Modulation of nitric oxide homeostasis in a mouse model of spinal cord injury

Journal of Neurosurgery: Spine

Volumn 4, Issue 2, 2006, Pages 145-153

  Genovese, Tiziana ^b   Mazzon, Emanuela ^b   Mariotto, Sofia ^b   Menegazzi, Marta ^b   Cardali, Salvatore ^b   Conti, Alfredo ^b   Suzuki, Hisanori ^b   Bramanti, Placido ^b   Cuzzocrea, Salvatore ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b NONE

Author keywords

Inducible nitric oxide synthetase; Mouse; Oxidative stress; Poly(adenosine diphosphate ribose); Secondary injury; Spinal cord injury

Indexed keywords

3 NITROTYROSINE; INDUCIBLE NITRIC OXIDE SYNTHASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVATION; HISTOPATHOLOGY; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; SPINAL CORD INJURY; UPREGULATION; ANIMAL; C57BL MOUSE; CELL DEATH; DISEASE MODEL; INFLAMMATION; MALE; METABOLISM; NERVE CELL; OXIDATIVE STRESS; PATHOLOGY; PATHOPHYSIOLOGY;

ANIMALS; CELL DEATH; DISEASE MODELS, ANIMAL; HOMEOSTASIS; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; NEURONS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; SPINAL CORD INJURIES;

EID: 33644927806     PISSN: 15475654     EISSN: None     Source Type: Journal    
DOI: 10.3171/spi.2006.4.2.145     Document Type: Article

References (39)

1. Bao F, Liu D: Peroxynitrite generated in the rat spinal cord induces neuron death and neurological deficits. Neuroscience 115:839-849, 2002
2. Bartholdi D, Schwab ME: Methylprednisolone inhibits early inflammatory processes but not ischemic cell death after experimental spinal cord lesion in the rat. Brain Res 672:177-86, 1995
3. Basso DM, Beattie MS, Bresnahan JC: A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12:1-21, 1995
4. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA: Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A 87:1620-1624,1990
5. 2+-dependent nitric-oxide synthase activity in human astrocytoma cells. J Biol Chem 272:7582-7585, 1997
6. Colasanti M, Suzuki H: The dual personality of NO. Trends Pharmacol Sci 21:249-252, 2000
7. Crow JP, Beckman JS: Reactions between nitric oxide, superoxide, and peroxynitrite: footprints of peroxynitrite in vivo. Adv Pharmacol 34:17-43, 1995
8. Cuzzocrea S, McDonald MC, Mazzon E, Mota-Filipe H, Centorrino T, Terranova ML, et al: Calpain inhibitor I reduces colon injury caused by dinitrobenzene sulphonic acid in the rat. Gut 48:478-488, 2001
9. Cuzzocrea S, Riley DP, Caputi AP, Salvemini D: Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacol Rev 53:135-159, 2001
10. Cuzzocrea S, Zingarelli B, Costantino G, Szabo A, Salzman AL, Caputi AP, et al: Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion. Br J Pharmacol 121:1065-1074, 1997
11. Cuzzocrea S, Zingarelli B, Gilad E, Hake P, Salzman AL, Szabo C: Protective effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthase in a carrageenan-induced model of local inflammation. Eur J Pharmacol 342:67-76, 1998
12. Hamada Y, Ikata T, Katoh S, Tsuchiya K, Niwa M, Tsutsumishita Y, et al: Roles of nitric oxide in compression injury of rat spinal cord. Free Radic Biol Med 20:1-9, 1996
13. Hitchon PW, Mouw LJ, Rogge TN, Torner JC, Miller AK: Response of spinal cord blood flow to the nitric oxide inhibitor nitroarginine. Neurosurgery 39:795-803, 1996
14. Joshi M, Fehlings MG: Development and characterization of a novel, graded model of clip compressive spinal cord injury in the mouse: Part 1. Clip design, behavioral outcomes, and histopathology. J Neurotrauma 19:175-190, 2002
15. Joshi M, Fehlings MG: Development and characterization of a novel, graded model of clip compressive spinal cord injury in the mouse: Part 2. Quantitative neuroanatomical assessment and analysis of the relationships between axonal tracts, residual tissue, and locomotor recovery. J Neurotrauma 19:191-203, 2002
16. Lee YB, Yune TY, Baik SY, Shin YH, Du S, Rhim H, et al: Role of tumor necrosis factor-α in neuronal and glial apoptosis after spinal cord injury. Exp Neurol 166:190-195, 2000
17. Liu D, Ling X, Wen J, Liu J: The role of reactive nitrogen species in secondary spinal cord injury: formation of nitric oxide, peroxynitrite, and nitrated protein. J Neurochem 75:2144-2154, 2000
18. Liu JB, Tang TS, Xiao DS: Changes of free iron contents and its correlation with lipid peroxidation after experimental spinal cord injury. Chin J Traumatol 7:229-232, 2004
19. MacMicking JD, Nathan C, Hom G, Chartrain N, Fletcher DS, Trumbauer M, et al: Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81:641-650, 1995
20. Miller MJ, Thompson JH, Zhang XJ, Sadowska-Krowicka H, Kakkis JL, Munshi UK, et al: Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis. Gastroenterology 109:1475-1483, 1995
21. Miscusi M: The role of constitutive nitric oxide synthase in pathogenesis of secondary lesion after spinal cord injury. Preliminary results. J Neurosurg Sci 46:55-59, 2002
22. Moncada S, Palmer RM, Higgs EA: Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109-142, 1991
23. Mullane KM, Kraemer R, Smith B: Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Methods 14:157-167, 1985
24. Nathan C: Nitric oxide as a secretory product of mammalian cells. FASEB J 6:3051-3064, 1992
25. Ohkawa H, Ohishi N, Yagi K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358, 1979
26. Phelps DT, Ferro TJ, Higgins PJ, Shankar R, Parker DM, Johnson A: TNF-α induces peroxynitrite-mediated depletion of lung endothelial glutathione via protein kinase C. Am J Physiol 269: L551-L559, 1995
27. Popovich PG, Reinhard JF Jr, Flanagan EM, Stokes BT: Elevation of the neurotoxin quinolinic acid occurs following spinal cord trauma. Brain Res 633:348-352, 1994
28. Pryor WA, Squadrito GL: The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. Am J Physiol 268:L699-L722, 1995
29. Scott GS, Jakeman LB, Stokes BT, Szabo C: Peroxynitrite production and activation of poly (adenosine diphosphate-ribose) synthetase in spinal cord injury. Ann Neurol 45:120-124, 1999
30. Sharma HS, Westman J, Olsson Y, Alm P: Involvement of nitric oxide in acute spinal cord injury: an immunocytochemical study using light and electron microscopy in the rat. Neurosci Res 24:373-384, 1996
31. Shea TB: Technical report. An inexpensive densitometric analysis system using a Macintosh computer and a desktop scanner. Biotechniques 16:1126-1128, 1994
32. Suzuki T, Tatsuoka H, Chiba T, Sekikawa T, Nemoto T, Moriya H, et al: Beneficial effects of nitric oxide synthase inhibition on the recovery of neurological function after spinal cord injury in rats. Naunyn Schmiedebergs Arch Pharmacol 363:94-100, 2001
33. Szabo C, Dawson VL: Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends Pharmacol Sci 19:287-298, 1998
34. Villa LM, Salas E, Darley-Usmar VM, Radomski MW, Moncada S: Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heart. Proc Natl Acad Sci U S A 91:12383-12387, 1994
35. Xu J, Kim GM, Chen S, Yan P, Ahmed SH, Ku G, et al: iNOS and nitrotyrosine expression after spinal cord injury. J Neurotrauma 18:523-532, 2001
36. Yamanishi Y, Boyle DL, Pinkoski MJ, Mahboubi A, Lin T, Han Z, et al: Regulation of joint destruction and inflammation by p53 in collagen-induced arthritis. Am J Pathol 160:123-130, 2002
37. Yezierski RP, Liu S, Ruenes GL, Busto R, Dietrich WD: Neuronal damage following intraspinal injection of a nitric oxide synthase inhibitor in the rat. J Cereb Blood Flow Metab 16:996-1004, 1996
38. Zhang J, Dawson VL, Dawson TM, Snyder SH: Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science 263:687-689, 1994
39. Zingarelli B, Day BJ, Crapo JD, Salzman AL, Szabo C: The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock. Br J Pharmacol 120:259-267, 1997