Synthesis and cytotoxicities of 7-aza rebeccamycin analogues bearing various substituents on the sugar moiety, on the imide nitrogen and on the carbazole framework

European Journal of Medicinal Chemistry

Volumn 40, Issue 10, 2005, Pages 961-971

  Messaoudi, Samir ^a   Anizon, Fabrice ^a   Léonce, Stéphane ^b   Pierré, Alain ^b   Pfeiffer, Bruno ^b   Prudhomme, Michelle ^a  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

7 Azaindole; Antitumor compounds; Rebeccamycin; Topoisomerase I inhibitors

Indexed keywords

13 (BETA DEXTRO GLUCOPYRANOS 1 YL) 5,7 DIHYDRO 12H PYRIDO[3',2':4,5] PYRROLO[2,3 A]FURO[3,4 C]CARBAZOLE 5,7 DIONE; 6 AMINO 13 (BETA DEXTRO GLUCOPYRANOS 1 YL) 5,7 DIHYDRO 12H PYRIDO[3',2':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7 DIONE; 6 DIETHYLAMINOETHYL 13 (BETA DEXTRO GLUCOPYRANOS 1 YL) 5,7 DIHYDRO 12H PYRIDO[3',2':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7 DIONE; 6 HYDROXY 13 (BETA DEXTRO GLUCOPYRANOS 1 YL) 5,7 DIHYDRO 12H PYRIDO[3',2':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7 DIONE; 6 METHYL 12 (3,6 DICHLORO 3,6 DIDEOXY BETA DEXTRO ALLOPYRANOSYL) 5,7 DIHYDRO 13H PYRIDO[3',2':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7 DIONE; 6 METHYL 12 (6 AZIDO 6 DEOXY BETA DEXTRO GLUCOPYRANOS 1 YL) 1 (2 OXOPROPYL) 5,7 DIHYDRO 13H PYRIDO[3',2':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7 DIONE; 6 METHYL 12 (6 AZIDO 6 DEOXY BETA DEXTRO GLUCOPYRANOS 1 YL) 5,7 DIHYDRO 13H PYRIDO[3',2':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7 DIONE; 6 METHYL 12 (6 CHLORO 6 DEOXY BETA DEXTRO GLUCOPYRANOS 1 YL) 5,7 DIHYDRO 13H PYRIDO[3',2':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7 DIONE; 6 METHYL 12 (6 IODO 6 DEOXY BETA DEXTRO GLUCOPYRANOS 1 YL) 5,7 DIHYDRO 13H PYRIDO[3',2':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7 DIONE; 6 METHYL 12 (BETA DEXTRO GLUCOPYRANOS 1 YL) 5 OXO 13H PYRIDO[3',2':4,5] PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 6 METHYL 12 (BETA DEXTRO GLUCOPYRANOS 1 YL) 7 OXO 13H PYRIDO[3',2':4,5] PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 6 METHYL 13 (6 CHLORO 6 DEOXY BETA DEXTRO GLUCOPYRANOS 1 YL) 5,7 DIHYDRO 12H PYRIDO[3',2':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7 DIONE; 6 METHYL 9 NITRO 13 (2,3,4,6 TETRA O ACETYL BETA DEXTRO GLUCOPYRANOS 1 YL) 5,7 DIHYDRO 12H PYRIDO[3',2':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7 DIONE; 6 METHYL 9 NITRO 13 (BETA DEXTRO GLUCOPYRANOS 1 YL) 5,7 DIHYDRO 12H PYRIDO[3',2':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7 DIONE; ANTINEOPLASTIC ANTIBIOTIC; CARBAZOLE DERIVATIVE; HETEROCYCLIC COMPOUND; INDOLE DERIVATIVE; LACTAM; NITROGEN; REBECCAMYCIN; SUGAR; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; COLON CARCINOMA; COMPARATIVE STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA; LUNG NON SMALL CELL CANCER; MOUSE; NONHUMAN; PROSTATE CARCINOMA; SUBSTITUTION REACTION; TUMOR CELL LINE;

ANIMALS; CARBAZOLES; CARBOHYDRATES; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; IMIDES; INDOLES; MICE; MOLECULAR STRUCTURE; NITROGEN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 26444518787     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.04.002     Document Type: Article

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