Dynamic combinatorial chemistry - A pharmaceutical perspective

Pharmaceutical News

Volumn 9, Issue 3, 2002, Pages 207-215

  Eliseev, Alexey V ^a  

^a Therascope AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; CHOLINESTERASE INHIBITOR; CISPLATIN; HYDRAZIDE DERIVATIVE; HYDRAZONE DERIVATIVE; LIGAND; VANCOMYCIN;

COMBINATORIAL CHEMISTRY; DRUG MANUFACTURE; DRUG RESEARCH; DRUG SCREENING; ENZYME INHIBITION; PHARMACEUTICS; REVIEW; TECHNOLOGY;

EID: 0036664119     PISSN: 1071894X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (36)

1. Bohacek R.S., McMartin C., Guida W.C. (1996). The art and practice of structure-based drug design: A molecular modeling perspective. Med. Res. Rev., 16(1), 3-50.
2. Zeng J. (2000). Mini-review: Computational structure-based design of inhibitors that target protein surfaces. Comb. Chem. High Throughput Screen, 3(5), 355-362.
3. Hajduk P.J., Meadows R.P., Fesik S.W. (1999). NMR-based screening in drug discovery. Q. Rev. Biophys., 32(3), 211-240.
4. Cousins G.R.L., Poulsen S.A., Sanders J.K.M. (2000). Molecular evolution: Dynamic combinatorial libraries, autocatalytic networks and the quest for molecular function. Curr. Opin. Chem. Biol., 4(3), 270-279.
5. Eliseev A.V., Lehn J.M. (1999). Dynamic combinatorial chemistry: Evolutionary formation and screening of molecular libraries. Combinatorial Chemistry in Biology. Curr. Top. Microbiol. Immunol., 243 159-172.
6. Ganesan A. (1998). Strategies for the dynamic integration of combinatorial synthesis and screening. Angew. Chem. Int. Ed. Engl., 37(20), 2828-2831.
7. Huc I., Nguyen R. (2001). Dynamic combinatorial chemistry. Comb. Chem. High Throughput Screen, 4(1), 53-74.
8. Klekota B., Miller B.L. (1999). Dynamic diversity and small-molecule evolution: A new paradigm for ligand identification. Trends Biotechnol., 17(5):205-209.
9. Lehn J.M. (1999). Dynamic combinatorial chemistry and virtual combinatorial libraries. Chem. Eur. J., 5(9), 2455-2463.
10. Lehn J.M., Eliseev A.V. (2001). Chemistry - Dynamic combina-torial chemistry. Science, 291(5512), 2331-2332.
11. Otto S., Furlan R.L.E., Sanders J.K.M. (2002). Dynamic combinatorial chemistry. Drug Discov. Today, 7(2), 117-125.
12. Ramström O., Lehn J.M. (2002). Drug discovery by dynamic combinatorial libraries. Nature Reviews, Drug Discovery 1(1), 26-36.
13. Huc I., Lehn J.M. (1997). Virtual combinatorial libraries - Dynamic generation of molecular and supramolecular diversity by self-assembly. Proc. Natl. Acad. Sci. USA, 94(15), 2106-2110.
14. Ramström O., Lehn J.M. (2000). In situ generation and screening of a dynamic combinatorial carbohydrate library against concanavalin A. ChemBioChem, 1, 41-48.
15. Swann P.G., Casanova R.A., Desai A. et al. (1996). Nonspecific protease-catalyzed hydrolysis synthesis of a mixture of peptides - Product diversity and ligand amplification by a molecular trap. Biopolymers, 40(6), 617-625.
16. Hioki H., Still W.C. (1998). Chemical evolution - A model system that selects and amplifies a receptor for the tripeptide (D)Pro(L)Val(D)Val. J. Org. Chem., 63(4), 904-905.
17. Karan C., Miller B.L. (2001). RNA-selective coordination complexes identified via dynamic combinatorial chemistry. J. Am. Chem. Soc., 123(30), 7455-7456.
18. Klekota B., Hammond M.H., Miller B.L. (1997). Generation of novel DNA-binding compounds by selection and amplification from self-assembled combinatorial libraries. Tetrahedron Lett., 38(50), 8639-8642.
19. Epstein D.M., Choudhary S., Churchill M.R. et al. (2001). Chloroform-soluble Schiff-base Zn(II) or Cd(II) complexes from a dynamic combinatorial library. Inorg. Chem. 40(7), 1591-1596.
20. Cousins G.R.L., Furlan R.L.E., Ng Y.F. et al. (2001). Identification and isolation of a receptor for N-methyl alkylammonium salts: Molecular amplification in a pseudo-peptide dynamic combinatorial library. Angew. Chem. Int. Ed. Engl., 40(2), 423-428.
21. Eliseev A.V., Nelen M.I. (1997). Use of molecular recognition to drive chemical evolution. 1. Controlling the composition of an equilibrating mixture of simple arginine receptors. J. Am. Chem. Soc., 119(5), 1147-1148.
22. Eliseev A.V., Nelen M.I. (1998). Use of molecular recognition to drive chemical evolution, Part 2 - Mechanisms of an automated genetic algorithm implementation. Chem. Eur. J., 4(5), 825-834.
23. Furlan R.L.E., Ng Y.F., Cousins G.R.L. et al. (2002). Molecular amplification in a dynamic system by ammonium cations. Tetrahedron 58(4), 771-778.
24. Calama M.C., Timmerman P., Reinhoudt D.N. (2000). Guest-templated selection and amplification of a receptor by noncovalent combinatorial synthesis. Angew. Chem, Int. Ed. Engl., 39(4), 755-758.
25. Bunyapaiboonsri T., Ramström O., Lohmann S. et al. (2001). Dynamic deconvolution of a pre-equilibrated dynamic combinatorial library of acetylcholinesterase inhibitors. Chembiochem 2(6), 438-444.
26. Nicolaou K.C., Hughes R., Cho S.Y et al. (2001). Synthesis and biological evaluation of vancomycin dimers with potent activity against vancomycin-resistant bacteria: Target-accelerated combinatorial synthesis. Chem. Eur. J. 7(17), 3824-3843.
27. Nicolaou K.C., Hughes R., Cho S.Y. et al. (2000). Target-accelerated combinatorial synthesis and discovery of highly potent antibiotics effective against vancomycin-resistant bacteria. Angew. Chem. Int. Ed. Engl. 39(21), 3823-3828.
28. + from a dynamic combinatorial library. J. Am. Chem. Soc., 123(36), 8876-8877.
29. Hochgürtel M., Kroth H., Piecha D. et al. (2002). Target-induced formation of neuraminidase inhibitors from in vitro virtual combinatorial libraries. Proc. Natl. Acad. Sci. USA, 99(6), 3382-3387.
30. Hochgürtel M., Biesinger R., Kroth H. et al. (2002). Submitted for publication.
31. Goral V., Nelen M.I., Eliseev A.V. et al. (2001) Double-level "orthogonal" dynamic combinatorial libraries on transition metal template. Proc. Natl. Acad. Sci. USA, 98(4), 1347-1352.
32. Rideout D. (1996). Self-assembling cytotoxins. Science, 233(4763), 561-563.
33. Nguyen R., Huc I. (2001). Using an enzyme's active site to template inhibitors. Angew. Chem. Int. Ed. Engl., 40(9), 1774-1776.
34. Lewis W.G., Green L.G., Grynszpan F. et al. (2002). Click chemistry in situ:acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks. Angew. Chem. Int. Ed. Engl. 41(6), 1053-1057.
35. Jencks W.P. (1987). Catalysis In Chemistry and Enzymology. New York: Dover; 836 p.
36. Kolb H.C., Finn M.G., Sharpless K.B. (2001). Click chemistry: Diverse chemical function from a few good reactions. Angew. Chem. Int. Ed. Engl., 40(11):2004-2021.