Physiologic self antigens rapidly capacitate autoimmune disease-specific polyclonal CD4+CD25+ regulatory T cells

Blood

Volumn 107, Issue 3, 2006, Pages 1056-1062

  Setiady, Yulius Y ^b   Ohno, Katsuhiro ^b   Samy, Eileen T ^b   Bagavant, Harini ^b   Qiao, Hui ^b   Sharp, Colin ^b   Jin, Xiong She ^b   Tung, Kenneth S K ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

PROSTATE ANTIGEN; SEX HORMONE;

ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; BIRTH; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; FEMALE; IMMUNOSTIMULATION; MALE; MOUSE; NEWBORN; NONHUMAN; OVARY DISEASE; PRIORITY JOURNAL; PROSTATITIS; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; TIME SERIES ANALYSIS;

EID: 31544460662     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2005-08-3088     Document Type: Article

References (34)

1. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of selftolerance causes various autoimmune diseases. J Immunol. 1995;155:1151-1164.
2. + regulatory T cells. Nat Immunol. 2003;4:330-336.
3. + regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2004;101:15434-15439.
4. Asano M, Toda M, Sakaguchi N, Sakaguchi S. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med. 1996;184:387-396.
5. Alard P, Thompson C, Agersborg SS, et al. Endogenous oocyte antigens are required for rapid induction and progression of autoimmune ovarian disease following day-3 thymectomy. J Immunol. 2001;166:4363-4369.
6. + T cell receptors. Immunity. 2004;21:267-277.
7. + regulatory T cells. J Immunol. 2003;171:5678-5682.
8. + regulatory T cells in the steady state. J Exp Med. 2003;198:737-746.
9. + regulatory T cells in vivo. J Exp Med. 2003;198:249-258.
10. + regulatory T cells by antigen-processing dendritic cells. J Exp Med. 2003;198:235-247.
11. Setoguchi R, Hori S, Takahashi T, Sakaguchi S. Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med. 2005;201:723-735.
12. Taguchi O, Nishizuka Y. Self tolerance and localized autoimmunity. Mouse models of autoimmune disease that suggest tissue-specific suppressor T cells are involved in self tolerance. J Exp Med. 1987;165:146-156.
13. Taguchi O, Kontani K, Ikeda H, et al. Tissue-specific suppressor T cells involved in self-tolerance are activated extrathymically by self-antigens. Immunology. 1994;82:365-369.
14. Seddon B, Mason D. Peripheral autoantigen induces regulatory T cells that prevent autoimmunity. J Exp Med. 1999;189:877-882.
15. Smith H, Sakamoto Y, Kasai K, Tung KS. Effector and regulatory cells in autoimmune oophoritis elicited by neonatal thymectomy. J Immunol. 1991;147:2928-2933.
16. Bluestone JA, Abbas AK. Natural versus adaptive regulatory T cells. Nat Rev Immunol. 2003;3:253-257.
17. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol. 2004;22:531-562.
18. Tong ZB, Gold L, Pfeifer KE, et al. Mater, a maternal effect gene required for early embryonic development in mice. Nat Genet. 2000;26:267-268.
19. Mandal A, Naaby-Hansen S, Wolkowicz MJ, et al. FSP95, a testis-specific 95-kilodalton fibrous sheath antigen that undergoes tyrosine phosphorylation in capacitated human spermatozoa. Biol Reprod. 1999;61:1184-1197.
20. Ho KC, Quarmby VE, French FS, Wilson EM. Molecular cloning of rat prostate transglutaminase complementary DNA. The major androgen-regulated protein DP1 of rat dorsal prostate and coagulating gland. J Biol Chem. 1992;267:12660-12667.
21. Grant FJ, Taylor DA, Sheppard PO, et al. Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library. Biochem Biophys Res Commun. 1994;203:1117-1123.
22. Gentile V, Saydak M, Chiocca EA, et al. Isolation and characterization of cDNA clones to mouse macrophage and human endothelial cell tissue transglutaminases. J Biol Chem. 1991;266:478-483.
23. Pitkanen J, Vahamurto P, Krohn K, Peterson P. Subcellular localization of the autoimmune regulator protein. characterization of nuclear targeting and transcriptional activation domain. J Biol Chem. 2001;276:19597-19602.
24. Pitkanen J, Peterson P. Autoimmune regulator: from loss of function to autoimmunity. Genes Immun. 2003;4:12-21.
25. Villasenor J, Benoist C, Mathis D. AIRE and APECED: molecular insights into an autoimmune disease. Immunol Rev. 2005;204:156-164.
26. Anderson MS, Venanzi ES, Klein L, et al. Projection of an immunological self shadow within the thymus by the aire protein. Science. 2002;298:1395-1401.
27. Kyprianou N, Isaacs JT. Quantal relationship between prostatic dihydrotestosterone and prostatic cell content: critical threshold concept. Prostate. 1987;11:41-50.
28. + regulatory T cells induced by an agonist self-peptide. Nat Immunol. 2001;2:301-306.
29. Roden AC, Moser MT, Tri SD, et al. Augmentation of T cell levels and responses induced by androgen deprivation. J Immunol. 2004;173:6098-6108.
30. Tong ZB, Nelson LM. A mouse gene encoding an oocyte antigen associated with autoimmune premature ovarian failure. Endocrinology. 1999;140:3720-3726.
31. + regulatory T cells in the regional lymph node. J Exp Med. 2005;202:771-781.
32. + T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J Exp Med. 2004;199:1467-1477.
33. + regulatory T cells. J Exp Med. 2004;199:303-313.
34. - regulatory T cells. Proc Natl Acad Sci U S A. 2002;99:13031-13036.