CD8+ suppressor T cells resurrected

Human Immunology

Volumn 69, Issue 11, 2008, Pages 715-720

  Kapp, Judith A ^a   Bucy, R Pat ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Bystander suppression; Foxp3; Linked suppression; Regulatory T cells; Suppressor T cells; Transplantation

Indexed keywords

T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ANTIGEN PRESENTING CELL; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL LINEAGE; CYTOKINE PRODUCTION; GRAFT REJECTION; HUMAN; IMMUNOMODULATION; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SUPPRESSOR CELL; THYMUS;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTE SUBSETS; TRANSFORMING GROWTH FACTOR BETA;

EID: 57649101657     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2008.07.018     Document Type: Article

References (86)

1. Wells G.H. Studies on the chemistry of anaphylaxis. (III). Experiments with isolated proteins, especially those of the hen's egg. J Infect Dis 9 (1911) 147-171
2. Gershon R.K., and Kondo K. Infectious immunological tolerance. Immunol 21 (1971) 903-914
3. Gershon R.K., Cohen P., Hencin R., and Liebhaber S.A. Suppressor T cells. J Immunol 108 (1972) 586-590
4. Cantor H., Shen F.W., and Boyse E.A. Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses. J Exp Med 143 (1976) 1391-1409
5. Jandinski J., Cantor H., Tadakuma T., Peavy D.L., and Pierce C.W. Separation of helper T cells from suppressor T cells expressing different Ly components. I. Polyclonal activation: suppressor and helper activities are inherent properties of distinct T-cell subclasses. J Exp Med 143 (1976) 1382-1390
6. Kapp J.A., Pierce C.W., Schlossman S., and Benacerraf B. Genetic control of immune responses in vitro. V. Stimulation of suppressor T cells in nonresponder mice by the terpolymer L-glutamic acid 60-L-alanine 30-L-tyrosine 10 (GAT). J Exp Med 140 (1974) 648-659
7. Jensen P.E., Pierce C.W., and Kapp J.A. Regulatory mechanisms in immune responses to heterologous insulins. II. Suppressor T cell activation associated with nonresponsiveness in H-2b mice. J Exp Med 160 (1984) 1012-1016
8. Whiteley P.J., Jensen P.E., Pierce C.W., Abruzzini A.F., and Kapp J.A. Helper T-cell clones that recognize autologous insulin are stimulated in nonresponder mice by pork insulin. Proc Natl Acad Sci USA 85 (1988) 2723-2727
9. Whiteley P.J., Poindexter N.J., Landon C., and Kapp J.A. A peripheral mechanism preserves self-tolerance to a secreted protein in transgenic mice. J Immunol 145 (1990) 1376-1381
10. Dorf M.E., and Benacerraf B. Suppressor cells and immunoregulation. Ann Rev Immunol 2 (1984) 127-158
11. Herzenberg L.A., Tokuhisa T., and Hayakawa K. Epitope-specific regulation. Annu Rev Immunol 1 (1983) 609-632
12. Steinmetz M., Minard K., Horvath S., McNicholas J., Srelinger J., Wake C., et al. A molecular map of the immune response region from the major histocompatibility complex of the mouse. Nature 300 (1982) 35-42
13. Kronenberg M., Steinmetz M., Kobori J., Kraig E., Kapp J.A., Pierce C.W., et al. RNA transcripts for I-J polypeptides are apparently not encoded between the I-A and I-E subregions of the murine major histocompatibility complex. Proc Natl Acad Sci USA 80 (1983) 5704-5708
14. Nishizuka Y., and Sakakura T. Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice. Science 166 (1969) 753-755
15. Taguchi O., and Nishizuka Y. Autoimmune oophoritis in thymectomized mice: T cell requirement in adoptive cell transfer. Clin Exp Immunol 42 (1980) 324-331
16. Smith H., Sakamoto Y., Kasai K., and Tung K.S.K. Effector and regulatory cells in autoimmune oophoritis elicited by neonatal thymectomy. J Immunol 147 (1991) 2928-2933
17. Samy E.T., Setiady Y.Y., Ohno K., Pramoonjago P., Sharp C., and Tung K.S. The role of physiological self-antigen in the acquisition and maintenance of regulatory T-cell function. Immunol Rev 212 (2006) 170-184
18. Seddon B., and Mason D. Peripheral autoantigen induces regulatory T cells that prevent autoimmunity. J Exp Med 189 (1999) 877-882
19. + regulatory T cells. Blood 107 (2006) 1056-1062
20. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., and Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155 (1995) 1151-1164
21. Schubert L.A., Jeffery E., Zhang Y., Ramsdell F., and Ziegler S.F. Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J Biol Chem 276 (2001) 37672-37679
22. + T regulatory cells. Nat Immunol 4 (2003) 337-342
23. Brunkow M.E., Jeffery E.W., Hjerrild K.A., Paeper B., Clark L.B., Yasayko S.A., et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 27 (2001) 68-73
24. + regulatory T cells. Nat Immunol 4 (2003) 330-336
25. Fontenot J.D., Rasmussen J.P., Williams L.M., Dooley J.L., Farr A.G., and Rudensky A.Y. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22 (2005) 329-341
26. Wan Y.Y., and Flavell R.A. Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc Natl Acad Sci USA 102 (2005) 5126-5131
27. Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441 (2006) 235-238
28. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J Exp Med 198 (2003) 1875-1886
29. - precursors. Am J Transplant 4 (2004) 1614-1627
30. +CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen. J Immunol 167 (2001) 188-195
31. Zhang X., Izikson L., Liu L., and Weiner H.L. Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration. J Immunol 167 (2001) 4245-4253
32. - precursors. J Immunol 169 (2002) 4183-4189
33. + regulatory T-cell selection. Immunol Rev 212 (2006) 74-85
34. Floess S., Freyer J., Siewert C., Baron U., Olek S., Polansky J., et al. Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol 5 (2007) e38
35. Polansky J.K., Kretschmer K., Freyer J., Floess S., Garbe A., Baron U., et al. DNA methylation controls Foxp3 gene expression. Eur J Immunol 38 (2008) 1654-1663
36. + T cell responses. J Immunol 179 (2007) 2105-2114
37. Holan V., and Mitchison N.A. Haplotype-specific suppressor T cells mediating linked suppression of immune responses elicited by third-party H-2 alloantigens. Eur J Immunol 13 (1983) 652-657
38. Bucy R.P. Alloantigen-specific suppressor T cells are not inhibited by cyclosporin A, but do require IL 2 for activation. J Immunol 137 (1986) 809-813
39. Wise M.P., Bemelman F., Cobbold S.P., and Waldmann H. Linked suppression of skin graft rejection can operate through indirect recognition. J Immunol 161 (1998) 5813-5816
40. + regulatory T cell function in alloimmunity. J Immunol 176 (2006) 329-334
41. + regulatory T cells from nonobese diabetic mice. J Immunol 175 (2005) 3053-3059
42. + T-helper and a T-killer cell. Nature 393 (1998) 474-478
43. Tang Q., Adams J.Y., Tooley A.J., Bi M., Fife B.T., Serra P., et al. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol 7 (2006) 83-92
44. Wilbanks G.A., Mammolenti M., and Streilein J.W. Studies on the induction of anterior chamber-associated immune deviation (ACAID). III. Induction of ACAID depends upon intraocular transforming growth factor-β. Eur J Immunol 22 (1992) 165-173
45. + T cells. J Immunol 155 (1995) 609-618
46. Ciubotariu R., Vasilescu R., Ho E., Cinti P., Cancedda C., Poli L., et al. Detection of T suppressor cells in patients with organ allografts. Hum Immunol 62 (2001) 15-20
47. +. Int Immunol 10 (1998) 775-783
48. Hogquist K.A., Jameson S.C., Heath W.R., Howard J.L., Bevan M.J., and Carbone F.R. T cell receptor antagonist peptides induce positive selection. Cell 76 (1994) 17-27
49. Ehst B.D., Ingulli E., and Jenkins M.K. Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection. Am J Transplant 3 (2003) 1355-1362
50. + TCR transgenic T cells alone can reject vascularized heart transplants via the indirect pathway of alloantigen recognition. Transplantation 77 (2004) 452-455
51. Honjo K., Xu X.Y., Kapp J.A., and Bucy R.P. Evidence for cooperativity in the rejection of cardiac grafts mediated by CD4 TCR Tg T cells specific for a defined allopeptide. Am J Transplant 4 (2004) 1762-1768
52. + T cells activated in the presence of TGFb express FoxP3 and mediate linked suppression of primary immune responses and cardiac allograft rejection. Int Immunol 18 (2006) 1549-1562
53. Xystrakis E., Dejean A.S., Bernard I., Druet P., Liblau R., Gonzalez-Dunia D., et al. Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation. Blood 104 (2004) 3294-3301
54. + T cells similar to those found in mice with anterior chamber-associated immune deviation. Invest Ophthalmol Vis Sci 41 (2000) 1803-1811
55. + regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells. Eur J Immunol 30 (2000) 1538-1543
56. + regulatory T-cell-mediated suppression. Immunol 118 (2006) 240-249
57. + T suppressor cells mediate tolerance to allogeneic heart transplants, inducing PIR-B in APC and rendering the graft invulnerable to rejection. Transpl Immunol 13 (2004) 239-247
58. Suciu-Foca N., Manavalan J.S., Scotto L., Kim-Schulze S., Galluzzo S., Naiyer A.J., et al. Molecular characterization of allospecific T suppressor and tolerogenic dendritic cells: review. Int Immunopharmacol 5 (2005) 7-11
59. Nakamura K., Kitani A., and Strober W. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor β. J Exp Med 194 (2001) 629-644
60. + regulatory T cell activity in both humans and mice. J Immunol 172 (2004) 834-842
61. Roncarolo M.G., Bacchetta R., Bordignon C., Narula S., and Levings M.K. Type 1 T regulatory cells. Immunol Rev 182 (2001) 68-79
62. Waldmann H., Graca L., Cobbold S., Adams E., Tone M., and Tone Y. Regulatory T cells and organ transplantation. Semin Immunol 16 (2004) 119-126
63. Akl A., Luo S., and Wood K.J. Induction of transplantation tolerance-the potential of regulatory T cells. Transpl Immunol 14 (2005) 225-230
64. + Tregs. J Clin Invest 115 (2005) 2904-2913
65. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 10 (1998) 1969-1980
66. + immunoregulatory T cells is antigen nonspecific. J Immunol 164 (2000) 183-190
67. LaFaille J.J., Nagashima K., Katsuki M., and Tonegawa S. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell 78 (1994) 399-408
68. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 162 (1999) 5317-5326
69. Zhou P., Borojevic R., Streutker C., Snider D., Liang H., and Croitoru K. Expression of dual TCR on DO11.10 T cells allows for ovalbumin-induced oral tolerance to prevent T cell-mediated colitis directed against unrelated enteric bacterial antigens. J Immunol 172 (2004) 1515-1523
70. + T suppressor cells mediate tolerance to allogeneic heart transplants, inducing PIR-B in APC and rendering the graft invulnerable to rejection. Transpl Immunol 13 (2004) 239-247
71. Jankowska-Gan E., Rhein T., Haynes L.D., Geissler F., Mulder A., Kalayoglu M., et al. Human liver allograft acceptance and the "tolerance assay". II. Donor HLA-A, -B but not DR antigens are able to trigger regulation of DTH. Hum Immunol 63 (2002) 862-870
72. Mellor A.L., Baban B., Chandler P., Marshall B., Jhaver K., Hansen A., et al. Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion. J Immunol 171 (2003) 1652-1655
73. Manavalan J.S., Rossi P.C., Vlad G., Piazza F., Yarilina A., Cortesini R., et al. High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells. Transpl Immunol 11 (2003) 245-258
74. + regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants. J Immunol 172 (2004) 6003-6010
75. Csencsits K., Wood S.C., Lu G., and Bishop D.K. Transforming growth factor-beta1 gene transfer is associated with the development of regulatory cells. Am J Transplant 5 (2005) 2378-2384
76. + regulatory T cells in normal and tumor-bearing mice. Int Immunopharmacol 4 (2004) 1785-1793
77. + regulatory cells, restores self-tolerance, and facilitates regeneration of β cell function in overtly diabetic nonobese diabetic mice. Transplantation 79 (2005) 1091-1096
78. + regulatory T cells. J Immunol 174 (2005) 6993-7005
79. Honjo K., Xu X.Y., Kapp J.A., and Bucy R.P. Activation and migration of allo-peptide specific TCR transgenic T cells in cardiac allograft rejection. Cell Immunol 230 (2004) 44-55
80. Huehn J., and Hamann A. Homing to suppress: address codes for Treg migration. Trends Immunol 26 (2005) 632-636
81. + regulatory T cells control Leishmania major persistence and immunity. Nature 420 (2002) 502-507
82. + suppressor T cells. Eur J Immunol 33 (2003) 1488-1496
83. Asseman C., Mauze S., Leach M.W., Coffman R.L., and Powrie F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 190 (1999) 995-1004
84. + T cells. J Immunol 173 (2004) 6526-6531
85. Velasquez-Lopera M.M., Eaton V.L., Lerret N.M., Correa L.A., Decresce R.P., Garcia L.F., et al. Induction of transplantation tolerance by allogeneic donor-derived CD4(+)CD25(+)Foxp3(+) regulatory T cells. Transpl Immunol 19 (2008) 127-135
86. Chen M.L., Pittet M.J., Gorelik L., Flavell R.A., Weissleder R., von Boehmer H., et al. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci USA 102 (2005) 419-424