Synthesis of furopyrazole analogs of 1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole (YC-1) as novel anti-leukemia agents

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 4, 2007, Pages 1732-1740

  Chou, Li Chen ^a   Huang, Li Jiau ^a   Yang, Jai Sing ^a   Lee, Fang Yu ^b   Teng, Che Ming ^c   Kuo, Sheng Chu ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b Yung Shin Pharmaceutical Industry Co Ltd   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Anti leukemia agent; Cell differentiation; Furopyrazole; YC 1

Indexed keywords

1 BENZYL 3 (4 HYDROXYCARBONYLPHENYL) 5 METHYLFURO[3,2 C]PYRAZOLE; 1 BENZYL 3 (4 HYDROXYMETHYLPHENYL) 5 METHYLFURO[3,2 C]PYRAZOLE; 1 BENZYL 3 (4 METHOXYCARBONYLPHENYL) 5 METHYLFURO[3,2 C]PYRAZOLE; 1 BENZYL 3 (5 HYDROXYCARBONYL 2 FURYL) 5 METHYLFURO[3,2 C]PYRAZOLE; 1 BENZYL 3 (5 HYDROXYMETHYL 2 FURYL) 5 METHYLFURO[3,2 C]PYRAZOLE; 1 BENZYL 3 (5 METHOXYCARBONYL 2 FURYL) 5 METHYLFURO[3,2 C]PYRAZOLE; 1 PHENYL 3 (4 HYDROXYCARBONYL 2 FURYL) 5 METHYLFURO[3,2 C]PYRAZOLE; 1 PHENYL 3 (4 HYDROXYMETHYLPHENYL) 5 METHYLFURO[3,2 C]PYRAZOLE; 1 PHENYL 3 (4 METHOXYCARBONYLPHENYL) 5 METHYLFURO[3,2 C]PYRAZOLE; 1 PHENYL 3 (5 HYDROXYCARBONYL 2 FURYL) 5 METHYLFURO[3,2 C]PYRAZOLE; 1 PHENYL 3 (5 HYDROXYMETHYL 2 FURYL) 5 METHYLFURO[3,2 C]PYRAZOLE; 1 PHENYL 3 (5 METHOXYCARBONYL 2 FURYL) 5 METHYLFURO[3,2 C]PYRAZOLE; ANTILEUKEMIC AGENT; INDAZOLE DERIVATIVE; MYC PROTEIN; PROTEIN BCL 2; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; GRANULOCYTE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL DIFFERENTIATION; GRANULOCYTES; HL-60 CELLS; HUMANS; INDAZOLES; LEUKEMIA; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MYC; PYRAZOLES;

EID: 33847789058     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.12.001     Document Type: Article

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