Methylmercury-induced toxicity is mediated by enhanced intracellular calcium through activation of phosphatidylcholine-specific phospholipase C

Toxicology and Applied Pharmacology

Volumn 216, Issue 2, 2006, Pages 206-215

  Kang, Mi Sun ^a   Jeong, Ju Yeon ^a   Seo, Ji Heui ^a   Jeon, Hyung Jun ^a   Jung, Kwang Mook ^a   Chin, Mi Reyoung ^a   Moon, Chang Kiu ^b   Bonventre, Joseph V ^c   Jung, Sung Yun ^a   Kim, Dae Kyong ^a  

^a Chung Ang University   (South Korea)

^b Seoul National University   (South Korea)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

A SMase; Ca2+; Ceramide; Cytosolic PLA2; Methylmercury; PC PLC; ROS

Indexed keywords

CALCIUM; DIACYLGLYCEROL; EGTAZIC ACID; METHYLMERCURY; PHOSPHATIDYLCHOLINE; PHOSPHOLIPASE A2; PHOSPHOLIPASE C; PROTEIN KINASE C; SPHINGOMYELIN PHOSPHODIESTERASE; TRICYCLO[4.3.0.1]DECAN 9 YL XANTHOGENATE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL DEATH; CELL PROTECTION; CELL STRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOSE TIME EFFECT RELATION; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MERCURIALISM; NONHUMAN; SIGNAL TRANSDUCTION;

ANIMALS; BRIDGED COMPOUNDS; CALCIUM; CELL LINE, TUMOR; CELL SURVIVAL; CHELATING AGENTS; DIGLYCERIDES; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; EGTAZIC ACID; ENVIRONMENTAL POLLUTANTS; ENZYME ACTIVATION; HUMANS; KIDNEY; METHYLMERCURY COMPOUNDS; NEUROBLASTOMA; PHOSPHATIDYLCHOLINES; PHOSPHODIESTERASE INHIBITORS; PHOSPHOLIPASE C; PHOSPHOLIPASES A; REACTIVE OXYGEN SPECIES; SPHINGOMYELIN PHOSPHODIESTERASE; THIONES;

EID: 33749042315     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.04.016     Document Type: Article

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