Oxidative stress modulates theophylline effects on steroid responsiveness

Biochemical and Biophysical Research Communications

Volumn 377, Issue 3, 2008, Pages 797-802

  Marwick, John A ^a,b   Wallis, Gillian ^a   Meja, Koremu ^a   Kuster, Bernhard ^c   Bouwmeester, Tewis ^c   Chakravarty, Probir ^a   Fletcher, Danielle ^a   Whittaker, Paul A ^a   Barnes, Peter J ^b   Ito, Kazuhiro ^b   Adcock, Ian M ^b   Kirkham, Paul A ^a,b  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Corticosteroid insensitivity; Histone acetylation; Histone deacetylase 2; Oxidative stress; Theophylline

Indexed keywords

BUDESONIDE; CORTICOSTEROID; DEXAMETHASONE; HISTONE; OXIDIZING AGENT; THEOPHYLLINE;

ACETYLATION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; MEDIATOR RELEASE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEOMICS; QUANTITATIVE ANALYSIS;

ACETYLATION; ADRENAL CORTEX HORMONES; ANTI-INFLAMMATORY AGENTS; BRONCHODILATOR AGENTS; CELL LINE; DEXAMETHASONE; DRUG RESISTANCE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HISTONES; HUMANS; OXIDANTS; OXIDATIVE STRESS; PHOSPHODIESTERASE INHIBITORS; PROTEOMICS; THEOPHYLLINE;

EID: 56249130433     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.10.065     Document Type: Article

References (24)

1. Ito K., Chung K.F., and Adcock I.M. Update on glucocorticoid action and resistance. J. Allergy Clin. Immunol. 117 (2006) 522-543
2. Barnes P.J., Shapiro S.D., and Pauwels R.A. Chronic obstructive pulmonary disease: molecular and cellular mechanisms. Eur. Respir. J. 22 (2003) 672-688
3. Marwick J.A., Ito K., Adcock I.M., and Kirkham P.A. Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC-2 as a therapeutic strategy. Expert Opin. Ther. Targets 11 (2007) 745-755
4. Ukena D., Harnest U., Sakalauskas R., Magyar P., Vetter N., Steffen H., Leichtl S., Rathgeb F., Keller A., and Steinijans V.W. Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma. Eur. Respir. J. 10 (1997) 2754-2760
5. Cosio B.G., Tsaprouni L., Ito K., Jazrawi E., Adcock I.M., and Barnes P.J. Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J. Exp. Med. 200 (2004) 689-695
6. Ito K., Yamamura S., Essilfie-Quaye S., Cosio B., Ito M., Barnes P.J., and Adcock I.M. Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-{kappa}B suppression. J. Exp. Med. 203 (2006) 7-13
7. Ito K., Ito M., Elliott W.M., Cosio B., Caramori G., Kon O.M., Barczyk A., Hayashi S., Adcock I.M., Hogg J.C., and Barnes P.J. Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N. Engl. J. Med. 352 (2005) 1967-1976
8. Hew M., Bhavsar P., Torrego A., Meah S., Khorasani N., Barnes P.J., Adcock I., and Fan Chung K. For the National Heart Lung and Blood Institute's Severe Asthma Research Program, relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma. Am. J. Respir. Crit. Care Med. 174 (2006) 134-141
9. Ito K., Lim S., Caramori G., Chung K.F., Barnes P.J., and Adcock I.M. Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. FASEB J. 15 (2001) 1110-1112
10. Ito K., Lim S., Caramori G., Cosio B., Chung K.F., Adcock I.M., and Barnes P.J. A molecular mechanism of action of theophylline: induction of histone deacetylase activity to decrease inflammatory gene expression. Proc. Natl. Acad. Sci. 99 (2002) 8921-8926
11. Kamata H., and Hirata H. Redox regulation of cellular signalling. Cell. Signal. 11 (1999) 1-14
12. Yao P.L., Tsai M.F., Lin Y.C., Wang C.H., Liao W.Y., Chen J.J., and Yang P.C. Global expression profiling of theophylline response genes in macrophages: evidence of airway anti-inflammatory regulation. Respir. Res. 6 (2005) 89
13. Mootha V.K., Lindgren C.M., Eriksson K.F., Subramanian A., Sihag S., Lehar J., Puigserver P., Carlsson E., Ridderstrale M., Laurila E., Houstis N., Daly M.J., Patterson N., Mesirov J.P., Golub T.R., Tamayo P., Spiegelman B., Lander E.S., Hirschhorn J.N., Altshuler D., and Groop L.C. PGC-1[alpha]-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. 34 (2003) 267-273
14. Bantscheff M., Eberhard D., Abraham Y., Bastuck S., Boesche M., Hobson S., Mathieson T., Perrin J., Raida M., Rau C., Reader V., Sweetman G., Bauer A., Bouwmeester T., Hopf C., Kruse U., Neubauer G., Ramsden N., Rick J., Kuster B., and Drewes G. Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors. Nat. Biotechnol. 25 (2007) 1035-1044
15. Bantscheff M., Boesche M., Eberhard D., Matthieson T., Sweetman G., and Kuster B. Robust and sensitive iTRAQ quantification on an LTQ Orbitrap mass spectrometer. Mol Cell Proteomics 7 (2008) 1702-1713
16. Ross P.L., Huang Y.N., Marchese J.N., Williamson B., Parker K., Hattan S., Khainovski N., Pillai S., Dey S., Daniels S., Purkayastha S., Juhasz P., Martin S., Bartlet-Jones M., He F., Jacobson A., and Pappin D.J. Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents. Mol. Cell. Proteomics 3 (2004) 1154-1169
17. Ito K., Hanazawa T., Tomita K., Barnes P.J., and Adcock I.M. Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration. Biochem. Biophys. Res. Commun. 315 (2004) 240-245
18. Marwick J.A., Kirkham P.A., Stevenson C.S., Danahay H., Giddings J., Butler K., Donaldson K., MacNee W., and Rahman I. Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs. Am. J. Respir. Cell Mol. Biol. 31 (2004) 633-642
19. Meja K.K., Rajendrasozhan S., Adenuga D., Biswas S.K., Sundar I.K., Spooner G., Marwick J.A., Chakravarty P., Fletcher D., Whittaker P., Megson I.L., Kirkham P.A., and Rahman I. Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. Am. J. Respir. Cell Mol. Biol. 39 (2008) 312-323
20. Rahman I., Marwick J., and Kirkham P. Redox modulation of chromatin remodeling: impact on histone acetylation deacetylation NF-[kappa]B and pro-inflammatory gene expression. Biochem. Pharmacol. 68 (2004) 1255-1267
21. Hunt S.N., Jusko W.J., and Yurchak A.M. Effect of smoking on theophylline deposition. Clin. Pharmacol. Therap. 5 (1976) 546-551
22. Calandre E.P., Perez de la Cruz A., Alferez N.P., Moreno Carretero E., Hinojosa R., and Vazquez Mata G. Theophylline binding to plasma proteins in patients with chronic obstructive pulmonary disease. Int. J. Pharmacol. Res. 6 (1986) 397-401
23. Moonen H.J.J., Geraets L., Vaarhorst A., Bast A., Wouters E.F.M., and Hageman G.J. Theophylline prevents NAD+ depletion via PARP-1 inhibition in human pulmonary epithelial cells. Biochem. Biophys. Res. Commun. 338 (2005) 1805-1810
24. Szustakowski J.D., Lee J.H., Marrese C.A., Kosinski P.A., Nirmala N.R., and Kemp D.M. Identification of novel pathway regulation during myogenic differentiation. Genomics 87 (2006) 129-138