Bovine leukocyte adhesion deficiency (BLAD): A review

Journal of Veterinary Medical Science

Volumn 66, Issue 12, 2004, Pages 1475-1482

  Nagahata, Hajime ^a  

^a RAKUNO GAKUEN UNIVERSITY   (Japan)

Author keywords

2 integrin; Adhesion deficiency; BLAD; Genetic defect; Holstein

Indexed keywords

BACTERIA (MICROORGANISMS); BOS TAURUS; BOVINAE;

CD18 ANTIGEN; INTEGRIN;

ANIMAL; ANIMAL DISEASE; CATTLE; CATTLE DISEASE; COMPARATIVE STUDY; GENETICS; GENOTYPE; LEUKOCYTE; LEUKOCYTE ADHESION DEFICIENCY; METABOLISM; MISSENSE MUTATION; NEUTROPHIL; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; REVIEW;

ANIMALS; ANTIGENS, CD18; CATTLE; CATTLE DISEASES; GENOTYPE; INTEGRINS; LEUKOCYTE-ADHESION DEFICIENCY SYNDROME; LEUKOCYTES; MUTATION, MISSENSE; NEUTROPHILS; PHENOTYPE;

EID: 14944366020     PISSN: 09167250     EISSN: None     Source Type: Journal    
DOI: 10.1292/jvms.66.1475     Document Type: Review

References (75)

1. Ackermann, M. R., Kehrli, M. E. Jr. and Morfitt, D. C. 1993. Ventral dermatitis and vasculitis in a calf with bovine leukocyte adhesion deficiency. J. Am. Vet. Med. Assoc. 202: 413-415.
2. 2- integrins in bovine neutrophils by scanning electron microscopy in the backscatter mode and transmission electron microscopy. Vet. Pathol. 30: 296-298.
3. Ackermann, M. R., Kehrli, M. E. Jr., Laufter, J. A. and Nusz, L. T. 1996. Alimentary and respiratory tract lesions in eight medically fragile Holstein cattle with bovine leukocyte adhesion deficiency (BLAD). Vet. Pathol. 33: 273-281.
4. Ackermann, M. R., Kehrli, M. E. Jr. and Brogden, K. A. 1996. Passage of CD18- and CD18+ bovine neutrophils into pulmonary alveoli during acute Pasteurella haemolytica pneumonia. Vet. Pathol. 33: 639-646.
5. Agerholm, J. S., Houe, H., Jorgensen, C. B. and Basse, A. 1993. Bovine leukocyte adhesion deficiency in Danish Holstein-Friesian cattle. II. Patho-anatomical description of affected calves. Acta Vet. Scand. 34: 237-243.
6. Agerholm, J. S., Bendixen, C., Andersen, O. and Ambjerg, J. 2001. Complex vertebral malformation in Holstein calves. J. Vet. Diagn. Invest. 13: 283-289.
7. Anderson, D. C., Miller, L. J., Schmalstieg, F. C., Rothlein, R. and Springer, T. A. 1986. Contributions of the Mac-1 glycoprotein family to adherence-dependent granulocyte functions: Structure function assessments employing subunit specific monoclonal antibodies. J. Immunol. 137: 15-27.
8. Anderson, D. C. and Springer, T. A. 1987. Leukocyte adhesion deficiency: An inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins. Ann. Rev. Med. 38: 175-194.
9. Andrews, A. H., Fishwick, J. and Waters, R. J. 1996. Bovine leukocyte adhesion deficiency (BLAD) in a one year old Holstein Friesian bull- The first report in the United Kingdom. Br. Vet. J. 152: 347-351.
10. Arrayet, J. L., Oberbauer, A. M., Famula, T. R., Garrett, I., Oltjen, J. W., Imhoof, J., Kehrli, M. E. Jr. and Graham, T. W. 2002. Growth of Holstein calves from birth to 90 days: the influence of dietary zinc and BLAD status. J. Anim. Sci. 80: 545-552.
11. Bernadina, W. E., Duits, A. J., Kalsbeek, H. C., Wensing, Th., Leibold, W., Elving, L. and Wentink, G. H. 1993. Leukocyte adhesion deficiency in a Dutch Holstein calf: A case with a clear-cut family history. Vet. Immunol. Immunopathol. 37: 295-308.
12. 2 integrins on blood leukocytes of cows with or without bovine leukocyte adhesion deficiency. Vet. Immunol. Immunopathol. 58: 249-263.
13. Fesus, L., Zsolnai, A., Anton, I., Barany, I. and Bozo, S. 1999. BLAD genotypes and cow production traits in Hungarian Holsteins. J. Anim. Breed. Genet. 116: 169-174.
14. Fischer, A., Descamps-Latscha, B., Scheinmetzler, C., Virelizier, J. L., Trung, P. H., Lisowska-Grospierre, B., Perez, N., Durandy, A. and Griscelli, C. 1983. Bone-marrow transplantation for inborn error of phagocytic cells associated with defective adherence, chemotaxis, and oxidative response during opsonised particle phagocytosis. Lancet 2: 473-476.
15. Gilbert, R. O., Rebhun, W. C., Kim, C. A., Kehrli, M. E. Jr., Shuster, D. E. and Ackermann, M. R. 1993. Clinical manifestations of leukocyte adhesion deficiency in cattle: 14 cases (1977-1991). J. Am. Vet. Med. Assoc. 202: 445-449.
16. Gourreau, J. M., Massen, L. V. and Braque, R. 1998. Cas clinique. Trois cas cliniques de BLAD. Point Vet. 29: 357-358.
17. Hagemoser, W. A., Roth, J. A., Lofstedt, J. and Fagerland, J. A. 1983. Granulocytopathy in a Holstein heifer. J. Am. Vet. Med. Assoc. 183: 1093-1094.
18. Huang, Y. C., Lin, D. Y., Tseng, C. Y., Chang, H. L., Huang, Y. C., Lin, D. Y., Tseng, C. Y. and Chang, H. L. 2001. Comparison of milk production and quality of BLAD-carrier and normal Holstein-Friesian cows in Taiwan. J. Taiwan Livestock Res. 34: 271-278.
19. Hynes, R. O. 1987. Integrins: A family of cell surface receptors. Cell 48: 549-554.
20. Jorgensen, Agerholm, J. S., Pedersen, J. and Thomsen, P. D. 1993. Bovine leukocyte adhesion deficiency in Danish Holstein-Friesian cattle. I. PCR screening and allele frequency estimation. Acta Vet. Scand. 34: 231-236.
21. Kehrli, M. E. Jr., Schmalstieg, F. C., Anderson, D. C., Van Der Maaten, M. J., Hughes, B. J., Ackermann, M. R., Wilhelmsen, C. L., Brown, G. B., Stevens, M. G. and Whetstone, C. A. 1990. Molecular definition of the bovine granulocytopathy syndrome: Identification of deficiency of the Mac-1 (CD11b/ CD18) glycoprotein. Am. J. Vet. Res. 51: 1826-1836.
22. 2 integrin deficiency in young Holstein cattle. Am. J. Pathol. 140: 1489-1492.
23. Kishimoto, T. K., Larson, R. S., Corbi, A. L., Dustin, M. L., Staunton, D. E. and Springer, T. A. 1989. The leukocyte integrins. Adv. Immunol. 46: 149-182.
24. Kriegesmann, B., Jansen, S., Baumgartner, B. G. and Brenig, B. 1997. Partial genomic structure of the bovine CD18 gene and the refinement of test for bovine leukocyte adhesion deficiency. J. Dairy Sci. 80: 2547-2549.
25. Kuwabara, M., Nishimura, Y., Sato, F., Takahashi, T., Tajima, M., Takahashi, K. and Nagahata, H. 1993. Spin-trapping and chemiluminescence studies of neutrophils from a Holstein-Friesian calf with bovine leukocyte adhesion deficiency. Free Rad. Res. Comms. 18: 309-318.
26. Larson, R. S. and Springer, T. A. 1990. Structure and function of leukocyte integrins. Immunol. Rev. 114: 181-217.
27. Malech, H. L. 1987. Current concepts. Immunology: neutrophils in human diseases. New Engl. J. Med. 317: 687-694.
28. Meylan, M., Abegg, R., Sager, H., Jungi, T. W. and Martig, J. 1997. Case report: bovine leukocyte adhesion deficiency (BLAD) syndrome in Switzerland. Schweiz. Arch. Tierheilkd. 139: 277-281.
29. Mueller, K. E., Bernadina, W. E., Kalsbeek, H. C., Hoek, A., Rutten, V. P. M. G. and Wentink, G. H. 1994. Bovine leukocyte adhesion deficiency- Clinical course and laboratory findings in eight affected animals. Vet. Quart. 16: 65-71.
30. Mueller, K. E., Rutten, V. P. M. G., Becker, C. K., Hoek, A., Bernadina, W. E., Wentink, G. H. and Figdor, C. G. 1995. Allograft rejection in cattle with bovine leukocyte adhesion deficiency. Vet. Immunol. Immunopathol. 48: 55-63.
31. Mueller, K. E., Hoek, A., Rutten, V. P. M. G., Bernandina, W. E. and Wentink, G. H. 1997. Antigen-specific immune responses in cattle with inherited beta 2-integrin deficiency. Vet. Immunol. Immunopathol. 58: 39-53.
32. Nagahata, H., Noda, H., Takahashi, K., Kurosawa, T. and Sonoda, M. 1987a. Bovine granulocytopathy syndrome: Neutrophil dysfunction in Holstein Friesian calves. J. Vet. Med. A34: 445-451.
33. Nagahata, H., Noda, H., Takahashi, K., Kurosawa, T. and Sonoda, M. 1987b. A suspected case of neutrophil dysfunction in a Holstein heifer. Jpn. J. Vet. Sci. 49: 1165-1167.
34. Nagahata, H., Nochi, H., Tamoto, K., Taniyama, H., Noda, H., Morita, M., Kanamaki, M. and Kociba, G. J. 1993. Bovine leukocyte adhesion deficiency in Holstein cattle. Can. J. Vet. Res. 57: 255-261.
35. Nagahata, H., Kehrli, M. E. Jr., Murata, H., Okada, H., Noda, H. and Kociba, G. J. 1994. Neutrophil function and pathologic findings in Holstein calves with leukocyte adhesion deficiency. Am. J. Vet. Res. 55: 40-48.
36. Nagahata, H., Tanaka, S., Oba, M., Minami, S. and Noda, H. 1994. Serum biochemical changes and chemiluminescent responses of whole blood in Holstein cattle with leukocyte adhesion deficiency. J. Vet. Med. Sci. 657-660.
37. Nagahata, H., Hatakeyama, K., Izumisawa, Y., Noda, H., Nochi, H. and Tamoto, K. 1994. Two cases of Holstein calves with bovine leukocyte adhesion deficiency (BLAD)(case Report). Dtsch. Tieraerztl. Wochenschr. 101: 53-56.
38. Nagahata, H., Nochi, H., Sanada, H., Tamoto, K., Noda, H. and Kociba, G. J. 1994. Analysis of mononuclear cell functions in Holstein cattle with leukocyte adhesion deficiency. Am. J. Vet. Res. 55: 1101-1106.
39. Nagahata, H., Nochi, H., Tamoto, K., Noda, H. and Kociba, G. J. 1995. Expression and role of adhesion molecule CD18 on bovine neutrophils. Can. J. Vet. Res. 59: 1-7.
40. Nagahata, H., Nochi, H., Tamoto, K., Yamashita, K., Noda, H. and Kociba, G. J. 1995. Characterization of functions of neutrophils from bone marrow of cattle with leukocyte adhesion deficiency. Am. J. Vet. Res. 56: 167-171.
41. Nagahata, H., Taniyama, H., Izumisawa, Y., Kotani, T., Noda, H. and Kociba, G. J. 1995. Radiographic and immunohistochemical analysis of leukocyte adhesion deficiency in Holstein heifers. Can. J. Vet. Res. 59: 316-318.
42. Nagahata, H., Higuchi, H., Nochi, H., Tamoto, K., Noda, H. and Kociba, G. J. 1995. Enhanced expression of Fc receptors on neutrophils from calves with leukocyte adhesion deficiency. Microbiol. Immunol. 39: 703-708.
43. 2- deficient bovine mononuclear phagocytes. Microbiol. Immunol. 40: 389-395.
44. 2- integrin-deficient bovine neutrophils. Microbiol. Immunol. 40: 783-786.
45. 2- integrin, intracellular calcium signaling and functional responses of normal and CD18-deficient bovine neutrophils. Res. Vet. Sci. 61: 95-101.
46. Nagahata, H., Miura, T., Tagaki, K., Ohtake, M., Noda, H., Yasuda, T. and Nioka, K. 1997. Prevalence and allele frequency estimation of bovine leukocyte adhesion deficiency (BLAD) in Holstein-Friesian cattle in Japan. J. Vet. Med. Sci. 59: 233-238.
47. 2 integrin-deficient bovine neutrophils. Microbiol. Immunol. 41: 747-750.
48. Nagahata, H., Masuyama, A., Masue, M., Higuchi, H., Ohtuka, H., Kurosawa, T., Sato, H. and Noda, H. 1997. Leukocyte emigration in normal calves and calves with leukocyte adhesion deficiency. J. Vet. Med. Sci. 59: 1143-1147.
49. Nagahata, H., Matsuki, S., Higuchi,H., Inanami, O., Kuwabara, M. and Kobayashi, K. 1998. Bone marrow transplantation in a Holstein heifer with bovine leucocyte adhesion deficiency. Vet. J. 156: 15-21.
50. Nagahata, H., Sakurai, N., Matsuki, S., Miura, T., Nioka, K. and Kociba, G. J. 1998. Survival of transfused CD18- positive granulocytes and their chemiluminescent response in a heifer with leukocyte adhesion deficiency. J. Vet. Med. Sci. 60: 261-262.
51. Nagahata, H., Higuchi, H., Yamashiki. N. and Yamaguchi, M. 2000. Analysis of the functional characteristics of L-selectin and its expression on normal and CD18-deficient bovine neutrophils. Immunol. Cell Biol. 78: 264-271.
52. Nagahata, H., Hagiwara, K., Higuchi, H., Kirisawa, R. and Iwai, H. 2002. Analysis of serum cytokine profile in a Holstein heifer with leukocyte adhesion deficiency which survived for long period. J. Vet. Med. Sci. 64: 683-687.
53. 2-integrin-deficient bovine neutrophils. Immunol. Cell Biol. 82: 32-37.
54. Natonek, M. 2000. Identification of BLAD mutation in cattle with PCR-RFLP method. Biul. Inf. Inst. Zootech. 38: 29-33.
55. Nielsen, J. S., Jorgensen, C. B. and Thomsen, P. D. 1992. Bovine leukocyte adhesion syndrome. A new hereditary disease in the danish Holstein-Friesian breed. Dan. Veterinaertidsskr. 75: 276-277.
56. Olchowy, T. W. J., Bochsler, P. N., Neilsen, N. R., Welborn, M. G. and Slauson, D. O. 1994. Bovine leukocyte adhesion deficiency: In vitro assessment of neutrophil function and leukocyte integrin expression. Can. J. Vet. Res. 58: 127-133.
57. Olchowy, T. W. J., Bochsler, P. N. and Welborn, M. G. 1994. Clinicopathological findings in a Holstein calf with peripheral leukocytosis and leukocyte adhesion deficiency. Can. Vet. J. 35: 242-243.
58. Poli, M. A., Dewey, R., Semorile, L., Lozano, M. E., Albarino, C. G., Romanowski, V. and Grau, O. 1996. PCR screening for carriers of bovine leukocyte adhesion deficiency (BLAD) and uridine monophosphate synthase (DUMPS) in Argentine Holstein cattle. J. Vet. Med. A 43: 163-168.
59. Powell, R. L., Norman, H. D. and Cowan, C. M. 1996. Relationship of bovine leukocyte adhesion deficiency with genetic merit for performance traits. J. Dairy Sci. 79: 895-899.
60. 2- integrins using peripheral blood leucocytes of normal and bovine leucocyte adhesion deficient (BLAD) cattle. Vet. Immunol. Immunopathol. 52: 341-345.
61. Schilcher, F., Hotter, H., Tammen, I. and Schuh, M. 1995. Bovine leukocyte adhesion deficiency among Holstein-Friesian cattle in Austria. Wien. Tieraerztl. Monschr. 82: 207-212.
62. Shuster, D. E., Bosworth, B. T. and Kehrli, M. E. Jr. 1992. Sequence of bovine CD18 cDNA: comparison with human and murine sequences. Gene 114: 267-271.
63. Shuster, D. E., Kehrli, M. E. Jr., Ackermann, M. R. and Gilbert, R. O. 1992. Identification and prevalence of a genetic defect that causes leukocyte adhesion deficiency in Holstein cattle. Proc. Natl. Acad. Sci. U.S.A. 89: 9225-9229.
64. Simon, M., Dusinsky, R., Horovska, L., Tomaskova, J., Vasicek, D., Chrenek, P. and Bulla, J. 2000. Neutrophil immune functions of BLAD heterozygous animals. Vet. Med. (Prague) 45: 337-341.
65. Sipes, K. M., Edens, H. A., Kehrli, M. E. Jr., Miettinen, H. M., cutler, J. E., Jutila, M. A. and Quinn, M. T. 1999. Analysis of surface antigen expression and host defense function in leukocytes from calves heterozygous or homozygous for bovine leukocyte adhesion deficiency. Am. J. Vet. Res. 60: 1255-1261.
66. Springer, T. A., Thompson, W. S., Miller, L. J., Schmalstieg, F. C. and Anderson, D. C. 1984. Inherited deficiency of the Mac-1, LFA-1, p150,95 glycoprotein family and its molecular basis. J. Exp. Med. 160: 1901-1918.
67. Springer, T. A. 1990. Adhesion receptors of the immune system. Nature (Lond.) 346: 425-434.
68. Stoeber, M., Kuczka, A. and Pohlenz, J. 1991. Bovine Leukozyten- Adhaesions-Defizienz (BLAD=Hagemoser-Takahashi-Syndrom): Klinische, pathologisch-anatomische undhistologische Befunde. Dtsch. Tieraertl. Wschr. 98: 441-476.
69. Tajima, M., Irie, M., Kirisawa, R., Hagiwara, K., Kurosawa, T. and Takahashi, K. 1993. The detection of a mutation of CD18 gene in bovine leukocyte adhesion deficiency (BLAD). J. Vet. Med. Sci. 55: 145-146.
70. Takahashi, K., Miyagawa, K., Abe, S., Kurosawa, T., Sonoda, M., Nakade, T., Nagahata, H., Noda, H., Chihaya, Y. and Isogai, E. 1987. Bovine granulocytopathy syndrome of Holstein Friesian calves and heifers. Jpn. J. Vet. Sci. 49: 733-736.
71. Tammen, I., Klippert, H., Kuczka, A., Treviranus, A., Stoeber, M., Simon, D. and Harlizius, B. 1996. An improved DNA test for bovine leucocyte adhesion deficiency. Res. Vet. Sci. 60: 218-221.
72. Taniyama, H., Yamamoto, S., Sako, T., Hirayama, K., Higuchi, H. and Nagahata, H. 2000. Systemic kAL amyloidosis associated with bovine leukocyte adhesion deficiency. Vet. Pathol. 37: 98-100.
73. Van Garderen, Mueller, K. E., Wentink, G. H. and Van den Ingh, T. S. G. A. M. 1994. Post-mortem findings in calves suffering from bovine leukocyte adhesion deficiency (BLAD). Vet. Quart. 16: 24-26.
74. Wanner, J. M., Rogers, G. W., Kehrli, M. E. and Cooper, J. B. 1998. Intramammary infections in primiparous Holsteins: Heritabilities and comparisons of bovine leukocyte adhesion deficiency and noncarriers. J. Dairy Sci. 81: 3293-3299.
75. Worku, M., Paape, M. J., Carlo, A. D., Kehrli, M. E. Jr. and Marquardt, W. W. 1995. Complement component C3b and immunoglobulin Fc receptors on neutrophils from calves with leukocyte adhesion deficiency. Am. J. Vet. Res. 56: 435-439.