메뉴 건너뛰기




Volumn 292, Issue 6, 2007, Pages

Interleukin-6 inhibits growth hormone-mediated gene expression in hepatocytes

Author keywords

Cytokine inflammation; Growth hormone resistance; Insulin like growth factor I; Janus kinase signal transducer and activator of transcription signaling; Mitogen activated protein kinase pathway; Serine protease inhibitor 2.1

Indexed keywords

DNA; GROWTH HORMONE RECEPTOR; INTERLEUKIN 6; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; STAT5B PROTEIN;

EID: 34447508349     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00547.2006     Document Type: Article
Times cited : (26)

References (65)
  • 2
    • 0034021675 scopus 로고    scopus 로고
    • Growth failure occurs through a decrease in insulin-like growth factor 1 which is independent of undernutrition in a rat model of colitis
    • Ballinger AB, Azooz O, El-Haj T, Poole S, Farthing MJ. Growth failure occurs through a decrease in insulin-like growth factor 1 which is independent of undernutrition in a rat model of colitis. Gut 46: 694-700, 2000.
    • (2000) Gut , vol.46 , pp. 694-700
    • Ballinger, A.B.1    Azooz, O.2    El-Haj, T.3    Poole, S.4    Farthing, M.J.5
  • 3
    • 0035077955 scopus 로고    scopus 로고
    • Growth failure and intestinal inflammation
    • Ballinger AB, Camacho-Hubner C, Croft NM. Growth failure and intestinal inflammation. QJM 94: 121-125, 2001.
    • (2001) QJM , vol.94 , pp. 121-125
    • Ballinger, A.B.1    Camacho-Hubner, C.2    Croft, N.M.3
  • 4
    • 0025268277 scopus 로고
    • An investigation of the anabolic activity of somatropin in normal and burned rats
    • Belcher HJ, Ellis H. An investigation of the anabolic activity of somatropin in normal and burned rats. Burns 16: 17-20, 1990.
    • (1990) Burns , vol.16 , pp. 17-20
    • Belcher, H.J.1    Ellis, H.2
  • 7
    • 0034635550 scopus 로고    scopus 로고
    • Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1beta on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells
    • Boisclair YR, Wang J, Shi J, Hurst KR, Ooi GT. Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1beta on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells. J Biol Chem 275: 3841-3847, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 3841-3847
    • Boisclair, Y.R.1    Wang, J.2    Shi, J.3    Hurst, K.R.4    Ooi, G.T.5
  • 8
    • 8944247747 scopus 로고    scopus 로고
    • Growth hormone stimulates tyrosine phosphorylation of JAK2 and STAT5, but not insulin receptor substrate-1 or SHC proteins in liver and skeletal muscle of normal rats in vivo
    • Chow JC, Ling PR, Qu Z, Laviola L, Ciccarone A, Bistrian BR, Smith RJ. Growth hormone stimulates tyrosine phosphorylation of JAK2 and STAT5, but not insulin receptor substrate-1 or SHC proteins in liver and skeletal muscle of normal rats in vivo. Endocrinology 137: 2880-2886, 1996.
    • (1996) Endocrinology , vol.137 , pp. 2880-2886
    • Chow, J.C.1    Ling, P.R.2    Qu, Z.3    Laviola, L.4    Ciccarone, A.5    Bistrian, B.R.6    Smith, R.J.7
  • 10
    • 0036480027 scopus 로고    scopus 로고
    • Suppressors of cytokine signaling (SOCS): Inhibitors of the JAK/STAT pathway
    • Cooney RN. Suppressors of cytokine signaling (SOCS): inhibitors of the JAK/STAT pathway. Shock 17: 83-90, 2002.
    • (2002) Shock , vol.17 , pp. 83-90
    • Cooney, R.N.1
  • 11
    • 0030638323 scopus 로고    scopus 로고
    • Regulation of skeletal muscle protein turnover during sepsis: Mechanisms and mediators
    • Cooney RN, Kimball SR, Vary TC. Regulation of skeletal muscle protein turnover during sepsis: mechanisms and mediators. Shock 7: 1-16, 1997.
    • (1997) Shock , vol.7 , pp. 1-16
    • Cooney, R.N.1    Kimball, S.R.2    Vary, T.C.3
  • 12
    • 0031946053 scopus 로고    scopus 로고
    • Systemic and splanchnic metabolic response to exogenous human growth hormone
    • Dahn MS, Lange MP. Systemic and splanchnic metabolic response to exogenous human growth hormone. Surgery 123: 528-538, 1998.
    • (1998) Surgery , vol.123 , pp. 528-538
    • Dahn, M.S.1    Lange, M.P.2
  • 13
    • 0023752178 scopus 로고
    • Insulinlike growth factor 1 production is inhibited in human sepsis
    • Dahn MS, Lange MP, Jacobs LA. Insulinlike growth factor 1 production is inhibited in human sepsis. Arch Surg 123: 1409-1414, 1988.
    • (1988) Arch Surg , vol.123 , pp. 1409-1414
    • Dahn, M.S.1    Lange, M.P.2    Jacobs, L.A.3
  • 15
    • 0031025204 scopus 로고    scopus 로고
    • Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation
    • De Benedetti F, Alonzi T, Moretta A, Lazzaro D, Costa P, Poli V, Martini A, Ciliberto G, Fattori E. Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation. J Clin Invest 99: 643-650, 1997.
    • (1997) J Clin Invest , vol.99 , pp. 643-650
    • De Benedetti, F.1    Alonzi, T.2    Moretta, A.3    Lazzaro, D.4    Costa, P.5    Poli, V.6    Martini, A.7    Ciliberto, G.8    Fattori, E.9
  • 16
  • 18
    • 0034994026 scopus 로고    scopus 로고
    • TNF-alpha downregulates murine hepatic growth hormone receptor expression by inhibiting Sp1 and Sp3 binding
    • Denson LA, Menon RK, Shaufl A, Bajwa HS, Williams CR, Karpen SJ. TNF-alpha downregulates murine hepatic growth hormone receptor expression by inhibiting Sp1 and Sp3 binding. J Clin Invest 107: 1451-1458, 2001.
    • (2001) J Clin Invest , vol.107 , pp. 1451-1458
    • Denson, L.A.1    Menon, R.K.2    Shaufl, A.3    Bajwa, H.S.4    Williams, C.R.5    Karpen, S.J.6
  • 20
  • 21
    • 0030004837 scopus 로고    scopus 로고
    • Regulation of insulin-like growth factor (IGF)-I mRNA and peptide and IGF-binding proteins by interleukin-1
    • Fan J, Wojnar MM, Theodorakis M, Lang CH. Regulation of insulin-like growth factor (IGF)-I mRNA and peptide and IGF-binding proteins by interleukin-1. Am J Physiol Regul Integr Comp Physiol 270: R621-R629, 1996.
    • (1996) Am J Physiol Regul Integr Comp Physiol , vol.270
    • Fan, J.1    Wojnar, M.M.2    Theodorakis, M.3    Lang, C.H.4
  • 22
    • 0032010176 scopus 로고    scopus 로고
    • Growth factors in critical illness: Regulation and therapeutic aspects
    • Frost RA, Lang CH. Growth factors in critical illness: regulation and therapeutic aspects. Curr Opin Clin Nutr Metab Care 1: 195-204, 1998.
    • (1998) Curr Opin Clin Nutr Metab Care , vol.1 , pp. 195-204
    • Frost, R.A.1    Lang, C.H.2
  • 23
    • 0033603361 scopus 로고    scopus 로고
    • Regulation of prolactin receptor (PRLR) gene expression in insulin-producing cells. Prolactin and growth hormone activate one of the rat prlr gene promoters via STAT5a and STAT5b
    • Galsgaard ED, Nielsen JH, Moldrup A. Regulation of prolactin receptor (PRLR) gene expression in insulin-producing cells. Prolactin and growth hormone activate one of the rat prlr gene promoters via STAT5a and STAT5b. J Biol Chem 274: 18686-18692, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 18686-18692
    • Galsgaard, E.D.1    Nielsen, J.H.2    Moldrup, A.3
  • 24
    • 0030944171 scopus 로고    scopus 로고
    • Regulation of signal transducer and activator of transcription (STAT) 5b activation by the temporal pattern of growth hormone stimulation
    • Gebert CA, Park SH, Waxman DJ. Regulation of signal transducer and activator of transcription (STAT) 5b activation by the temporal pattern of growth hormone stimulation. Mol Endocrinol 11: 400-414, 1997.
    • (1997) Mol Endocrinol , vol.11 , pp. 400-414
    • Gebert, C.A.1    Park, S.H.2    Waxman, D.J.3
  • 25
    • 0032894684 scopus 로고    scopus 로고
    • Termination of growth hormone pulse-induced STAT5b signaling
    • Gebert CA, Park SH, Waxman DJ. Termination of growth hormone pulse-induced STAT5b signaling. Mol Endocrinol 13: 38-56, 1999.
    • (1999) Mol Endocrinol , vol.13 , pp. 38-56
    • Gebert, C.A.1    Park, S.H.2    Waxman, D.J.3
  • 26
    • 0028201322 scopus 로고
    • Interleukin-6 induces skeletal muscle protein breakdown in rats
    • Goodman MN. Interleukin-6 induces skeletal muscle protein breakdown in rats. Proc Soc Exp Biol Med 205: 182-185, 1994.
    • (1994) Proc Soc Exp Biol Med , vol.205 , pp. 182-185
    • Goodman, M.N.1
  • 27
    • 0033883449 scopus 로고    scopus 로고
    • Regulation of the trans-activation potential of STAT5 through its DNA-binding activity and interactions with heterologous transcription factors
    • Groner B, Fritsche M, Stocklin E, Berchtold S, Merkle C, Moriggl R, Pfitzner E. Regulation of the trans-activation potential of STAT5 through its DNA-binding activity and interactions with heterologous transcription factors. Growth Horm IGF Res 10, Suppl B: S15-S20, 2000.
    • (2000) Growth Horm IGF Res , vol.10 , Issue.SUPPL. B
    • Groner, B.1    Fritsche, M.2    Stocklin, E.3    Berchtold, S.4    Merkle, C.5    Moriggl, R.6    Pfitzner, E.7
  • 28
    • 0033305402 scopus 로고    scopus 로고
    • Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins
    • Hansen JA, Lindberg K, Hilton DJ, Nielsen JH, Billestrup N. Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins. Mol Endocrinol 13: 1832-1843, 1999.
    • (1999) Mol Endocrinol , vol.13 , pp. 1832-1843
    • Hansen, J.A.1    Lindberg, K.2    Hilton, D.J.3    Nielsen, J.H.4    Billestrup, N.5
  • 29
    • 0023601993 scopus 로고
    • Relationship of somatomedin-C/insulin-like growth factor I levels to conventional nutritional indices in critically ill patients
    • Hawker FH, Stewart PM, Baxter RC, Borkmann M, Tan K, Caterson ID, McWilliam DB. Relationship of somatomedin-C/insulin-like growth factor I levels to conventional nutritional indices in critically ill patients. Crit Care Med 15: 732-736, 1987.
    • (1987) Crit Care Med , vol.15 , pp. 732-736
    • Hawker, F.H.1    Stewart, P.M.2    Baxter, R.C.3    Borkmann, M.4    Tan, K.5    Caterson, I.D.6    McWilliam, D.B.7
  • 30
    • 0035434522 scopus 로고    scopus 로고
    • Signaling pathways activated by the growth hormone receptor
    • Herrington J, Carter-Su C. Signaling pathways activated by the growth hormone receptor. Trends Endocrinol Metab 12: 252-257, 2001.
    • (2001) Trends Endocrinol Metab , vol.12 , pp. 252-257
    • Herrington, J.1    Carter-Su, C.2
  • 31
    • 0034657348 scopus 로고    scopus 로고
    • The role of STAT proteins in growth hormone signaling
    • Herrington J, Smit LS, Schwartz J, Carter-Su C. The role of STAT proteins in growth hormone signaling. Oncogene 19: 2585-2597, 2000.
    • (2000) Oncogene , vol.19 , pp. 2585-2597
    • Herrington, J.1    Smit, L.S.2    Schwartz, J.3    Carter-Su, C.4
  • 32
    • 0028920598 scopus 로고
    • Responsiveness of an SV40-immortalized hepatocyte cell line to growth hormone
    • Kempe KC, Isom HC, Greene FE. Responsiveness of an SV40-immortalized hepatocyte cell line to growth hormone. Biochem Pharmacol 49: 1091-1098, 1995.
    • (1995) Biochem Pharmacol , vol.49 , pp. 1091-1098
    • Kempe, K.C.1    Isom, H.C.2    Greene, F.E.3
  • 33
    • 0029984415 scopus 로고    scopus 로고
    • IL-1 receptor antagonist attenuates sepsis-induced alterations in the IGF system and protein synthesis
    • Lang CH, Fan J, Cooney R, Vary TC. IL-1 receptor antagonist attenuates sepsis-induced alterations in the IGF system and protein synthesis. Am J Physiol Endocrinol Metab 270: E430-E437, 1996.
    • (1996) Am J Physiol Endocrinol Metab , vol.270
    • Lang, C.H.1    Fan, J.2    Cooney, R.3    Vary, T.C.4
  • 34
    • 0032545341 scopus 로고    scopus 로고
    • Growth hormone-mediated transcriptional activation of the rat serine protease inhibitor 2.1 gene involves both interleukin-1 beta-sensitive and -insensitive pathways
    • Le Cam A, Paul C, Thissen JP. Growth hormone-mediated transcriptional activation of the rat serine protease inhibitor 2.1 gene involves both interleukin-1 beta-sensitive and -insensitive pathways. Biochem Biophys Res Commun 253: 311-314, 1998.
    • (1998) Biochem Biophys Res Commun , vol.253 , pp. 311-314
    • Le Cam, A.1    Paul, C.2    Thissen, J.P.3
  • 36
    • 0024357074 scopus 로고
    • Stimulation of the acute-phase response in simian virus 40-hepatocyte cell lines
    • Liao WS, Ma KT, Woodworth CD, Mengel L, Isom HC. Stimulation of the acute-phase response in simian virus 40-hepatocyte cell lines. Mol Cell Biol 9: 2779-2786, 1989.
    • (1989) Mol Cell Biol , vol.9 , pp. 2779-2786
    • Liao, W.S.1    Ma, K.T.2    Woodworth, C.D.3    Mengel, L.4    Isom, H.C.5
  • 37
    • 0036893473 scopus 로고    scopus 로고
    • IL-6-overexpression brings about growth impairment potentially through a GH receptor defect
    • Lieskovska J, Guo D, Derman E. IL-6-overexpression brings about growth impairment potentially through a GH receptor defect. Growth Horm IGF Res 12: 388-398, 2002.
    • (2002) Growth Horm IGF Res , vol.12 , pp. 388-398
    • Lieskovska, J.1    Guo, D.2    Derman, E.3
  • 39
    • 0028103767 scopus 로고
    • Insulin-like growth factor I: Molecular biology and relevance to tissue-specific expression and action
    • Lund PK. Insulin-like growth factor I: molecular biology and relevance to tissue-specific expression and action. Recent Prog Horm Res 49: 125-148, 1994.
    • (1994) Recent Prog Horm Res , vol.49 , pp. 125-148
    • Lund, P.K.1
  • 41
    • 0029930425 scopus 로고    scopus 로고
    • In vitro transcription of the rat insulin-like growth factor-I gene
    • Pao CI, Lin KW, Zhu J, Wu G, Farmer PK, Phillips LS. In vitro transcription of the rat insulin-like growth factor-I gene. J Biol Chem 271: 8667-8674, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 8667-8674
    • Pao, C.I.1    Lin, K.W.2    Zhu, J.3    Wu, G.4    Farmer, P.K.5    Phillips, L.S.6
  • 42
    • 0033808087 scopus 로고    scopus 로고
    • Regulation of expression of the rat SOCS-3 gene in hepatocytes by growth hormone, interleukin-6 and glucocorticoids mRNA analysis and promoter characterization
    • Paul C, Seiliez I, Thissen JP, Le Cam A. Regulation of expression of the rat SOCS-3 gene in hepatocytes by growth hormone, interleukin-6 and glucocorticoids mRNA analysis and promoter characterization. Eur J Biochem 267: 5849-5857, 2000.
    • (2000) Eur J Biochem , vol.267 , pp. 5849-5857
    • Paul, C.1    Seiliez, I.2    Thissen, J.P.3    Le Cam, A.4
  • 43
    • 0030804219 scopus 로고    scopus 로고
    • The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs)
    • Pellegrini S, Dusanter-Fourt I. The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs). Eur J Biochem 248: 615-633, 1997.
    • (1997) Eur J Biochem , vol.248 , pp. 615-633
    • Pellegrini, S.1    Dusanter-Fourt, I.2
  • 44
    • 0032230282 scopus 로고    scopus 로고
    • p300/CREB-binding protein enhances the prolactin-mediated transcriptional induction through direct interaction with the transactivation domain of Stat5, but does not participate in the Stat5-mediated suppression of the glucocorticoid response
    • Pfitzner E, Jahne R, Wissler M, Stoecklin E, Groner B. p300/CREB-binding protein enhances the prolactin-mediated transcriptional induction through direct interaction with the transactivation domain of Stat5, but does not participate in the Stat5-mediated suppression of the glucocorticoid response. Mol Endocrinol 12: 1582-1593, 1998.
    • (1998) Mol Endocrinol , vol.12 , pp. 1582-1593
    • Pfitzner, E.1    Jahne, R.2    Wissler, M.3    Stoecklin, E.4    Groner, B.5
  • 46
    • 0029865558 scopus 로고    scopus 로고
    • Growth hormone activation of Stat 1, Stat 3, and Stat 5 in rat liver. Differential kinetics of hormone desensitization and growth hormone stimulation of both tyrosine phosphorylation and serine/threonine phosphorylation
    • Ram PA, Park SH, Choi HK, Waxman DJ. Growth hormone activation of Stat 1, Stat 3, and Stat 5 in rat liver. Differential kinetics of hormone desensitization and growth hormone stimulation of both tyrosine phosphorylation and serine/threonine phosphorylation. J Biol Chem 271: 5929-5940, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 5929-5940
    • Ram, P.A.1    Park, S.H.2    Choi, H.K.3    Waxman, D.J.4
  • 47
    • 0030878257 scopus 로고    scopus 로고
    • Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase
    • Ram PA, Waxman DJ. Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase. J Biol Chem 272: 17694-17702, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 17694-17702
    • Ram, P.A.1    Waxman, D.J.2
  • 48
    • 0033544899 scopus 로고    scopus 로고
    • SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms
    • Ram PA, Waxman DJ. SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. J Biol Chem 274: 35553-35561, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 35553-35561
    • Ram, P.A.1    Waxman, D.J.2
  • 49
  • 51
    • 0034870176 scopus 로고    scopus 로고
    • LY 294002, an inhibitor of phosphatidylinositol 3-kinase, inhibits GH-mediated expression of the IGF-I gene in rat hepatocytes
    • Shoba LN, Newman M, Liu W, Lowe WL Jr. LY 294002, an inhibitor of phosphatidylinositol 3-kinase, inhibits GH-mediated expression of the IGF-I gene in rat hepatocytes. Endocrinology 142: 3980-3986, 2001.
    • (2001) Endocrinology , vol.142 , pp. 3980-3986
    • Shoba, L.N.1    Newman, M.2    Liu, W.3    Lowe Jr, W.L.4
  • 52
    • 22544444238 scopus 로고    scopus 로고
    • Interleukin-1 inhibits the induction of insulin-like growth factor-I by growth hormone in CWSV-1 hepatocytes
    • Shumate ML, Yumet G, Ahmed TA, Cooney RN. Interleukin-1 inhibits the induction of insulin-like growth factor-I by growth hormone in CWSV-1 hepatocytes. Am J Physiol Gastrointest Liver Physiol 289: G227-G239, 2005.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.289
    • Shumate, M.L.1    Yumet, G.2    Ahmed, T.A.3    Cooney, R.N.4
  • 53
    • 0032230272 scopus 로고    scopus 로고
    • Transcription of the rat serine protease inhibitor 21 gene in vivo: Correlation with GAGA box promoter occupancy and mechanism of cytokine-mediated down-regulation
    • Simar-Blanchet AE, Legraverend C, Thissen JP, Le Cam A. Transcription of the rat serine protease inhibitor 21 gene in vivo: correlation with GAGA box promoter occupancy and mechanism of cytokine-mediated down-regulation. Mol Endocrinol 12: 391-404, 1998.
    • (1998) Mol Endocrinol , vol.12 , pp. 391-404
    • Simar-Blanchet, A.E.1    Legraverend, C.2    Thissen, J.P.3    Le Cam, A.4
  • 54
    • 0031046710 scopus 로고    scopus 로고
    • Inhibition by interleukin-1 beta and tumor necrosis factor-alpha of the insulin-like growth factor I messenger ribonucleic acid response to growth hormone in rat hepatocyte primary culture
    • Thissen JP, Verniers J. Inhibition by interleukin-1 beta and tumor necrosis factor-alpha of the insulin-like growth factor I messenger ribonucleic acid response to growth hormone in rat hepatocyte primary culture. Endocrinology 138: 1078-1084, 1997.
    • (1997) Endocrinology , vol.138 , pp. 1078-1084
    • Thissen, J.P.1    Verniers, J.2
  • 56
    • 0030967949 scopus 로고    scopus 로고
    • Signaling molecules involved in coupling growth hormone receptor to mitogen-activated protein kinase activation
    • Vanderkuur JA, Butch ER, Waters SB, Pessin JE, Guan KL, Carter-Su C. Signaling molecules involved in coupling growth hormone receptor to mitogen-activated protein kinase activation. Endocrinology 138: 4301-4307, 1997.
    • (1997) Endocrinology , vol.138 , pp. 4301-4307
    • Vanderkuur, J.A.1    Butch, E.R.2    Waters, S.B.3    Pessin, J.E.4    Guan, K.L.5    Carter-Su, C.6
  • 57
    • 15744398235 scopus 로고    scopus 로고
    • Identification of a distal STAT5-binding DNA region that may mediate growth hormone regulation of insulin-like growth factor-I gene expression
    • Wang Y, Jiang H. Identification of a distal STAT5-binding DNA region that may mediate growth hormone regulation of insulin-like growth factor-I gene expression. J Biol Chem 280: 10955-10963, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 10955-10963
    • Wang, Y.1    Jiang, H.2
  • 58
    • 0037590103 scopus 로고    scopus 로고
    • Acute control of insulin-like growth factor-I gene transcription by growth hormone through Stat5b
    • Woelfle J, Billiard J, Rotwein P. Acute control of insulin-like growth factor-I gene transcription by growth hormone through Stat5b. J Biol Chem 278: 22696-22702, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 22696-22702
    • Woelfle, J.1    Billiard, J.2    Rotwein, P.3
  • 59
    • 0346435095 scopus 로고    scopus 로고
    • Mechanisms of growth hormone (GH) action. Identification of conserved Stat5 binding sites that mediate GH-induced insulin-like growth factor-I gene activation
    • Woelfle J, Chia DJ, Rotwein P. Mechanisms of growth hormone (GH) action. Identification of conserved Stat5 binding sites that mediate GH-induced insulin-like growth factor-I gene activation. J Biol Chem 278: 51261-51266, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 51261-51266
    • Woelfle, J.1    Chia, D.J.2    Rotwein, P.3
  • 61
    • 0023429407 scopus 로고
    • Regulation of albumin gene expression in a series of rat hepatocyte cell lines immortalized by simian virus 40 and maintained in chemically defined medium
    • Woodworth CD, Isom HC. Regulation of albumin gene expression in a series of rat hepatocyte cell lines immortalized by simian virus 40 and maintained in chemically defined medium. Mol Cell Biol 7: 3740-3748, 1987.
    • (1987) Mol Cell Biol , vol.7 , pp. 3740-3748
    • Woodworth, C.D.1    Isom, H.C.2
  • 62
    • 0032934069 scopus 로고    scopus 로고
    • Glucocorticoid receptor/signal transducer and activator of transcription 5 (STAT5) interactions enhance STAT5 activation by prolonging STAT5 DNA binding and tyrosine phosphorylation
    • Wyszomierski SL, Yeh J, Rosen JM. Glucocorticoid receptor/signal transducer and activator of transcription 5 (STAT5) interactions enhance STAT5 activation by prolonging STAT5 DNA binding and tyrosine phosphorylation. Mol Endocrinol 13: 330-343, 1999.
    • (1999) Mol Endocrinol , vol.13 , pp. 330-343
    • Wyszomierski, S.L.1    Yeh, J.2    Rosen, J.M.3
  • 63
    • 33646560290 scopus 로고    scopus 로고
    • Hepatic growth hormone resistance during sepsis is associated with increased suppressors of cytokine signaling expression and impaired growth hormone signaling
    • Yumet G, Shumate ML, Bryant DP, Lang CH, Cooney RN. Hepatic growth hormone resistance during sepsis is associated with increased suppressors of cytokine signaling expression and impaired growth hormone signaling. Crit Care Med 34: 1420 -1427, 2006.
    • (2006) Crit Care Med , vol.34 , pp. 1420-1427
    • Yumet, G.1    Shumate, M.L.2    Bryant, D.P.3    Lang, C.H.4    Cooney, R.N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.