메뉴 건너뛰기




Volumn 124, Issue 5, 2001, Pages 953-961

Proton MR spectroscopy with metabolite-nulling reveals elevated macromolecules in acute multiple sclerosis

Author keywords

Absolute quantitation; Lipids; Macromolecules; Multiple sclerosis; NMR spectroscopy

Indexed keywords

ALANINE; CHOLINE; CREATINE; INOSITOL; ISOLEUCINE; LEUCINE; LIPID; MYELIN BASIC PROTEIN; N ACETYLASPARTIC ACID; POLYPEPTIDE; PROTEOLIPID PROTEIN; THREONINE; VALINE;

EID: 0035011595     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: 10.1093/brain/124.5.953     Document Type: Article
Times cited : (90)

References (40)
  • 1
    • 0004330947 scopus 로고    scopus 로고
    • Alterations in brain metabolism after high-dose glucocorticoid therapy: A proton magnetic resonance spectroscopy study
    • 1997 Apr 12-18; Vancouver, Canada. Berkeley (CA): International Society for Magnetic Resonance in Medicine
    • Auer P, Then Bergh F, Kraft E, Trenkwalder C, Holsboer F. Alterations in brain metabolism after high-dose glucocorticoid therapy: a proton magnetic resonance spectroscopy study. In: Proceedings of the 5th Scientific Meeting and Exhibition of the ISMRM; 1997 Apr 12-18; Vancouver, Canada. Berkeley (CA): International Society for Magnetic Resonance in Medicine; 1997. p. 407.
    • (1997) Proceedings of the 5th Scientific Meeting and Exhibition of the ISMRM , pp. 407
    • Auer, P.1    Then Bergh, F.2    Kraft, E.3    Trenkwalder, C.4    Holsboer, F.5
  • 2
    • 0027177399 scopus 로고
    • Characterization of macromolecule resonances in the 1H NMR spectrum of rat brain
    • Behar KL, Ogino T. Characterization of macromolecule resonances in the 1H NMR spectrum of rat brain. Magn Reson Med 1993; 30: 38-44.
    • (1993) Magn Reson Med , vol.30 , pp. 38-44
    • Behar, K.L.1    Ogino, T.2
  • 3
    • 0027936437 scopus 로고
    • Analysis of macromolecule resonances in 1H NMR spectra of human brain
    • Behar KL, Rothman DL, Spencer DD, Petroff OA. Analysis of macromolecule resonances in 1H NMR spectra of human brain. Magn Reson Med 1994; 32: 294-302.
    • (1994) Magn Reson Med , vol.32 , pp. 294-302
    • Behar, K.L.1    Rothman, D.L.2    Spencer, D.D.3    Petroff, O.A.4
  • 4
    • 0342641401 scopus 로고    scopus 로고
    • N-acetyl-aspartate: In-vitro expression in oligodendrocytes; implications for proton-MRS signal in vivo
    • 2000 Apr 1-7; Denver (CO), USA. Berkeley (CA): International Society for Magnetic Resonance in Medicine
    • Bhakoo KK, Styles P. N-acetyl-aspartate: in-vitro expression in oligodendrocytes; implications for proton-MRS signal in vivo. In: Proceedings of the 8th Scientific Meeting and Exhibition of the ISMRM; 2000 Apr 1-7; Denver (CO), USA. Berkeley (CA): International Society for Magnetic Resonance in Medicine; 2000. p. 567.
    • (2000) Proceedings of the 8th Scientific Meeting and Exhibition of the ISMRM , pp. 567
    • Bhakoo, K.K.1    Styles, P.2
  • 5
    • 0032706872 scopus 로고    scopus 로고
    • Inflammatory CNS demyelination: Histopathologic correlation with in vivo quantitative proton MR spectroscopy
    • Bitsch A, Bruhn H, Vougioukas V, Stringaris A, Lassmann H, Frahm J, et al. Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy. AJNR Am J Neuroradiol 1999; 20: 1619-27.
    • (1999) AJNR Am J Neuroradiol , vol.20 , pp. 1619-1627
    • Bitsch, A.1    Bruhn, H.2    Vougioukas, V.3    Stringaris, A.4    Lassmann, H.5    Frahm, J.6
  • 7
    • 0030780349 scopus 로고    scopus 로고
    • Inflammatory central nervous system demyelination: Correlation of magnetic resonance imaging findings with lesion pathology
    • Brück W, Bitsch A, Kolenda H, Brück Y, Stiefel M, Lassmann H. Inflammatory central nervous system demyelination: correlation of magnetic resonance imaging findings with lesion pathology. Ann Neurol 1997; 42: 783-93.
    • (1997) Ann Neurol , vol.42 , pp. 783-793
    • Brück, W.1    Bitsch, A.2    Kolenda, H.3    Brück, Y.4    Stiefel, M.5    Lassmann, H.6
  • 8
    • 0026751712 scopus 로고
    • Multiple sclerosis in children: Cerebral metabolic alterations monitored by localized proton magnetic resonance spectroscopy in vivo
    • Bruhn H, Frahm J, Merboldt KD, Hanicke W, Hanefeld F, Christen HJ, et al. Multiple sclerosis in children: cerebral metabolic alterations monitored by localized proton magnetic resonance spectroscopy in vivo. Ann Neurol 1992; 32: 140-50.
    • (1992) Ann Neurol , vol.32 , pp. 140-150
    • Bruhn, H.1    Frahm, J.2    Merboldt, K.D.3    Hanicke, W.4    Hanefeld, F.5    Christen, H.J.6
  • 9
    • 0027533911 scopus 로고
    • The appearance of neutral lipid signals in the 1H NMR spectra of a myeloma cell line correlates with the induced formation of cytoplasmic lipid droplets
    • Callies R, Sri-Pathmanathan RM, Ferguson DY, Brindle KM. The appearance of neutral lipid signals in the 1H NMR spectra of a myeloma cell line correlates with the induced formation of cytoplasmic lipid droplets. Magn Reson Med 1993; 29: 546-50.
    • (1993) Magn Reson Med , vol.29 , pp. 546-550
    • Callies, R.1    Sri-Pathmanathan, R.M.2    Ferguson, D.Y.3    Brindle, K.M.4
  • 10
    • 0027402937 scopus 로고
    • Detection of myelin breakdown products by proton magnetic resonance spectroscopy
    • Davie CA, Hawkins CP, Barker GJ, Brennan A, Tofts PS, Miller DH, et al. Detection of myelin breakdown products by proton magnetic resonance spectroscopy [letter]. Lancet 1993; 341: 630-1.
    • (1993) Lancet , vol.341 , pp. 630-631
    • Davie, C.A.1    Hawkins, C.P.2    Barker, G.J.3    Brennan, A.4    Tofts, P.S.5    Miller, D.H.6
  • 11
    • 0028265609 scopus 로고
    • Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions
    • Davie CA, Hawkins CP, Barker GJ, Brennan A, Tofts PS, Miller DH, et al. Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain 1994; 117: 49-58.
    • (1994) Brain , vol.117 , pp. 49-58
    • Davie, C.A.1    Hawkins, C.P.2    Barker, G.J.3    Brennan, A.4    Tofts, P.S.5    Miller, D.H.6
  • 13
    • 0029981235 scopus 로고    scopus 로고
    • Short echo time proton magnetic resonance spectroscopic imaging of macromolecule and metabolite signal intensities in the human brain
    • Hwang JH, Graham GD, Behar KL, Alger JR, Prichard JW, Rothman DL. Short echo time proton magnetic resonance spectroscopic imaging of macromolecule and metabolite signal intensities in the human brain. Magn Reson Med 1996; 35: 633-9.
    • (1996) Magn Reson Med , vol.35 , pp. 633-639
    • Hwang, J.H.1    Graham, G.D.2    Behar, K.L.3    Alger, J.R.4    Prichard, J.W.5    Rothman, D.L.6
  • 14
    • 0027503708 scopus 로고
    • Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis
    • Katz D, Taubenberger JK, Cannella B, McFarlin DE, Raine CS, McFarland HF. Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis. Ann Neurol 1993; 34: 661-9.
    • (1993) Ann Neurol , vol.34 , pp. 661-669
    • Katz, D.1    Taubenberger, J.K.2    Cannella, B.3    McFarlin, D.E.4    Raine, C.S.5    McFarland, H.F.6
  • 15
    • 0032849567 scopus 로고    scopus 로고
    • Brain metabolic alterations in gushing's syndrome as monitored by proton magnetic resonance spectroscopy
    • Khiat A, Bard C, Lacroix A, Rousseau J, Boulanger Y. Brain metabolic alterations in Gushing's syndrome as monitored by proton magnetic resonance spectroscopy. NMR Biomed 1999; 12: 357-63.
    • (1999) NMR Biomed , vol.12 , pp. 357-363
    • Khiat, A.1    Bard, C.2    Lacroix, A.3    Rousseau, J.4    Boulanger, Y.5
  • 16
    • 0027518677 scopus 로고
    • Magnetic resonance spectroscopy of multiple sclerosis: In-vivo detection of myelin breakdown products
    • Koopmans RA, Li DK, Zhu G, Allen PS, Penn A, Paty DW. Magnetic resonance spectroscopy of multiple sclerosis: in-vivo detection of myelin breakdown products [letter]. Lancet 1993; 341: 631-2.
    • (1993) Lancet , vol.341 , pp. 631-632
    • Koopmans, R.A.1    Li, D.K.2    Zhu, G.3    Allen, P.S.4    Penn, A.5    Paty, D.W.6
  • 17
    • 0033870097 scopus 로고    scopus 로고
    • Multiple sclerosis and chronic autoimmune encephalomyelitis. A comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions
    • Kornek B, Storch MK, Weissert R, Wallstroem R, Stefferl A, Olsson T, et al. Multiple sclerosis and chronic autoimmune encephalomyelitis. A comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions. Am J Pathol 2000; 157: 267-76.
    • (2000) Am J Pathol , vol.157 , pp. 267-276
    • Kornek, B.1    Storch, M.K.2    Weissert, R.3    Wallstroem, R.4    Stefferl, A.5    Olsson, T.6
  • 19
    • 0031684646 scopus 로고    scopus 로고
    • Neuropathology in multiple sclerosis: New concepts
    • Lassmann H. Neuropathology in multiple sclerosis: new concepts. [Review], Mult Scler 1998; 4: 93-8.
    • (1998) Mult Scler , vol.4 , pp. 93-98
    • Lassmann, H.1
  • 20
    • 0000029565 scopus 로고
    • Proteins of myelin
    • Morell P, editor. New York: Plenum Press
    • Lees MB, Brostoff SW. Proteins of myelin. In: Morell P, editor. Myelin. 2nd ed. New York: Plenum Press; 1984. p. 197-224.
    • (1984) Myelin. 2nd Ed. , pp. 197-224
    • Lees, M.B.1    Brostoff, S.W.2
  • 21
    • 0030056764 scopus 로고    scopus 로고
    • Distinct patterns of multiple sclerosis pathology indicates heterogeneity on pathogenesis
    • Lucchinetti CF, Brück W, Rodriguez M, Lassmann H. Distinct patterns of multiple sclerosis pathology indicates heterogeneity on pathogenesis. [Review]. Brain Pathol 1996; 6: 259-74.
    • (1996) Brain Pathol , vol.6 , pp. 259-274
    • Lucchinetti, C.F.1    Brück, W.2    Rodriguez, M.3    Lassmann, H.4
  • 22
    • 0345633543 scopus 로고    scopus 로고
    • A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 113 cases
    • Lucchinetti C, Brück W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H. A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 113 cases. Brain 1999; 122: 2279-95.
    • (1999) Brain , vol.122 , pp. 2279-2295
    • Lucchinetti, C.1    Brück, W.2    Parisi, J.3    Scheithauer, B.4    Rodriguez, M.5    Lassmann, H.6
  • 23
    • 0031973909 scopus 로고    scopus 로고
    • The role of magnetic resonance techniques in understanding and managing multiple sclerosis
    • Miller DH, Grossman RI, Reingold SC, McFarland HF. The role of magnetic resonance techniques in understanding and managing multiple sclerosis. [Review]. Brain 1998; 121: 3-24.
    • (1998) Brain , vol.121 , pp. 3-24
    • Miller, D.H.1    Grossman, R.I.2    Reingold, S.C.3    McFarland, H.F.4
  • 25
    • 0031891884 scopus 로고    scopus 로고
    • Serial proton magnetic resonance spectroscopic imaging, contrast-enhanced magnetic resonance imaging, and quantitative lesion volumetry in multiple sclerosis
    • Narayana PA, Doyle TJ, Lai D, Wolinsky JS. Serial proton magnetic resonance spectroscopic imaging, contrast-enhanced magnetic resonance imaging, and quantitative lesion volumetry in multiple sclerosis. Ann Neurol 1998; 43: 56-71.
    • (1998) Ann Neurol , vol.43 , pp. 56-71
    • Narayana, P.A.1    Doyle, T.J.2    Lai, D.3    Wolinsky, J.S.4
  • 28
    • 0027375098 scopus 로고
    • Estimation of metabolite concentrations from localized in vivo proton NMR spectra
    • Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 1993; 30: 672-9.
    • (1993) Magn Reson Med , vol.30 , pp. 672-679
    • Provencher, S.W.1
  • 29
    • 0342641396 scopus 로고    scopus 로고
    • Metabolic changes of primary Gd-enhancing MS-plaques during medical treatment
    • 1996 Apr 27-May 18; New York (NY), USA. Berkeley (CA): International Society for Magnetic Resonance in Medicine
    • Roser W, Mader I, Hagberg G, Seelig J, Kappos L, Radue E.W, et al. Metabolic changes of primary Gd-enhancing MS-plaques during medical treatment. In: Proceedings of the 4th Scientific Meeting and Exhibition of the ISMRM; 1996 Apr 27-May 18; New York (NY), USA. Berkeley (CA): International Society for Magnetic Resonance in Medicine; 1996. p. 940.
    • (1996) Proceedings of the 4th Scientific Meeting and Exhibition of the ISMRM , pp. 940
    • Roser, W.1    Mader, I.2    Hagberg, G.3    Seelig, J.4    Kappos, L.5    Radue, E.W.6
  • 31
    • 0032985039 scopus 로고    scopus 로고
    • Absolute quantification of brain metabolites by proton magnetic resonance spectroscopy in normal-appearing white matter of multiple sclerosis patients
    • Sarchielli P, Presciutti O, Pelliccioli GP, Tarducci R, Gobbi G, Chiarini P, et al. Absolute quantification of brain metabolites by proton magnetic resonance spectroscopy in normal-appearing white matter of multiple sclerosis patients. Brain 1999; 122: 513-21.
    • (1999) Brain , vol.122 , pp. 513-521
    • Sarchielli, P.1    Presciutti, O.2    Pelliccioli, G.P.3    Tarducci, R.4    Gobbi, G.5    Chiarini, P.6
  • 32
    • 0031401414 scopus 로고    scopus 로고
    • Discrimination of metabolite from lipid and macromolecule resonances in cerebral infarction in humans using short echo proton spectroscopy
    • Saunders DE, Howe FA, van den Boogaart A, Griffiths JR, Brown MM. Discrimination of metabolite from lipid and macromolecule resonances in cerebral infarction in humans using short echo proton spectroscopy. J Magn Reson Imaging 1997; 7: 1116-21.
    • (1997) J Magn Reson Imaging , vol.7 , pp. 1116-1121
    • Saunders, D.E.1    Howe, F.A.2    Van Den Boogaart, A.3    Griffiths, J.R.4    Brown, M.M.5
  • 33
    • 0027457161 scopus 로고
    • Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: Two lipid compartments in muscle tissue
    • Schick F, Eismann B, Jung WI, Bongers H, Bunse M, Lutz O. Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: two lipid compartments in muscle tissue. Magn Reson Med 1993; 29: 158-67.
    • (1993) Magn Reson Med , vol.29 , pp. 158-167
    • Schick, F.1    Eismann, B.2    Jung, W.I.3    Bongers, H.4    Bunse, M.5    Lutz, O.6
  • 34
    • 0032829929 scopus 로고    scopus 로고
    • Elimination of residual lipid contamination in single volume proton MR spectra of human brain
    • Seeger U, Klose U, Lutz O, Grodd W. Elimination of residual lipid contamination in single volume proton MR spectra of human brain. Magn Reson Imaging 1999; 17: 1219-26.
    • (1999) Magn Reson Imaging , vol.17 , pp. 1219-1226
    • Seeger, U.1    Klose, U.2    Lutz, O.3    Grodd, W.4
  • 36
    • 0032217171 scopus 로고    scopus 로고
    • 1H MR spectroscopy monitoring of changes in choline peak area and line shape after Gd-contrast administration
    • Sijens PE, Oudkerk M, van Dijk P, Levendag PC, Vecht CJ. 1H MR spectroscopy monitoring of changes in choline peak area and line shape after Gd-contrast administration. Magn Reson Imaging 1998; 16: 1273-80.
    • (1998) Magn Reson Imaging , vol.16 , pp. 1273-1280
    • Sijens, P.E.1    Oudkerk, M.2    Van Dijk, P.3    Levendag, P.C.4    Vecht, C.J.5
  • 37
    • 0034130058 scopus 로고    scopus 로고
    • Effects of contrast material on single-volume proton MR spectroscopy
    • Smith KJ, Kwock L, Castillo M. Effects of contrast material on single-volume proton MR spectroscopy. AJNR Am J Neuroradiol 2000; 21: 1084-9.
    • (2000) AJNR Am J Neuroradiol , vol.21 , pp. 1084-1089
    • Smith, K.J.1    Kwock, L.2    Castillo, M.3
  • 39
    • 0025188002 scopus 로고
    • Proton magnetic resonance spectroscopy in multiple sclerosis
    • Wolinsky JS, Narayana PA, Fenstermacher MJ. Proton magnetic resonance spectroscopy in multiple sclerosis. Neurology 1990; 40: 1764-9.
    • (1990) Neurology , vol.40 , pp. 1764-1769
    • Wolinsky, J.S.1    Narayana, P.A.2    Fenstermacher, M.J.3
  • 40
    • 0033962548 scopus 로고    scopus 로고
    • Oligodendrocyte survival, loss and birth in lesions of chronic-stage multiple sclerosis
    • Wolswijk G. Oligodendrocyte survival, loss and birth in lesions of chronic-stage multiple sclerosis. Brain 2000; 123: 105-15.
    • (2000) Brain , vol.123 , pp. 105-115
    • Wolswijk, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.