Synthesis and antiprotozoal activity of cationic 2-phenylbenzofurans

Journal of Medicinal Chemistry

Volumn 51, Issue 21, 2008, Pages 6927-6944

  Bakunov, Stanislav A ^a   Bakunova, Svetlana M ^a   Wenzler, Tanja ^b   Barszcz, Todd ^c   Werbovetz, Karl A ^c   Brun, Reto ^b   Tidwell, Richard R ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 HYDROXY 4 N ISOPROPYLAMIDINOPHENYL) 5 N ISOPROPYLAMIDINOBENZOFURAN 7 OL; 2 (3 AMIDINOPHENYL) 5 AMIDINOBENZOFURAN; 2 (3 AMIDINOPHENYL) 6 AMIDINOBENZOFURAN; 2 (3 N ISOPROPYLAMIDINOPHENYL) 5 N ISOPROPYLAMIDINOBENZOFURAN; 2 (3 N ISOPROPYLAMIDINOPHENYL) 6 N ISOPROPYLAMIDINOBENZOFURAN; 2 (4 AMIDINO 2 HYDROXYPHENYL) 5 AMIDINOBENZOFURAN 7 OL; 2 (4 AMIDINOPHENYL) 5 AMIDINO 7 METHOXYBENZOFURAN; 2 (4 AMIDINOPHENYL) 5 AMIDINOBENZOFURAN; 2 (4 AMIDINOPHENYL) 5 AMIDINOBENZOFURAN 7 OL; 2 (4 AMIDINOPHENYL) 6 AMIDINOBENZOFURAN; 2 (4 N ISOPROPYLAMIDINOPHENYL) 5 N ISOPROPYLAMIDINO 7 METHOXYBENZOFURAN; 2 (4 N ISOPROPYLAMIDINOPHENYL) 5 N ISOPROPYLAMIDINOBENZOFURAN; 2 (4 N ISOPROPYLAMIDINOPHENYL) 5 N ISOPROPYLAMIDINOBENZOFURAN 7 OL; 2 (4 N ISOPROPYLAMIDINOPHENYL) 6 N ISOPROPYLAMIDINOBENZOFURAN; 4',6 DIAMIDINO 2 PHENYLINDOLE; 5 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 2 [3 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]BENZOFURAN; 5 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 2 [4 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 2 HYDROXYPHENYL]BENZOFURAN 7 OL; 5 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 2 [4 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL] 7 METHOXYBENZOFURAN; 5 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 2 [4 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]BENZOFURAN; 5 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 2 [4 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]BENZOFURAN 7 OL; 6 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 2 [3 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]BENZOFURAN; 6 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 2 [4 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]BENZOFURAN; ANTIPROTOZOAL AGENT; ARTEMISININ; BENZOFURAN DERIVATIVE; DI(N ISOPROPYL)AMIDINE; DIAMIDINE DERIVATIVE; MELARSOPROL; PENTAMIDINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; IN VIVO STUDY; LEISHMANIA DONOVANI; MAMMAL CELL; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TRYPANOSOMA RHODESIENSE; TRYPANOSOMIASIS;

ANIMALS; ANTIPROTOZOAL AGENTS; BENZOFURANS; CATIONS; DISEASE MODELS, ANIMAL; LEISHMANIA; MICE; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA; TRYPANOSOMIASIS;

EID: 56249137922     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800918v     Document Type: Article

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