Fragment-based design of small molecule X-linked inhibitor of apoptosis protein inhibitors

Journal of Medicinal Chemistry

Volumn 51, Issue 22, 2008, Pages 7111-7118

  Huang, Jui Wen ^a   Zhang, Ziming ^a   Wu, Bainan ^a   Cellitti, Jason F ^a   Zhang, Xiyun ^a   Dahl, Russell ^a   Shiau, Chung Wai ^a   Welsh, Kate ^a   Emdadi, Aras ^a   Stebbins, John L ^a   Reed, John C ^a   Pellecchia, Maurizio ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 9; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; TETRAPEPTIDE; X LINKED INHIBITOR OF APOPTOSIS;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; BACULOVIRUS; BINDING AFFINITY; CELL ACTIVITY; CELL CULTURE; CELL DEATH; CELL MEMBRANE PERMEABILITY; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN PROTEIN INTERACTION;

APOPTOSIS; CASPASES; CELL LINE; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR WEIGHT; PEPTIDE FRAGMENTS; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 56749182336     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8006992     Document Type: Article

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