Does base composition help predispose the complementarity-determining regions of antibodies to hypermutation?

Molecular Immunology

Volumn 34, Issue 11, 1997, Pages 765-770

  Padlan, Eduardo A A ^a,b  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Base pair mismatches; Base usage bias; Somatic hypermutation

Indexed keywords

ANTIGEN SPECIFICITY; ARTICLE; BASE PAIRING; COMPLEMENTARITY DETERMINING REGION; GENE MUTATION; GENE REARRANGEMENT; GENE TARGETING; HUMAN; PRIORITY JOURNAL; SOMATIC MUTATION;

ANTIBODIES; BASE COMPOSITION; DNA, COMPLEMENTARY; HUMANS; IMMUNOGLOBULIN CONSTANT REGIONS; IMMUNOGLOBULIN VARIABLE REGION; MUTATION;

EID: 0031469982     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(97)00074-6     Document Type: Article

References (36)

1. Berek C. and Milstein C. (1988) The dynamic nature of the antibody repertoire. Immun. Rev. 105, 5-26.
2. Betz A. G., Neuberger M. S. and Milstein C. (1993) Discriminating intrinsic and antigen-selected mutational hot-spots in immunoglobulin V genes. Immun. Today 14, 405-411.
3. Betz A. G., Milstein C., Gonzalez-Fernandez A., Pannell R., Larson T. and Neuberger M. S. (1994) Elements regulating somatic hypermutation of an immunoglobulin κ gene: critical role for the intron enhancer/matrix attachment region. Cell 77, 239-248.
4. Breslauer K. J., Frank R., Bloecker H. and Marky L. A. (1986) Predicting DNA duplex stability from the base sequence. Proc. natn. Acad. Sci. U.S.A. 83, 3746-3750.
5. H genes are inherently susceptible to amino acid replacement. Immun. Today 15, 367-373.
6. H locus completed by analysis of the telomeric region of chromosome 14q. Nature Genet. 7, 162-168.
7. κ segments reveals a strong bias in their usage. Eur. J. Immun. 24, 827-836.
8. Doerner T., Brezinschek H.-P., Brezinschek R. I., Foster S. J., Domiati-Saad R. and Lipsky P. E. (1997) Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes. J. Immun. 158, 2779-2789.
9. Golding G. B., Gearhart P. J. and Glickman B. W. (1987) Patterns of somatic mutations in immunoglobulin variable genes. Genetics 115, 169-176.
10. Gonzalez-Fernandez A., Gupta S. K., Pannell R., Neuberger M. S. and Milstein C. (1994) Somatic mutation of immunoglobulin λ chains: a segment of the major intron hypermutates as much as the complementary-determining regions. Proc. natn. Acad. Sci. U.S.A. 91, 12614-12618.
11. Goyenechea B. and Milstein C. (1996) Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation. Proc. natn. Acad. Sci. U.S.A. 93, 13979-13984.
12. Jolly C. J., Wagner S. D., Rada C., Klix N., Milstein C., Neuberger M. S. (1996) Sem. Immun. 8, 159-168.
13. Kabat E. A., Wu T. T., Perry H. M., Gottesman K. S. and Foeller C. (1991) Sequences of Proteins of Immunological Interest, 5th Edition, U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health (NIH Publication No. 91-3242).
14. Kolchanov N. A., Solovyov V. V. and Rogozin I. B. (1987) Pecularities of immunoglobulin gene structures as a basis for somatic mutation emergence. FEBS Lett. 214, 87-91.
15. Kowalski D., Natale D. A. and Eddy M. J. (1988) Stable DNA unwinding, not "breathing", accounts for single-strand-specific nuclease hypersensitivity of specific A + T-rich sequences. Proc. natn. Acad. Sci. U.S.A. 85, 9464-9468.
16. Kuchino Y., Mori F., Kasai H., Inoue H., Iwai S., Miura K., Ohtsuka E. and Nishimura S. (1987) Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues. Nature 327, 77-79.
17. Kudritskaya Z. G. and Danilov V. I. (1976) Quantum mechanical study of bases interactions in various associates in atomic dipole approximation. J. theor. Biol. 59, 303-318.
18. McKean D., Huppi K., Bell M., Staudt L., Gerhard W. and Weigert M. (1984) Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. Proc. natn. Acad. Sci. U.S.A. 81, 3180-3194
19. Milstein C. and Neuberger M. S. (1996) Maturation of the immune response. Adv. Prot. Chem. 49, 451-485.
20. Mortari F., Newton J. A., Wang J. Y., Schroeder H. W. Jr. (1992) The human cord blood antibody repertoire. Frequent usage of the VH7 gene family. Eur. J. Immun. 22, 241-245.
21. Natale D. A., Schubert A. E. and Kowalski D. (1992) DNA helical stability accounts for mutational defects in a yeast replication origin. Proc. natn. Acad. Sci. U.S.A. 89, 2654-2658.
22. Peters A. and Storb U. (1996) Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity 4, 57-65.
23. Reynaud C.-A., Garcia C., Hein W. R. and Weill J.-C. (1995) Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process. Cell 80, 115-125.
24. Rogozin I. B. and Kolchanov N. A. (1992) Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis. Biochim. Biophys. Acta 1171, 11-18.
25. Rogozin I. B., Solovyov V. V. and Kolchanov N. A. (1991) Somatic hypermutagenesis in immunoglobulin genes. I. Correlation between somatic mutations and repeats. Somatic mutation properties and clonal selection. Biochim. Biophys. Acta 1089, 175-182.
26. Selsing E. and Storb U. (1981) Somatic mutation of immunoglobulin light-chain variable-region genes. Cell 25, 47-58.
27. κ and occurs on passenger transgenes. EMBO J. 10, 2139-2145
28. Steele E. J. (1991) Somatic Hypermutation in V-Regions. CRC Press, Boca Raton, FL.
29. Storb U., Peters A., Klotz E., Rogerson B. and Hackett J. Jr. (1996) The mechanism of somatic hypermutation studied with transgenic and transfected target genes. Sem. Immun. 8, 131-140.
30. Wagner S. D., Milstein C. and Neuberger M. S. (1995) Codon bias targets mutations. Nature 376, 732.
31. Wagner S. D., Elvin J. G., Norris P., McGregor J. M. and Neuberger M. S. (1996) Somatic hypermutation of Ig genes in patients with veroderma pigmentosum (XP-D). Int. Immun. 8, 701-705.
32. Weber J. S., Berry J., Litwin S. and Claflin J. L. (1991) Somatic hypermutation of the JC intron is markedly reduced in unrearranged κ and H alleles and is unevenly distributed in rearranged alleles. J. Immun. 146, 3218-3226.
33. Weigert M. G., Cesari I. M., Yonkovich S. J. and Cohn M. (1970) Variability in the lambda light chain sequences of mouse antibody. Nature 228, 1045-1047.
34. Weiss U., Zoebelein R. and Rajewsky K. (1992) Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell-dependent antigen. Eur. J. Immun. 22, 511-517.
35. λ repertoire. J. molec. Biol. 264, 220-232.
36. Yelamos J., Klix N., Goyenechea B., Lozano F., Chui Y. L., Gonzalez Fernandez A., Pannell R., Neuberger M. S. and Milstein C. (1995) Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. Nature 376, 225-229.