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Volumn 234, Issue 1, 2005, Pages 211-217

Relapsing-remitting multiple sclerosis: Metabolic abnormality in nonenhancing lesions and normal-appearing white matter at MR imaging: Initial experience

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE; CREATINE; N ACETYLASPARTIC ACID;

EID: 10644295634     PISSN: 00338419     EISSN: None     Source Type: Journal    
DOI: 10.1148/radiol.2341031895     Document Type: Review
Times cited : (55)

References (46)
  • 1
    • 0031973909 scopus 로고    scopus 로고
    • The role of magnetic resonance techniques in understanding and managing multiple sclerosis
    • Miller DH, Grossman RI, Reingold SC, McFarland HF. The role of magnetic resonance techniques in understanding and managing multiple sclerosis. Brain 1998; 121:3-24.
    • (1998) Brain , vol.121 , pp. 3-24
    • Miller, D.H.1    Grossman, R.I.2    Reingold, S.C.3    McFarland, H.F.4
  • 2
    • 0037161235 scopus 로고    scopus 로고
    • MRI in the diagnosis and management of multiple sclerosis
    • Arnold DL, Matthews PM. MRI in the diagnosis and management of multiple sclerosis. Neurology 2002; 58(8 suppl 4): S23-S31.
    • (2002) Neurology , vol.58 , Issue.8 SUPPL. 4
    • Arnold, D.L.1    Matthews, P.M.2
  • 3
    • 0034957951 scopus 로고    scopus 로고
    • Linking structural, metabolic and functional changes in multiple sclerosis
    • Filippi M. Linking structural, metabolic and functional changes in multiple sclerosis. Eur J Neurol 2001; 8:291-297.
    • (2001) Eur J Neurol , vol.8 , pp. 291-297
    • Filippi, M.1
  • 4
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
    • Lucchinetti C, Bruck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 2000; 47:707-717.
    • (2000) Ann Neurol , vol.47 , pp. 707-717
    • Lucchinetti, C.1    Bruck, W.2    Parisi, J.3    Scheithauer, B.4    Rodriguez, M.5    Lassmann, H.6
  • 5
    • 0028847641 scopus 로고
    • Magnetization transfer effects in MR-detected multiple sclerosis lesions: Comparison with gadolinium-enhanced spin-echo images and nonenhanced T1-weighted images
    • Hiehle JF Jr, Grossman RI, Ramer KN, Gonzalez-Scarano F, Cohen JA. Magnetization transfer effects in MR-detected multiple sclerosis lesions: comparison with gadolinium-enhanced spin-echo images and nonenhanced T1-weighted images. AJNR Am J Neuroradiol 1995; 16:69-77.
    • (1995) AJNR Am J Neuroradiol , vol.16 , pp. 69-77
    • Hiehle Jr., J.F.1    Grossman, R.I.2    Ramer, K.N.3    Gonzalez-Scarano, F.4    Cohen, J.A.5
  • 6
    • 0031844371 scopus 로고    scopus 로고
    • Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis
    • van Walderveen MA, Kamphorst W, Scheltens P, et al. Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis. Neurology 1998; 50:1282-1288.
    • (1998) Neurology , vol.50 , pp. 1282-1288
    • Van Walderveen, M.A.1    Kamphorst, W.2    Scheltens, P.3
  • 7
    • 0032231764 scopus 로고    scopus 로고
    • Patterns of lesion development in multiple sclerosis: Longitudinal observations with T1-weighted spin-echo and magnetization transfer MR
    • van Waesberghe JH, van Walderveen MA, Castelijns JA, et al. Patterns of lesion development in multiple sclerosis: longitudinal observations with T1-weighted spin-echo and magnetization transfer MR. AJNR Am J Neuroradiol 1998; 19:675-683.
    • (1998) AJNR Am J Neuroradiol , vol.19 , pp. 675-683
    • Van Waesberghe, J.H.1    Van Walderveen, M.A.2    Castelijns, J.A.3
  • 8
    • 0032971730 scopus 로고    scopus 로고
    • Neuronal damage in T1-hypointense multiple sclerosis lesions demonstrated in vivo using proton magnetic resonance spectroscopy
    • van Walderveen MA, Barkhof F, Pouwels PJ, van Schijndel RA, Polman CH, Castelijns JA. Neuronal damage in T1-hypointense multiple sclerosis lesions demonstrated in vivo using proton magnetic resonance spectroscopy. Ann Neurol 1999; 46:79-87.
    • (1999) Ann Neurol , vol.46 , pp. 79-87
    • Van Walderveen, M.A.1    Barkhof, F.2    Pouwels, P.J.3    Van Schijndel, R.A.4    Polman, C.H.5    Castelijns, J.A.6
  • 9
    • 0034058783 scopus 로고    scopus 로고
    • Lesion heterogeneity in multiple sclerosis: A study of the relations between appearances on T1 weighted images, T1 relaxation times, and metabolite concentrations
    • Brex PA, Parker GJM, Leary SM, et al. Lesion heterogeneity in multiple sclerosis: a study of the relations between appearances on T1 weighted images, T1 relaxation times, and metabolite concentrations. J Neurol Neurosurg Psychiatry 2000; 68:627-632.
    • (2000) J Neurol Neurosurg Psychiatry , vol.68 , pp. 627-632
    • Brex, P.A.1    Parker, G.J.M.2    Leary, S.M.3
  • 10
    • 0034982632 scopus 로고    scopus 로고
    • A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions
    • Bitsch A, Kuhlmann T, Stadelmann C, Lassmann H, Lucchinetti C, Bruck W. A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions. Ann Neurol 2001; 49:793-796.
    • (2001) Ann Neurol , vol.49 , pp. 793-796
    • Bitsch, A.1    Kuhlmann, T.2    Stadelmann, C.3    Lassmann, H.4    Lucchinetti, C.5    Bruck, W.6
  • 12
    • 0030780349 scopus 로고    scopus 로고
    • Inflammatory central nervous system demyelination: Correlation of magnetic resonance imaging findings with lesion pathology
    • Bruck W, Bitsch A, Kolenda H, Bruck Y, Stiefel M, Lassmann H. Inflammatory central nervous system demyelination: correlation of magnetic resonance imaging findings with lesion pathology. Ann Neurol 1997; 42:783-793.
    • (1997) Ann Neurol , vol.42 , pp. 783-793
    • Bruck, W.1    Bitsch, A.2    Kolenda, H.3    Bruck, Y.4    Stiefel, M.5    Lassmann, H.6
  • 13
    • 0025295740 scopus 로고
    • Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: Assessment of the load of disease
    • Arnold DL, Matthews PM, Francis G, Antel J. Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: assessment of the load of disease. Magn Reson Med 1990; 14:154-159.
    • (1990) Magn Reson Med , vol.14 , pp. 154-159
    • Arnold, D.L.1    Matthews, P.M.2    Francis, G.3    Antel, J.4
  • 14
    • 0031964291 scopus 로고    scopus 로고
    • 3D multivoxel proton spectroscopy of human brain using a hybrid of 8th-order Hadamard encoding with 2D chemical shift imaging
    • Gonen O, Murdoch JB, Stoyanova R, Goelman G. 3D multivoxel proton spectroscopy of human brain using a hybrid of 8th-order Hadamard encoding with 2D chemical shift imaging. Magn Reson Med 1998; 39:34-40.
    • (1998) Magn Reson Med , vol.39 , pp. 34-40
    • Gonen, O.1    Murdoch, J.B.2    Stoyanova, R.3    Goelman, G.4
  • 15
    • 0342976767 scopus 로고
    • Improved solvent suppression in one- and two-dimensional NMR spectra by convolution of time domain data
    • Marion D, Ikura M, Bax A. Improved solvent suppression in one- and two-dimensional NMR spectra by convolution of time domain data. J Magn Reson 1989; 84:425-430.
    • (1989) J Magn Reson , vol.84 , pp. 425-430
    • Marion, D.1    Ikura, M.2    Bax, A.3
  • 16
    • 0001354662 scopus 로고
    • Resolution enhancement of protein PMR spectra using the difference between a broadened and normal spectrum
    • Campbell ID, Dobson CM, Williams RJP, Xavier ZV. Resolution enhancement of protein PMR spectra using the difference between a broadened and normal spectrum. J Magn Reson 1973; 11:172-181.
    • (1973) J Magn Reson , vol.11 , pp. 172-181
    • Campbell, I.D.1    Dobson, C.M.2    Williams, R.J.P.3    Xavier, Z.V.4
  • 17
    • 0025224536 scopus 로고
    • Chemical shift imaging of human brain: Axial, sagittal and coronal 31P metabolite images
    • Vigneron DB, Nelson SJ, Murphy-Boesch J, et al. Chemical shift imaging of human brain: axial, sagittal and coronal 31P metabolite images. Radiology 1990; 177:643-649.
    • (1990) Radiology , vol.177 , pp. 643-649
    • Vigneron, D.B.1    Nelson, S.J.2    Murphy-Boesch, J.3
  • 19
    • 0031756714 scopus 로고    scopus 로고
    • Automated spectral analysis III: Application to in vivo proton MR spectroscopy and spectroscopic imaging
    • Soher BJ, Young K, Govindaraju V, Maudsley AA. Automated spectral analysis III: application to in vivo proton MR spectroscopy and spectroscopic imaging. Magn Reson Med 1998; 40:822-831.
    • (1998) Magn Reson Med , vol.40 , pp. 822-831
    • Soher, B.J.1    Young, K.2    Govindaraju, V.3    Maudsley, A.A.4
  • 20
    • 0030050039 scopus 로고    scopus 로고
    • Quantitative proton MR spectroscopic imaging of the human brain
    • Soher BJ, van Zijl PC, Duyn JH, Barker PB. Quantitative proton MR spectroscopic imaging of the human brain. Magn Reson Med 1996; 35:356-363.
    • (1996) Magn Reson Med , vol.35 , pp. 356-363
    • Soher, B.J.1    Van Zijl, P.C.2    Duyn, J.H.3    Barker, P.B.4
  • 21
    • 49549133678 scopus 로고
    • The signal-to-noise ratio of the nuclear magnetic resonance experiment
    • Hoult DI, Richards RE. The signal-to-noise ratio of the nuclear magnetic resonance experiment. J Magn Reson 1976; 24:71-85.
    • (1976) J Magn Reson , vol.24 , pp. 71-85
    • Hoult, D.I.1    Richards, R.E.2
  • 22
    • 0029312360 scopus 로고
    • In vivo quantitation of metabolite concentrations in the brain by means of proton MRS
    • Henriksen O. In vivo quantitation of metabolite concentrations in the brain by means of proton MRS. NMR Biomed 1995; 8:139-148.
    • (1995) NMR Biomed , vol.8 , pp. 139-148
    • Henriksen, O.1
  • 23
    • 43949163052 scopus 로고
    • Absolute quantitation of water and metabolites in the human brain. II. Metabolite concentrations
    • Kreis R, Ernst T, Ross BD. Absolute quantitation of water and metabolites in the human brain. II. Metabolite concentrations. J Magn Reson B 1993; 102:9-19.
    • (1993) J Magn Reson B , vol.102 , pp. 9-19
    • Kreis, R.1    Ernst, T.2    Ross, B.D.3
  • 24
    • 0027169607 scopus 로고
    • The concentration of N-acetyl aspartate, creatine + phosphocreatine, and choline in different parts of the brain in adulthood and senium
    • Christiansen P, Toft P, Larsson HB, Stubgaard M, Henriksen O. The concentration of N-acetyl aspartate, creatine + phosphocreatine, and choline in different parts of the brain in adulthood and senium. Magn Reson Imaging 1993; 11:799-806.
    • (1993) Magn Reson Imaging , vol.11 , pp. 799-806
    • Christiansen, P.1    Toft, P.2    Larsson, H.B.3    Stubgaard, M.4    Henriksen, O.5
  • 26
    • 0034908686 scopus 로고    scopus 로고
    • Volume correction for edema in single-volume proton MR spectroscopy of contrast-enhancing multiple sclerosis lesions
    • Helms G. Volume correction for edema in single-volume proton MR spectroscopy of contrast-enhancing multiple sclerosis lesions. Magn Reson Med 2001; 46:256-263.
    • (2001) Magn Reson Med , vol.46 , pp. 256-263
    • Helms, G.1
  • 27
    • 0028265609 scopus 로고
    • Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions
    • Davie CA, Hawkins CP, Barker GJ, et al. Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain 1994; 117:49-58.
    • (1994) Brain , vol.117 , pp. 49-58
    • Davie, C.A.1    Hawkins, C.P.2    Barker, G.J.3
  • 28
    • 0026000851 scopus 로고
    • Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies
    • Simmons ML, Frondoza CG, Coyle JT. Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience 1991; 45:37-45.
    • (1991) Neuroscience , vol.45 , pp. 37-45
    • Simmons, M.L.1    Frondoza, C.G.2    Coyle, J.T.3
  • 29
    • 0031852514 scopus 로고    scopus 로고
    • Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis: Results of a longitudinal magnetic resonance spectroscopy study
    • De Stefano N, Matthews PM, Fu LQ, et al. Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis: results of a longitudinal magnetic resonance spectroscopy study. Brain 1998; 121:1469-1477.
    • (1998) Brain , vol.121 , pp. 1469-1477
    • De Stefano, N.1    Matthews, P.M.2    Fu, L.Q.3
  • 30
    • 0027450301 scopus 로고
    • Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types
    • Urenjak J, Williams SR, Gadian DG, Noble M. Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J Neurosci 1993; 13:981-989.
    • (1993) J Neurosci , vol.13 , pp. 981-989
    • Urenjak, J.1    Williams, S.R.2    Gadian, D.G.3    Noble, M.4
  • 31
    • 0026531884 scopus 로고
    • Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques
    • Arnold DL, Matthews PM, Francis GS, O'Connor J, Antel JP. Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques. Ann Neurol 1992; 31:235-241.
    • (1992) Ann Neurol , vol.31 , pp. 235-241
    • Arnold, D.L.1    Matthews, P.M.2    Francis, G.S.3    O'Connor, J.4    Antel, J.P.5
  • 32
    • 0028147810 scopus 로고
    • Biochemical alterations in multiple sclerosis lesions and normal-appearing white matter detected by in vivo 31P and 1H spectroscopic imaging
    • Husted CA, Goodin DS, Hugg JW, et al. Biochemical alterations in multiple sclerosis lesions and normal-appearing white matter detected by in vivo 31P and 1H spectroscopic imaging. Ann Neurol 1994; 36:157-165.
    • (1994) Ann Neurol , vol.36 , pp. 157-165
    • Husted, C.A.1    Goodin, D.S.2    Hugg, J.W.3
  • 33
    • 0024345480 scopus 로고
    • The value of T1-weighted images in the differentiation between MS, white matter lesions, and subcortical arteriosclerotic encephalopathy (SAE)
    • Uhlenbrock D, Sehlen S. The value of T1-weighted images in the differentiation between MS, white matter lesions, and subcortical arteriosclerotic encephalopathy (SAE). Neuroradiology 1989; 31:203-212.
    • (1989) Neuroradiology , vol.31 , pp. 203-212
    • Uhlenbrock, D.1    Sehlen, S.2
  • 34
    • 0032724612 scopus 로고    scopus 로고
    • Axonal loss in multiple sclerosis lesions: Magnetic resonance imaging insights into substrates of disability
    • van Waesberghe JH, Kamphorst W, De Groot CJ, et al. Axonal loss in multiple sclerosis lesions: magnetic resonance imaging insights into substrates of disability. Ann Neurol 1999; 46:747-754.
    • (1999) Ann Neurol , vol.46 , pp. 747-754
    • Van Waesberghe, J.H.1    Kamphorst, W.2    De Groot, C.J.3
  • 35
    • 0029730733 scopus 로고    scopus 로고
    • Accumulation of hypointense lesions ("black holes") on T1 spin-echo MRI correlates with disease progression in multiple sclerosis
    • Truyen L, van Waesberghe JH, van Walderveen MA, et al. Accumulation of hypointense lesions ("black holes") on T1 spin-echo MRI correlates with disease progression in multiple sclerosis. Neurology 1996; 47:1469-1476.
    • (1996) Neurology , vol.47 , pp. 1469-1476
    • Truyen, L.1    Van Waesberghe, J.H.2    Van Walderveen, M.A.3
  • 36
    • 0028802646 scopus 로고
    • Correlating MRI and clinical disease activity in multiple sclerosis: Relevance of hypointense lesions on short-TR/short-TE (T1-weighted) spin-echo images
    • van Walderveen MA, Barkhof F, Hommes OR, et al. Correlating MRI and clinical disease activity in multiple sclerosis: relevance of hypointense lesions on short-TR/short-TE (T1-weighted) spin-echo images. Neurology 1995; 45:1684-1690.
    • (1995) Neurology , vol.45 , pp. 1684-1690
    • Van Walderveen, M.A.1    Barkhof, F.2    Hommes, O.R.3
  • 37
    • 0033549125 scopus 로고    scopus 로고
    • Diffusion tensor imaging of lesions and normal-appearing white matter in multiple sclerosis
    • Werring DJ, Clark CA, Barker GJ, Thompson AJ, Miller DH. Diffusion tensor imaging of lesions and normal-appearing white matter in multiple sclerosis. Neurology 1999; 52:1626-1632.
    • (1999) Neurology , vol.52 , pp. 1626-1632
    • Werring, D.J.1    Clark, C.A.2    Barker, G.J.3    Thompson, A.J.4    Miller, D.H.5
  • 38
    • 0030935805 scopus 로고    scopus 로고
    • Gadolinium enhanced MRI predicts clinical and MRI disease activity in relapsing-remitting multiple sclerosis
    • Koudriavtseva T, Thompson AJ, Fiorelli M, et al. Gadolinium enhanced MRI predicts clinical and MRI disease activity in relapsing-remitting multiple sclerosis. J Neurol Neurosurg Psychiatry 1997; 62:285-287.
    • (1997) J Neurol Neurosurg Psychiatry , vol.62 , pp. 285-287
    • Koudriavtseva, T.1    Thompson, A.J.2    Fiorelli, M.3
  • 39
    • 0033852514 scopus 로고    scopus 로고
    • A longitudinal study of T1 hypointense lesions in relapsing MS: MSCRG trial of interferon beta-1a
    • Simon JH, Lull J, Jacobs LD, et al. A longitudinal study of T1 hypointense lesions in relapsing MS: MSCRG trial of interferon beta-1a. Neurology 2000; 55:185-192.
    • (2000) Neurology , vol.55 , pp. 185-192
    • Simon, J.H.1    Lull, J.2    Jacobs, L.D.3
  • 40
    • 0344771115 scopus 로고    scopus 로고
    • Evolution of multiple sclerosis lesions on serial contrast-enhanced T1-weighted and magnetization-transfer MR images
    • Rovira A, Alonso J, Cucurella G, et al. Evolution of multiple sclerosis lesions on serial contrast-enhanced T1-weighted and magnetization-transfer MR images. AJNR Am J Neuroradiol 1999; 20:1939-1945.
    • (1999) AJNR Am J Neuroradiol , vol.20 , pp. 1939-1945
    • Rovira, A.1    Alonso, J.2    Cucurella, G.3
  • 41
    • 0033842931 scopus 로고    scopus 로고
    • Serial proton MR spectroscopy of contrast-enhancing multiple sclerosis plaques: Absolute metabolic values over 2 years during a clinical pharmacological study
    • Mader I, Roser W, Kappos L, et al. Serial proton MR spectroscopy of contrast-enhancing multiple sclerosis plaques: absolute metabolic values over 2 years during a clinical pharmacological study. AJNR Am J Neuroradiol 2000; 21:1220-1227.
    • (2000) AJNR Am J Neuroradiol , vol.21 , pp. 1220-1227
    • Mader, I.1    Roser, W.2    Kappos, L.3
  • 42
    • 0035198891 scopus 로고    scopus 로고
    • N-acetylaspartate: Usefulness as an indicator of viable neuronal tissue
    • Arnold DL, de Stefano N, Matthews PM, Trapp BD. N-acetylaspartate: usefulness as an indicator of viable neuronal tissue. Ann Neurol 2001; 50:823-825.
    • (2001) Ann Neurol , vol.50 , pp. 823-825
    • Arnold, D.L.1    De Stefano, N.2    Matthews, P.M.3    Trapp, B.D.4
  • 43
    • 0018394631 scopus 로고
    • A histological, histochemical and biochemical study of the macroscopically normal white matter in multiple sclerosis
    • Allen IV, McKeown SR. A histological, histochemical and biochemical study of the macroscopically normal white matter in multiple sclerosis. J Neurol Sci 1979; 41:81-91.
    • (1979) J Neurol Sci , vol.41 , pp. 81-91
    • Allen, I.V.1    McKeown, S.R.2
  • 45
    • 0032985039 scopus 로고    scopus 로고
    • Absolute quantification of brain metabolites by proton magnetic resonance spectroscopy in normal-appearing white matter of multiple sclerosis patients
    • Sarchielli P, Presciutti O, Pelliccioli GP, et al. Absolute quantification of brain metabolites by proton magnetic resonance spectroscopy in normal-appearing white matter of multiple sclerosis patients. Brain 1999; 122:513-521.
    • (1999) Brain , vol.122 , pp. 513-521
    • Sarchielli, P.1    Presciutti, O.2    Pelliccioli, G.P.3
  • 46
    • 0037925129 scopus 로고    scopus 로고
    • Diffusely elevated cerebral choline and creatine in relapsing-remitting multiple sclerosis
    • Inglese M, Li BS, Rusinek H, Babb JS, Grossman RI, Gonen O. Diffusely elevated cerebral choline and creatine in relapsing-remitting multiple sclerosis. Magn Reson Med 2003; 50:190-195.
    • (2003) Magn Reson Med , vol.50 , pp. 190-195
    • Inglese, M.1    Li, B.S.2    Rusinek, H.3    Babb, J.S.4    Grossman, R.I.5    Gonen, O.6


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