Prevention of methylmercury-induced mitochondrial depolarization, glutathione depletion and cell death by 15-deoxy-delta-12,14-prostaglandin J2

NeuroToxicology

Volumn 29, Issue 6, 2008, Pages 1054-1061

  Chang, Jason Y ^a   Tsai, Pao Feng ^b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

15d PGJ2; Glutathione; Methylmercury; Mitochondrial membrane potential

Indexed keywords

15 DEOXY DELTA 12,14 PROSTAGLANDIN J2; BUTHIONINE SULFOXIMINE; GLUTATHIONE; HEME OXYGENASE 1; METHYLMERCURY; PROSTAGLANDIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DEATH; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DEPOLARIZATION; GLIA CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINE STABILIZATION;

ANIMALS; ANIMALS, NEWBORN; BENZIMIDAZOLES; BUTHIONINE SULFOXIMINE; CARBOCYANINES; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTATHIONE; MEMBRANE POTENTIAL, MITOCHONDRIAL; METHYLMERCURY COMPOUNDS; MICE; MICE, INBRED C57BL; MITOCHONDRIA; NEUROGLIA; TIME FACTORS; UP-REGULATION;

ANIMALIA;

EID: 56249149197     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2008.08.003     Document Type: Article

References (62)

1. Allen J.W., El-Oqayli H., Aschner M., Syversen T., and Sonnewald U. Methylmercury has a selective effect on mitochondria in cultured astrocytes in the presence of [U-(13)C]glutamate. Brain Res 908 (2001) 149-154
2. 2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes. J Biol Chem 279 (2004) 21929-21937
3. Aoun P., Simpkins J.W., and Agarwal N. Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells. Invest Ophthalmol Vis Sci 44 (2003) 2999-3004
4. Aschner M. Methylmercury in astrocytes-what possible significance?. Neurotoxicology 17 (1996) 93-106
5. Aschner M., Allen J.W., Kimelberg H.K., LoPachin R.M., and Streit W.J. Glial cells in neurotoxicity development. Annu Rev Pharmacol Toxicol 39 (1999) 151-173
6. Belletti S., Orlandini G., Vettori M.V., Mutti A., Uggeri J., Scandroglio R., et al. Time course assessment of methylmercury effects on C6 glioma cells: submicromolar concentrations induce oxidative DNA damage and apoptosis. J Neurosci Res 70 (2002) 703-711
7. 2 in the regulation of microglial functions. Eur J Neurosci 12 (2000) 2215-2223
8. Castrillo A., Diaz-Guerra M.J., Hortelano S., Martin-Sanz P., and Bosca L. Inhibition of IkappaB kinase and IkappaB phosphorylation by 15-deoxy-delta(12,14)-prostaglandin J(2) in activated murine macrophages. Mol Cell Biol 20 (2000) 1692-1698
9. Chang J.Y., and Liu L. Peroxisome proliferator-activated receptor agoinsts prevent 25-OH-cholesterol induced c-jun activation and cell death. BMC Pharmacol 1 (2001) 10
10. Clarkson T.W., Magos L., and Myers G.J. The toxicology of mercury-current exposures and clinical manifestations. N Engl J Med 349 (2003) 1731-1737
11. Dreiem A., and Seegal R.F. Methylmercury-induced changes in mitochondrial function in striatal synaptosomes are calcium-dependent and ROS-independent. Neurotoxicology 28 (2007) 720-726
12. Dwyer B.E., Lu S.Y., Laitinen J.T., and Nishimura R.N. Protective properties of tin- and manganese-centered porphyrins against hydrogen peroxide-mediated injury in rat astroglial cells. J Neurochem 71 (1998) 2497-2504
13. 2. BMC Ophthalmol 3 (2003) 5
14. 2 prevents reactive oxygen species generation and mitochondrial membrane depolarization induced by oxidative stress. BMC Pharmacol 4 (2004) 6
15. 2. J Neuroimmunol 171 (2006) 17-28
16. Gatti R., Belletti S., Uggeri J., Vettori M.V., Mutti A., Scandroglio R., et al. Methylmercury cytotoxicity in PC12 cells is mediated by primary glutathione depletion independent of excess reactive oxygen species generation. Toxicology 204 (2004) 175-185
17. Gilroy D.W., Colville-Nash P.R., Willis D., Chivers J., Paul-Clark M.J., and Willoughby D.A. Inducible cyclooxygenase may have anti-inflammatory properties. Nat Med 5 (1999) 698-701
18. Gong P., Stewart D., Hu B., Li N., Cook J., Nel A., et al. Activation of the mouse heme oxygenase-1 gene by 15-deoxy-delta(12,14)-prostaglandin J(2) is mediated by the stress response elements and transcription factor Nrf2. Antioxid Redox Signal 4 (2002) 249-257
19. Hegazy K.A., Dunn M.W., and Sharma S.C. Functional human heme oxygenase has a neuroprotective effect on adult rat ganglion cells after pressure-induced ischemia. Neuroreport 11 (2000) 1185-1189
20. Imuta N., Hori O., Kitao Y., Tabata Y., Yoshimoto T., Matsuyama T., et al. Hypoxia-mediated induction of heme oxygenase type I and carbon monoxide release from astrocytes protects nearby cerebral neurons from hypoxia-mediated apoptosis. Antioxid Redox Signal 9 (2007) 543-552
21. InSug O., Datar S., Koch C.J., Shapiro I.M., and Shenker B.J. Mercuric compounds inhibit human monocyte function by inducing apoptosis: evidence for formation of reactive oxygen species, development of mitochondrial membrane permeability transition and loss of reductive reserve. Toxicology 124 (1997) 211-224
22. Itoh K., Mochizuki M., Ishii Y., Ishii T., Shibata T., Kawamoto Y., et al. Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-delta(12,14)-prostaglandin J(2). Mol Cell Biol 24 (2004) 36-45
23. Jiang C., Ting A.T., and Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 391 (1998) 82-86
24. Kang M.S., Jeong J.Y., Seo J.H., Jeon H.J., Jung K.M., Chin M.R., et al. Methylmercury-induced toxicity is mediated by enhanced intracellular calcium through activation of phosphatidylcholine-specific phospholipase C. Toxicol Appl Pharmacol 216 (2006) 206-215
25. Kaur P., Aschner M., and Syversen T. Glutathione modulation influences methyl mercury induced neurotoxicity in primary cell cultures of neurons and astrocytes. Neurotoxicology 27 (2006) 492-500
26. 2-induced expression of glutathione S-transferases. J Biol Chem 275 (2000) 11291-11299
27. Kensler T.W., Wakabayashi N., and Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 47 (2007) 89-116
28. 2 prime eotaxin-induced chemotaxis on human eosinophils through peroxisome proliferator-activated receptor-gamma ligation. J Immunol 175 (2005) 5744-5750
29. Koppal T., Petrova T.V., and Van Eldik L.J. Cyclopentenone prostaglandin 15-deoxy-delta(12,14)-prostaglandin J(2) acts as a general inhibitor of inflammatory responses in activated BV-2 microglial cells. Brain Res 867 (2000) 115-121
30. Landar A., Zmijewski J.W., Dickinson D.A., Le Goffe C., Johnson M.S., Milne G.L., et al. Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species. Am J Physiol Heart Circ Physiol 290 (2006) H1777-H1787
31. Le W.D., Xie W.J., and Appel S.H. Protective role of heme oxygenase-1 in oxidative stress-induced neuronal injury. J Neurosci Res 56 (1999) 652-658
32. Lee Y.W., Ha M.S., and Kim Y.K. Role of reactive oxygen species and glutathione in inorganic mercury-induced injury in human glioma cells. Neurochem Res 26 (2001) 1187-1193
33. Levonen A.L., Dickinson D.A., Moellering D.R., Mulcahy R.T., Forman H.J., and Darley-Usmar V.M. Biphasic effects of 15-deoxy-delta(12,14)-prostaglandin J(2) on glutathione induction and apoptosis in human endothelial cells. Arterioscler Thromb Vasc Biol 21 (2001) 1846-1851
34. Lim S.Y., Jang J.H., Na H.K., Lu S.C., Rahman I., and Surh Y.J. 15-Deoxy-delta12,14-prostaglandin J(2) protects against nitrosative PC12 cell death through up-regulation of intracellular glutathione synthesis. J Biol Chem 279 (2004) 46263-46270
35. Limke T.L., and Atchison W.D. Acute exposure to methylmercury opens the mitochondrial permeability transition pore in rat cerebellar granule cells. Toxicol Appl Pharmacol 178 (2002) 52-61
36. Limke T.L., Otero-Montanez J.K., and Atchison W.D. Evidence for interactions between intracellular calcium stores during methylmercury-induced intracellular calcium dysregulation in rat cerebellar granule neurons. J Pharmacol Exp Ther 304 (2003) 949-958
37. Limke T.L., Heidemann S.R., and Atchison W.D. Disruption of intraneuronal divalent cation regulation by methylmercury: are specific targets involved in altered neuronal development and cytotoxicity in methylmercury poisoning?. Neurotoxicology 25 (2004) 741-760
38. 2+ entry in rat cerebellar granule cells following in vitro exposure to methyl mercury. Toxicol Appl Pharmacol 147 (1997) 319-330
39. 2 are potent activators of human eosinophils. J Immunol 168 (2002) 3563-3569
40. Mundy W.R., and Freudenrich T.M. Sensitivity of immature neurons in culture to metal-induced changes in reactive oxygen species and intracellular free calcium. Neurotoxicology 21 (2000) 1135-1144
41. Na H.K., and Surh Y.J. Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands as bifunctional regulators of cell proliferation. Biochem Pharmacol 66 (2003) 1381-1391
42. Otterbein L.E., Soares M.P., Yamashita K., and Bach F.H. Heme oxygenase-1: unleashing the protective properties of heme. Trends Immunol 24 (2003) 449-455
43. Ou Y.C., White C.C., Krejsa C.M., Ponce R.A., Kavanagh T.J., and Faustman E.M. The role of intracellular glutathione in methylmercury-induced toxicity in embryonic neuronal cells. Neurotoxicology 20 (1999) 793-804
44. 2. Proc Natl Acad Sci USA 96 (1999) 4668-4673
45. 2 by augmenting GSH and activating MAPK. Invest Ophthalmol Vis Sci 47 (2006) 5098-5105
46. Ricote M., Li A.C., Willson T.M., Kelly C.J., and Glass C.K. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391 (1998) 79-82
47. Ryter S.W., Alam J., and Choi A.M. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev 86 (2006) 583-650
48. 2 against glutamate-induced cell death in primary cortical neuron cultures: induction of adaptive response and enhancement of cell tolerance primarily through up-regulation of cellular glutathione. J Neurochem 102 (2007) 1625-1634
49. Sakaue M., Okazaki M., and Hara S. Very low levels of methylmercury induce cell death of cultured rat cerebellar neurons via calpain activation. Toxicology 213 (2005) 97-106
50. Satoh T., Baba M., Nakatsuka D., Ishikawa Y., Aburatani H., Furuta K., et al. Role of heme oxygenase-1 protein in the neuroprotective effects of cyclopentenone prostaglandin derivatives under oxidative stress. Eur J Neurosci 17 (2003) 2249-2255
51. Sebastia J., Cristofol R., Martin M., Rodriguez-Farre E., and Sanfeliu C. Evaluation of fluorescent dyes for measuring intracellular glutathione content in primary cultures of human neurons and neuroblastoma SH-SY5Y. Cytometry 51 (2003) 16-25
52. Shenker B.J., Mayro J.S., Rooney C., Vitale L., and Shapiro I.M. Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. IV. Alterations in cellular glutathione content. Immunopharmacol Immunotoxicol 15 (1993) 273-290
53. Shenker B.J., Guo T.L., and Shapiro I.M. Low-level methylmercury exposure causes human T-cells to undergo apoptosis: evidence of mitochondrial dysfunction. Environ Res 77 (1998) 149-159
54. Shenker B.J., Guo T.L., and O I Shapiro I.M. Induction of apoptosis in human T-cells by methyl mercury: temporal relationship between mitochondrial dysfunction and loss of reductive reserve. Toxicol Appl Pharmacol 157 (1999) 23-35
55. 2 on rat cultured cerebellar granule neuronal viability. J Neurosci Res 72 (2003) 747-755
56. Song W., Su H., Song S., Paudel H.K., and Schipper H.M. Over-expression of heme oxygenase-1 promotes oxidative mitochondrial damage in rat astroglia. J Cell Physiol 206 (2006) 655-663
57. Song L., Song W., and Schipper H.M. Astroglia overexpressing heme oxygenase-1 predispose co-cultured PC12 cells to oxidative injury. J Neurosci Res 85 (2007) 2186-2195
58. Straus D.S., and Glass C.K. Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Med Res Rev 21 (2001) 185-210
59. Taylor-Clark T.E., Undem B.J., Macglashan Jr. D.W., Ghatta S., Carr M.J., and McAlexander M.A. Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1 (TRPA1). Mol Pharmacol 73 (2008) 274-281
60. 2 alters pro-survival and pro-death gene expression patterns and 26 S proteasome assembly in human neuroblastoma cells. J Biol Chem 281 (2006) 21377-21386
61. Yee S., and Choi B.H. Oxidative stress in neurotoxic effects of methylmercury poisoning. Neurotoxicology 17 (1996) 17-26
62. Zander T., Kraus J.A., Grommes C., Schlegel U., Feinstein D., Klockgether T., et al. Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma. J Neurochem 81 (2002) 1052-1060