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Volumn 19, Issue 1, 2009, Pages 45-58

Proton Magnetic Resonance Spectroscopy in Multiple Sclerosis

Author keywords

Brain metabolites; Multiple sclerosis; Proton magnetic resonance spectroscopy

Indexed keywords

N ACETYLASPARTIC ACID;

EID: 57049160388     PISSN: 10525149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nic.2008.08.002     Document Type: Review
Times cited : (112)

References (118)
  • 1
    • 0035340184 scopus 로고    scopus 로고
    • The role of non-conventional MR techniques to study multiple sclerosis patients
    • Rovaris M., Comi G., and Filippi M. The role of non-conventional MR techniques to study multiple sclerosis patients. J Neurol Sci 186 Suppl 1 (2001) S3-S9
    • (2001) J Neurol Sci , vol.186 , Issue.SUPPL. 1
    • Rovaris, M.1    Comi, G.2    Filippi, M.3
  • 2
    • 0031891884 scopus 로고    scopus 로고
    • Serial proton magnetic resonance spectroscopic imaging, contrast-enhanced magnetic resonance imaging, and quantitative lesion volumetry in multiple sclerosis
    • Narayana P.A., Doyle T.J., Lai D., et al. Serial proton magnetic resonance spectroscopic imaging, contrast-enhanced magnetic resonance imaging, and quantitative lesion volumetry in multiple sclerosis. Ann Neurol 43 1 (1998) 56-71
    • (1998) Ann Neurol , vol.43 , Issue.1 , pp. 56-71
    • Narayana, P.A.1    Doyle, T.J.2    Lai, D.3
  • 3
    • 29444431598 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy in the monitoring of multiple sclerosis
    • Narayana P.A. Magnetic resonance spectroscopy in the monitoring of multiple sclerosis. J Neuroimaging 15 4 Suppl (2005) 46S-57S
    • (2005) J Neuroimaging , vol.15 , Issue.4 SUPPL
    • Narayana, P.A.1
  • 4
    • 0036263673 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy in multiple sclerosis: window into the diseased brain
    • Wolinsky J.S., and Narayana P.A. Magnetic resonance spectroscopy in multiple sclerosis: window into the diseased brain. Curr Opin Neurol 15 3 (2002) 247-251
    • (2002) Curr Opin Neurol , vol.15 , Issue.3 , pp. 247-251
    • Wolinsky, J.S.1    Narayana, P.A.2
  • 5
    • 33646807404 scopus 로고    scopus 로고
    • Role of magnetic resonance spectroscopy in diagnosis and management of multiple sclerosis
    • Gonzalez-Toledo E., Kelley R.E., and Minagar A. Role of magnetic resonance spectroscopy in diagnosis and management of multiple sclerosis. Neurol Res 28 3 (2006) 280-283
    • (2006) Neurol Res , vol.28 , Issue.3 , pp. 280-283
    • Gonzalez-Toledo, E.1    Kelley, R.E.2    Minagar, A.3
  • 6
    • 16344364888 scopus 로고    scopus 로고
    • Efficacy of proton magnetic resonance spectroscopy in neurological diagnosis and neurotherapeutic decision making
    • Lin A., Ross B.D., Harris K., et al. Efficacy of proton magnetic resonance spectroscopy in neurological diagnosis and neurotherapeutic decision making. NeuroRx 2 2 (2005) 197-214
    • (2005) NeuroRx , vol.2 , Issue.2 , pp. 197-214
    • Lin, A.1    Ross, B.D.2    Harris, K.3
  • 7
    • 0032706872 scopus 로고    scopus 로고
    • Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy
    • Bitsch A., Bruhn H., Vougioukas V., et al. Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy. AJNR Am J Neuroradiol 20 9 (1999) 1619-1627
    • (1999) AJNR Am J Neuroradiol , vol.20 , Issue.9 , pp. 1619-1627
    • Bitsch, A.1    Bruhn, H.2    Vougioukas, V.3
  • 8
    • 1542316822 scopus 로고    scopus 로고
    • Measurement of brain glutamate using TE-averaged PRESS at 3 T
    • Hurd R., Sailasuta N., Srinivasan R., et al. Measurement of brain glutamate using TE-averaged PRESS at 3 T. Magn Reson Med 51 3 (2004) 435-440
    • (2004) Magn Reson Med , vol.51 , Issue.3 , pp. 435-440
    • Hurd, R.1    Sailasuta, N.2    Srinivasan, R.3
  • 9
    • 18744407587 scopus 로고    scopus 로고
    • Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T
    • Srinivasan R., Sailasuta N., Hurd R., et al. Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T. Brain 128 Pt 5 (2005) 1016-1025
    • (2005) Brain , vol.128 , Issue.PART 5 , pp. 1016-1025
    • Srinivasan, R.1    Sailasuta, N.2    Hurd, R.3
  • 10
    • 0000898027 scopus 로고    scopus 로고
    • Localized proton magnetic resonance spectroscopy of brain disorders in childhood
    • Bachelard H.S. (Ed), Plenum, New York
    • Frahm J., and Hanefeld F. Localized proton magnetic resonance spectroscopy of brain disorders in childhood. In: Bachelard H.S. (Ed). Advances in neurochemistry vol. 18 (1997), Plenum, New York 329-402
    • (1997) Advances in neurochemistry , vol.18 , pp. 329-402
    • Frahm, J.1    Hanefeld, F.2
  • 11
    • 0027749707 scopus 로고
    • Multinuclear NMR studies on the energy metabolism of glial and neuronal cells
    • Brand A., Richter-Landsberg C., and Leibfritz D. Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev Neurosci 15 3-5 (1993) 289-298
    • (1993) Dev Neurosci , vol.15 , Issue.3-5 , pp. 289-298
    • Brand, A.1    Richter-Landsberg, C.2    Leibfritz, D.3
  • 12
    • 34147189667 scopus 로고    scopus 로고
    • MR spectroscopy in multiple sclerosis
    • De Stefano N., and Filippi M. MR spectroscopy in multiple sclerosis. J Neuroimaging 17 Suppl 1 (2007) 31S-35S
    • (2007) J Neuroimaging , vol.17 , Issue.SUPPL. 1
    • De Stefano, N.1    Filippi, M.2
  • 13
    • 36049000228 scopus 로고    scopus 로고
    • Guidelines for using proton MR spectroscopy in multicenter clinical MS studies
    • De Stefano N., Filippi M., Miller D., et al. Guidelines for using proton MR spectroscopy in multicenter clinical MS studies. Neurology 69 20 (2007) 1942-1952
    • (2007) Neurology , vol.69 , Issue.20 , pp. 1942-1952
    • De Stefano, N.1    Filippi, M.2    Miller, D.3
  • 14
    • 0031725315 scopus 로고    scopus 로고
    • Total brain N-acetylaspartate concentration in normal, age-grouped females: quantitation with non-echo proton NMR spectroscopy
    • Gonen O., Viswanathan A.K., Catalaa I., et al. Total brain N-acetylaspartate concentration in normal, age-grouped females: quantitation with non-echo proton NMR spectroscopy. Magn Reson Med 40 5 (1998) 684-689
    • (1998) Magn Reson Med , vol.40 , Issue.5 , pp. 684-689
    • Gonen, O.1    Viswanathan, A.K.2    Catalaa, I.3
  • 15
    • 0023636904 scopus 로고
    • Spatial localization in NMR spectroscopy in vivo
    • Bottomley P.A. Spatial localization in NMR spectroscopy in vivo. Ann N Y Acad Sci 508 (1987) 333-348
    • (1987) Ann N Y Acad Sci , vol.508 , pp. 333-348
    • Bottomley, P.A.1
  • 16
    • 45949114306 scopus 로고
    • Localized proton spectroscopy using stimulated echoes
    • Frahm J., Merboldt K.-D., and Hanicke W. Localized proton spectroscopy using stimulated echoes. J Magn Reson 72 3 (1987) 502-508
    • (1987) J Magn Reson , vol.72 , Issue.3 , pp. 502-508
    • Frahm, J.1    Merboldt, K.-D.2    Hanicke, W.3
  • 17
    • 0028087680 scopus 로고
    • Three-dimensional echo-planar MR spectroscopic imaging at short echo times in the human brain
    • Posse S., DeCarli C., and Le Bihan D. Three-dimensional echo-planar MR spectroscopic imaging at short echo times in the human brain. Radiology 192 3 (1994) 733-738
    • (1994) Radiology , vol.192 , Issue.3 , pp. 733-738
    • Posse, S.1    DeCarli, C.2    Le Bihan, D.3
  • 18
    • 0034892303 scopus 로고    scopus 로고
    • Grey matter abnormalities in multiple sclerosis: proton magnetic resonance spectroscopic imaging
    • Sharma R., Narayana P.A., and Wolinsky J.S. Grey matter abnormalities in multiple sclerosis: proton magnetic resonance spectroscopic imaging. Mult Scler 7 4 (2001) 221-226
    • (2001) Mult Scler , vol.7 , Issue.4 , pp. 221-226
    • Sharma, R.1    Narayana, P.A.2    Wolinsky, J.S.3
  • 19
    • 0028455583 scopus 로고
    • Reduced phase encoding in spectroscopic imaging
    • Maudsley A.A., Matson G.B., Hugg J.W., et al. Reduced phase encoding in spectroscopic imaging. Magn Reson Med 31 6 (1994) 645-651
    • (1994) Magn Reson Med , vol.31 , Issue.6 , pp. 645-651
    • Maudsley, A.A.1    Matson, G.B.2    Hugg, J.W.3
  • 20
    • 0028978906 scopus 로고
    • High speed 1H spectroscopic imaging in human brain by echo planar spatial-spectral encoding
    • Posse S., Tedeschi G., Risinger R., et al. High speed 1H spectroscopic imaging in human brain by echo planar spatial-spectral encoding. Magn Reson Med 33 1 (1995) 34-40
    • (1995) Magn Reson Med , vol.33 , Issue.1 , pp. 34-40
    • Posse, S.1    Tedeschi, G.2    Risinger, R.3
  • 21
    • 16444386385 scopus 로고    scopus 로고
    • Multi-slice echo-planar spectroscopic MR imaging provides both global and local metabolite measures in multiple sclerosis
    • Mathiesen H.K., Tscherning T., Sorensen P.S., et al. Multi-slice echo-planar spectroscopic MR imaging provides both global and local metabolite measures in multiple sclerosis. Magn Reson Med 53 4 (2005) 750-759
    • (2005) Magn Reson Med , vol.53 , Issue.4 , pp. 750-759
    • Mathiesen, H.K.1    Tscherning, T.2    Sorensen, P.S.3
  • 23
    • 0036263907 scopus 로고    scopus 로고
    • Generalized autocalibrating partially parallel acquisitions (GRAPPA)
    • Griswold M.A., Jakob P.M., Heidemann R.M., et al. Generalized autocalibrating partially parallel acquisitions (GRAPPA). Magn Reson Med 47 6 (2002) 1202-1210
    • (2002) Magn Reson Med , vol.47 , Issue.6 , pp. 1202-1210
    • Griswold, M.A.1    Jakob, P.M.2    Heidemann, R.M.3
  • 24
    • 33846783246 scopus 로고    scopus 로고
    • Sensitivity-encoded (SENSE) proton echo-planar spectroscopic imaging (PEPSI) in the human brain
    • Lin F.H., Tsai S.Y., Otazo R., et al. Sensitivity-encoded (SENSE) proton echo-planar spectroscopic imaging (PEPSI) in the human brain. Magn Reson Med 57 2 (2007) 249-257
    • (2007) Magn Reson Med , vol.57 , Issue.2 , pp. 249-257
    • Lin, F.H.1    Tsai, S.Y.2    Otazo, R.3
  • 25
    • 42549158041 scopus 로고    scopus 로고
    • Accelerated proton echo planar spectroscopic imaging (PEPSI) using GRAPPA with a 32-channel phased-array coil
    • Tsai S.Y., Otazo R., Posse S., et al. Accelerated proton echo planar spectroscopic imaging (PEPSI) using GRAPPA with a 32-channel phased-array coil. Magn Reson Med 59 5 (2008) 989-998
    • (2008) Magn Reson Med , vol.59 , Issue.5 , pp. 989-998
    • Tsai, S.Y.1    Otazo, R.2    Posse, S.3
  • 26
    • 36849082930 scopus 로고    scopus 로고
    • Accelerated short-TE 3D proton echo-planar spectroscopic imaging using 2D-SENSE with a 32-channel array coil
    • Otazo R., Tsai S.Y., Lin F.H., et al. Accelerated short-TE 3D proton echo-planar spectroscopic imaging using 2D-SENSE with a 32-channel array coil. Magn Reson Med 58 6 (2007) 1107-1116
    • (2007) Magn Reson Med , vol.58 , Issue.6 , pp. 1107-1116
    • Otazo, R.1    Tsai, S.Y.2    Lin, F.H.3
  • 27
    • 0035011595 scopus 로고    scopus 로고
    • Proton MR spectroscopy with metabolite-nulling reveals elevated macromolecules in acute multiple sclerosis
    • Mader I., Seeger U., Weissert R., et al. Proton MR spectroscopy with metabolite-nulling reveals elevated macromolecules in acute multiple sclerosis. Brain 124 Pt 5 (2001) 953-961
    • (2001) Brain , vol.124 , Issue.PART 5 , pp. 953-961
    • Mader, I.1    Seeger, U.2    Weissert, R.3
  • 28
    • 0034495799 scopus 로고    scopus 로고
    • The accuracy of whole brain N-acetylaspartate quantification
    • Gonen O., and Grossman R.I. The accuracy of whole brain N-acetylaspartate quantification. Magn Reson Imaging 18 10 (2000) 1255-1258
    • (2000) Magn Reson Imaging , vol.18 , Issue.10 , pp. 1255-1258
    • Gonen, O.1    Grossman, R.I.2
  • 29
    • 33846441280 scopus 로고    scopus 로고
    • Reproducibility of the whole-brain N-acetylaspartate level across institutions, MR scanners, and field strengths
    • Benedetti B., Rigotti D.J., Liu S., et al. Reproducibility of the whole-brain N-acetylaspartate level across institutions, MR scanners, and field strengths. AJNR Am J Neuroradiol 28 1 (2007) 72-75
    • (2007) AJNR Am J Neuroradiol , vol.28 , Issue.1 , pp. 72-75
    • Benedetti, B.1    Rigotti, D.J.2    Liu, S.3
  • 30
    • 36549058713 scopus 로고    scopus 로고
    • Whole-brain N-acetylaspartate as a surrogate marker of neuronal damage in diffuse neurologic disorders
    • Rigotti D.J., Inglese M., and Gonen O. Whole-brain N-acetylaspartate as a surrogate marker of neuronal damage in diffuse neurologic disorders. AJNR Am J Neuroradiol 28 10 (2007) 1843-1849
    • (2007) AJNR Am J Neuroradiol , vol.28 , Issue.10 , pp. 1843-1849
    • Rigotti, D.J.1    Inglese, M.2    Gonen, O.3
  • 31
    • 33746220435 scopus 로고    scopus 로고
    • 1H MR spectroscopy of the brain: absolute quantification of metabolites
    • Jansen J.F., Backes W.H., Nicolay K., et al. 1H MR spectroscopy of the brain: absolute quantification of metabolites. Radiology 240 2 (2006) 318-332
    • (2006) Radiology , vol.240 , Issue.2 , pp. 318-332
    • Jansen, J.F.1    Backes, W.H.2    Nicolay, K.3
  • 32
    • 0242580198 scopus 로고    scopus 로고
    • Metabolite ratios to assumed stable creatine level may confound the quantification of proton brain MR spectroscopy
    • Li B.S., Wang H., and Gonen O. Metabolite ratios to assumed stable creatine level may confound the quantification of proton brain MR spectroscopy. Magn Reson Imaging 21 8 (2003) 923-928
    • (2003) Magn Reson Imaging , vol.21 , Issue.8 , pp. 923-928
    • Li, B.S.1    Wang, H.2    Gonen, O.3
  • 33
    • 3042639536 scopus 로고    scopus 로고
    • Multicentre proton magnetic resonance spectroscopy imaging of primary progressive multiple sclerosis
    • Narayana P.A., Wolinsky J.S., Rao S.B., et al. Multicentre proton magnetic resonance spectroscopy imaging of primary progressive multiple sclerosis. Mult Scler 10 Suppl 1 (2004) S73-S78
    • (2004) Mult Scler , vol.10 , Issue.SUPPL. 1
    • Narayana, P.A.1    Wolinsky, J.S.2    Rao, S.B.3
  • 34
    • 0032411567 scopus 로고    scopus 로고
    • Absolute metabolite quantification by in vivo NMR spectroscopy: II. a multicentre trial of protocols for in vivo localised proton studies of human brain
    • Keevil S.F., Barbiroli B., Brooks J.C., et al. Absolute metabolite quantification by in vivo NMR spectroscopy: II. a multicentre trial of protocols for in vivo localised proton studies of human brain. Magn Reson Imaging 16 9 (1998) 1093-1106
    • (1998) Magn Reson Imaging , vol.16 , Issue.9 , pp. 1093-1106
    • Keevil, S.F.1    Barbiroli, B.2    Brooks, J.C.3
  • 35
    • 0027375098 scopus 로고
    • Estimation of metabolite concentrations from localized in vivo proton NMR spectra
    • Provencher S.W. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 30 6 (1993) 672-679
    • (1993) Magn Reson Med , vol.30 , Issue.6 , pp. 672-679
    • Provencher, S.W.1
  • 36
    • 0034959727 scopus 로고    scopus 로고
    • Automatic quantitation of localized in vivo 1H spectra with LCModel
    • Provencher S.W. Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR Biomed 14 4 (2001) 260-264
    • (2001) NMR Biomed , vol.14 , Issue.4 , pp. 260-264
    • Provencher, S.W.1
  • 37
    • 0029192461 scopus 로고
    • Automated proton spectroscopic image processing
    • Doyle T.J., Pathak R., Wolinsky J.S., et al. Automated proton spectroscopic image processing. J Magn Reson B 106 1 (1995) 58-63
    • (1995) J Magn Reson B , vol.106 , Issue.1 , pp. 58-63
    • Doyle, T.J.1    Pathak, R.2    Wolinsky, J.S.3
  • 38
    • 0028361905 scopus 로고
    • Automated processing for proton spectroscopic imaging using water reference deconvolution
    • Maudsley A.A., Wu Z., Meyerhoff D.J., et al. Automated processing for proton spectroscopic imaging using water reference deconvolution. Magn Reson Med 31 6 (1994) 589-595
    • (1994) Magn Reson Med , vol.31 , Issue.6 , pp. 589-595
    • Maudsley, A.A.1    Wu, Z.2    Meyerhoff, D.J.3
  • 39
    • 0034963584 scopus 로고    scopus 로고
    • MR spectroscopy quantitation: a review of frequency domain methods
    • Mierisova S., and Ala-Korpela M. MR spectroscopy quantitation: a review of frequency domain methods. NMR Biomed 14 4 (2001) 247-259
    • (2001) NMR Biomed , vol.14 , Issue.4 , pp. 247-259
    • Mierisova, S.1    Ala-Korpela, M.2
  • 40
    • 0032163906 scopus 로고    scopus 로고
    • Automated quantification of human brain metabolites by artificial neural network analysis from in vivo single-voxel 1H NMR spectra
    • Kaartinen J., Mierisova S., Oja J.M., et al. Automated quantification of human brain metabolites by artificial neural network analysis from in vivo single-voxel 1H NMR spectra. J Magn Reson 134 1 (1998) 176-179
    • (1998) J Magn Reson , vol.134 , Issue.1 , pp. 176-179
    • Kaartinen, J.1    Mierisova, S.2    Oja, J.M.3
  • 41
    • 0036290142 scopus 로고    scopus 로고
    • Quantification of human brain metabolites from in vivo 1H NMR magnitude spectra using automated artificial neural network analysis
    • Hiltunen Y., Kaartinen J., Pulkkinen J., et al. Quantification of human brain metabolites from in vivo 1H NMR magnitude spectra using automated artificial neural network analysis. J Magn Reson 154 1 (2002) 1-5
    • (2002) J Magn Reson , vol.154 , Issue.1 , pp. 1-5
    • Hiltunen, Y.1    Kaartinen, J.2    Pulkkinen, J.3
  • 42
    • 0031002527 scopus 로고    scopus 로고
    • Use of Voigt lineshape for quantification of in vivo 1H spectra
    • Marshall I., Higinbotham J., Bruce S., et al. Use of Voigt lineshape for quantification of in vivo 1H spectra. Magn Reson Med 37 5 (1997) 651-657
    • (1997) Magn Reson Med , vol.37 , Issue.5 , pp. 651-657
    • Marshall, I.1    Higinbotham, J.2    Bruce, S.3
  • 43
    • 33750633616 scopus 로고    scopus 로고
    • Fast quantification of proton magnetic resonance spectroscopic imaging with artificial neural networks
    • Bhat H., Sajja B.R., and Narayana P.A. Fast quantification of proton magnetic resonance spectroscopic imaging with artificial neural networks. J Magn Reson 183 1 (2006) 110-122
    • (2006) J Magn Reson , vol.183 , Issue.1 , pp. 110-122
    • Bhat, H.1    Sajja, B.R.2    Narayana, P.A.3
  • 44
    • 0034989141 scopus 로고    scopus 로고
    • Java-based graphical user interface for the MRUI quantitation package
    • Naressi A., Couturier C., Devos J.M., et al. Java-based graphical user interface for the MRUI quantitation package. MAGMA 12 2-3 (2001) 141-152
    • (2001) MAGMA , vol.12 , Issue.2-3 , pp. 141-152
    • Naressi, A.1    Couturier, C.2    Devos, J.M.3
  • 45
    • 33745726459 scopus 로고    scopus 로고
    • Comprehensive processing, display and analysis for in vivo MR spectroscopic imaging
    • Maudsley A.A., Darkazanli A., Alger J.R., et al. Comprehensive processing, display and analysis for in vivo MR spectroscopic imaging. NMR Biomed 19 4 (2006) 492-503
    • (2006) NMR Biomed , vol.19 , Issue.4 , pp. 492-503
    • Maudsley, A.A.1    Darkazanli, A.2    Alger, J.R.3
  • 46
    • 0032979685 scopus 로고    scopus 로고
    • Hypointense and hyperintense lesions on magnetic resonance imaging in secondary-progressive MS patients
    • Adams H.P., Wagner S., Sobel D.F., et al. Hypointense and hyperintense lesions on magnetic resonance imaging in secondary-progressive MS patients. Eur Neurol 42 1 (1999) 52-63
    • (1999) Eur Neurol , vol.42 , Issue.1 , pp. 52-63
    • Adams, H.P.1    Wagner, S.2    Sobel, D.F.3
  • 47
    • 0030609055 scopus 로고    scopus 로고
    • 1H magnetic resonance spectroscopy of chronic cerebral white matter lesions and normal appearing white matter in multiple sclerosis
    • Davie C.A., Barker G.J., Thompson A.J., et al. 1H magnetic resonance spectroscopy of chronic cerebral white matter lesions and normal appearing white matter in multiple sclerosis. J Neurol Neurosurg Psychiatr 63 6 (1997) 736-742
    • (1997) J Neurol Neurosurg Psychiatr , vol.63 , Issue.6 , pp. 736-742
    • Davie, C.A.1    Barker, G.J.2    Thompson, A.J.3
  • 48
    • 10644295634 scopus 로고    scopus 로고
    • Relapsing-remitting multiple sclerosis: metabolic abnormality in nonenhancing lesions and normal-appearing white matter at MR imaging: initial experience
    • He J., Inglese M., Li B.S., et al. Relapsing-remitting multiple sclerosis: metabolic abnormality in nonenhancing lesions and normal-appearing white matter at MR imaging: initial experience. Radiology 234 1 (2005) 211-217
    • (2005) Radiology , vol.234 , Issue.1 , pp. 211-217
    • He, J.1    Inglese, M.2    Li, B.S.3
  • 49
  • 50
    • 0025188002 scopus 로고
    • Proton magnetic resonance spectroscopy in multiple sclerosis
    • Wolinsky J.S., Narayana P.A., and Fenstermacher M.J. Proton magnetic resonance spectroscopy in multiple sclerosis. Neurology 40 11 (1990) 1764-1769
    • (1990) Neurology , vol.40 , Issue.11 , pp. 1764-1769
    • Wolinsky, J.S.1    Narayana, P.A.2    Fenstermacher, M.J.3
  • 51
    • 0025838250 scopus 로고
    • Localized in vivo proton spectroscopy in the brain of patients with multiple sclerosis
    • Larsson H.B., Christiansen P., Jensen M., et al. Localized in vivo proton spectroscopy in the brain of patients with multiple sclerosis. Magn Reson Med 22 1 (1991) 23-31
    • (1991) Magn Reson Med , vol.22 , Issue.1 , pp. 23-31
    • Larsson, H.B.1    Christiansen, P.2    Jensen, M.3
  • 52
    • 0028265609 scopus 로고
    • Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions
    • Davie C.A., Hawkins C.P., Barker G.J., et al. Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain 117 Pt 1 (1994) 49-58
    • (1994) Brain , vol.117 , Issue.PART 1 , pp. 49-58
    • Davie, C.A.1    Hawkins, C.P.2    Barker, G.J.3
  • 53
    • 0032576752 scopus 로고    scopus 로고
    • Axonal transection in the lesions of multiple sclerosis
    • Trapp B.D., Peterson J., Ransohoff R.M., et al. Axonal transection in the lesions of multiple sclerosis. N Engl J Med 338 5 (1998) 278-285
    • (1998) N Engl J Med , vol.338 , Issue.5 , pp. 278-285
    • Trapp, B.D.1    Peterson, J.2    Ransohoff, R.M.3
  • 54
    • 0033981063 scopus 로고    scopus 로고
    • Relating axonal injury to functional recovery in MS
    • Reddy H., Narayanan S., Matthews P.M., et al. Relating axonal injury to functional recovery in MS. Neurology 54 1 (2000) 236-239
    • (2000) Neurology , vol.54 , Issue.1 , pp. 236-239
    • Reddy, H.1    Narayanan, S.2    Matthews, P.M.3
  • 55
    • 0028792005 scopus 로고
    • Reversible decreases in N-acetylaspartate after acute brain injury
    • De Stefano N., Matthews P.M., and Arnold D.L. Reversible decreases in N-acetylaspartate after acute brain injury. Magn Reson Med 34 5 (1995) 721-727
    • (1995) Magn Reson Med , vol.34 , Issue.5 , pp. 721-727
    • De Stefano, N.1    Matthews, P.M.2    Arnold, D.L.3
  • 56
    • 0033842931 scopus 로고    scopus 로고
    • Serial proton MR spectroscopy of contrast-enhancing multiple sclerosis plaques: absolute metabolic values over 2 years during a clinical pharmacological study
    • Mader I., Roser W., Kappos L., et al. Serial proton MR spectroscopy of contrast-enhancing multiple sclerosis plaques: absolute metabolic values over 2 years during a clinical pharmacological study. AJNR Am J Neuroradiol 21 7 (2000) 1220-1227
    • (2000) AJNR Am J Neuroradiol , vol.21 , Issue.7 , pp. 1220-1227
    • Mader, I.1    Roser, W.2    Kappos, L.3
  • 57
    • 0026531884 scopus 로고
    • Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques
    • Arnold D.L., Matthews P.M., Francis G.S., et al. Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques. Ann Neurol 31 3 (1992) 235-241
    • (1992) Ann Neurol , vol.31 , Issue.3 , pp. 235-241
    • Arnold, D.L.1    Matthews, P.M.2    Francis, G.S.3
  • 58
    • 0029609682 scopus 로고
    • Chemical pathology of acute demyelinating lesions and its correlation with disability
    • De Stefano N., Matthews P.M., Antel J.P., et al. Chemical pathology of acute demyelinating lesions and its correlation with disability. Ann Neurol 38 6 (1995) 901-909
    • (1995) Ann Neurol , vol.38 , Issue.6 , pp. 901-909
    • De Stefano, N.1    Matthews, P.M.2    Antel, J.P.3
  • 59
    • 34147186825 scopus 로고    scopus 로고
    • Magnetization transfer MRI in multiple sclerosis
    • Filippi M., and Agosta F. Magnetization transfer MRI in multiple sclerosis. J Neuroimaging 17 Suppl 1 (2007) 22S-26S
    • (2007) J Neuroimaging , vol.17 , Issue.SUPPL. 1
    • Filippi, M.1    Agosta, F.2
  • 60
    • 34147180059 scopus 로고    scopus 로고
    • Diffusion tensor MRI in multiple sclerosis
    • Rovaris M., and Filippi M. Diffusion tensor MRI in multiple sclerosis. J Neuroimaging 17 Suppl 1 (2007) 27S-30S
    • (2007) J Neuroimaging , vol.17 , Issue.SUPPL. 1
    • Rovaris, M.1    Filippi, M.2
  • 61
    • 0031962941 scopus 로고    scopus 로고
    • Imaging axonal damage of normal-appearing white matter in multiple sclerosis
    • Fu L., Matthews P.M., De Stefano N., et al. Imaging axonal damage of normal-appearing white matter in multiple sclerosis. Brain 121 Pt 1 (1998) 103-113
    • (1998) Brain , vol.121 , Issue.PART 1 , pp. 103-113
    • Fu, L.1    Matthews, P.M.2    De Stefano, N.3
  • 62
    • 0028147810 scopus 로고
    • Biochemical alterations in multiple sclerosis lesions and normal-appearing white matter detected by in vivo 31P and 1H spectroscopic imaging
    • Husted C.A., Goodin D.S., Hugg J.W., et al. Biochemical alterations in multiple sclerosis lesions and normal-appearing white matter detected by in vivo 31P and 1H spectroscopic imaging. Ann Neurol 36 2 (1994) 157-165
    • (1994) Ann Neurol , vol.36 , Issue.2 , pp. 157-165
    • Husted, C.A.1    Goodin, D.S.2    Hugg, J.W.3
  • 63
    • 0031048695 scopus 로고    scopus 로고
    • Imaging of axonal damage in multiple sclerosis: spatial distribution of magnetic resonance imaging lesions
    • Narayanan S., Fu L., Pioro E., et al. Imaging of axonal damage in multiple sclerosis: spatial distribution of magnetic resonance imaging lesions. Ann Neurol 41 3 (1997) 385-391
    • (1997) Ann Neurol , vol.41 , Issue.3 , pp. 385-391
    • Narayanan, S.1    Fu, L.2    Pioro, E.3
  • 64
    • 0032985039 scopus 로고    scopus 로고
    • Absolute quantification of brain metabolites by proton magnetic resonance spectroscopy in normal-appearing white matter of multiple sclerosis patients
    • Sarchielli P., Presciutti O., Pelliccioli G.P., et al. Absolute quantification of brain metabolites by proton magnetic resonance spectroscopy in normal-appearing white matter of multiple sclerosis patients. Brain 122 Pt 3 (1999) 513-521
    • (1999) Brain , vol.122 , Issue.PART 3 , pp. 513-521
    • Sarchielli, P.1    Presciutti, O.2    Pelliccioli, G.P.3
  • 65
    • 0035833965 scopus 로고    scopus 로고
    • Axonal loss in normal-appearing white matter in a patient with acute MS
    • Bjartmar C., Kinkel R.P., Kidd G., et al. Axonal loss in normal-appearing white matter in a patient with acute MS. Neurology 57 7 (2001) 1248-1252
    • (2001) Neurology , vol.57 , Issue.7 , pp. 1248-1252
    • Bjartmar, C.1    Kinkel, R.P.2    Kidd, G.3
  • 66
    • 0036407449 scopus 로고    scopus 로고
    • Choline is increased in pre-lesional normal appearing white matter in multiple sclerosis
    • Tartaglia M.C., Narayanan S., De Stefano N., et al. Choline is increased in pre-lesional normal appearing white matter in multiple sclerosis. J Neurol 249 10 (2002) 1382-1390
    • (2002) J Neurol , vol.249 , Issue.10 , pp. 1382-1390
    • Tartaglia, M.C.1    Narayanan, S.2    De Stefano, N.3
  • 67
    • 0031839220 scopus 로고    scopus 로고
    • Magnetization transfer changes in the normal appearing white matter precede the appearance of enhancing lesions in patients with multiple sclerosis
    • Filippi M., Rocca M.A., Martino G., et al. Magnetization transfer changes in the normal appearing white matter precede the appearance of enhancing lesions in patients with multiple sclerosis. Ann Neurol 43 6 (1998) 809-814
    • (1998) Ann Neurol , vol.43 , Issue.6 , pp. 809-814
    • Filippi, M.1    Rocca, M.A.2    Martino, G.3
  • 68
    • 0036788493 scopus 로고    scopus 로고
    • Brain metabolite changes in cortical grey and normal-appearing white matter in clinically early relapsing-remitting multiple sclerosis
    • Chard D.T., Griffin C.M., McLean M.A., et al. Brain metabolite changes in cortical grey and normal-appearing white matter in clinically early relapsing-remitting multiple sclerosis. Brain 125 Pt 10 (2002) 2342-2352
    • (2002) Brain , vol.125 , Issue.PART -10 , pp. 2342-2352
    • Chard, D.T.1    Griffin, C.M.2    McLean, M.A.3
  • 69
    • 32844475368 scopus 로고    scopus 로고
    • Metabolite changes in early relapsing-remitting multiple sclerosis. A two year follow-up study
    • Tiberio M., Chard D.T., Altmann D.R., et al. Metabolite changes in early relapsing-remitting multiple sclerosis. A two year follow-up study. J Neurol 253 2 (2006) 224-230
    • (2006) J Neurol , vol.253 , Issue.2 , pp. 224-230
    • Tiberio, M.1    Chard, D.T.2    Altmann, D.R.3
  • 70
    • 0032585691 scopus 로고    scopus 로고
    • 1H magnetic resonance spectroscopy of normal appearing white matter in primary progressive multiple sclerosis
    • Leary S.M., Davie C.A., Parker G.J., et al. 1H magnetic resonance spectroscopy of normal appearing white matter in primary progressive multiple sclerosis. J Neurol 246 11 (1999) 1023-1026
    • (1999) J Neurol , vol.246 , Issue.11 , pp. 1023-1026
    • Leary, S.M.1    Davie, C.A.2    Parker, G.J.3
  • 71
    • 0037925129 scopus 로고    scopus 로고
    • Diffusely elevated cerebral choline and creatine in relapsing-remitting multiple sclerosis
    • Inglese M., Li B.S., Rusinek H., et al. Diffusely elevated cerebral choline and creatine in relapsing-remitting multiple sclerosis. Magn Reson Med 50 1 (2003) 190-195
    • (2003) Magn Reson Med , vol.50 , Issue.1 , pp. 190-195
    • Inglese, M.1    Li, B.S.2    Rusinek, H.3
  • 72
    • 0033624030 scopus 로고    scopus 로고
    • 1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS
    • Suhy J., Rooney W.D., Goodkin D.E., et al. 1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS. Mult Scler 6 3 (2000) 148-155
    • (2000) Mult Scler , vol.6 , Issue.3 , pp. 148-155
    • Suhy, J.1    Rooney, W.D.2    Goodkin, D.E.3
  • 73
    • 0033437173 scopus 로고    scopus 로고
    • Normal-appearing white matter in optic neuritis and multiple sclerosis: a comparative proton spectroscopy study
    • Tourbah A., Stievenart J.L., Abanou A., et al. Normal-appearing white matter in optic neuritis and multiple sclerosis: a comparative proton spectroscopy study. Neuroradiology 41 10 (1999) 738-743
    • (1999) Neuroradiology , vol.41 , Issue.10 , pp. 738-743
    • Tourbah, A.1    Stievenart, J.L.2    Abanou, A.3
  • 74
    • 2942627700 scopus 로고    scopus 로고
    • Elevated white matter myo-inositol in clinically isolated syndromes suggestive of multiple sclerosis
    • Fernando K.T., McLean M.A., Chard D.T., et al. Elevated white matter myo-inositol in clinically isolated syndromes suggestive of multiple sclerosis. Brain 127 Pt 6 (2004) 1361-1369
    • (2004) Brain , vol.127 , Issue.PART 6 , pp. 1361-1369
    • Fernando, K.T.1    McLean, M.A.2    Chard, D.T.3
  • 75
    • 34648831410 scopus 로고    scopus 로고
    • Axonal damage but no increased glial cell activity in the normal-appearing white matter of patients with clinically isolated syndromes suggestive of multiple sclerosis using high-field magnetic resonance spectroscopy
    • Wattjes M.P., Harzheim M., Lutterbey G.G., et al. Axonal damage but no increased glial cell activity in the normal-appearing white matter of patients with clinically isolated syndromes suggestive of multiple sclerosis using high-field magnetic resonance spectroscopy. AJNR Am J Neuroradiol 28 8 (2007) 1517-1522
    • (2007) AJNR Am J Neuroradiol , vol.28 , Issue.8 , pp. 1517-1522
    • Wattjes, M.P.1    Harzheim, M.2    Lutterbey, G.G.3
  • 76
    • 38549105525 scopus 로고    scopus 로고
    • High field MR imaging and 1H-MR spectroscopy in clinically isolated syndromes suggestive of multiple sclerosis: correlation between metabolic alterations and diagnostic MR imaging criteria
    • Wattjes M.P., Harzheim M., Lutterbey G.G., et al. High field MR imaging and 1H-MR spectroscopy in clinically isolated syndromes suggestive of multiple sclerosis: correlation between metabolic alterations and diagnostic MR imaging criteria. J Neurol 255 1 (2008) 56-63
    • (2008) J Neurol , vol.255 , Issue.1 , pp. 56-63
    • Wattjes, M.P.1    Harzheim, M.2    Lutterbey, G.G.3
  • 77
    • 0141455245 scopus 로고    scopus 로고
    • Gray matter involvement in multiple sclerosis: a new window into pathogenesis
    • Minagar A. Gray matter involvement in multiple sclerosis: a new window into pathogenesis. J Neuroimaging 13 4 (2003) 291-292
    • (2003) J Neuroimaging , vol.13 , Issue.4 , pp. 291-292
    • Minagar, A.1
  • 78
    • 43249107238 scopus 로고    scopus 로고
    • Cortical pathology in multiple sclerosis
    • Stadelmann C., Albert M., Wegner C., et al. Cortical pathology in multiple sclerosis. Curr Opin Neurol 21 3 (2008) 229-234
    • (2008) Curr Opin Neurol , vol.21 , Issue.3 , pp. 229-234
    • Stadelmann, C.1    Albert, M.2    Wegner, C.3
  • 79
    • 0031805988 scopus 로고    scopus 로고
    • Implementation and evaluation of a new pulse sequence for rapid acquisition of double inversion recovery images for simultaneous suppression of white matter and CSF
    • Bedell B.J., and Narayana P.A. Implementation and evaluation of a new pulse sequence for rapid acquisition of double inversion recovery images for simultaneous suppression of white matter and CSF. J Magn Reson Imaging 8 3 (1998) 544-547
    • (1998) J Magn Reson Imaging , vol.8 , Issue.3 , pp. 544-547
    • Bedell, B.J.1    Narayana, P.A.2
  • 80
    • 20744442122 scopus 로고    scopus 로고
    • Intracortical lesions in multiple sclerosis: improved detection with 3D double inversion-recovery MR imaging
    • Geurts J.J., Pouwels P.J., Uitdehaag B.M., et al. Intracortical lesions in multiple sclerosis: improved detection with 3D double inversion-recovery MR imaging. Radiology 236 1 (2005) 254-260
    • (2005) Radiology , vol.236 , Issue.1 , pp. 254-260
    • Geurts, J.J.1    Pouwels, P.J.2    Uitdehaag, B.M.3
  • 81
    • 16844364980 scopus 로고    scopus 로고
    • Cortical lesions in multiple sclerosis: combined postmortem MR imaging and histopathology
    • Geurts J.J., Bo L., Pouwels P.J., et al. Cortical lesions in multiple sclerosis: combined postmortem MR imaging and histopathology. AJNR Am J Neuroradiol 26 3 (2005) 572-577
    • (2005) AJNR Am J Neuroradiol , vol.26 , Issue.3 , pp. 572-577
    • Geurts, J.J.1    Bo, L.2    Pouwels, P.J.3
  • 82
    • 35349014120 scopus 로고    scopus 로고
    • Improved identification of intracortical lesions in multiple sclerosis with phase-sensitive inversion recovery in combination with fast double inversion recovery MR imaging
    • Nelson F., Poonawalla A.H., Hou P., et al. Improved identification of intracortical lesions in multiple sclerosis with phase-sensitive inversion recovery in combination with fast double inversion recovery MR imaging. AJNR Am J Neuroradiol 28 9 (2007) 1645-1649
    • (2007) AJNR Am J Neuroradiol , vol.28 , Issue.9 , pp. 1645-1649
    • Nelson, F.1    Poonawalla, A.H.2    Hou, P.3
  • 83
    • 0037273985 scopus 로고    scopus 로고
    • The normal appearing grey matter in primary progressive multiple sclerosis: a magnetisation transfer imaging study
    • Dehmeshki J., Chard D.T., Leary S.M., et al. The normal appearing grey matter in primary progressive multiple sclerosis: a magnetisation transfer imaging study. J Neurol 250 1 (2003) 67-74
    • (2003) J Neurol , vol.250 , Issue.1 , pp. 67-74
    • Dehmeshki, J.1    Chard, D.T.2    Leary, S.M.3
  • 84
    • 0036717266 scopus 로고    scopus 로고
    • Assessment of normal-appearing white and gray matter in patients with primary progressive multiple sclerosis: a diffusion-tensor magnetic resonance imaging study
    • Rovaris M., Bozzali M., Iannucci G., et al. Assessment of normal-appearing white and gray matter in patients with primary progressive multiple sclerosis: a diffusion-tensor magnetic resonance imaging study. Arch Neurol 59 9 (2002) 1406-1412
    • (2002) Arch Neurol , vol.59 , Issue.9 , pp. 1406-1412
    • Rovaris, M.1    Bozzali, M.2    Iannucci, G.3
  • 85
    • 40949115437 scopus 로고    scopus 로고
    • Diffusion-tensor MR imaging of cortical lesions in multiple sclerosis: initial findings
    • Poonawalla A.H., Hasan K.M., Gupta R.K., et al. Diffusion-tensor MR imaging of cortical lesions in multiple sclerosis: initial findings. Radiology 246 3 (2008) 880-886
    • (2008) Radiology , vol.246 , Issue.3 , pp. 880-886
    • Poonawalla, A.H.1    Hasan, K.M.2    Gupta, R.K.3
  • 86
    • 0035077346 scopus 로고    scopus 로고
    • Preliminary evidence for neuronal damage in cortical grey matter and normal appearing white matter in short duration relapsing-remitting multiple sclerosis: a quantitative MR spectroscopic imaging study
    • Kapeller P., McLean M.A., Griffin C.M., et al. Preliminary evidence for neuronal damage in cortical grey matter and normal appearing white matter in short duration relapsing-remitting multiple sclerosis: a quantitative MR spectroscopic imaging study. J Neurol 248 2 (2001) 131-138
    • (2001) J Neurol , vol.248 , Issue.2 , pp. 131-138
    • Kapeller, P.1    McLean, M.A.2    Griffin, C.M.3
  • 87
    • 31444453179 scopus 로고    scopus 로고
    • (1)H MR spectroscopy of the brain in multiple sclerosis subtypes with analysis of the metabolite concentrations in gray and white matter: initial findings
    • Sijens P.E., Mostert J.P., Oudkerk M., et al. (1)H MR spectroscopy of the brain in multiple sclerosis subtypes with analysis of the metabolite concentrations in gray and white matter: initial findings. Eur Radiol 16 2 (2006) 489-495
    • (2006) Eur Radiol , vol.16 , Issue.2 , pp. 489-495
    • Sijens, P.E.1    Mostert, J.P.2    Oudkerk, M.3
  • 88
    • 34347350708 scopus 로고    scopus 로고
    • Relationships between gray matter metabolic abnormalities and white matter inflammation in patients at the very early stage of MS: a MRSI study
    • Van Au Duong M., Audoin B., Le Fur Y., et al. Relationships between gray matter metabolic abnormalities and white matter inflammation in patients at the very early stage of MS: a MRSI study. J Neurol 254 7 (2007) 914-923
    • (2007) J Neurol , vol.254 , Issue.7 , pp. 914-923
    • Van Au Duong, M.1    Audoin, B.2    Le Fur, Y.3
  • 89
    • 33644802314 scopus 로고    scopus 로고
    • MR spectroscopic evidence for thalamic and hippocampal, but not cortical, damage in multiple sclerosis
    • Geurts J.J., Reuling I.E., Vrenken H., et al. MR spectroscopic evidence for thalamic and hippocampal, but not cortical, damage in multiple sclerosis. Magn Reson Med 55 3 (2006) 478-483
    • (2006) Magn Reson Med , vol.55 , Issue.3 , pp. 478-483
    • Geurts, J.J.1    Reuling, I.E.2    Vrenken, H.3
  • 90
    • 0344392030 scopus 로고    scopus 로고
    • Gray matter N-acetyl aspartate deficits in secondary progressive but not relapsing-remitting multiple sclerosis
    • Adalsteinsson E., Langer-Gould A., Homer R.J., et al. Gray matter N-acetyl aspartate deficits in secondary progressive but not relapsing-remitting multiple sclerosis. AJNR Am J Neuroradiol 24 10 (2003) 1941-1945
    • (2003) AJNR Am J Neuroradiol , vol.24 , Issue.10 , pp. 1941-1945
    • Adalsteinsson, E.1    Langer-Gould, A.2    Homer, R.J.3
  • 91
    • 0036310111 scopus 로고    scopus 로고
    • Localized (1)H magnetic resonance spectroscopy in mainly cortical gray matter of patients with multiple sclerosis
    • Sarchielli P., Presciutti O., Tarducci R., et al. Localized (1)H magnetic resonance spectroscopy in mainly cortical gray matter of patients with multiple sclerosis. J Neurol 249 7 (2002) 902-910
    • (2002) J Neurol , vol.249 , Issue.7 , pp. 902-910
    • Sarchielli, P.1    Presciutti, O.2    Tarducci, R.3
  • 92
    • 0036830526 scopus 로고    scopus 로고
    • Thalamic neurodegeneration in multiple sclerosis
    • Cifelli A., Arridge M., Jezzard P., et al. Thalamic neurodegeneration in multiple sclerosis. Ann Neurol 52 5 (2002) 650-653
    • (2002) Ann Neurol , vol.52 , Issue.5 , pp. 650-653
    • Cifelli, A.1    Arridge, M.2    Jezzard, P.3
  • 93
    • 0036141452 scopus 로고    scopus 로고
    • T2 hypointensity in the deep gray matter of patients with multiple sclerosis: a quantitative magnetic resonance imaging study
    • Bakshi R., Benedict R.H., Bermel R.A., et al. T2 hypointensity in the deep gray matter of patients with multiple sclerosis: a quantitative magnetic resonance imaging study. Arch Neurol 59 1 (2002) 62-68
    • (2002) Arch Neurol , vol.59 , Issue.1 , pp. 62-68
    • Bakshi, R.1    Benedict, R.H.2    Bermel, R.A.3
  • 94
    • 0038376324 scopus 로고    scopus 로고
    • Thalamic neurodegeneration in relapsing-remitting multiple sclerosis
    • Wylezinska M., Cifelli A., Jezzard P., et al. Thalamic neurodegeneration in relapsing-remitting multiple sclerosis. Neurology 60 12 (2003) 1949-1954
    • (2003) Neurology , vol.60 , Issue.12 , pp. 1949-1954
    • Wylezinska, M.1    Cifelli, A.2    Jezzard, P.3
  • 95
    • 34249814916 scopus 로고    scopus 로고
    • Commentary I: pathophysiologic construct for neuronal degeneration/regeneration in multiple sclerosis
    • Birnbaum G., Leist T.P., and Lublin F.D. Commentary I: pathophysiologic construct for neuronal degeneration/regeneration in multiple sclerosis. Neurology 68 Suppl 3 (2007) S2-S4
    • (2007) Neurology , vol.68 , Issue.SUPPL. 3
    • Birnbaum, G.1    Leist, T.P.2    Lublin, F.D.3
  • 96
    • 0033985654 scopus 로고    scopus 로고
    • Total brain N-acetylaspartate: a new measure of disease load in MS
    • Gonen O., Catalaa I., Babb J.S., et al. Total brain N-acetylaspartate: a new measure of disease load in MS. Neurology 54 1 (2000) 15-19
    • (2000) Neurology , vol.54 , Issue.1 , pp. 15-19
    • Gonen, O.1    Catalaa, I.2    Babb, J.S.3
  • 97
    • 20844442446 scopus 로고    scopus 로고
    • Axonal injury and overall tissue loss are not related in primary progressive multiple sclerosis
    • Rovaris M., Gallo A., Falini A., et al. Axonal injury and overall tissue loss are not related in primary progressive multiple sclerosis. Arch Neurol 62 6 (2005) 898-902
    • (2005) Arch Neurol , vol.62 , Issue.6 , pp. 898-902
    • Rovaris, M.1    Gallo, A.2    Falini, A.3
  • 98
    • 1342266972 scopus 로고    scopus 로고
    • Neuronal cell injury precedes brain atrophy in multiple sclerosis
    • Ge Y., Gonen O., Inglese M., et al. Neuronal cell injury precedes brain atrophy in multiple sclerosis. Neurology 62 4 (2004) 624-627
    • (2004) Neurology , vol.62 , Issue.4 , pp. 624-627
    • Ge, Y.1    Gonen, O.2    Inglese, M.3
  • 99
    • 0037312536 scopus 로고    scopus 로고
    • Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis
    • Filippi M., Bozzali M., Rovaris M., et al. Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis. Brain 126 Pt 2 (2003) 433-437
    • (2003) Brain , vol.126 , Issue.PART 2 , pp. 433-437
    • Filippi, M.1    Bozzali, M.2    Rovaris, M.3
  • 100
    • 0029004984 scopus 로고
    • Multiple sclerosis in the spinal cord: MR appearance and correlation with clinical parameters
    • Tartaglino L.M., Friedman D.P., Flanders A.E., et al. Multiple sclerosis in the spinal cord: MR appearance and correlation with clinical parameters. Radiology 195 3 (1995) 725-732
    • (1995) Radiology , vol.195 , Issue.3 , pp. 725-732
    • Tartaglino, L.M.1    Friedman, D.P.2    Flanders, A.E.3
  • 102
    • 0033372792 scopus 로고    scopus 로고
    • Spinal cord axonal loss in multiple sclerosis: a post-mortem study
    • Ganter P., Prince C., and Esiri M.M. Spinal cord axonal loss in multiple sclerosis: a post-mortem study. Neuropathol Appl Neurobiol 25 6 (1999) 459-467
    • (1999) Neuropathol Appl Neurobiol , vol.25 , Issue.6 , pp. 459-467
    • Ganter, P.1    Prince, C.2    Esiri, M.M.3
  • 103
    • 2442555263 scopus 로고    scopus 로고
    • Axonal loss in multiple sclerosis: a pathological survey of the corticospinal and sensory tracts
    • DeLuca G.C., Ebers G.C., and Esiri M.M. Axonal loss in multiple sclerosis: a pathological survey of the corticospinal and sensory tracts. Brain 127 Pt 5 (2004) 1009-1018
    • (2004) Brain , vol.127 , Issue.PART 5 , pp. 1009-1018
    • DeLuca, G.C.1    Ebers, G.C.2    Esiri, M.M.3
  • 104
    • 35948938070 scopus 로고    scopus 로고
    • Axonal damage in the spinal cord of multiple sclerosis patients detected by magnetic resonance spectroscopy
    • Blamire A.M., Cader S., Lee M., et al. Axonal damage in the spinal cord of multiple sclerosis patients detected by magnetic resonance spectroscopy. Magn Reson Med 58 5 (2007) 880-885
    • (2007) Magn Reson Med , vol.58 , Issue.5 , pp. 880-885
    • Blamire, A.M.1    Cader, S.2    Lee, M.3
  • 105
    • 33846071071 scopus 로고    scopus 로고
    • Quantitative proton magnetic resonance spectroscopy of the human cervical spinal cord at 3 Tesla
    • Marliani A.F., Clementi V., Albini-Riccioli L., et al. Quantitative proton magnetic resonance spectroscopy of the human cervical spinal cord at 3 Tesla. Magn Reson Med 57 1 (2007) 160-163
    • (2007) Magn Reson Med , vol.57 , Issue.1 , pp. 160-163
    • Marliani, A.F.1    Clementi, V.2    Albini-Riccioli, L.3
  • 106
    • 4644313555 scopus 로고    scopus 로고
    • MR spectroscopy of cervical spinal cord in patients with multiple sclerosis
    • Kendi A.T., Tan F.U., Kendi M., et al. MR spectroscopy of cervical spinal cord in patients with multiple sclerosis. Neuroradiology 46 9 (2004) 764-769
    • (2004) Neuroradiology , vol.46 , Issue.9 , pp. 764-769
    • Kendi, A.T.1    Tan, F.U.2    Kendi, M.3
  • 107
    • 34547777428 scopus 로고    scopus 로고
    • Spinal cord spectroscopy and diffusion-based tractography to assess acute disability in multiple sclerosis
    • Ciccarelli O., Wheeler-Kingshott C.A., McLean M.A., et al. Spinal cord spectroscopy and diffusion-based tractography to assess acute disability in multiple sclerosis. Brain 130 Pt 8 (2007) 2220-2231
    • (2007) Brain , vol.130 , Issue.PART 8 , pp. 2220-2231
    • Ciccarelli, O.1    Wheeler-Kingshott, C.A.2    McLean, M.A.3
  • 108
    • 34249790279 scopus 로고    scopus 로고
    • Evidence for neuroprotection and remyelination using imaging techniques
    • [discussion: S86-91]
    • Arnold D.L. Evidence for neuroprotection and remyelination using imaging techniques. Neurology 68 22 Suppl 3 (2007) S83-S90 [discussion: S86-91]
    • (2007) Neurology , vol.68 , Issue.22 SUPPL. 3
    • Arnold, D.L.1
  • 109
    • 28044444326 scopus 로고    scopus 로고
    • Axonal metabolic recovery and potential neuroprotective effect of glatiramer acetate in relapsing-remitting multiple sclerosis
    • Khan O., Shen Y., Caon C., et al. Axonal metabolic recovery and potential neuroprotective effect of glatiramer acetate in relapsing-remitting multiple sclerosis. Mult Scler 11 6 (2005) 646-651
    • (2005) Mult Scler , vol.11 , Issue.6 , pp. 646-651
    • Khan, O.1    Shen, Y.2    Caon, C.3
  • 110
    • 0035091667 scopus 로고    scopus 로고
    • European/Canadian multicenter, double-blind, randomized, placebo-controlled study of the effects of glatiramer acetate on magnetic resonance imaging-measured disease activity and burden in patients with relapsing multiple sclerosis. European/Canadian glatiramer acetate study group
    • Comi G., Filippi M., and Wolinsky J.S. European/Canadian multicenter, double-blind, randomized, placebo-controlled study of the effects of glatiramer acetate on magnetic resonance imaging-measured disease activity and burden in patients with relapsing multiple sclerosis. European/Canadian glatiramer acetate study group. Ann Neurol 49 3 (2001) 290-297
    • (2001) Ann Neurol , vol.49 , Issue.3 , pp. 290-297
    • Comi, G.1    Filippi, M.2    Wolinsky, J.S.3
  • 111
    • 0027521002 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS/MRI study group and the IFNB multiple sclerosis study group
    • Paty D.W., and Li D.K. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS/MRI study group and the IFNB multiple sclerosis study group. Neurology 43 4 (1993) 662-667
    • (1993) Neurology , vol.43 , Issue.4 , pp. 662-667
    • Paty, D.W.1    Li, D.K.2
  • 112
    • 28044470328 scopus 로고    scopus 로고
    • The effect of glatiramer acetate treatment on axonal integrity in multiple sclerosis
    • [abstract] Abstract P633
    • Narayanan S., Caramanos Z., and Arnold D. The effect of glatiramer acetate treatment on axonal integrity in multiple sclerosis. [abstract]. Mult Scler 10 Suppl 2 (2004) S256 Abstract P633
    • (2004) Mult Scler , vol.10 , Issue.SUPPL. 2
    • Narayanan, S.1    Caramanos, Z.2    Arnold, D.3
  • 113
    • 51349128198 scopus 로고    scopus 로고
    • 1H-MRS study in multiple sclerosis: effect of glatiramer acetate therapy on axonal metabolic function and feasibility of long-term H-MRS monitoring in multiple sclerosis
    • 1H-MRS study in multiple sclerosis: effect of glatiramer acetate therapy on axonal metabolic function and feasibility of long-term H-MRS monitoring in multiple sclerosis. J Neuroimaging 18 3 (2008) 314-319
    • (2008) J Neuroimaging , vol.18 , Issue.3 , pp. 314-319
    • Khan, O.1    Shen, Y.2    Bao, F.3
  • 114
    • 42149098368 scopus 로고    scopus 로고
    • Longitudinal magnetic resonance spectroscopic imaging of primary progressive multiple sclerosis patients treated with glatiramer acetate: multicenter study
    • Sajja B.R., Narayana P.A., Wolinsky J.S., et al. Longitudinal magnetic resonance spectroscopic imaging of primary progressive multiple sclerosis patients treated with glatiramer acetate: multicenter study. Mult Scler 14 1 (2008) 73-80
    • (2008) Mult Scler , vol.14 , Issue.1 , pp. 73-80
    • Sajja, B.R.1    Narayana, P.A.2    Wolinsky, J.S.3
  • 115
    • 33846833929 scopus 로고    scopus 로고
    • Glatiramer acetate in primary progressive multiple sclerosis: results of a multinational, multicenter, double-blind, placebo-controlled trial
    • Wolinsky J.S., Narayana P.A., O'Connor P., et al. Glatiramer acetate in primary progressive multiple sclerosis: results of a multinational, multicenter, double-blind, placebo-controlled trial. Ann Neurol 61 1 (2007) 14-24
    • (2007) Ann Neurol , vol.61 , Issue.1 , pp. 14-24
    • Wolinsky, J.S.1    Narayana, P.A.2    O'Connor, P.3
  • 116
    • 0036063734 scopus 로고    scopus 로고
    • Serial 1H-MRS in relapsing-remitting multiple sclerosis: effects of interferon-beta therapy on absolute metabolite concentrations
    • Schubert F., Seifert F., Elster C., et al. Serial 1H-MRS in relapsing-remitting multiple sclerosis: effects of interferon-beta therapy on absolute metabolite concentrations. MAGMA 14 3 (2002) 213-222
    • (2002) MAGMA , vol.14 , Issue.3 , pp. 213-222
    • Schubert, F.1    Seifert, F.2    Elster, C.3
  • 117
    • 0031594381 scopus 로고    scopus 로고
    • 1H-MRS in patients with multiple sclerosis undergoing treatment with interferon beta-1a: results of a preliminary study
    • Sarchielli P., Presciutti O., Tarducci R., et al. 1H-MRS in patients with multiple sclerosis undergoing treatment with interferon beta-1a: results of a preliminary study. J Neurol Neurosurg Psychiatr 64 2 (1998) 204-212
    • (1998) J Neurol Neurosurg Psychiatr , vol.64 , Issue.2 , pp. 204-212
    • Sarchielli, P.1    Presciutti, O.2    Tarducci, R.3
  • 118
    • 0035788425 scopus 로고    scopus 로고
    • Axonal metabolic recovery in multiple sclerosis patients treated with interferon beta-1b
    • Narayanan S., De Stefano N., Francis G.S., et al. Axonal metabolic recovery in multiple sclerosis patients treated with interferon beta-1b. J Neurol 248 11 (2001) 979-986
    • (2001) J Neurol , vol.248 , Issue.11 , pp. 979-986
    • Narayanan, S.1    De Stefano, N.2    Francis, G.S.3


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