Are high-affinity progesterone binding site(s) from porcine liver microsomes members of the σ receptor family?

European Journal of Pharmacology

Volumn 347, Issue 2-3, 1998, Pages 293-299

  Meyer, Christiane ^a   Schmieding, Kerstin ^a   Falkenstein, Elisabeth ^b   Wehling, Martin ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

receptor; Membrane receptor; Microsome, pig, liver; Progesterone

Indexed keywords

1,3 BIS(2 METHYLPHENYL)GUANIDINE; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; AMPHETAMINE DERIVATIVE; DOPAMINE RECEPTOR; EMOPAMIL; HALOPERIDOL; IFENPRODIL; N ALLYLNORMETAZOCINE; PENTAZOCINE; PENTOXYVERINE; PHENYTOIN; PRECLAMOL; PROGESTERONE; RADIOLIGAND; RIMCAZOLE; SIGMA OPIATE RECEPTOR; SIGMA RECEPTOR LIGAND;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; LIGAND BINDING; LIVER MEMBRANE; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; SWINE;

ANIMALS; BINDING, COMPETITIVE; BUTACLAMOL; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; INTRACELLULAR MEMBRANES; LIGANDS; MICROSOMES, LIVER; PROGESTERONE; RECEPTORS, DOPAMINE; RECEPTORS, SIGMA; SWINE; TRITIUM;

EID: 0032562487     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00103-4     Document Type: Article

References (29)

1. Bradford M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye-binding. Anal. Biochem. 72:1976;248-254.
2. Brodgen R.N., Speight T.M., Avery G.S. Pentazocine: a review of its pharmacological properties, therapeutics efficacy and dependence liability. Drug. 5:1973;6-91.
3. 1 receptors. Eur. J. Pharmacol. 266:1994;131-138.
4. 50) of an enzymatic reaction. Biochem. Pharmacol. 22:1973;3099-3108.
5. Falkenstein E., Meyer C., Eisen C., Scriba P.C., Wehling M. Full-length cDNA sequence of a progesterone membrane binding protein from porcine vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 229:1996;86-89.
6. Glennon R.A., Battaglia G., Smith J.D. (-)PPAP: A new selective ligand for sigma binding sites. Pharmacol. Biochem. Behav. 37:1990;557-559.
7. 2+ antagonist binding protein. J. Biol. Chem. 270:1995;7551-7557.
8. 1-binding site. Proc. Natl. Acad. Sci. USA. 93:1996;8072-8077.
9. Itzhak Y. Pharmacological specificity of some psychotomimetic and antipsychotic agents for the σ and PCP binding sites. Life Sci. 42:1988;745-752.
10. 125I)Iodoazidococaine, a photoaffinity label for the haloperidol-sensitive sigma receptor. Proc. Natl. Acad. Sci. USA. 89:1992;1393-1397.
11. 3H]phenyl)guanidine. Proc. Natl. Acad. Sci. USA. 85:1988;2844-2848.
12. 3H]3-(3-Hydroxyphenyl)-N-(1-propyl)-piperidine binding to sigma receptors in mouse brain in vivo. Eur. J. Pharmacol. 161:1989;263-266.
13. Martin W.R., Eades C.G., Thompson J.A., Huppler R.E., Gilbert P.E. The effects of morphine- and nalorphine-like drugs in the non-dependent and morphine-dependent chronic spinal dog. J. Pharmacol. Exp. Ther. 197:1976;517-532.
14. Meyer C., Christ M., Wehling M. Characterization and solubilization of novel aldosterone-binding-proteins in porcine liver microsomes. Eur. J. Biochem. 229:1995;736-740.
15. Meyer C., Schmid R., Scriba P.C., Wehling M. Purification and partial sequencing of a putative progesterone-receptor from porcine liver membranes. Eur. J. Biochem. 239:1996;726-731.
16. Meyer, C., Schmid, R., Schmieding, K., Falkenstein, E., Wehling, M., 1998. Characterization of high affinity progesterone-membrane binding proteins by an anti-peptide antiserum. Steroids, in press.
17. 1 binding site by photoaffinity labeling and ligand-directed antibodies. Mol. Pharmacol. 44:1993;966-971.
18. 2+ antagonist binding protein from guineas pig liver endoplasmic reticulum. J. Biol. Chem. 269:1994;29314-29320.
19. Quirion R., Bowen W.D., Itzhak Y., Junien J.L., Musacchio J.M., Rothman R.B., Su T.-P., Tam S.W., Taylor D.P. A proposal for the classification of sigma binding sites. Trends Pharmacol. Sci. 13:1992;85-86.
20. Schuster D.I., Ehrlich G.K., Murphy R.B. Purification and partial amino acid sequence of a 28-kDa cyclophilin-like component of the rat liver sigma receptor. Life Sci. 55:1994;151-156.
21. Schuster D.I., Arnold F.J., Murphy R.B. Purification, pharmacological characterization and photoaffinity labeling of sigma receptors from rat and bovine brain. Brain Res. 670:1995;14-28.
22. Sonders M.S., Keana F.W., Weber E. Phencyclidine and psychotomimetic sigma opiates: recent insights into their biochemical and physiological site of action. Trends Neurosci. 11:1988;37-40.
23. Su T.-P. σ Receptors - putative links between nervous, endocrine and immune systems. Eur. J. Biochem. 200:1991;633-642.
24. Su T.-P. Delineating biochemical and functional properties of sigma receptors: emerging concepts. Crit. Rev. Neurobiol. 7:1993;187-203.
25. Walker J.M., Bowen W.D., Walker F.O., Matsumoto R.R., de Costa B., Rice K. Sigma receptors: biology and function. Pharmacol. Rev. 42:1990;355-402.
26. 3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs. Proc. Natl. Acad. Sci. USA. 83:1986;8784-8788.
27. Wehling M. Looking beyond the dogma of genomic steroid action: insights and facts of the 90s. J. Mol. Med. 73:1995;439-447.
28. Wehling M. Specific, nongenomic actions of steroid hormones. Annu. Rev. Physiol. 59:1997;365-393.
29. Yamada M., Nishigami T., Nakasho K., Nishimoto Y., Miyaji H. Relationship between sigma-like site and progesterone-binding site of adult male rat liver microsomes. Hepatology. 20:1994;1271-1280.