Rebeccamycin derivatives as dual DNA-damaging agents and potent checkpoint kinase 1 inhibitors

Molecular Pharmacology

Volumn 74, Issue 6, 2008, Pages 1620-1629

  Marminon, Christelle ^a   Anizon, Fabrice ^a   Moreau, Pascale ^a   Pfeiffer, Bruno ^b   Pierré, Alain ^b   Golsteyn, Roy M ^b,f   Peixoto, Paul ^c,d   Hildebrand, Marie Paule ^c,d   David Cordonnier, Marie Hélène ^c,d   Lozach, Olivier ^e   Meijer, Laurent ^e   Prudhomme, Michelle ^a  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b INSTITUT DE RECHERCHES SERVIER   (France)

^c INSERM   (France)

^d UNIV LILLE   (France)

^e STATION BIOLOGIQUE   (France)

^f UNIVERSITY OF LETHBRIDGE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYSTAUROSPORINE; ANTINEOPLASTIC AGENT; CHECKPOINT KINASE 1; CHECKPOINT KINASE 1 INHIBITOR; ENZYME INHIBITOR; REBECCAMYCIN; STAUROSPORINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA CLEAVAGE; DNA DAMAGE; DRUG STRUCTURE; ENZYME INHIBITION; GENOTOXICITY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CARBAZOLES; CELL PROLIFERATION; DNA; DNA CLEAVAGE; DNA DAMAGE; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICE; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 57349113871     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.049346     Document Type: Article

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