Endogenous expression levels of autoantigens influence success or failure of DNA immunizations to prevent type 1 diabetes: Addition of IL-4 increases safety

European Journal of Immunology

Volumn 32, Issue 1, 2002, Pages 113-121

  Wolfe, Tom ^a   Bot, Adrian ^a   Hughes, Anna ^a   Möhrle, Ursula ^a   Rodrigo, Evelyn ^a   Jaume, Juan Carlos ^b   Baekkeskov, Steinunn ^b   Von Herrath, Matthias ^a,c  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

Diabetes; DNA vaccine; Glutamic acid decarboxylase; Insulin; Prevention

Indexed keywords

AUTOANTIGEN; CD4 ANTIGEN; DNA VACCINE; GAMMA INTERFERON; GLUTAMATE DECARBOXYLASE; INTERLEUKIN 4; INVIVOGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG SAFETY; IMMUNIZATION; IMMUNOREGULATION; IMMUNOTHERAPY; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK MANAGEMENT; TH1 CELL; TH2 CELL; TREATMENT FAILURE; VIRUS INDUCTION;

ANIMALS; ANTIGENS, VIRAL; AUTOANTIBODIES; AUTOANTIGENS; CELL LINE; CERCOPITHECUS AETHIOPS; CONSUMER PRODUCT SAFETY; CRICETINAE; DIABETES MELLITUS, TYPE 1; FEMALE; GENE EXPRESSION; GLUTAMATE DECARBOXYLASE; GLYCOPROTEINS; HUMANS; INSULIN; INTERLEUKIN-4; ISLETS OF LANGERHANS; ISOENZYMES; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, TRANSGENIC; PLASMIDS; TH1 CELLS; TH2 CELLS; TREATMENT OUTCOME; VACCINATION; VACCINES, DNA; VERO CELLS; VIRAL PROTEINS;

EID: 0036146319     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200201)32:1<113::AID-IMMU113>3.0.CO;2-C     Document Type: Article

References (26)

1. Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitipe dependent
2. Antigen-specific immunotherapy: Is it a real possibility to combat T cell-mediated autoimmunity?
3. Systemic antigen in the treatment of T cell-mediated autoimmune diseases
4. DNA vaccines for the treatment of autoimmune disease
5. Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice
6. Suppression of diabetes in NOD mice by oral administration of porcine insulin
7. Insulin in oral immune "tolerance": A one-amino acid change in the B chain makes the difference
8. DNA immunization to prevent autoimmune diabetes
9. DNA vaccination to treat autoimmune diabetes
10. Induction of autoimmune diabetes by oral administration of autoantigen
11. + lymphocytes protect from autoimmune diabetes via bystander suppression using the IL-4/STAT6 pathway
12. Oral tolerance, an active immunologic process mediated by multiple mechanisms
13. Induction of GAD65-specific regulatory T cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice
14. Antigen-specific mediated suppression of beta cell autoimmunity by plasmid DNA vaccination
15. How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model
16. Virus-induced autoimmune diabetes: Most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) CTL
17. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
18. Glutamate decarboxylase and GABA in pancreatic islets: Lessons from knock-out mice
19. Control of autoimmune diabetes in NOD mice by GAD expression or suppression in betta cells
20. Increased expression of GAD65 and GABA in pancreatic beta-cells impairs first-phase insulin secretion
21. Plasmid vaccination with insulin b chain prevents autoimmune diabetes in nonobese diabetic mice
22. Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library
23. + T cell differentiation
24. Regulation of naive T cell differentiation by varying the potency of TCR signal transduction
25. Coexpression of B7.1 and viral (self) transgenes in pancreatic B cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes
26. Genomic and biological variation among commonly used lymphocytic choriomeningitis virus strains