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Volumn 149, Issue 12, 2008, Pages 6378-6388

Nuclear factor-κB mediates the inhibitory effects of tumor necrosis factor-α on growth hormone-inducible gene expression in liver

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CYCLOHEXIMIDE; FUMONISIN B1; HUMAN GROWTH HORMONE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P50; SPHINGOMYELIN PHOSPHODIESTERASE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; GROWTH HORMONE; GUANOSINE 3',5' POLYPHOSPHATE SYNTHETASES; GUANOSINE 3',5'-POLYPHOSPHATE SYNTHETASES; LIGASE; STAT5 PROTEIN;

EID: 57349099190     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-1574     Document Type: Article
Times cited : (10)

References (53)
  • 1
    • 0036882395 scopus 로고    scopus 로고
    • Serpin structure, mechanism, and function
    • Gettins PG 2002 Serpin structure, mechanism, and function. Chem Rev 102:4751-4804
    • (2002) Chem Rev , vol.102 , pp. 4751-4804
    • Gettins, P.G.1
  • 2
    • 0031946053 scopus 로고    scopus 로고
    • Systemic and splanchnic metabolic response to exogenous human growth hormone
    • Dahn MS, Lange MP 1998 Systemic and splanchnic metabolic response to exogenous human growth hormone. Surgery 123:528-538
    • (1998) Surgery , vol.123 , pp. 528-538
    • Dahn, M.S.1    Lange, M.P.2
  • 3
    • 0023752178 scopus 로고
    • Insulinlike growth factor 1 production is inhibited in human sepsis
    • Dahn MS, Lange MP, Jacobs LA 1988 Insulinlike growth factor 1 production is inhibited in human sepsis. Arch Surg 123:1409-1414
    • (1988) Arch Surg , vol.123 , pp. 1409-1414
    • Dahn, M.S.1    Lange, M.P.2    Jacobs, L.A.3
  • 4
    • 0035077955 scopus 로고    scopus 로고
    • Growth failure and intestinal inflammation
    • Ballinger AB, Camacho-Hubner C, Croft NM 2001 Growth failure and intestinal inflammation. QJM 94:121-125
    • (2001) QJM , vol.94 , pp. 121-125
    • Ballinger, A.B.1    Camacho-Hubner, C.2    Croft, N.M.3
  • 5
    • 33646560290 scopus 로고    scopus 로고
    • Hepatic growth hormone resistance during sepsis is associated with increased suppressors of cytokine signaling expression and impaired growth hormone signaling
    • Yumet G, Shumate ML, Bryant DP, Lang CH, Cooney RN 2006 Hepatic growth hormone resistance during sepsis is associated with increased suppressors of cytokine signaling expression and impaired growth hormone signaling. Crit Care Med 34:1420-1427
    • (2006) Crit Care Med , vol.34 , pp. 1420-1427
    • Yumet, G.1    Shumate, M.L.2    Bryant, D.P.3    Lang, C.H.4    Cooney, R.N.5
  • 8
    • 34250840799 scopus 로고    scopus 로고
    • Hepatic tumor necrosis factor signaling and nuclear factor-κB: Effects on liver homeostasis and beyond
    • Wullaert A, van Loo G, Heyninck K, Beyaert R 2007 Hepatic tumor necrosis factor signaling and nuclear factor-κB: effects on liver homeostasis and beyond. Endocr Rev 28:365-386
    • (2007) Endocr Rev , vol.28 , pp. 365-386
    • Wullaert, A.1    van Loo, G.2    Heyninck, K.3    Beyaert, R.4
  • 9
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-κB puzzle
    • Ghosh S, Karin M 2002 Missing pieces in the NF-κB puzzle. Cell 109(Suppl):S81-S96
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • Ghosh, S.1    Karin, M.2
  • 10
    • 0032230272 scopus 로고    scopus 로고
    • Transcription of the rat serine protease inhibitor 2.1 gene in vivo: Correlation with GAGA box promoter occupancy and mechanism of cytokine-mediated down-regulation
    • Simar-Blanchet AE, Legraverend C, Thissen JP, Le Cam A 1998 Transcription of the rat serine protease inhibitor 2.1 gene in vivo: correlation with GAGA box promoter occupancy and mechanism of cytokine-mediated down-regulation. Mol Endocrinol 12:391-404
    • (1998) Mol Endocrinol , vol.12 , pp. 391-404
    • Simar-Blanchet, A.E.1    Legraverend, C.2    Thissen, J.P.3    Le Cam, A.4
  • 11
    • 0034654832 scopus 로고    scopus 로고
    • NF-κB p65 (RelA) homodimer uses distinct mechanisms to recognize DNA targets
    • Chen YQ, Sengchanthalangsy LL, Hackett A, Ghosh G 2000 NF-κB p65 (RelA) homodimer uses distinct mechanisms to recognize DNA targets. Structure 8:419-428
    • (2000) Structure , vol.8 , pp. 419-428
    • Chen, Y.Q.1    Sengchanthalangsy, L.L.2    Hackett, A.3    Ghosh, G.4
  • 12
    • 33645116785 scopus 로고    scopus 로고
    • NF-κB activation as a pathological mechanism of septic shock and inflammation
    • Liu SF, Malik AB 2006 NF-κB activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol 290:L622-L645
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.290
    • Liu, S.F.1    Malik, A.B.2
  • 13
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: The control of NF-κB activity
    • Karin M, Ben-Neriah Y 2000 Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu Rev Immunol 18:621-663
    • (2000) Annu Rev Immunol , vol.18 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 14
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-κB
    • Hayden MS, Ghosh S 2004 Signaling to NF-κB. Genes Dev 18:2195-2224
    • (2004) Genes Dev , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 15
    • 2342464085 scopus 로고    scopus 로고
    • The two NF-κB activation pathways and their role in innate and adaptive immunity
    • Bonizzi G, Karin M 2004 The two NF-κB activation pathways and their role in innate and adaptive immunity. Trends Immunol 25:280-288
    • (2004) Trends Immunol , vol.25 , pp. 280-288
    • Bonizzi, G.1    Karin, M.2
  • 16
    • 0141594607 scopus 로고    scopus 로고
    • Regulation of distinct biological activities of the NF-κB transcription factor complex by acetylation
    • Chen LF, Greene WC 2003 Regulation of distinct biological activities of the NF-κB transcription factor complex by acetylation. J Mol Med 81:549-557
    • (2003) J Mol Med , vol.81 , pp. 549-557
    • Chen, L.F.1    Greene, W.C.2
  • 17
    • 0030026562 scopus 로고    scopus 로고
    • Both amino- and carboxyl-terminal sequences within IκBα regulate its inducible degradation
    • Sun S, Elwood J, Greene WC 1996 Both amino- and carboxyl-terminal sequences within IκBα regulate its inducible degradation. Mol Cell Biol 16:1058-1065
    • (1996) Mol Cell Biol , vol.16 , pp. 1058-1065
    • Sun, S.1    Elwood, J.2    Greene, W.C.3
  • 18
    • 0029896512 scopus 로고    scopus 로고
    • Multiple structural domains within IκBα are required for its inducible degradation by both cytokines and phosphatase inhibitors
    • Good LF, Maggirwar SB, Kealiher A, Uhlik M, Sun SC 1996 Multiple structural domains within IκBα are required for its inducible degradation by both cytokines and phosphatase inhibitors. Biochem Biophys Res Commun 223:123-128
    • (1996) Biochem Biophys Res Commun , vol.223 , pp. 123-128
    • Good, L.F.1    Maggirwar, S.B.2    Kealiher, A.3    Uhlik, M.4    Sun, S.C.5
  • 19
    • 0027333345 scopus 로고
    • A novel NF-κB complex containing p65 homodimers: Implications for transcriptional control at the level of subunit dimerization
    • Ganchi PA, Sun SC, Greene WC, Ballard DW 1993 A novel NF-κB complex containing p65 homodimers: implications for transcriptional control at the level of subunit dimerization. Mol Cell Biol 13:7826-7835
    • (1993) Mol Cell Biol , vol.13 , pp. 7826-7835
    • Ganchi, P.A.1    Sun, S.C.2    Greene, W.C.3    Ballard, D.W.4
  • 20
    • 0026527184 scopus 로고
    • The 65-kDa subunit of human NF-κB functions as a potent transcriptional activator and a target for v-Rel-mediated repression
    • Ballard DW, Dixon EP, Peffer NJ, Bogerd H, Doerre S, Stein B, Greene WC 1992 The 65-kDa subunit of human NF-κB functions as a potent transcriptional activator and a target for v-Rel-mediated repression. Proc Natl Acad Sci USA 89:1875-1879
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1875-1879
    • Ballard, D.W.1    Dixon, E.P.2    Peffer, N.J.3    Bogerd, H.4    Doerre, S.5    Stein, B.6    Greene, W.C.7
  • 21
    • 0027078835 scopus 로고
    • IκB/MAD-3 masks the nuclear localization signal of NF-κB p65 and requires the transactivation domain to inhibit NF-κB p65 DNA binding
    • Ganchi PA, Sun SC, Greene WC, Ballard DW 1992 IκB/MAD-3 masks the nuclear localization signal of NF-κB p65 and requires the transactivation domain to inhibit NF-κB p65 DNA binding. Mol Biol Cell 3:1339-1352
    • (1992) Mol Biol Cell , vol.3 , pp. 1339-1352
    • Ganchi, P.A.1    Sun, S.C.2    Greene, W.C.3    Ballard, D.W.4
  • 22
    • 0346435095 scopus 로고    scopus 로고
    • Mechanisms of growth hormone (GH) action. Identification of conserved Stat5 binding sites that mediate GH-induced insulin-like growth factor-I gene activation
    • Woelfle J, Chia DJ, Rotwein P 2003 Mechanisms of growth hormone (GH) action. Identification of conserved Stat5 binding sites that mediate GH-induced insulin-like growth factor-I gene activation. J Biol Chem 278:51261-51266
    • (2003) J Biol Chem , vol.278 , pp. 51261-51266
    • Woelfle, J.1    Chia, D.J.2    Rotwein, P.3
  • 24
    • 0023429407 scopus 로고
    • Regulation of albumin gene expression in a series of rat hepatocyte cell lines immortalized by simian virus 40 and maintained in chemically defined medium
    • Woodworth CD, Isom HC 1987 Regulation of albumin gene expression in a series of rat hepatocyte cell lines immortalized by simian virus 40 and maintained in chemically defined medium. Mol Cell Biol 7:3740-3748
    • (1987) Mol Cell Biol , vol.7 , pp. 3740-3748
    • Woodworth, C.D.1    Isom, H.C.2
  • 25
    • 0028920598 scopus 로고
    • Responsiveness of an SV40-immortalized hepatocyte cell line to growth hormone
    • Kempe KC, Isom HC, Greene FE 1995 Responsiveness of an SV40-immortalized hepatocyte cell line to growth hormone. Biochem Pharmacol 49:1091-1098
    • (1995) Biochem Pharmacol , vol.49 , pp. 1091-1098
    • Kempe, K.C.1    Isom, H.C.2    Greene, F.E.3
  • 26
    • 4644221064 scopus 로고    scopus 로고
    • Proinflammatory cytokine impairment of insulin-like growth factor I-induced protein synthesis in skeletal muscle myoblasts requires ceramide
    • Strle K, Broussard SR, McCusker RH, Shen WH, Johnson RW, Freund GG, Dantzer R, Kelley KW 2004 Proinflammatory cytokine impairment of insulin-like growth factor I-induced protein synthesis in skeletal muscle myoblasts requires ceramide. Endocrinology 145:4592-4602
    • (2004) Endocrinology , vol.145 , pp. 4592-4602
    • Strle, K.1    Broussard, S.R.2    McCusker, R.H.3    Shen, W.H.4    Johnson, R.W.5    Freund, G.G.6    Dantzer, R.7    Kelley, K.W.8
  • 27
    • 0041326612 scopus 로고    scopus 로고
    • Protection of rat hepatocytes from apoptosis by inhibition of c-Jun N-terminal kinase
    • Marderstein EL, Bucher B, Guo Z, Feng X, Reid K, Geller DA 2003 Protection of rat hepatocytes from apoptosis by inhibition of c-Jun N-terminal kinase. Surgery 134:280-284
    • (2003) Surgery , vol.134 , pp. 280-284
    • Marderstein, E.L.1    Bucher, B.2    Guo, Z.3    Feng, X.4    Reid, K.5    Geller, D.A.6
  • 28
    • 22544444238 scopus 로고    scopus 로고
    • Interleukin-1 inhibits the induction of insulin-like growth factor-I by growth hormone in CWSV-1 hepatocytes
    • Shumate ML, Yumet G, Ahmed TA, Cooney RN 2005 Interleukin-1 inhibits the induction of insulin-like growth factor-I by growth hormone in CWSV-1 hepatocytes. Am J Physiol Gastrointest Liver Physiol 289:G227-G239
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.289
    • Shumate, M.L.1    Yumet, G.2    Ahmed, T.A.3    Cooney, R.N.4
  • 29
    • 33645649507 scopus 로고    scopus 로고
    • Characterization of distinct Stat5b binding sites that mediate growth hormone-stimulated IGF-I gene transcription
    • Chia DJ, Ono M, Woelfle J, Schlesinger-Massart M, Jiang H, Rotwein P 2006 Characterization of distinct Stat5b binding sites that mediate growth hormone-stimulated IGF-I gene transcription. J Biol Chem 281:3190-3197
    • (2006) J Biol Chem , vol.281 , pp. 3190-3197
    • Chia, D.J.1    Ono, M.2    Woelfle, J.3    Schlesinger-Massart, M.4    Jiang, H.5    Rotwein, P.6
  • 30
    • 0037590103 scopus 로고    scopus 로고
    • Acute control of insulin-like growth factor-I gene transcription by growth hormone through Stat5b
    • Woelfle J, Billiard J, Rotwein P 2003 Acute control of insulin-like growth factor-I gene transcription by growth hormone through Stat5b. J Biol Chem 278:22696-22702
    • (2003) J Biol Chem , vol.278 , pp. 22696-22702
    • Woelfle, J.1    Billiard, J.2    Rotwein, P.3
  • 31
    • 0030064407 scopus 로고    scopus 로고
    • Acute nuclear actions of growth hormone (GH): Cycloheximide inhibits inducible activator protein-1 activity, but does not block GH-regulated signal transducer and activator of transcription activation or gene expression
    • Gronowski AM, Le Stunff C, Rotwein P 1996 Acute nuclear actions of growth hormone (GH): cycloheximide inhibits inducible activator protein-1 activity, but does not block GH-regulated signal transducer and activator of transcription activation or gene expression. Endocrinology 137:55-64
    • (1996) Endocrinology , vol.137 , pp. 55-64
    • Gronowski, A.M.1    Le Stunff, C.2    Rotwein, P.3
  • 34
    • 8944247747 scopus 로고    scopus 로고
    • Growth hormone stimulates tyrosine phosphorylation of JAK2 and STAT5, but not insulin receptor substrate-1 or SHC proteins in liver and skeletal muscle of normal rats in vivo
    • Chow JC, Ling PR, Qu Z, Laviola L, Ciccarone A, Bistrian BR, Smith RJ 1996 Growth hormone stimulates tyrosine phosphorylation of JAK2 and STAT5, but not insulin receptor substrate-1 or SHC proteins in liver and skeletal muscle of normal rats in vivo. Endocrinology 137:2880-2886
    • (1996) Endocrinology , vol.137 , pp. 2880-2886
    • Chow, J.C.1    Ling, P.R.2    Qu, Z.3    Laviola, L.4    Ciccarone, A.5    Bistrian, B.R.6    Smith, R.J.7
  • 36
    • 0028829590 scopus 로고
    • Growth hormone induction of hepatic serine protease inhibitor 2.1 transcription is mediated by a Stat5-related factor binding synergistically to two γ-activated sites
    • Bergad PL, Shih HM, Towle HC, Schwarzenberg SJ, Berry SA 1995 Growth hormone induction of hepatic serine protease inhibitor 2.1 transcription is mediated by a Stat5-related factor binding synergistically to two γ-activated sites. J Biol Chem 270:24903-24910
    • (1995) J Biol Chem , vol.270 , pp. 24903-24910
    • Bergad, P.L.1    Shih, H.M.2    Towle, H.C.3    Schwarzenberg, S.J.4    Berry, S.A.5
  • 37
    • 0035215369 scopus 로고    scopus 로고
    • Serine phosphorylation of GH-activated signal transducer and activator of transcription 5a (STAT5a) and STAT5b: Impact on STAT5 transcriptional activity
    • Park SH, Yamashita H, Rui H, Waxman DJ 2001 Serine phosphorylation of GH-activated signal transducer and activator of transcription 5a (STAT5a) and STAT5b: impact on STAT5 transcriptional activity. Mol Endocrinol 15:2157-2171
    • (2001) Mol Endocrinol , vol.15 , pp. 2157-2171
    • Park, S.H.1    Yamashita, H.2    Rui, H.3    Waxman, D.J.4
  • 38
    • 0033330660 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT) 5a
    • Pircher TJ, Petersen H, Gustafsson JA, Haldosen LA 1999 Extracellular signal-regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT) 5a. Mol Endocrinol 13:555-565
    • (1999) Mol Endocrinol , vol.13 , pp. 555-565
    • Pircher, T.J.1    Petersen, H.2    Gustafsson, J.A.3    Haldosen, L.A.4
  • 40
    • 0032934069 scopus 로고    scopus 로고
    • Glucocorticoid receptor/signal transducer and activator of transcription 5 (STAT5) interactions enhance STAT5 activation by prolonging STAT5 DNA binding and tyrosine phosphorylation
    • Wyszomierski SL, Yeh J, Rosen JM 1999 Glucocorticoid receptor/signal transducer and activator of transcription 5 (STAT5) interactions enhance STAT5 activation by prolonging STAT5 DNA binding and tyrosine phosphorylation. Mol Endocrinol 13:330-343
    • (1999) Mol Endocrinol , vol.13 , pp. 330-343
    • Wyszomierski, S.L.1    Yeh, J.2    Rosen, J.M.3
  • 42
    • 0242664926 scopus 로고    scopus 로고
    • NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the α-helical region of the STAT5 transactivation domain
    • Litterst CM, Kliem S, Marilley D, Pfitzner E 2003 NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the α-helical region of the STAT5 transactivation domain. J Biol Chem 278:45340-45351
    • (2003) J Biol Chem , vol.278 , pp. 45340-45351
    • Litterst, C.M.1    Kliem, S.2    Marilley, D.3    Pfitzner, E.4
  • 43
    • 23744455019 scopus 로고    scopus 로고
    • Endogenous CCAAT/enhancer binding protein β and p300 are both regulated by growth hormone to mediate transcriptional activation
    • Cui TX, Piwien-Pilipuk G, Huo JS, Kaplani J, Kwok R, Schwartz J 2005 Endogenous CCAAT/enhancer binding protein β and p300 are both regulated by growth hormone to mediate transcriptional activation. Mol Endocrinol 19:2175-2186
    • (2005) Mol Endocrinol , vol.19 , pp. 2175-2186
    • Cui, T.X.1    Piwien-Pilipuk, G.2    Huo, J.S.3    Kaplani, J.4    Kwok, R.5    Schwartz, J.6
  • 44
    • 0032230282 scopus 로고    scopus 로고
    • p300/CREB-binding protein enhances the prolactin-mediated transcriptional induction through direct interaction with the transactivation domain of Stat5, but does not participate in the Stat5-mediated suppression of the glucocorticoid response
    • Pfitzner E, Jahne R, Wissler M, Stoecklin E, Groner B 1998 p300/CREB-binding protein enhances the prolactin-mediated transcriptional induction through direct interaction with the transactivation domain of Stat5, but does not participate in the Stat5-mediated suppression of the glucocorticoid response. Mol Endocrinol 12:1582-1593
    • (1998) Mol Endocrinol , vol.12 , pp. 1582-1593
    • Pfitzner, E.1    Jahne, R.2    Wissler, M.3    Stoecklin, E.4    Groner, B.5
  • 45
    • 0031557104 scopus 로고    scopus 로고
    • Essential promoter elements are located within the 5′ untranslated region of human insulin-like growth factor-I exon I
    • Mittanck DW, Kim SW, Rotwein P 1997 Essential promoter elements are located within the 5′ untranslated region of human insulin-like growth factor-I exon I. Mol Cell Endocrinol 126:153-163
    • (1997) Mol Cell Endocrinol , vol.126 , pp. 153-163
    • Mittanck, D.W.1    Kim, S.W.2    Rotwein, P.3
  • 46
    • 15744398235 scopus 로고    scopus 로고
    • Identification of a distal STAT5-binding DNA region that may mediate growth hormone regulation of insulin-like growth factor-I gene expression
    • Wang Y, Jiang H 2005 Identification of a distal STAT5-binding DNA region that may mediate growth hormone regulation of insulin-like growth factor-I gene expression. J Biol Chem 280:10955-10963
    • (2005) J Biol Chem , vol.280 , pp. 10955-10963
    • Wang, Y.1    Jiang, H.2
  • 47
    • 0025943986 scopus 로고
    • The p65 subunit is responsible for the strong transcription activating potential of NF-κB
    • Schmitz ML, Baeuerle PA 1991 The p65 subunit is responsible for the strong transcription activating potential of NF-κB. EMBO J 10:3805-3817
    • (1991) EMBO J , vol.10 , pp. 3805-3817
    • Schmitz, M.L.1    Baeuerle, P.A.2
  • 48
    • 0028116117 scopus 로고
    • Structural and functional analysis of the NF-κB p65 C terminus. An acidic and modular transactivation domain with the potential to adopt an α-helical conformation
    • Schmitz ML, dos Santos Silva MA, Altmann H, Czisch M, Holak TA, Baeuerle PA 1994 Structural and functional analysis of the NF-κB p65 C terminus. An acidic and modular transactivation domain with the potential to adopt an α-helical conformation. J Biol Chem 269:25613-25620
    • (1994) J Biol Chem , vol.269 , pp. 25613-25620
    • Schmitz, M.L.1    dos Santos Silva, M.A.2    Altmann, H.3    Czisch, M.4    Holak, T.A.5    Baeuerle, P.A.6
  • 49
    • 0029058962 scopus 로고
    • Transactivation domain 2 (TA2) of p65 NF-κB. Similarity to TA1 and phorbol ester-stimulated activity and phosphorylation in intact cells
    • Schmitz ML, dos Santos Silva MA, Baeuerle PA 1995 Transactivation domain 2 (TA2) of p65 NF-κB. Similarity to TA1 and phorbol ester-stimulated activity and phosphorylation in intact cells. J Biol Chem 270:15576-15584
    • (1995) J Biol Chem , vol.270 , pp. 15576-15584
    • Schmitz, M.L.1    dos Santos Silva, M.A.2    Baeuerle, P.A.3
  • 50
    • 0034201442 scopus 로고    scopus 로고
    • Activation of NF-κB p50/p65 is regulated in the developing mammary gland and inhibits STAT5-mediated β-casein gene expression
    • Geymayer S, Doppler W 2000 Activation of NF-κB p50/p65 is regulated in the developing mammary gland and inhibits STAT5-mediated β-casein gene expression. FASEB J 14:1159-1170
    • (2000) FASEB J , vol.14 , pp. 1159-1170
    • Geymayer, S.1    Doppler, W.2
  • 51
    • 0034335409 scopus 로고    scopus 로고
    • Stat5b inhibits NFκB-mediated signaling
    • Luo G, Yu-Lee L 2000 Stat5b inhibits NFκB-mediated signaling. Mol Endocrinol 14:114-123
    • (2000) Mol Endocrinol , vol.14 , pp. 114-123
    • Luo, G.1    Yu-Lee, L.2
  • 52
    • 0033580229 scopus 로고    scopus 로고
    • Binding of c-Rel to STAT5 target sequences in HTLV-I-transformed T cells
    • Sun SC, Maggirwar SB, Harhaj EW, Uhlik M 1999 Binding of c-Rel to STAT5 target sequences in HTLV-I-transformed T cells. Oncogene 18:1401-1409
    • (1999) Oncogene , vol.18 , pp. 1401-1409
    • Sun, S.C.1    Maggirwar, S.B.2    Harhaj, E.W.3    Uhlik, M.4
  • 53
    • 34447572787 scopus 로고    scopus 로고
    • Endotoxin attenuates growth hormone-induced hepatic insulin-like growth factor I expression by inhibiting JAK2/STAT5 signal transduction and STAT5b DNA binding
    • Chen Y, Sun D, Krishnamurthy VM, Rabkin R 2007 Endotoxin attenuates growth hormone-induced hepatic insulin-like growth factor I expression by inhibiting JAK2/STAT5 signal transduction and STAT5b DNA binding. Am J Physiol Endocrinol Metab 292:E1856-E1862
    • (2007) Am J Physiol Endocrinol Metab , vol.292
    • Chen, Y.1    Sun, D.2    Krishnamurthy, V.M.3    Rabkin, R.4


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