J. (1976). - Development of immunoglobulin-containing cell populations in intestine, spleen and mesenteric lymph node of the young pig as demonstrated by peroxidase-conjugated antiserum. Am. J. vet. Res., 37, 1309-1314.
21. Brown W.R. & Butler J.E. (1994). - Characterisation of the single Cα gene of swine. Molec. Immunol., 31, 633-642.
22. Brown W.R., Kacskovics I., Amendt B., Shinde R., Blackmore N., Rothschild M. & Butler J.E. (1995). - The hinge deletion variant of porcine IgA results from a mutation at the splice acceptor site in the first Cα intron. J. Immunol., 154, 3836-3842.
23. Brown W.R., Rabbani H.H., Butler J.E. & Hammarström L. (1997). - Characterisation of a bovine Cα gene. Immunology, 91, 1-6.
24. Butler J.E. (1969). - Bovine immunoglobulins. J. Dairy Sci., 52, 1895-1909.
25. Butler J.E. (1971). - Physicochemical and immunochemical studies of bovine IgA and glycoprotein a. Biochim. biophys. acta, 251, 435-449.
26. Butler J.E. (1974). - Immunoglobulins of the mammary secretions. In Lactation: a comprehensive treatise, Vol. III (B.L. Larson & V. Smith, eds). Academic Press, New York, 217-255.
27. Butler J.E. (1979). - Immunologic aspects of breast-feeding, anti-infections activity of breast milk. In Human lactation (T.K. Oliver & T.H. Kirschaum, eds). Semin. Perinatol., 3, 255-270.
28. Butler J.E. (1981). - A concept of humoral immunity among ruminants and an approach to its investigation. In The ruminant immune system (J.E. Butler, ed.). Plenum Press, New York, 3-55.
29. Butler J.E. (1983). - Bovine immunoglobulins: an augmented review. Vet. Immunol. Immunopathol., 4, 43-152.
30. Butler J.E. (1985). - Biochemistry and biology of ruminant immunoglobulins. In Progress in veterinary microbiology and immunology (R. Pandey, ed.). S. Karger, Basel, 1-53.
31. Butler J.E. (1995). - Antigen receptors, their immunomodulation and the immunoglobulin genes of cattle and swine. In Immunomodulation (T. Van der Lende, ed.). Livestock Prod. Sci., 42, 105-121.
32. Butler J.E. (1997). - Immunoglobulin gene organization and the mechanism of repertoire development. Scand. J. Immunol., 45, 455-462.
33. Butler J.E. (1998). - Immunoglobulins and immune cells in animal milks. In Mucosal immunology, chapter 97 (P.L. Ogra, J. Mestecky, M.E. Lamm, W. Strober, J.R. McGhee & J. Bienenstock, eds). Academic Press, New York (in press).
34. Butler J.E., Coulson E.J. & Groves M.L. (1968). -Identification of glycoprotein-a as a probably fragment of bovine IgA. Fed. Proc., 27, 617.
35. Butler J.E., Maxwell C.F., Pierce C.S., Hylton M.B., Asofsky R. & Kiddy C.A. (1972). - Studies on the relative synthesis and distribution of IgA and IgG1 in various tissues and body fluids of the cow. J. Immunol., 109, 38-46.
36. Butler J.E., Klobasa F. & Werhahn E. (1981). - The differential localisation of IgA, IgM, and IgG in the gut of suckled neonatal piglets. Vet. Immunol. Immunopathol., 2, 53-65.
37. Butler J.E., Frenyo L.V., Whipp S.C., Wilson R.A. & Koertge T.E. (1986). - The metabolism and transport of bovine serum IgA. Comp. Immunol. Microbiol. infect. Dis., 9, 303-315.
38. Butler J.E. & Heyermann H. (1986). - The heterogeneity of bovine IgG2. I. The A1 allotype is a major determinant recognized by rabbit antibodies to bovine IgG2. Molec. Immunol., 23, 291-296.
39. Butler J.E., Heyermann H., Frenyo V.L. & Kiernan J. (1987). - The heterogeneity of bovine IgG2. II. The identification of IgG2b. Immunol. Lett., 16, 31-38.
40. Butler J.E., Navarro P. & Heyermann H. (1994). - The heterogeneity of bovine IgG2. VI. The comparative specificity of monoclonal and polyclonal capture antibodies for IgG2a (A1) and IgG2a (A2). Vet. Immunol. Immunopathol., 40, 119-133.
41. H and no identifiable IgD. Int. Immunol., 8, 1897-1904.
42. H immunoglobulin genes of swine: implications for repertoire development. Vet. Immunol. Immunopathol., 54, 7-17.
43. Casali P. & Schettino E.W. (1996). - Structure and function of natural antibodies. Curr. Top. Microbiol. Immunol., 210, 167-179.
44. Corbeil L.B., Gogolewski R.P., Kacskovics I., Corbeil R.R. & Butler J.E. (1997). - Bovine IgG2a antibodies to Haemophilus somnus and allotype expression. Can. J. vet. Med., 61, 207-213.
45. - B cells. Immunology, 88, 611-617.
46. H chromosomal region. J. Immunol., 140, 1651-1659.
47. Curtis J. & Bourne F.J. (1971). - Immunoglobulin quantitation in sow serum, colostrum and milk and the serum of young pigs. Biochim. biophys. acta, 236, 319-332.
48. DeBenedictis G., Capalbo P. & Dragone A. (1984). -Identification of an allotype IgA in cattle serum. Comp. Immunol. Microbiol. infect. Dis., 7, 35-42.
49. Delassus S., Darche S., Kourilsky P. & Cumano A. (1997). -Maternal immunoglobulins have no effect on the rate of maturation of the B cell compartment of the offspring. Eur. J. Immunol., 27, 1737-1742.
50. Dighiero G., Lymberi P., Holmberg D., Lundquist I., Coutinho A. & Avrameas S. (1985). - High frequency of natural antibodies in normal newborn mice. J. Immunol., 134, 765-771.
51. Dixon F.J., Weigle W.O. & Vazques J.J. (1961). - Metabolism and mammary secretion of serum proteins in the cow. Lab. Invest., 10, 216-237.
52. H family. J. Immunol., 156, 2163-2170.
53. Duncan J.R., Wilkie B.N., Hiestand F. & Winter A.J. (1972). - The serum and secretory immunoglobulins of cattle: characterisation and quantitation. J. Immunol., 108, 965-976.
54. Engwerda C.R., Sandeman R.A., Stuart S.J. & Sandeman R.M. (1992). - Isolation and sequences of sheep immunoglobulin E heavy chain complementary DNA. Vet. Immunol. Immunopathol., 34, 115-126.
55. Foley R.C. & Beh K.J. (1989). - Isolation and sequence of sheep IgH and L chain cDNA. J. Immunol., 142, 708-711.
56. Ford J.E., Home W.A. & Gibson D.M. (1994). - Light chain isotype regulation in the horse: characterisation of IgK genes. J. Immunol., 153, 1099-1111.
57. Franek F. & Zorina O.M. (1967). - Isolation and characterisation of lambda and kappa-chains representing structural types of pig gamma G-globulin light chains. Collection Czechoslov. Chem. Commun., 32, 3229-3241.
58. Frenyo L.V., Butler J.E. & Guidry A.J. (1986). - The association of extrinsic bovine IgG1, IgG2, SIgA and IgM with the major fractions and cells of milk. Vet. Immunol. Immunopathol., 13, 239-254.
59. Frenyo L.V., Butler J.E., Wilson R.A. & Kavanagh J. (1987). -The transport and metabolism of bovine IgM. Molec. Immunol., 24, 207-219.
60. Frenyo L.V., Zolnai A., Pethes G., Ceren-Ocinin E. & Butler J.E. (1989). - Biliary transport of porcine IgM and IgA. Immunobiology, 4, 76.
61. Gerber H.A., Morris B. & Trevella W. (1986). - The role of gut-associated lymphoid tissues in the generation of immunoglobulin-bearing lymphocytes in sheep. Aust. J. expl Biol. med. Sci., 64, 201-213.
62. Goudswaard J., Virella G., Noordzij A. & Pol J. (1997). -Isolation of equine IgG(T) by hydrophobic interaction chromatography. Immunochemistry, 14, 717-719.
63. Griffiths A.D., Williams S.C., Hartley O., Tomlinson I.M., Waterhouse P., Crosby W.L., Kontermann R.E., Jones P.T., Low N.M., Allison T.J., Prospero T.D., Hogenboom H.R., Nissim A., Cox J.P.L., Harrison J.L., Zaccolo M., Gherardi E. & Winter G. (1994). - Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J., 13, 3245-3260.
64. Groves M.L. & Gordon W.G. (1967). - Isolation of a new glycoprotein-a and a γG-globulin from individual cow milks. Biochemistry, 6, 2388-2394.
65. Guidry A.J., Butler J.E., Pearson R.E. & Weiland B. (1980) -IgA, IgG1, IgG2, IgM and BSA secretion by the bovine mammary gland throughout lactation. Vet. Immunol. Immunopathol., 1, 329-341.
66. Han S., Zheng B., Schatz D.G., Spanopoulou E. & Kelsoe G. (1996). - Neotony in lymphocytes: RAG1 and RAG2 expression in germinal center B cells. Science, 274, 2094-2097.
67. Hardy R.R. & Hayakawa K. (1994). - CD5 B cells are a fetal B cell lineage. Adv. Immunol., 55, 297-339.
68. Hein W.R. & Dudler L. (1993). - Nucleotide sequence of the membrane form of sheep IgM and identification of two Cμ allotypes. Molec. Immunol., 30, 783-784.
69. Helms C.M. & Allen P.Z. (1970). - Studies on equine immunoglobulins. II. Antigenic interrelationships among horse IgG, IgG(T) and anti-pneumococcal component. J. Immunol., 105, 1253-1263.
70. Heyermann H. & Butler J.E. (1987) - The heterogeneity of bovine IgG2. IV. Structural differences between IgG2a bearing the A1 and A2 allotypic determinants. Molec. Immunol., 24, 1327-1334.
71. Heyermann H., Butler J.E. & Frangione B. (1992). - The heterogeneity of bovine IgG2. V. Differences in the primary structure of bovine IgG2 allotypes. Molec. Immunol., 29 (9), 1147-1152.
72. Home W.A., Ford J.E. & Gibson D.M. (1992). - L-chain isotype regulation in horse. I. Characterisation of Ig lambda genes. J. Immunol., 149, 3927-3936.
73. Honkanen-Buzalski T. & Sandholm M. (1981). - Association of bovine secretory immunoglobulins with milk fat globule membranes. Comp. Immunol. Microbiol. infect. Dis., 4, 329-342.
74. Hood L., Gray W.R., Sanders G. & Dryer W.J. (1967). - Light chain evolution: antibodies. Cold Spring Harb. Symp. quant. Biol., 32, 133-146.
75. Husband A.J. & Lascelles A.K. (1975). - Antibody responses in neonatal immunisation in calves. Res. vet. Sci., 18, 201-207.
76. Hussein A.M., Newby T.J. & Bourne F.J. (1983). -Immunohistochemical studies of the local immune system in the reproductive tract of the sow. J. reprod. Immunol., 1, 1-15.
77. Ivanov V., Karginov V., Morozov I. & Gorodetsky S. (1988). - Molecular cloning of a bovine immunoglobulin lambda chain cDNA. Gene, 67, 41-48.
78. Janeway C.P. & Travers P. (1996). - Immunobiology. Garland Press, New York.
79. Jarvis M.R. & Voss E.W. Jr (1984). - Fluorescein in kinetic studies of affinity maturation. In Fluorescein hapten: an immunological probe (E.W. Voss Jr, ed.). CRC Press, Boca Raton, 131-154.
80. Kacskovics I., Sun J. & Butler J.E. (1994). - Five subclasses of swine IgG identified from the cDNA sequences of a single animal. J. Immunol., 153, 3566-3573.
81. Kacskovics I., Wittum T., Littledike T. & Butler J.E. (1995). -The heterogeneity of bovine IgG2. VII. The phenotypic distribution of the A1 and A2 allotypes of IgG2a among beef cows with known clinical history. Vet. Immunol. Immunopathol., 48, 89-96.
82. Kacskovics I. & Butler J.E. (1996). - The heterogeneity of bovine IgG2. VIII. The complete cDNA and deduced amino acid sequence of IgG2a(A) and an IgG1. Molec. Immunol., 33, 189-195.
83. Kaltreider H.B. & Johnson J.S. (1972). - Porcine immunoglobulins I. Identification of classes and preparation of specific antisera. J. Immunol., 109, 992-998.
84. H sequences from B-1a, B-1b and conventional B-cells. J. Immunol., 158, 1175-1186.
85. Karlsson B.W. (1966). - Immunoelectrophoretic studies on relationships between proteins of porcine colostrum, milk and blood serum. Acta pathol. microbiol. scand., 67, 83-101.
86. Kikida M., Mori M. Takai T., Tomochika K., Hamatani K. & Ohmori H. (1996). - Re-expression of RAG1 and RAG2 genes in activated mature mouse B-cells. Science, 274, 2092-2094.
87. Kim Y.B. (1975). - Developmental immunity in the piglets. In Immunodeficiency diseases in man and animals (R.A. Good & J. Finnstad, eds). Sinauer Sunderland, Massachussetts, 549-559.
88. Klobasa F., Werhahn E. & Butler J.E. (1981). - Regulation of humoral immunity in the piglet by immunoglobulins of maternal origin. Res vet. Sci., 31, 195-206.
89. H gene usage and generation of antibody diversity in rabbit. Annu. Rev. Immunol., 10, 593-616.
90. Knight K.L., Suter M. & Becker R.S. (1988). - Genetic engineering of bovine Ig. Construction and characterisation of hapten binding bovine/murine chimeric IgE, IgA, IgG1, IgG2 and IgG3 molecules. J. Immunol., 140, 3654-3659.
91. Knight K.L. & Winstead C.R. (1997). - Generation of antibody diversity in rabbits. Curr. Opin. Immunol., 9, 228-232.
92. Kraj P., Rao S.P., Glas A.M., Hardy R.R., Milner E.C.B. & Silberstein L.E. (1997). - The human heavy chain Ig V-region gene repertoire is biased at all stages of B cell ontogeny, including early pre-B cells. J. Immunol., 158, 5824-5837.
93. Lammers B.M., Beaman K.D. & Kim Y.B. (1991). - Sequence analysis of porcine immunoglobulin light chain cDNAs. Molec. Immunol., 28, 877-880.
94. Lavens G.T., Crago S.S., Kutch W.H. & Mestecky J. (1981). - Hemolytic plaque formation by cellular and non-cellular elements in human colostrum. J. Immunol., 127, 1967-1972.
95. Lefrançois L. & Olson S. (1997). - Reconstitution of the extra thymic intestinal T-cell compartment in the absence of irradiation. J. Immunol., 159, 538-541.
96. Lucier M., Jackson S., Hyun T., Thompson R., Goldsby R. & Osborne B. (1997). - Multiple sites and mechanisms of diversification in the primary antibody repertoire of cattle. J. Allergy clin. Immunol., 99, 5248 (Abstract 1015).
97. Lunn D.P., Holmes M.A., Schram B. & Duffus W.P. (1995). - Monoclonal antibodies specific for equine IgG sub-isotypes including an antibody which recognises B lymphocytes. Vet. Immunol. Immunopathol., 47, 239-251.
98. McGuire T.C. & Poppie M.J. (1973). -Hypogammaglobulinemia and thymic hypoplasia in horses. A primary combined immunodeficiency disorder. Infect. Immun., 8, 272-277.
99. McGuire T.C., Crawford T.B., Hallowell A.L. & Macomber L.E. (1977). - Failure of colostral immunoglobulin transfer as an explanation for most infections and deaths in neonatal foals. J. Am. vet. med. Assoc., 170 (11), 1302-1304.
100. Mach J.P., Pahud J.J. & Isliker H. (1969). - IgA with 'secretory piece' in bovine colostrum and saliva. Nature, 223, 953-954.
101. Mach J.P. & Pahud J.J. (1971). - Secretory IgA, a major immunoglobulin in most bovine external secretions. J. Immunol., 106, 552-563.
102. Mair T.S., Stokes C.R. & Bourne F.J. (1987). - Quantitation of immunoglobulins in respiratory tract secretions of the horse. Vet. Immunol. Immunopathol., 14, 197-203.
103. Medzhitov R. & Janeway C.A. Jr (1997). - Innate immunity: impact on the adaptive immune response. Curr. Opin. Immunol., 9, 4-9.
104. Mehta P.D., Reichlin M. & Tomasi T.B. Jr (1972). -Comparative studies of vertebrate immunoglobulins. J. Immunol., 109, 1272-1281.
105. Melchers F., Haasner D., Grawunder U., Kalberer C., Karasuyama H., Winkler T. & Rolink A.G. (1994). - Roles of IgH and L chains and surrogate H and L chains in the development of cells of the B lymphocyte lineage. Annu. Rev. Immunol., 12, 209-225.
106. Metzger J.J. & Fougereau M. (1967). - Caractérisation de deux sous-classes d'immunoglobulines gamma G chez le porc. C.R. Acad. Sci., Paris, 265, 724-727.
107. Miyasaka M. & Morris B. (1988). - The ontogeny of the lymphoid system and immune responsiveness in sheep. Prog. vet. Microbiol. Immunol., 4, 21-55.
108. Morgan K.L., Hussein A.M., Newby T.J. & Bourne F.J. (1980). - Quantitation and origin of the immunoglobulins in porcine respiratory tract secretions. Immunology, 41, 729-736.
109. Mousavi M., Rabbani H. & Hammarström L. (1998). -Characterisation of the bovine ε gene. Immunology, 92 (in press).
110. Mousavi M., Rabbani H. & Hammarström L. (1998). -Characterisation of the gene for the membrane and secretory form of the IgM heavy chain constant region gene (Cμ) of the cow. Immunology (in press).
111. H domain from naturally occurring camel heavy chain immunoglobulins lacking light chains. Protein Eng., 7, 1129-1135.
112. Naessens J. (1997). - Surface Ig on B lymphocytes from cattle and sheep. Int. Immunol., 9, 349-354.
113. Naessens J., Nelson J., Williams D.J. & Lutje V. (1988). -Identification of isotypes and allotypes of bovine immunoglobulin M with monoclonal antibodies. Immunology, 63, 569-574.
114. + B cells in normal and Trypanosoma coagulase-infected cattle. Eur. J. Immunol., 22, 1713-1718.
115. Navarro P., Barbis D.P., Antczak D. & Butler J.E. (1995). -The complete cDNA and deduced amino acid sequence of equine IgE. Molec. Immunol., 32, 1-8.
116. Newby T.J. & Bourne F.J. (1977). - The nature of the local immune system of the bovine mammary gland. J. Immunol., 118, 461-465.
117. Olsovska Z., Franek F. & Matousek V. (1982). - Limited enzymatic cleavage of pig immunoglobulin G and of specific antibodies. I. Different resistance of various antibody types to cleavage by pepsin. Folia biol. (Prague), 28, 87-97.
118. Osmond D.G. (1991). - Proliferation kinetics and the lifespan of B cells in central and peripheral lymphoid organs. Curr. Opin. Immunol., 3, 179-185.
119. Pahud J.J. & Mach J.P. (1970). - Identification of secretory IgA, free secretory piece and serum IgA in the ovine and caprine species. Immunochemistry, 7, 679-686.
120. Parng C.-L., Hansal S., Goldsby R.A. & Osborne B.A. (1966). - Gene conversion contributes to Ig light chain diversity in cattle. J. Immunol., 157, 5478-5486.
121. H genes. Science, 227, 1597-1601.
122. Porter P. & Allen W.D. (1969). - Immunoglobulin IgA in the urine of conventional and colostrum-deprived hypogammaglobulinemic pig. Immunology, 17, 789.
123. H-mutant rabbits. Proc. natl Acad. Sci. USA, 92, 6961-6965.
124. Press C.M., Hein W.R. & Landsverk T. (1993). - Ontogeny of leucocyte populations in the spleen of fetal lambs with emphasis on the early prominence of B-cells. Immunology, 80, 598-604.
125. 2-microglobulin and bovine-associated mucoprotein (BAMP) in cow's milk. Vet. Immunol. Immunopathol., 9, 143-160.
126. Rabbani H., Hammarström L., Brown W.R. & Butler J.E. (1997). - Genetic polymorphism of bovine IgG3. Immunogenetics, 46, 326-331.
127. Rapacz J. & Hasler-Rapacz J. (1982). - Immunogenetic studies on polymorphism, postnata passive acquisition and development of immunoglobulin gamma (IgG) in swine. Proc. 2nd World Congr. Genet. Appl. Livestock Prod., Vol. VIII, 601-606.
128. Reid R.R., Prodeus A.P., Khan W. Hsu T., Rosen F.S. & Carroll M.C. (1997). - Erdotoxin shock in antibody-deficient mice. J. Immunol., 159, 970-975.
129. Rejnek J., Kostka J. & Travnicek J. (1966). - Studies on the immunoglobulin spectrum of porcine serum and colostrum. Folia microbiol (Prague), 11, 173-178.
130. Reynaud C.A., Anquez V., Grimal H. & Weill J.C. (1987). -A hyperconversion mechanism generates the chicken light chain pre-immune repertoire. Cell, 48, 379-388.
131. Reynaud C.A., McKay C.R., Müller R.G. & Weill J.C. (1991). - Somatic generation of diversity in a mammalian primary lymphoid organ: the sheep ileal Peyer's patches. Cell, 64, 995-1005.
132. Reynaud C.A., Garcia C., Hein W.R. & Weill J.C. (1995). -Hypermutation generating the sheep immunoglobulin repertoire in an antigen-independent process. Cell, 80, 115-125.
133. Reynolds J.D. (1986). - Evidence of extensive lymphocyte death in sheep Peyer's patches. I. A comparison of lymphocyte production and export. J. Immunol., 136, 2005-2010.
134. Reynolds J.D. & Morris B. (1984). - The effect of antigen en the development of Peyer's patches in sheep. Eur. J. Immunol., 14, 1-6.
135. Rockey J.H., Montgomery P.C. & Dorrington K.J. (1970). -Equine anti-hapten antibody. Studies on the primary structure and conformation of equine immunoglobulins. Biochemistry, 9, 4310-4321.
136. Roux M.E., McWilliams M., Phillips-Quagliata J.M., Weisz-Carrington P. & Lamm M.E. (1977). - Origin of IgA-secreting plasma cells in the mammary gland. J. expl Med., 146, 1311-1322.
137. Ruffilli A. & Baglioni C. (1970). - Species comparison of the antigenic determinants of the variable region of light chain immunoglobulins. J. Immunol., 104, 1247-1255.
138. H family, related to mammalian group 1/Clan II, is identified in cattle. Molec. Immunol., 34, 641-651.
139. Salami M.A., Simpson-Morgan M.W. & Morris B. (1985). -Haemopoiesis ard the development of immunological reactivity in sheep foetus. In Immunology of the sheep (B. Morris & M. Miyasaka, eds). Hoffmann-LaRoche, Basel, 19-36.
140. Schrenzel M.D., King D.P., McKnight M.L. & Ferrick D.A. (1997). - Characterisation of horse (Equus caballus) immunoglobulin mμ chain-encoding genes. Immunogenetics, 45, 386-393.
141. Schroeder H.W. Jr, Haillson J.L. & Permutter R.M. (1987). -Early restriction of the human antibody repertoire. Science, 238, 791-793.
142. Sheldrake R.F., Husband A.J., Watson D.L. & Cripps A.W. (1984). - Selective transport of serum-derived IgA in mucosal secretions. J. Immunol., 132, 363-368.
143. Shin E.K., Perryman L.E. & Meek K. (1997). - A kinase-negative mutation of DNA-PKcs in equine SCID results in defective coding and signal joint formation. J. Immunol., 158 (8), 3565-3569.
144. H family-specific interactions with human immunoglobulins. J. Immunol., 157, 4496-4502.
145. Silverstein A.M., Uhr J.W., Kraner K.L. & Kukes R.J. (1963). - Fetal response to antigenic stimulus. II. Antibody production by the fetal lamb. J. expl Med., 117, 799-812.
146. Sinclair M.C., Gilchrist J. & Aitken R. (1995). - Molecular characterisation of bovine Vλ regions. J. Immunol., 155, 3068-3078.
147. Sinclair A.G., Shaw J.M., Edwards S.A., Hoste S. & McCartney A. (1996). - The effect of dietary protein level on milk yield and composition, and piglet growth and composition of Meishan synthetic and European White breeds of sow. In Abstracts 47th Meeting of the European Association for Animal Production (J.A.M. Arendonk, ed.), 25-29 August, Lillehammer, Norway, 262.
148. H gene family. J. Immunol., 159, 3883-3889.
149. Sullivan A.L., Prendergast R.A., Antunes L.J., Silverstein A.M. & Tomasi T.B. Jr (1969). - Characterisation of the serum and secretory immune systems of the cow and sheep. J. Immunol., 103, 334-344.
150. HIII. J. Immunol., 153, 5618-5627.
151. Sun J. & Butler J.E. (1996). - Molecular characterisation of VDJ transcripts from a newborn piglet. Immunology, 88, 331-339.
152. Sun J. & Butler J.E. (1997). - Sequence analysis of swine switch μ, Cμ and Cμm. Immunogenetics, 46, 452-460.
153. H usage during 84 days of fetal life (submitted for publication).
154. Symons D.B.A. & Clarkson C.A. (1980). - Isoelectric heterogeneity of immunoglobulins secreted by LPS-activated neonatal and adult lymphocytes in vitro. Immunology, 41, 875-881.
155. Symons D.B.A., Clarkson C.A. & Beal D. (1989). - Structure of bovine immunoglobulin constant region heavy chain gamma 1 and gamma 2 genes. Molec. Immunol., 26, 841-850.
156. Thompson C.B. & Neiman P.E. (1987). - Somatic diversification of the chicken immunoglobulin light chain is limited to the rearranged variable gene segment. Cell, 48, 369-378.
157. Trebichavsky I., Thaskalova H., Curkrowska B., Splichal I., Sinkora J., Rehakova Z., Sinkova M., Pospisil R., Kovaru F., Charley B., Binns R. & White A. (1996). - Early ontogeny of immune cells and their functions in the fetal pig. Vet. Immunol. Immunopathol., 54, 75-81.
158. Trnka Z. & Morris B. (1985). - The physiological and anatomical complexity of the lymphoid system. In Immunology of the sheep (B. Morris & M. Miyasaka, eds). Hoffmann-LaRoche, Basel, 1-36.
159. Vaerman J.-P. (1970). - Studies on IgA immunoglobulins in man and animals. Thesis, University of Louvain, Sintal-Louvain, Belgium, 292 pp.
160. Van Zaane D. & Hulst M.M. (1987). - Monoclonal antibodies against porcine immunoglobulin isotypes. Vet. Immunol. Immunopathol., 16, 23-36.
161. Wagner B., Siebenkotten G., Leibold W. & Radbruch A. (1998). - Organisation of the equine immunoglobulin constant heavy chain genes. I. Cε and Cα genes. Vet. Immunol. Immunopathol. (in press).
162. Weill J.C. & Reynaud C.A. (1995). - Generation of diversity by post-rearrangement diversification mechanism: the chicken and sheep antibody repertoires. In Immunoglobulin genes (T. Honjo & F.W. Alt, eds). Academic Press, New York, 267-288.
163. Widders P.R., Stokes C.R. & Bourne F.J. (1986). -Investigation of the antigenic relationship between equine IgG and IgG(T). Vet. Immunol. Immunopathol., 13, 255-259.
164. Widders P.R., Stokes C.R., David J.S. & Bourne F.J. (1984). - Quantitation of the immunoglobulins in reproductive tract secretions of the mare. Res. vet. Sci., 37, 324-330.
165. Wiler R., Leber R., Moore B.B., Van Dyk L.F., Perryman L.E. & Meek K. (1995). - Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity. Proc. natl Acad. Sci. USA, 92, 11485-11489.
166. H gene segments in pre-B-cell lines. Nature (London), 31, 727-733.
167. Yother J., Forman C., Gray O. & Briles D. (1982). -Protection of mice from infection with Streptococcus pneumoniae by anti-phosphocholine antibody. Inject. Immun., 36, 184-188.