Semi-synthesis, topoisomerase I and kinases inhibitory properties, and antiproliferative activities of new rebeccamycin derivatives

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 23, 2003, Pages 4871-4879

  Moreau, Pascale ^a   Gaillard, Nathalie ^a   Marminon, Christelle ^a   Anizon, Fabrice ^a   Dias, Nathalie ^b   Baldeyrou, Brigitte ^b   Bailly, Christian ^b   Pierré, Alain ^c   Hickman, John ^c   Pfeiffer, Bruno ^d   Renard, Pierre ^d   Prudhomme, Michelle ^a  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b INSERM   (France)

^c INSTITUT DE RECHERCHES SERVIER   (France)

^d INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1,11 DICHLORO 12 (2,3 ANHYDRO 4 O METHYL BETA DEXTRO GLUCOPYRANOSYL) 6,7,12,13 TETRAHYDRO 5H INDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7 DIONE; 3,9 DIAMINO 12 (4 O METHYL BETA DEXTRO GLUCOPYRANOSYL) 6 METHYL 6,7,12,13 TETRAHYDRO 5H INDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7 DIONE; 3,9 DIFORMYL 12 (4 O METHYL BETA DEXTRO GLUCOPYRANOSYL) 6 METHYL 6,7,12,13 TETRAHYDRO 5H INDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7 DIONE; 3,9 DIHYDROXY 12 (4 O METHYL BETA DEXTRO GLUCOPYRANOSYL) 6,7,12,13 TETRAHYDRO 5H INDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7 DIONE; 3,9 DIHYDROXYMETHYL 12 (4 O METHYL BETA DEXTRO GLUCOPYRANOSYL) 6 METHYL 6,7,12,13 TETRAHYDRO 5H INDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7 DIONE; 3,9 DIMETHOXYCARBONYL 12 (4 O METHYL BETA DEXTRO GLUCOPYRANOSYL) 6,7,12,13 TETRAHYDRO 5H INDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7 DIONE; 3,9 DINITRO 12 (4 O METHYL BETA DEXTRO GLUCOPYRANOSYL) 6 METHYL 6,7,12,13 TETRAHYDRO 5H INDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7 DIONE; ANTINEOPLASTIC ANTIBIOTIC; CYCLIN DEPENDENT KINASE INHIBITOR; DNA TOPOISOMERASE INHIBITOR; REBECCAMYCIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DNA BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

MURINAE;

EID: 0242361216     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.09.014     Document Type: Article

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