Mitogen-activated protein kinase kinase inhibition decreases growth hormone stimulated transcription mediated by STAT5

Molecular and Cellular Endocrinology

Volumn 133, Issue 2, 1997, Pages 169-176

  Pircher, Tony J ^a   Flores Morales, Amilcar ^a   Mui, Alice L F ^c   Saltiel, Alan R ^b   Norstedt, Gunnar ^a,b   Gustafsson, Jan Åke ^a   Haldosén, Lars Arne ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b PFIZER INC   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Gene regulation; Growth hormone; Serine phosphorylation; Signal transduction

Indexed keywords

CELL EXTRACT; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; STAT5 PROTEIN; STAT5B PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CHO CELL; CONTROLLED STUDY; ENZYME INHIBITION; EXPRESSION VECTOR; GENE EXPRESSION; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RAT; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL EXTRACTS; CELL NUCLEUS; CHO CELLS; CRICETINAE; DNA; DNA-BINDING PROTEINS; ENZYME INHIBITORS; FLAVONOIDS; GROWTH HORMONE; MILK PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MOLECULAR SEQUENCE DATA; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; RECEPTORS, SOMATOTROPIN; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS;

EID: 0030828180     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(97)00164-0     Document Type: Article

References (29)

1. Alessi D.R., Cuenda A., Cohen P., Dudley D.T., Saltiel A.R. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270:1995;27489-27494.
2. Argetsinger L.S., Campbell G.S., Yang X., Witthuhn B.A., Silvennoinen O., Ihle J.N., Carter-Su C. Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell. 74:1993;237-244.
3. Bazan J.F. Haemopoietic receptors and helical cytokines. Immunol. Today. 11:1990;350-354.
4. Beadling C., Ng J., Babbage J.W., Cantrell D.A. Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway. EMBO J. 15:1996;1902-1913.
5. Boulton T.G., Zhong Z., Wen Z., Darnell J.E. Jr., Stahl N., Yancopoulos G.D. STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase. Proc. Natl. Acad. Sci. USA. 92:1995;6915-6919.
6. Campbell G.S., Pang L., Miyasaka T., Saltiel A.R., Carter-Su C. Stimulation by growth hormone of MAP kinase activity in 3T3-F442A fibroblasts. J. Biol. Chem. 267:1992;6074-6080.
7. Campbell G.S., Meyer D.J., Raz R., Levy D.E., Schwartz J., Carter-Su C. Activation of acute phase response factor (APRF)/STAT3 transcription factor by growth hormone. J. Biol. Chem. 270:1995;3974-3979.
8. Cosman D., Lyman S.D., Idzerda R.L., Beckmann M.P., Park L.S., Goodwin R.G., March C.J. A new cytokine receptor superfamily. Trends Biochem. Sci. 15:1990;265-270.
9. David M., Petricoin E.R., Benjamin C., Pine R., Weber M.J., Larner A.C. Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins. Science. 269:1995;1721-1723.
10. Ihle J.N., Kerr I.M. JAKs and STATs in signaling by the cytokine receptor superfamily. Trends Genet. 11:1995;69-74.
11. Kitamura T., Ogorochi T., Miyajima A. Multimeric cytokine receptors. Trends Endocrinol. Metab. 5:1994;8-13.
12. Lazar D.F., Wiese R.J., Brady M.J., Mastick C.C., Waters S.B., Yamauchi K., Pessin J.E., Cuatrecasas P., Saltiel A.R. Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin. J. Biol. Chem. 270:1995;20801-20807.
13. Lin J.X., Mietz J., Modi W.S., John S., Leonard W.J. Cloning of human STAT5b. Reconstitution of interleukin-2-induced STAT5a and STAT5b DNA binding activity in COS-7 cells. J. Biol. Chem. 271:1996;10738-10744.
14. Liu X., Robinson G.W., Gouilleux F., Groner B., Hennighausen L. Cloning and expression of STAT5 and an additional homolog (STAT5b) involved in prolactin signal transduction in mouse mammary tissue. Proc. Natl. Acad. Sci. USA. 92:1995;8831-8835.
15. Meyer D.J., Campbell G.S., Cochran B.H., Argetsinger L.S., Larner A.C., Finbloom D.S., Carter-Su C., Schwartz J. Growth hormone induces a DNA binding factor related to the interferon-stimulated 91 kDa transcription factor. J. Biol. Chem. 269:1994;4701-4704.
16. Moller C., Hansson A., Enberg B., Lobie P.E., Norstedt G. Growth hormone (GH) induction of tyrosine phosphorylation and activation of mitogen-activated protein kinases in cells transfected with rat GH receptor cDNA. J. Biol. Chem. 267:1992;23403-23408.
17. Moriggl R., Gouilleux-Gruart V., Jahne R., Berchtold S., Gartmann C., Liu X., Hennighausen L., Sotiropoulos A., Groner B., Gouilleux F. Deletion of the carboxyl-terminal transactivation domain of MGF-STAT5 results in sustained DNA binding and a dominant negative phenotype. Mol. Cell. Biol. 16:1996;5691-5700.
18. Mui A.L., Wakao H., M O.F.A., Harada N., Miyajima A. Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J. 14:1995;1166-1175.
19. Ram P.A., Park S.H., Choi H.K., Waxman D.J. Growth hormone activation of STAT 1, STAT 3, and STAT 5 in rat liver. Differential kinetics of hormone desensitization and growth hormone stimulation of both tyrosine phosphorylation and serine/threonine phosphorylation. J. Biol. Chem. 271:1996;5929-5940.
20. Schindler C., Darnell J.E. Jr. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 64:1995;621-651.
21. Schmitt-Ney M., Happ B., Ball R.K., Groner B. Developmental and environmental regulation of a mammary gland-specific nuclear factor essential for transcription of the gene encoding beta-casein. Proc. Natl. Acad. Sci. USA. 89:1992;3130-3134.
22. Sliva D., Wood T.J., Schindler C., Lobie P.E., Norstedt G. Growth hormone specifically regulates serine protease inhibitor gene transcription via gamma-activated sequence-like DNA elements. J. Biol. Chem. 269:1994;26208-26214.
23. Wartmann M., Cella N., Hofer P., Groner B., Liu X.W., Hennighausen L., Hynes N.E. Lactogenic hormone activation of STAT5 and transcription of the beta-casein gene in mammary epithelial cells is independent of p42 erk2 mitogen-activated protein kinase activity. J. Biol. Chem. 271:1996;31863-31868.
24. Wen Z., Zhong Z., Darnell J.E. Jr. Maximal activation of transcription by STAT1 and STAT3 requires both tyrosine and serine phosphorylation. Cell. 82:1995;241-250.
25. Winston L.A., Bertics P.J. Growth hormone stimulates the tyrosine phosphorylation of 42- and 45-kDa ERK-related proteins. J. Biol. Chem. 267:1992;4747-4751.
26. Winston L.A., Hunter T. JAK2, Ras, and Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth hormone. J. Biol. Chem. 270:1995;30837-30840.
27. Wood T.J., Sliva D., Lobie P.E., Pircher T.J., Gouilleux F., Wakao H., Gustafsson J.A., Groner B., Norstedt G., Haldosen L.A. Mediation of growth hormone-dependent transcriptional activation by mammary gland factor/STAT5. J. Biol. Chem. 270:1995;9448-9453.
28. Wood T.J.J., Sliva D., Lobie P.E., Goullieux F., Mui A.L., Groner B., Nordstedt G., Haldosen L.-A. Specificity of Transcription Enhancement via the STAT Responsive Element in the Serine Protease Inhibitor 2.1 Promoter. Mol. Cell. Endocrinol. 130:1997;69-81.
29. Zhang X., Blenis J., Li H.C., Schindler C., Chen-Kiang S. Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science. 267:1995;1990-1994.