메뉴 건너뛰기




Volumn 46, Issue 1, 2009, Pages 79-86

Melatonin reduces stress-activated/mitogen-activated protein kinases in spinal cord injury

Author keywords

Free radicals; Inflammation; Protein kinase signaling; Spinal cord injury

Indexed keywords

MELATONIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 57149142404     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2008.00633.x     Document Type: Article
Times cited : (56)

References (61)
  • 1
    • 20244366420 scopus 로고    scopus 로고
    • Characterization of a new rat model of experimental combined neurotrauma
    • Maegele M, Riess P, Sauerland S et al. Characterization of a new rat model of experimental combined neurotrauma. Shock 2005 23 : 476 481.
    • (2005) Shock , vol.23 , pp. 476-481
    • Maegele, M.1    Riess, P.2    Sauerland, S.3
  • 2
    • 1842419475 scopus 로고    scopus 로고
    • Degenerative and regenerative mechanisms governing spinal cord injury
    • Profyris C, Cheema SS, Zang D et al. Degenerative and regenerative mechanisms governing spinal cord injury. Neurobiol Dis 2004 15 : 415 436.
    • (2004) Neurobiol Dis , vol.15 , pp. 415-436
    • Profyris, C.1    Cheema, S.S.2    Zang, D.3
  • 3
    • 0036939328 scopus 로고    scopus 로고
    • Macrophages and microglia produce local trophic gradients that stimulate axonal sprouting toward but not beyond the wound edge
    • Batchelor PE, Porritt MJ, Martinello P et al. Macrophages and microglia produce local trophic gradients that stimulate axonal sprouting toward but not beyond the wound edge. Mol Cell Neurosci 2002 21 : 436 453.
    • (2002) Mol Cell Neurosci , vol.21 , pp. 436-453
    • Batchelor, P.E.1    Porritt, M.J.2    Martinello, P.3
  • 4
    • 33644768268 scopus 로고    scopus 로고
    • Immunomodulatory effects of etanercept in an experimental model of spinal cord injury
    • Genovese T, Mazzon E, Crisafulli C et al. Immunomodulatory effects of etanercept in an experimental model of spinal cord injury. J Pharmacol Exp Ther 2006 316 : 1006 1016.
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 1006-1016
    • Genovese, T.1    Mazzon, E.2    Crisafulli, C.3
  • 5
    • 3042816808 scopus 로고    scopus 로고
    • The role of excitotoxicity in secondary mechanisms of spinal cord injury: A review with an emphasis on the implications for white matter degeneration
    • Park E, Velumian AA, Fehlings MG. The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration. J Neurotrauma 2004 21 : 754 774.
    • (2004) J Neurotrauma , vol.21 , pp. 754-774
    • Park, E.1    Velumian, A.A.2    Fehlings, M.G.3
  • 6
    • 0032032424 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures
    • Bhat NR, Zhang P, Lee JC et al. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J Neurosci 1998 18 : 1633 1641.
    • (1998) J Neurosci , vol.18 , pp. 1633-1641
    • Bhat, N.R.1    Zhang, P.2    Lee, J.C.3
  • 7
    • 0346101881 scopus 로고    scopus 로고
    • C-jun n-terminal kinase and, to a lesser extent, p38 mitogen-activated protein kinase regulate inducible nitric oxide synthase expression in hyaluronan fragments-stimulated bv-2 microglia
    • Wang MJ, Jeng KC, Kuo JS et al. C-jun n-terminal kinase and, to a lesser extent, p38 mitogen-activated protein kinase regulate inducible nitric oxide synthase expression in hyaluronan fragments-stimulated bv-2 microglia. J Neuroimmunol 2004 146 : 50 62.
    • (2004) J Neuroimmunol , vol.146 , pp. 50-62
    • Wang, M.J.1    Jeng, K.C.2    Kuo, J.S.3
  • 8
    • 1042302901 scopus 로고    scopus 로고
    • Activated glia induce neuron death via map kinase signaling pathways involving jnk and p38
    • Xie Z, Smith CJ, Van Eldik LJ. Activated glia induce neuron death via map kinase signaling pathways involving jnk and p38. Glia 2004 45 : 170 179.
    • (2004) Glia , vol.45 , pp. 170-179
    • Xie, Z.1    Smith, C.J.2    Van Eldik, L.J.3
  • 9
    • 0034711334 scopus 로고    scopus 로고
    • Signal transduction. An arresting start for mapk
    • Pouyssegur J. Signal transduction. An arresting start for mapk. Science (New York, NY) 2000 290 : 1515 1518.
    • (2000) Science (New York, NY) , vol.290 , pp. 1515-1518
    • Pouyssegur, J.1
  • 10
    • 14844327760 scopus 로고    scopus 로고
    • Reactive oxygen species promote tnfalpha-induced death and sustained jnk activation by inhibiting map kinase phosphatases
    • Kamata H, Honda S, Maeda S et al. Reactive oxygen species promote tnfalpha-induced death and sustained jnk activation by inhibiting map kinase phosphatases. Cell 2005 120 : 649 661.
    • (2005) Cell , vol.120 , pp. 649-661
    • Kamata, H.1    Honda, S.2    Maeda, S.3
  • 11
    • 19444384370 scopus 로고    scopus 로고
    • Jnk activation limits dendritic cell maturation in response to reactive oxygen species by the induction of apoptosis
    • Handley ME, Thakker M, Pollara G et al. Jnk activation limits dendritic cell maturation in response to reactive oxygen species by the induction of apoptosis. Free Radic Biol Med 2005 38 : 1637 1652.
    • (2005) Free Radic Biol Med , vol.38 , pp. 1637-1652
    • Handley, M.E.1    Thakker, M.2    Pollara, G.3
  • 12
    • 0033538467 scopus 로고    scopus 로고
    • Hmg-1 as a late mediator of endotoxin lethality in mice
    • Wang H, Bloom O, Zhang M et al. Hmg-1 as a late mediator of endotoxin lethality in mice. Science (New York, NY) 1999 285 : 248 251.
    • (1999) Science (New York, NY) , vol.285 , pp. 248-251
    • Wang, H.1    Bloom, O.2    Zhang, M.3
  • 13
    • 17144376810 scopus 로고    scopus 로고
    • High-mobility group box 1 protein (hmgb1): Nuclear weapon in the immune arsenal
    • Lotze MT, Tracey KJ. High-mobility group box 1 protein (hmgb1): nuclear weapon in the immune arsenal. Nat Rev 2005 5 : 331 342.
    • (2005) Nat Rev , vol.5 , pp. 331-342
    • Lotze, M.T.1    Tracey, K.J.2
  • 14
    • 22144447819 scopus 로고    scopus 로고
    • The cytokine activity of hmgb1
    • Yang H, Wang H, Czura CJ et al. The cytokine activity of hmgb1. J Leukoc Biol 2005 78 : 1 8.
    • (2005) J Leukoc Biol , vol.78 , pp. 1-8
    • Yang, H.1    Wang, H.2    Czura, C.J.3
  • 15
    • 0034664791 scopus 로고    scopus 로고
    • Hmg-1 as a mediator of acute lung inflammation
    • Abraham E, Arcaroli J, Carmody A et al. Hmg-1 as a mediator of acute lung inflammation. J Immunol 2000 165 : 2950 2954.
    • (2000) J Immunol , vol.165 , pp. 2950-2954
    • Abraham, E.1    Arcaroli, J.2    Carmody, A.3
  • 16
    • 0036724929 scopus 로고    scopus 로고
    • Hmgb1 b box increases the permeability of caco-2 enterocytic monolayers and impairs intestinal barrier function in mice
    • Sappington PL, Yang R, Yang H et al. Hmgb1 b box increases the permeability of caco-2 enterocytic monolayers and impairs intestinal barrier function in mice. Gastroenterology 2002 123 : 790 802.
    • (2002) Gastroenterology , vol.123 , pp. 790-802
    • Sappington, P.L.1    Yang, R.2    Yang, H.3
  • 17
    • 34848844459 scopus 로고    scopus 로고
    • Reactions of the no redox forms NO+, *nO and HNO (protonated NO-) with the melatonin metabolite n1-acetyl-5-methoxykynuramine
    • Hardeland R, Backhaus C, Fadavi A. Reactions of the no redox forms NO+, *NO and HNO (protonated NO-) with the melatonin metabolite n1-acetyl-5-methoxykynuramine. J Pineal Res 2007 43 : 382 388.
    • (2007) J Pineal Res , vol.43 , pp. 382-388
    • Hardeland, R.1    Backhaus, C.2    Fadavi, A.3
  • 18
    • 0037246752 scopus 로고    scopus 로고
    • Melatonin: A hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin
    • Tan DX, Manchester LC, Hardeland R et al. Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin. J Pineal Res 2003 34 : 75 78.
    • (2003) J Pineal Res , vol.34 , pp. 75-78
    • Tan, D.X.1    Manchester, L.C.2    Hardeland, R.3
  • 19
    • 34147201601 scopus 로고    scopus 로고
    • Afmk, a melatonin metabolite, attenuates x-ray-induced oxidative damage to DNA, proteins and lipids in mice
    • Manda K, Ueno M, Anzai K. Afmk, a melatonin metabolite, attenuates x-ray-induced oxidative damage to DNA, proteins and lipids in mice. J Pineal Res 2007 42 : 386 393.
    • (2007) J Pineal Res , vol.42 , pp. 386-393
    • Manda, K.1    Ueno, M.2    Anzai, K.3
  • 20
    • 0342894684 scopus 로고    scopus 로고
    • Melatonin is a scavenger of peroxynitrite
    • Gilad E, Cuzzocrea S, Zingarelli B et al. Melatonin is a scavenger of peroxynitrite. Life Sci 1997 60 : PL169 PL174.
    • (1997) Life Sci , vol.60
    • Gilad, E.1    Cuzzocrea, S.2    Zingarelli, B.3
  • 21
    • 0031226491 scopus 로고    scopus 로고
    • Protective effect of melatonin in carrageenan-induced models of local inflammation: Relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity
    • Cuzzocrea S, Zingarelli B, Gilad E et al. Protective effect of melatonin in carrageenan-induced models of local inflammation: relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity. J Pineal Res 1997 23 : 106 116.
    • (1997) J Pineal Res , vol.23 , pp. 106-116
    • Cuzzocrea, S.1    Zingarelli, B.2    Gilad, E.3
  • 22
    • 0031823823 scopus 로고    scopus 로고
    • Melatonin as a hydroxyl radical scavenger
    • Stasica P, Ulanski P, Rosiak JM. Melatonin as a hydroxyl radical scavenger. J Pineal Res 1998 25 : 65 66.
    • (1998) J Pineal Res , vol.25 , pp. 65-66
    • Stasica, P.1    Ulanski, P.2    Rosiak, J.M.3
  • 23
    • 33748042003 scopus 로고    scopus 로고
    • Inhibition of neuronal nitric oxide synthase activity by n1-acetyl-5-methoxykynuramine, a brain metabolite of melatonin
    • Leon J, Escames G, Rodriguez MI et al. Inhibition of neuronal nitric oxide synthase activity by n1-acetyl-5-methoxykynuramine, a brain metabolite of melatonin. J Neurochem 2006 98 : 2023 2033.
    • (2006) J Neurochem , vol.98 , pp. 2023-2033
    • Leon, J.1    Escames, G.2    Rodriguez, M.I.3
  • 24
    • 0032702845 scopus 로고    scopus 로고
    • The protective role of endogenous melatonin in carrageenan-induced pleurisy in the rat
    • Cuzzocrea S, Tan DX, Costantino G et al. The protective role of endogenous melatonin in carrageenan-induced pleurisy in the rat. FASEB J 1999 13 : 1930 1938.
    • (1999) FASEB J , vol.13 , pp. 1930-1938
    • Cuzzocrea, S.1    Tan, D.X.2    Costantino, G.3
  • 25
    • 34447527588 scopus 로고    scopus 로고
    • Effects of combination of melatonin and dexamethasone on secondary injury in an experimental mice model of spinal cord trauma
    • Genovese T, Mazzon E, Crisafulli C et al. Effects of combination of melatonin and dexamethasone on secondary injury in an experimental mice model of spinal cord trauma. J Pineal Res 2007 43 : 140 153.
    • (2007) J Pineal Res , vol.43 , pp. 140-153
    • Genovese, T.1    Mazzon, E.2    Crisafulli, C.3
  • 26
    • 15444378210 scopus 로고    scopus 로고
    • Attenuation in the evolution of experimental spinal cord trauma by treatment with melatonin
    • Genovese T, Mazzon E, Muia C et al. Attenuation in the evolution of experimental spinal cord trauma by treatment with melatonin. J Pineal Res 2005 38 : 198 208.
    • (2005) J Pineal Res , vol.38 , pp. 198-208
    • Genovese, T.1    Mazzon, E.2    Muia, C.3
  • 27
    • 0032080219 scopus 로고    scopus 로고
    • Traumatic spinal cord injury induces nuclear factor-kappab activation
    • Bethea JR, Castro M, Keane RW et al. Traumatic spinal cord injury induces nuclear factor-kappab activation. J Neurosci 1998 18 : 3251 3260.
    • (1998) J Neurosci , vol.18 , pp. 3251-3260
    • Bethea, J.R.1    Castro, M.2    Keane, R.W.3
  • 28
    • 0028919411 scopus 로고
    • A sensitive and reliable locomotor rating scale for open field testing in rats
    • Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995 12 : 1 21.
    • (1995) J Neurotrauma , vol.12 , pp. 1-21
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3
  • 29
    • 0036187882 scopus 로고    scopus 로고
    • Development and characterization of a novel, graded model of clip compressive spinal cord injury in the mouse: Part 2. Quantitative neuroanatomical assessment and analysis of the relationships between axonal tracts, residual tissue, and locomotor recovery
    • Joshi M, Fehlings MG. Development and characterization of a novel, graded model of clip compressive spinal cord injury in the mouse: Part 2. Quantitative neuroanatomical assessment and analysis of the relationships between axonal tracts, residual tissue, and locomotor recovery. J Neurotrauma 2002 19 : 191 203.
    • (2002) J Neurotrauma , vol.19 , pp. 191-203
    • Joshi, M.1    Fehlings, M.G.2
  • 30
    • 0036190467 scopus 로고    scopus 로고
    • Development and characterization of a novel, graded model of clip compressive spinal cord injury in the mouse: Part 1. Clip design, behavioral outcomes, and histopathology
    • Joshi M, Fehlings MG. Development and characterization of a novel, graded model of clip compressive spinal cord injury in the mouse: part 1. Clip design, behavioral outcomes, and histopathology. J Neurotrauma 2002 19 : 175 190.
    • (2002) J Neurotrauma , vol.19 , pp. 175-190
    • Joshi, M.1    Fehlings, M.G.2
  • 31
    • 33644927806 scopus 로고    scopus 로고
    • Modulation of nitric oxide homeostasis in a mouse model of spinal cord injury
    • Genovese T, Mazzon E, Mariotto S et al. Modulation of nitric oxide homeostasis in a mouse model of spinal cord injury. J Neurosurg Spine 2006 4 : 145 153.
    • (2006) J Neurosurg Spine , vol.4 , pp. 145-153
    • Genovese, T.1    Mazzon, E.2    Mariotto, S.3
  • 32
    • 12244312473 scopus 로고    scopus 로고
    • Peroxynitrite generated in the rat spinal cord induces oxidation and nitration of proteins: Reduction by mn (iii) tetrakis (4-benzoic acid) porphyrin
    • Bao F, Dewitt DS, Prough DS et al. Peroxynitrite generated in the rat spinal cord induces oxidation and nitration of proteins: reduction by mn (iii) tetrakis (4-benzoic acid) porphyrin. J Neurosci Res 2003 71 : 220 227.
    • (2003) J Neurosci Res , vol.71 , pp. 220-227
    • Bao, F.1    Dewitt, D.S.2    Prough, D.S.3
  • 33
    • 33749040000 scopus 로고    scopus 로고
    • Poly(adp-ribose) glycohydrolase activity mediates post-traumatic inflammatory reaction after experimental spinal cord trauma
    • Cuzzocrea S, Genovese T, Mazzon E et al. Poly(adp-ribose) glycohydrolase activity mediates post-traumatic inflammatory reaction after experimental spinal cord trauma. J Pharmacol Exp Ther 2006 319 : 127 138.
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 127-138
    • Cuzzocrea, S.1    Genovese, T.2    Mazzon, E.3
  • 34
    • 33748564678 scopus 로고    scopus 로고
    • Neutralization of the chemokine cxcl10 reduces apoptosis and increases axon sprouting after spinal cord injury
    • Glaser J, Gonzalez R, Sadr E et al. Neutralization of the chemokine cxcl10 reduces apoptosis and increases axon sprouting after spinal cord injury. J Neurosci Res 2006 84 : 724 734.
    • (2006) J Neurosci Res , vol.84 , pp. 724-734
    • Glaser, J.1    Gonzalez, R.2    Sadr, E.3
  • 35
    • 35948931812 scopus 로고    scopus 로고
    • The effects of prophylactic zinc and melatonin application on experimental spinal cord ischemia-reperfusion injury in rabbits: Experimental study
    • Kalkan E, Cicek O, Unlu A et al. The effects of prophylactic zinc and melatonin application on experimental spinal cord ischemia-reperfusion injury in rabbits: experimental study. Spinal Cord 2007 45 : 722 730.
    • (2007) Spinal Cord , vol.45 , pp. 722-730
    • Kalkan, E.1    Cicek, O.2    Unlu, A.3
  • 36
    • 2342613518 scopus 로고    scopus 로고
    • Antioxidation of melatonin against spinal cord injury in rats
    • Liu JB, Tang TS, Yang HL et al. Antioxidation of melatonin against spinal cord injury in rats. Chin J Traumatol 2004 117 : 571 575.
    • (2004) Chin J Traumatol , vol.117 , pp. 571-575
    • Liu, J.B.1    Tang, T.S.2    Yang, H.L.3
  • 37
    • 38149092274 scopus 로고    scopus 로고
    • Melatonin attenuates calpain upregulation, axonal damage and neuronal death in spinal cord injury in rats
    • Samantaray S, Sribnick EA, Das A et al. Melatonin attenuates calpain upregulation, axonal damage and neuronal death in spinal cord injury in rats. J Pineal Res 2008 44 : 348 357.
    • (2008) J Pineal Res , vol.44 , pp. 348-357
    • Samantaray, S.1    Sribnick, E.A.2    Das, A.3
  • 38
    • 0025986461 scopus 로고
    • Review of experimental spinal cord injury with emphasis on the local and systemic circulatory effects
    • Tator CH. Review of experimental spinal cord injury with emphasis on the local and systemic circulatory effects. Neurochirurgie 1991 37 : 291 302.
    • (1991) Neurochirurgie , vol.37 , pp. 291-302
    • Tator, C.H.1
  • 39
    • 0027288332 scopus 로고
    • Pathophysiology of spinal cord trauma
    • Anderson DK, Hall ED. Pathophysiology of spinal cord trauma. Ann Emerg Med 1993 22 : 987 992.
    • (1993) Ann Emerg Med , vol.22 , pp. 987-992
    • Anderson, D.K.1    Hall, E.D.2
  • 40
    • 34547133030 scopus 로고    scopus 로고
    • Spinal pathways involved in the control of forelimb motor function in rats
    • Anderson KD, Gunawan A, Steward O. Spinal pathways involved in the control of forelimb motor function in rats. Exp Neurol 2007 206 : 318 331.
    • (2007) Exp Neurol , vol.206 , pp. 318-331
    • Anderson, K.D.1    Gunawan, A.2    Steward, O.3
  • 41
    • 0036703627 scopus 로고    scopus 로고
    • Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and akt
    • Wick A, Wick W, Waltenberger J et al. Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and akt. J Neurosci 2002 22 : 6401 6407.
    • (2002) J Neurosci , vol.22 , pp. 6401-6407
    • Wick, A.1    Wick, W.2    Waltenberger, J.3
  • 42
    • 33749257099 scopus 로고    scopus 로고
    • Erk1/2 and p38 mitogen-activated protein kinase mediate inos-induced spinal neuron degeneration after acute traumatic spinal cord injury
    • Xu Z, Wang BR, Wang X et al. Erk1/2 and p38 mitogen-activated protein kinase mediate inos-induced spinal neuron degeneration after acute traumatic spinal cord injury. Life Sci 2006 79 : 1895 1905.
    • (2006) Life Sci , vol.79 , pp. 1895-1905
    • Xu, Z.1    Wang, B.R.2    Wang, X.3
  • 43
    • 0032895885 scopus 로고    scopus 로고
    • Induction of apoptosis signal regulating kinase 1 (ask1) after spinal cord injury in rats: Possible involvement of ask1-jnk and -p38 pathways in neuronal apoptosis
    • Nakahara S, Yone K, Sakou T et al. Induction of apoptosis signal regulating kinase 1 (ask1) after spinal cord injury in rats: possible involvement of ask1-jnk and -p38 pathways in neuronal apoptosis. J Neuropathol Exp Neurol 1999 58 : 442 450.
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 442-450
    • Nakahara, S.1    Yone, K.2    Sakou, T.3
  • 44
    • 15944397267 scopus 로고    scopus 로고
    • Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous transplantation in the rat
    • Jin K, Sun Y, Xie L et al. Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous transplantation in the rat. Neurobiol Dis 2005 18 : 366 374.
    • (2005) Neurobiol Dis , vol.18 , pp. 366-374
    • Jin, K.1    Sun, Y.2    Xie, L.3
  • 45
    • 0032589563 scopus 로고    scopus 로고
    • Activation of nf-kappab and c-jun transcription factors in multiple sclerosis lesions. Implications for oligodendrocyte pathology
    • Bonetti B, Stegagno C, Cannella B et al. Activation of nf-kappab and c-jun transcription factors in multiple sclerosis lesions. Implications for oligodendrocyte pathology. Am J Pathol 1999 155 : 1433 1438.
    • (1999) Am J Pathol , vol.155 , pp. 1433-1438
    • Bonetti, B.1    Stegagno, C.2    Cannella, B.3
  • 46
    • 0035866060 scopus 로고    scopus 로고
    • Beta-amyloid stimulation of microglia and monocytes results in tnfalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis
    • Combs CK, Karlo JC, Kao SC et al. Beta-amyloid stimulation of microglia and monocytes results in tnfalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J Neurosci 2001 21 : 1179 1188.
    • (2001) J Neurosci , vol.21 , pp. 1179-1188
    • Combs, C.K.1    Karlo, J.C.2    Kao, S.C.3
  • 47
    • 0038383698 scopus 로고    scopus 로고
    • Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo
    • Choi SH, Joe EH, Kim SU et al. Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo. J Neurosci 2003 23 : 5877 5886.
    • (2003) J Neurosci , vol.23 , pp. 5877-5886
    • Choi, S.H.1    Joe, E.H.2    Kim, S.U.3
  • 48
    • 41149087320 scopus 로고    scopus 로고
    • Evidence for the role of mitogen-activated protein kinase signaling pathways in the development of spinal cord injury
    • Genovese T, Esposito E, Mazzon E et al. Evidence for the role of mitogen-activated protein kinase signaling pathways in the development of spinal cord injury. J Pharmacol Exp Ther 2008 325 : 100 114.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 100-114
    • Genovese, T.1    Esposito, E.2    Mazzon, E.3
  • 49
    • 0031815256 scopus 로고    scopus 로고
    • Cytokine mrna profiles in contused spinal cord and axotomized facial nucleus suggest a beneficial role for inflammation and gliosis
    • Streit WJ, Semple-Rowland SL, Hurley SD et al. Cytokine mrna profiles in contused spinal cord and axotomized facial nucleus suggest a beneficial role for inflammation and gliosis. Exp Neurol 1998 152 : 74 87.
    • (1998) Exp Neurol , vol.152 , pp. 74-87
    • Streit, W.J.1    Semple-Rowland, S.L.2    Hurley, S.D.3
  • 50
    • 0141830087 scopus 로고    scopus 로고
    • Ifn-gamma induces high mobility group box 1 protein release partly through a tnf-dependent mechanism
    • Rendon-Mitchell B, Ochani M, Li J et al. Ifn-gamma induces high mobility group box 1 protein release partly through a tnf-dependent mechanism. J Immunol 2003 170 : 3890 3897.
    • (2003) J Immunol , vol.170 , pp. 3890-3897
    • Rendon-Mitchell, B.1    Ochani, M.2    Li, J.3
  • 51
    • 17644383284 scopus 로고    scopus 로고
    • Heat shock response inhibits release of high mobility group box 1 protein induced by endotoxin in murine macrophages
    • Tang D, Shi Y, Jang L et al. Heat shock response inhibits release of high mobility group box 1 protein induced by endotoxin in murine macrophages. Shock (Augusta, GA) 2005 23 : 434 440.
    • (2005) Shock (Augusta, GA) , vol.23 , pp. 434-440
    • Tang, D.1    Shi, Y.2    Jang, L.3
  • 52
    • 0032816123 scopus 로고    scopus 로고
    • Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes
    • Wang H, Vishnubhakat JM, Bloom O et al. Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes. Surgery 1999 126 : 389 392.
    • (1999) Surgery , vol.126 , pp. 389-392
    • Wang, H.1    Vishnubhakat, J.M.2    Bloom, O.3
  • 53
    • 0037062934 scopus 로고    scopus 로고
    • Release of chromatin protein hmgb1 by necrotic cells triggers inflammation
    • Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein hmgb1 by necrotic cells triggers inflammation. Nature 2002 418 : 191 195.
    • (2002) Nature , vol.418 , pp. 191-195
    • Scaffidi, P.1    Misteli, T.2    Bianchi, M.E.3
  • 54
    • 4444261780 scopus 로고    scopus 로고
    • Hmgb1 is an endogenous immune adjuvant released by necrotic cells
    • Rovere-Querini P, Capobianco A, Scaffidi P et al. Hmgb1 is an endogenous immune adjuvant released by necrotic cells. EMBO Rep 2004 5 : 825 830.
    • (2004) EMBO Rep , vol.5 , pp. 825-830
    • Rovere-Querini, P.1    Capobianco, A.2    Scaffidi, P.3
  • 55
    • 2942700201 scopus 로고    scopus 로고
    • High mobility group box protein 1: An endogenous signal for dendritic cell maturation and th1 polarization
    • Messmer D, Yang H, Telusma G et al. High mobility group box protein 1: an endogenous signal for dendritic cell maturation and th1 polarization. J Immunol 2004 173 : 307 313.
    • (2004) J Immunol , vol.173 , pp. 307-313
    • Messmer, D.1    Yang, H.2    Telusma, G.3
  • 56
    • 22544445228 scopus 로고    scopus 로고
    • Requirement of hmgb1 and rage for the maturation of human plasmacytoid dendritic cells
    • Dumitriu IE, Baruah P, Bianchi ME et al. Requirement of hmgb1 and rage for the maturation of human plasmacytoid dendritic cells. Eur J Immunol 2005 35 : 2184 2190.
    • (2005) Eur J Immunol , vol.35 , pp. 2184-2190
    • Dumitriu, I.E.1    Baruah, P.2    Bianchi, M.E.3
  • 57
    • 20444426542 scopus 로고    scopus 로고
    • Release of high mobility group box 1 by dendritic cells controls t cell activation via the receptor for advanced glycation end products
    • Dumitriu IE, Baruah P, Valentinis B et al. Release of high mobility group box 1 by dendritic cells controls t cell activation via the receptor for advanced glycation end products. J Immunol 2005 174 : 7506 7515.
    • (2005) J Immunol , vol.174 , pp. 7506-7515
    • Dumitriu, I.E.1    Baruah, P.2    Valentinis, B.3
  • 58
    • 33847775295 scopus 로고    scopus 로고
    • Hydrogen peroxide stimulates macrophages and monocytes to actively release hmgb1
    • Tang D, Shi Y, Kang R et al. Hydrogen peroxide stimulates macrophages and monocytes to actively release hmgb1. J Leukoc Biol 2007 81 : 741 747.
    • (2007) J Leukoc Biol , vol.81 , pp. 741-747
    • Tang, D.1    Shi, Y.2    Kang, R.3
  • 59
    • 33845536018 scopus 로고    scopus 로고
    • One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species?
    • Tan DX, Manchester LC, Terron MP et al. One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res 2007 42 : 28 42.
    • (2007) J Pineal Res , vol.42 , pp. 28-42
    • Tan, D.X.1    Manchester, L.C.2    Terron, M.P.3
  • 60
    • 0028245211 scopus 로고
    • Melatonin as a free radical scavenger: Implications for aging and age-related diseases
    • Reiter RJ, Tan DX, Poeggeler B et al. Melatonin as a free radical scavenger: implications for aging and age-related diseases. Ann N Y Acad Sci 1994 719 : 1 12.
    • (1994) Ann N Y Acad Sci , vol.719 , pp. 1-12
    • Reiter, R.J.1    Tan, D.X.2    Poeggeler, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.