Resuscitating adaptive Tregs with combination therapies?

Novartis Foundation Symposium

Volumn 292, Issue , 2008, Pages 50-60

  Bresson, Damien ^a   Von Herrath, Matthias ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; FORKHEAD TRANSCRIPTION FACTOR; HISTOCOMPATIBILITY ANTIGEN;

ANIMAL; CONFERENCE PAPER; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; MOUSE; NONOBESE DIABETIC MOUSE; PANCREAS ISLET BETA CELL; REGULATORY T LYMPHOCYTE; VACCINATION;

ANIMALS; AUTOANTIGENS; DIABETES MELLITUS, TYPE 1; FORKHEAD TRANSCRIPTION FACTORS; HISTOCOMPATIBILITY ANTIGENS; HUMANS; IMMUNE TOLERANCE; INSULIN-SECRETING CELLS; MICE; MICE, INBRED NOD; T-LYMPHOCYTES, REGULATORY; VACCINATION;

EID: 56249133523     PISSN: 15282511     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (33)

1. Akbar AN, Vukmanovic-Stejic M, Taams LS, Macallan DC 2007 The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery. Nat Rev Immunol 7:231-237
2. Allan SE, Crome SQ, Crellin NK et al 2007 Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int Immunol 19:345-354
3. Arif S, Tree TI, Astill TP et al 2004 Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J Clin Invest 113:451-463
4. Bielekova B, Goodwin B, Richert N et al 2000 Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat Med 6:1167-1175
5. Bresson D, von Herrath M 2007 Moving towards efficient therapies in type 1 diabetes: To combine or not to combine? Autoimmun Rev 6:315-322
6. Bresson D, Togher L, Rodrigo E et al 2006 Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J Clin Invest 116:1371-1381
7. Desai BM, Oliver-Krasinski J, De Leon DD et al 2007 Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration. J Clin Invest 117:971-977
8. Di Lorenzo TP, Peakman M, Roep BO 2007 Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes. Clin Exp Immunol 148:1-16
9. Fehervari Z, Yamaguchi T, Sakaguchi S 2006 The dichotomous role of IL-2: tolerance versus immunity. Trends Immunol 27:109-111
10. Fousteri G, von Herrath M, Bresson D 2007 Mucosal exposure to antigen: cause or cure of type 1 diabetes? Curr Diab Rep 7:91-98
11. Godfrey DI, Kronenberg M 2004 Going both ways: immune regulation via CD1d-dependent NKT cells. J Clin Invest 114:1379-1388
12. Harrison LC, Solly NR, Martinez NR 2003 (Pro)insulin-specific regulatory T cells. In: Generation and effector functions of regulatory lymphocytes, Wiley, Chichester (Novartis Found Symp 252) p 132-141; discussion 141-135, 203-210
13. Herold KC, Ablamunits V, Sherry NA, Kushner JA 2007 Autoimmunity and beta cell regeneration in mouse and human Type 1 diabetes: The peace is not enough. Ann N Y Acad Sci 1103: 19-32
14. Homann D, Holz A, Bot A et al 1999 Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway. Immunity 11:463-472
15. Homann D, Jahreis A, Wolfe T et al 2002 CD40L blockade prevents autoimmune diabetes by induction of bitypic NK/DC regulatory cells. Immunity 16:403-415
16. Hori S, Nomura T, Sakaguchi S 2003 Control of regulatory T cell development by the transcription factor Foxp3. Science 299:1057-1061
17. Kent SC, Chen Y, Bregoli L et al 2005 Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature 435:224-228
18. Liu W, Putnam AL, Xu-Yu Z et al 2006 CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 203:1701-1711
19. Maier LM, Wicker LS 2005 Genetic susceptibility to type 1 diabetes. Curr Opin Immunol 17:601-608
20. Nakayama M, Abiru N, Moriyama H et al 2005 Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 435:220-223
21. Oling V, Marttila J, Ilonen J et al 2005 GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects. J Autoimmun 25:235-243
22. Phillips JM, O'Reilly L, Bland C, Foulis AK, Cooke A 2007 Patients with chronic pancreatitis have islet progenitor cells in their ducts, but reversal of overt diabetes in NOD mice by anti-CD3 shows no evidence for islet regeneration. Diabetes 56:634-640
23. Piccirillo CA, Letterio JJ, Thornton AM et al 2002 CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J Exp Med 196:237-246
24. Roncarolo MG, Gregori S, Levings M 2003 Type 1 T regulatory cells and their relationship with CD4+CD25+ T regulatory cells. In: Generation and effector functions of regulatory lymphocytes. Wiley, Chichester (Novartis Found Symp 252) p 115-127; discussion 127-131, 203-210
25. Sakaguchi S, Fukuma K, Kuribayashi K, Masuda T 1985 Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease. J Exp Med 161:72-87
26. Schubert LA, Jeffery E, Zhang Y, Ramsdell F, Ziegler SF 2001 Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J Biol Chem 276:37672-37679
27. Seddiki N, Santner-Nanan B, Martinson J et al 2006 Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 203: 1693-1700
28. Trucco M 2005 Regeneration of the pancreatic beta cell. J Clin Invest 115:5-12
29. Walker MR, Carson BD, Nepom GT, Ziegler SF, Buckner JH 2005 De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells. Proc Natl Acad Sci USA 102:4103-4108
30. Wang J, Ioan-Facsinay A, van der Voort EI, Huizinga TW, Toes RE 2007 Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells. Eur J Immunol 37:129-138
31. Wolfe T, Bot A, Hughes A et al 2002 Endogenous expression levels of autoantigens influence success or failure of DNA immunizations to prevent type 1 diabetes: addition of IL-4 increases safety. Eur J Immunol 32:113-121
32. You S, Leforban B, Garcia C, Bach JF, Bluestone JA, Chatenoud L 2007 Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment. Proc Natl Acad Sci USA 104:6335-6340
33. Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA 2007 IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J Immunol 178:2018-2027