Differential post-transcriptional regulation of two Ink4 proteins, p18 Ink4c and p19Ink4d

Cell Cycle

Volumn 7, Issue 23, 2008, Pages 3737-3746

  Forget, Antoine ^a   Ayrault, Olivier ^a   Den Besten, Willem ^a   Kuo, Mei Ling ^a   Sherr, Charles J ^a   Roussel, Martine F ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b Mail Stop #350   (United States)

Author keywords

Cdk4; Cdk6; Cyclin D1; Ink4 genes; p18Ink4c; p19Ink4d; Ubiquitin proteasome pathway

Indexed keywords

CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 2C; CYCLIN DEPENDENT KINASE INHIBITOR 2D;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CATALYSIS; CELL CYCLE; CELL CYCLE PROGRESSION; CELL DIVISION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN PROCESSING; PROTEIN STABILITY; UBIQUITINATION;

EID: 57349192791     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.7.23.7187     Document Type: Article

References (56)

1. 1 cyclin-dependent kinases. Genes Dev 1995; 9:1149-63.
2. 1-phase progression. Genes Dev 1999; 13:1501-12.
3. Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature 1996; 382:325-31.
4. Pavletich NP. Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and cip and INK4 inhibitors. J Mol Biol 1999; 287:821-8.
5. Kip1 are directly regulated by oncogenic tyrosine kinases. Cell 2007; 128:269-80.
6. Chu I, Sun J, Arnaout A, Kahn H, Hanna W, Narod S, Sun P, Tan CK, Hengst L, Slingerland J. p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2. Cell 2007; 128:281-94.
7. INK4a/CDKN2A tumor suppressor and its relatives. Biochim Biophys Acta 1998; 1378:115-77.
8. INK4a. Nature 1998; 395:237-43.
9. INK4 mutations. Nat Struct Mol Biol 1998; 5:74-81.
10. Jeffrey PD, Tong L, Pavletich NP. Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors. Genes Dev 2000; 14:3115-25.
11. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993; 366:704-7.
12. INK4B is a potential effector of TGFβ-induced cell cycle arrest. Nature 1994; 371:257-61.
13. INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev 1994; 8:2939-52.
14. Hirai H, Roussel MF, Kato JY, Ashmun RA, Sherr CJ. Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol Cell Biol 1995; 15:2672-81.
15. ink4. Mol Cell Biol 1995; 15:2682-6.
16. INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene 1997; 15:203-11.
17. Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L, Sharpless NE. Ink4a/Arf expression is a biomarker of aging. J Clin Invest 2004; 114:1299-307.
18. Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, Cheng T, DePinho RA, Sharpless NE, Scadden DT. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 2006; 443:421-6.
19. INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 2006; 443:448-52.
20. INK4a induces an age-dependent decline in islet regenerative potential. Nature 2006; 443:453-7.
21. Lowe SW, Cepero E, Evan G. Intrinsic tumour suppression. Nature 2004; 432:307-15.
22. Ink4a. Nature 2007; 448:943-6.
23. Zindy F, Soares H, Herzog KH, Morgan J, Sherr CJ, Roussel MF. Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development. Cell Growth Differ 1997; 8:1139-50.
24. Kip1 mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. Genes Dev 1998; 12:2899-911.
25. Zindy F, Cunningham JJ, Sherr CJ, Jogal S, Smeyne RJ, Roussel MF. Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases. Proc Natl Acad Sci USA 1999; 96:13462-7.
26. INK4c cell cycle inhibitors in proliferation and tumorigenesis. EMBO J 2000; 19:3496-506.
27. Ink4d. Mol Cell Biol 2001; 21:3244-55.
28. Chen P, Zindy F, Abdala C, Liu F, Li X, Roussel MF, Segil N. Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d. Nat Cell Biol 2003; 5:422-6.
29. Zindy F, van Deursen J, Grosveld G, Sherr CJ, Roussel MF. INK4d-deficient mice are fertile despite testicular atrophy. Mol Cell Biol 2000; 20:372-8.
30. INK4/MTS1 tumour suppressor gene product. EMBO J 1995; 14:503-11.
31. INK4A inactivation in non-small cell lung cancer cell lines. Cancer Res 1995; 55:6200-9.
32. INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells. Mol Cell Biol 1997; 17:2458-67.
33. INK4a and the human papillomavirus oncoprotein-58 E7 are naturally occurring lysine-less proteins that are degraded by the ubiquitin system. Direct evidence for ubiquitination at the N-terminal residue. J Biol Chem 2004; 279:41414-21.
34. Chen X, Barton LF, Chi Y, Clurman BE, Roberts JM. Ubiquitin-independent degradation of cell cycle inhibitors by the REGγ proteasome. Mol Cell 2007; 26:843-52.
35. Tokumoto YM, Apperly JA, Gao FB, Raff MC. Posttranscriptional regulation of p18 and p27 Cdk inhibitor proteins and the timing of oligodendrocyte differentiation. Dev Biol 2002; 245:224-34.
36. INK4d determines its periodic expression during the cell cycle. Oncogene 2000; 19:2870-6.
37. INK4c expression during myogenesis. Mol Cell Biol 1998; 18:2334-43.
38. Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev 1994; 8:9-22.
39. 1 cyclin-Cdk protein kinase activity, is related to p21. Cell 1994; 78:67-74.
40. Matsushime H, Roussel MF, Ashmun RA, Sherr CJ. Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 1991; 65:701-13.
41. Matsushime H, Quelle DE, Shurtleff SA, Shibuya M, Sherr CJ, Kato J-Y. D-type cyclin-dependent kinase activity in mammalian cells. Mol Cell Biol 1994; 14:2066-76.
42. Uziel T, Zindy F, Xie S, Lee Y, Forget A, Magdaleno S, Rehg JE, Calabrese C, Solecki D, Eberhart CG, Sherr SE, Plimmer S, Clifford SC, Hatten ME, McKinnon PJ, Gilbertson RJ, Curran T, Sherr CJ, Roussel MF. The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev 2005; 19:2656-67.
43. Pickart CM, Fushman D. Polyubiquitin chains: polymeric protein signals. Curr Opin Chem Biol 2004; 8:610-6.
44. Ciechanover A, Ben-Saadon R. N-terminal ubiquitination: more protein substrates join in. Trends Cell Biol 2004; 14:103-6.
45. Tang KS, Guralnick BJ, Wang WK, Fersht AR, Itzhaki LS. Stability and folding of the tumour suppressor protein p16. J Mol Biol 1999; 285:1869-86.
46. INK4c proteins with increased thermodynamic stability and cell cycle inhibitory activity. J Biol Chem 2002; 277:48827-33.
47. Barton LF, Runnels HA, Schell TD, Cho Y, Gibbons R, Tevethia SS, Deepe GS Jr, Monaco JJ. Immune defects in 28-kDa proteasome activator γ-deficient mice. J Immunol 2004; 172:3948-54.
48. INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science 1995; 269:1281-4.
49. INK4a-independent mechanisms. Mol Cell Biol 2007; 27:4273-82.
50. Murray AW. Recycling the cell cycle: cyclins revisited. Cell 2004; 116:221-34.
51. INK4d in response to ultraviolet light improves DNA repair and confers resistance to apoptosis in neuroblastoma cells. Oncogene 2005; 24:4065-80.
52. INK4d, promotes cell survival and decreases chromosomal aberrations after genotoxic insult due to enhanced DNA repair. DNA Repair 2007; 6:626-38.
53. Rechsteiner M, Hill CP. Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitors. Trends Cell Biol 2005; 15:27-33.
54. INK4- and p18-containing complexes in human cell lines. J Biol Chem 1996; 271:15942-9.
55. Hawley RG, Lieu FH, Fong AZ, Hawley TS. Versatile retroviral vectors for potential use in gene therapy. Gene Ther 1994; 1:136-8.
56. Treier M, Staszewski LM, Bohmann D. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the ? domain. Cell 1994; 78:787-98.