Intestinal microflora and diversification of the rabbit antibody repertoire

Journal of Immunology

Volumn 165, Issue 4, 2000, Pages 2012-2019

  Lanning, D ^a   Sethupathi, P ^a   Rhee, K J ^a   Zhai, S K ^a   Knight, K L ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ARTICLE; GENE REARRANGEMENT; INTESTINE FLORA; INTESTINE LYMPHATIC TISSUE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RABBIT;

EID: 0034663923     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.4.2012     Document Type: Article

References (55)

1. Partial molecular genetic map of the rabbit V(H) chromosomal region
2. Restricted V(H) gene usage and generation of antibody diversity in rabbit
3. Neonatal V(H), D, and J(H) gene usage in rabbit B lineage cells
4. Somatic diversification of immunoglobulin heavy chain VDJ genes: Evidence for somatic gene conversion in rabbits
5. Somatic hypermutation: Mutations 3' of rabbit VDJ H-chain genes
6. VDJ genes in V(H)a2 allotype-suppressed rabbits: Limited germline V(H) gene usage and accumulation of somatic mutations in D regions
7. Rabbit IgH sequences in appendix germinal centers: V(H) diversification by gene conversion-like and hypermutation mechanisms
8. Production of an antibody deficiency syndrome in rabbits by neonatal removal of organized intestinal lymphoid tissues
9. Dependence of antibody somatic diversification on gut-associated lymphoid tissue in rabbits
10. Experimental arrest and induction of lymphoid development in intestinal lymphoepitherlial tissues of rabbits
11. Development of the lymphoid tissue in the rabbit appendix isolated from the intestinal tract
12. Development of lymphatic tissues in germfree and conventionally reared rabbits
13. Immunoglobulin-producing cells in lymphatic tissues of germfree and conventional rabbits as detected by an immuno-fluorescence method
14. Development of antibody formation in germ-free and conventionally reared rabbits: The role of intestinal lymphoid tissue in antibody formation to E. coli antigens
15. A single rearrangement event generates most of the chicken immunoglobulin light chain diversity
16. A hyperconversion mechanism generates the chicken light chain preimmune repertoire
17. Somatic hyperconversion diversifies the single V(H) gene of the chicken with a high incidence in the D region
18. Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment
19. Gene conversion contributes to Ig light chain diversity in cattle
20. Multiple sites of Vλ diversification in cattle
21. Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process
22. Somatic generating of diversity in a mammalian primary lymphoid organ: The sheep ileal Peyer's patches
23. Antibody repertoire development in fetal and neonatal piglets I. Four V(H) genes account for 80 percent of V(H) usage during 84 days of fetal life
24. Evidence for limited B-lymphopoiesis in adult rabbits
25. Rearing of germfree rabbits
26. Mitomycin C-induced colitis in rats: A new animal model of acute colonic inflammation implicating reactive oxygen species
27. First strand cDNA synthesis primed with oligo(dT)
28. B lymphocyte selection and age-related changes in V(H) gene usage in mutant Alicia rabbits
29. Evolutionary conservation in various mammalian species of the human proliferation-associated epitope recognized by the Ki-67 monoclonal antibody
30. Sulfation-dependent recognition of high endothelial venules (HEV)- ligands by L-selectin and MECA-79, an adhesion-blocking monoclonal antibody
31. Function and evolutionary conservation of distinct epitopes on the leukocyte adhesion molecule-1 (TQ-1, Leu-8) that regulate leukocyte migration
32. Co-localization of vimentin and cytokeratins in M-cells of rabbit gut- associated lymphoid tissue (GALT)
33. Differential binding of lectins to M cells and enterocytes in the rabbit cecum
34. Chimeric-transgenic mice represent a powerful tool for studying how the proliferation and differentiation programs of intestinal epithelial cell lineages are regulated
35. In vitro induction of the expression of multiple IgA isotype genes in rabbit B cells by TGF-β and IL-2
36. Changes in the digestive microflora of holoxenic rabbits from birth until adulthood
37. Lymphatic tissue of the intestinal tract of germfree and conventional rabbits
38. B-cell superantigens may play a role in B-cell development and selection in the young rabbit appendix
39. Human IgM molecules that bind staphylococcal protein A contain V(H)III H chains
40. Immunoglobulin V(H)3 gene products: Natural ligands for HIV gp120
41. Phylogenetic perspectives in innate immunity
42. The Toll-receptor family and control of innate immunity
43. Innate immunity: Impact on the adaptive immune response
44. RP105 is associated with MD-1 and transmits an activation signal in human B cells
45. Themolecular mechanism of B cell activation by toll-like receptor protein RP-105
46. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components
47. Creating and maintaining the gastrointestinal ecosystem: What we know and need to know from gnotobiology
48. Effects of microbial contamination on the cecum enlargement of germ- free rats
49. Differential cell kinetics in the ileum and colon of germ-free rats
50. Intestinal microflora stimulates myoelectric activity of rat intestinal wall by promoting cyclic initiation and aboral propagation of migrating myoelectric complexes
51. Effect of some biologically active amines on the cecum wall of germ- free rats
52. Paneth cell differentiation in the developing intestine of normal and transgenic mice
53. A model of host-microbial interactions in an open mammalian ecosystem
54. Segmented filamentous bacteria are indigenous intestinal bacteria that activate intraepithelial lymphocytes and induce MHC class II molecules and fucosyl asialo GM1 glycolipids on the small intestinal epithelial cells in the ex-germ-free mouse
55. Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut