Endotoxin attenuates growth hormone-induced hepatic insulin-like growth factor I expression by inhibiting JAK2/STAT5 signal transduction and STAT5b DNA binding

American Journal of Physiology - Endocrinology and Metabolism

Volumn 292, Issue 6, 2007, Pages

  Chen, Yu ^a   Sun, Difei ^a   Krishnamurthy, Vidya M R ^b   Rabkin, Ralph ^a,b  

^a Stanford California and Cofounder   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

Cytokines; Inflammation; Insulin like growth factor I; Lipopolysaccharide

Indexed keywords

DNA; ENDOTOXIN; GROWTH HORMONE; INTERLEUKIN 6; JANUS KINASE 2; MESSENGER RNA; PROTEIN SH2; SOMATOMEDIN C; STAT5 PROTEIN; STAT5B PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ACUTE DISEASE; ANIMALS; CYTOKINES; DNA; ENDOTOXEMIA; ENDOTOXINS; GENE EXPRESSION; GROWTH HORMONE; INFLAMMATION MEDIATORS; INSULIN-LIKE GROWTH FACTOR I; JANUS KINASE 2; LIVER; MALE; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANSCRIPTION, GENETIC;

EID: 34447572787     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00581.2006     Document Type: Article

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