Synthesis of new N-phenylpyrazole derivatives with potent antimicrobial activity

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 8, 2008, Pages 4569-4578

  Farag, Ahmad M ^a   Mayhoub, Abdelrahman S ^b   Barakat, Saber E ^b   Bayomi, Ashraf H ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b Al Azhar University   (Egypt)

Author keywords

1,2,4 Triazolo 4,3 a pyrimidine; 2 Aminothiazole; Antibacterial; Anticandidal; Antifungal; Enaminones; Imidazo 2,1 b benzothiazole; Phenylcarbamoylpyrazole; Pyrazolo 1,5 a pyrimidine; Structure activity relationship (SAR)

Indexed keywords

4 (2 AMINOTHIAZOL 4 YL) 5 METHYL 1 PHENYL 3 PHENYLCARBAMOYL 1H PYRAZOLE; 4 (2 BROMOACETYL) 5 METHYL 1 PHENYL 3 PHENYLCARBAMOYL 1H PYRAZOLE; 4 (IMIDAZO[2,1 B]BENZOTHIAZOL 3 YL) 5 METHYL 1 PHENYL 3 PHENYLCARBAMOYL 1H PYRAZOLE; 4 (ISOXAZOL 3 YL) 5 METHYL 1 PHENYL 3 PHENYLCARBAMOYL 1H PYRAZOLE; 4 [2 (4,4 DIMETHYL 2,6 DIOXOCYCLOHEXYL) 1 OXOETHYL] 5 METHYL 1 PHENYL 3 PHENYLCARBAMOYL 1H PYRAZOLE; 4 [3 (DIMETHYLAMINO)ACRYLOYL] 5 METHYL 1 PHENYL 3 PHENYLCARBAMOYL 1H PYRAZOLE; 4 ACETYL 5 METHYL 1 PHENYL 3 PHENYLCARBAMOYL 1H PYRAZOLE; 5 METHYL 1 PHENYL 3 PHENYLCARBAMOYL 4 (3 PYRAZOLYL) 1H PYRAZOLE; 5 METHYL 1 PHENYL 3 PHENYLCARBAMOYL 4 ([1,2,4]TRIAZOLO[4,3 A]PYRIMIDIN 5 YL) 1H PYRAZOLE; 5 METHYL 1 PHENYL 3 PHENYLCARBAMOYL 4 (QUINOXALIN 2 YL) 1H PYRAZOLE; 5 METHYL 1 PHENYL 4 PHENYLCARBAMOYL 4 [3 (THIOCARBAMOYLHYDRAZINO)ACRYLOYL] 1H PYRAZOLE; 5 METHYL 4 (2 METHYL 3 (4 CHLOROPHENYL)PYRAZOLO[1,5 A]PYRIMIDIN 7 YL) 1 PHENYL 3 PHENYLCARBAMOYL 1H PYRAZOLE; 5 METHYL 4 (2 METHYL 3 PHENYLPYRAZOLO[1,5 A]PYRIMIDIN 7 YL) 1 PHENYL 3 PHENYLCARBAMOYL 1H PYRAZOLE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS; CANDIDA ALBICANS; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CHELATING AGENTS; DRUG EVALUATION, PRECLINICAL; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; POLYMYXINS; PSEUDOMONAS; PYRAZOLES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

ASPERGILLUS; CANDIDA ALBICANS;

EID: 42249108135     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.02.043     Document Type: Article

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