New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity

Journal of Medicinal Chemistry

Volumn 51, Issue 4, 2008, Pages 909-923

  Rodríguez, Fernando ^a   Rozas, Isabel ^a   Kaiser, Marcel ^b   Brun, Reto ^b   Nguyen, Binh ^c   Wilson, W David ^c   García, Rory Nelson ^d   Dardonville, Christophe ^e  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c GEORGIA STATE UNIVERSITY   (United States)

^d UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^e INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 GUANIDINOPHENYL) 3 PHENYLUTHIOUREA TRIFLUOROACETATE; 1 [4 (2 IMIDAZOLIDINYLIMINO)PHENYL] 3 PHENYLUREA TRIFLUOROACETATE; 1,4 BIS(4 GUANIDINOPHENYL)PIPERIDINE; 1,4 BIS[4 (4,5 DIHYDRO 1H 2 IMIDAZOLYLAMINO)PHENYL]PIPERIDINE; 4 (2 IMIDAZOLIDINYLIMINO)BENZOPHENONE; 4 GUANIDINOBENZOPHENONE; 4' (2 IMIDAZOLIDINYLIMINO)BENZANILIDE; BIPHENYL; CHLOROQUINE; GUANIDINE DERIVATIVE; HEMATIN; IMIDAZOLE DERIVATIVE; L,3 BIS(4 GUANIDINOPHENYL)UREA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; BINDING AFFINITY; BIOMINERALIZATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG DETERMINATION; DRUG DNA BINDING; DRUG MECHANISM; DRUG POTENCY; DRUG SAFETY; DRUG STRUCTURE; FEMALE; IC 50; IN VITRO STUDY; MALARIA FALCIPARUM; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; TRYPANOSOMA RHODESIENSE; TRYPANOSOMIASIS;

ANIMALS; ANTIMALARIALS; CELL LINE; DNA; FEMALE; GUANIDINES; HEMEPROTEINS; HEMIN; IMIDAZOLINES; MALARIA; MICE; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSITION TEMPERATURE; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMIASIS, AFRICAN;

EID: 39749126154     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm7013088     Document Type: Article

References (52)