Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 22, 2006, Pages 7551-7562

  Messaoudi, Samir ^a   Anizon, Fabrice ^a   Peixoto, Paul ^b   David Cordonnier, Marie Hélène ^b   Golsteyn, Roy M ^c   Léonce, Stéphane ^c   Pfeiffer, Bruno ^c   Prudhomme, Michelle ^a  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b Institut de Recherche sur le Cancer de Lille   (France)

^c INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

7 Azaindole; Antitumor compounds; Chk1 inhibitors; DNA binding agents; Rebeccamycin; Topoisomerase I inhibitors

Indexed keywords

1 (2 O TOSYL BETA DEXTRO GLUCOPYRANOS 1 YL) 1H PYRIDO[3',2':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,12H)DIONE; 1 (BETA DEXTRO GLUCOPYRANOS 1 YL) 1H PYRIDO[3',2':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,12H)DIONE; 1 (BETA DEXTRO GLUCOPYRANOS 1 YL) 6 METHYL 1H PYRIDO[3',2':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(12H)DIONE; 3 (1H INDOL 3 YL) 1 METHYL 4 [(7 BETA DEXTRO GLUCOPYRANOS 1 YL) 7H PYRROLO[2,3 B]PYRIDIN 3 YL]PYRROLE 2,5 DIONE; 3 (1H INDOL 3 YL) 1 METHYL 4 [1 (3,4,6 TRI O BENZYL BETA DEXTRO GLUCOPYRANOS 1 YL) 1H PYRROLO[2,3 B]PYRIDIN 3 YL]PYRROLE 2,5 DIONE; CHECKPOINT KINASE 1; DNA; DNA TOPOISOMERASE; NITROGEN; PYRIDINE; REBECCAMYCIN; SUGAR; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CELL STRAIN HT29; COLON CARCINOMA; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; LEUKEMIA L 1210; LUNG SMALL CELL CANCER; MURINE LEUKEMIA; PROSTATE CARCINOMA; TUMOR CELL LINE;

ANIMALS; AZA COMPOUNDS; CARBAZOLES; CARBOHYDRATES; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; HUMANS; INDOLES; MICE; MOLECULAR STRUCTURE; NITROGEN; PROTEIN KINASES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE I INHIBITORS;

MURINAE;

EID: 33749234576     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.07.013     Document Type: Article

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