Global expression profiling of theophylline response genes in macrophages: Evidence of airway anti-inflammatory regulation

Respiratory Research

Volumn 6, Issue , 2005, Pages

  Yao, Pei Li ^a,b   Tsai, Meng Feng ^a,b   Lin, Yi Chen ^a,b   Wang, Chien Hsun ^b,c   Liao, Wei Yu ^a   Chen, Jeremy J W ^b,c   Yang, Pan Chyr ^a,b  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BUCLADESINE; CYCLIC AMP; ETAZOLATE; FORSKOLIN; INTERLEUKIN 13; LEUKOTRIENE C4; MESSENGER RNA; ROLIPRAM; THEOPHYLLINE; ANTIINFLAMMATORY AGENT; IMMUNOLOGIC FACTOR; PROTEOME;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ADHESION; CELL CYCLE; CELL ISOLATION; CELL METABOLISM; CELL MOTILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DNA MICROARRAY; DNA RESPONSIVE ELEMENT; DOSE RESPONSE; DOWN REGULATION; DRUG RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE IDENTIFICATION; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; MACROPHAGE; NORTHERN BLOTTING; RESPIRATORY TRACT INFLAMMATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VALIDATION PROCESS; WESTERN BLOTTING; BRONCHITIS; CELL LINE; DRUG EFFECTS; GENE EXPRESSION REGULATION; LUNG ALVEOLUS; MACROPHAGE ACTIVATION; METABOLISM; PATHOLOGY;

ANTI-INFLAMMATORY AGENTS; BRONCHITIS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; IMMUNOLOGIC FACTORS; INTERLEUKIN-13; LEUKOTRIENE C4; MACROPHAGE ACTIVATION; MACROPHAGES; PROTEOME; PULMONARY ALVEOLI; THEOPHYLLINE;

EID: 26244453996     PISSN: 1465993X     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-6-89     Document Type: Article

References (47)

1. McFadden ER Jr, Warren EL: Observations on asthma mortality. Ann Intern Med 1997, 127:142-147.
2. Myers TR: Pediatric asthma epidemiology: incidence, morbidity, and mortality. Respir Care Clin N Am 2000, 6:1-14.
3. O'Byrne PM: Leukotrienes in the pathogenesis of asthma. Chest 1997, 111:27S-34S.
4. Laprise C, Sladek R, Ponton A, Bernier MC, Hudson TJ, Laviolette M: Functional classes of bronchial mucosa genes that are differentially expressed in asthma. BMC Genomics 2004, 5:21.
5. Hamid Q, Tulic' MK, Liu MC, Moqbel R: Inflammatory cells in asthma: mechanisms and implications for therapy. J Allergy Clin Immunol 2003, 111:S5-S17.
6. Shepherd MC, Baillie GS, Stirling DI, Houslay MD: Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells. Br J Pharmacol 2004, 142:339-351.
7. Heller RA, Schena M, Chai A, Shalon D, Bedilion T, Gilmore J, Woolley DE, Davis RW: Discovery and analysis of inflammatory disease-related genes using cDNA microarrays. Proc Natl Acad Sci USA 1997, 94:2150-2155.
8. Peters-Golden M: The alveolar macrophage: the forgotten cell in asthma. Am J Respir Cell Mol Biol 2004, 31:3-7.
9. Fuller RW, Morris PK, Richmond R, Sykes D, Varndell IM, Kemeny DM, Cole PJ, Dollery CT, MacDermot J: Immunoglobulin E-dependent stimulation of human alveolar macrophages: significance in type 1 hypersensitivity. Clin Exp Immunol 1986, 65:416-426.
10. Joseph M, Tonnel AB, Capron A, Voisin C: Enzyme release and superoxide anion production by human alveolar macrophages stimulated with immunoglobulin E. Clin Exp Immunol 1980, 40:416-422.
11. Arnoux B, Duval D, Benveniste J: Release of platelet-activating factor (PAF-acether) from alveolar macrophages by the calcium ionophore A23187 and phagocytosis. Eur J Clin Invest 1980, 10:437-441.
12. Janson RW, Hance KR, King TE Jr: Human alveolar macrophages produce predominantly the 35-kD pro-forms of interleukin-1 alpha and interleukin-1 beta when stimulated with lipopolysaccharide. Am J Respir Crit Care Med 1995, 151:1613-1620.
13. Lohmann-Matthes ML, Steinmuller C, Franke-Ullmann G: Pulmonary macrophages. Eur Respir J 1994, 7:1678-1689.
14. Wang N, Tabas I, Winchester R, Ravalli S, Rabbani LE, Tall A: Interleukin 8 is induced by cholesterol loading of macrophages and expressed by macrophage foam cells in human atheroma. J Biol Chem 1996, 271:8837-8842.
15. Barnes PJ: Theophylline: new perspectives for an old drug. Am J Respir Crit Care Med 2003, 167:813-818.
16. Wang CH, Lin HC, Lin CH, Yu CT, Liu SL, Huang KH, Chung KF, Kuo HP: Effect of theophylline and specific phosphodiesterase IV inhibition on proliferation and apoptosis of progenitor cells in bronchial asthma. Br J Pharmacol 2003, 138:1147-1155.
17. Ito K, Lim S, Caramori G, Cosio B, Chung KF, Adcock IM, Barnes PJ: A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci USA 2002, 99:8921-8926.
18. Tomita K, Chikumi H, Tokuyasu H, Yajima H, Hitsuda Y, Matsumoto Y, Sasaki T: Functional assay of NF-kappaB translocation into nuclei by laser scanning cytometry: inhibitory effect by dexamethasone or theophylline. Naunyn Schmiedebergs Arch Pharmacol 1999, 359:249-255.
19. Calhoun WJ, Stevens CA, Lambert SB: Modulation of superoxide production of alveolar macrophages and peripheral blood mononuclear cells by beta-agonists and theophylline. J Lab Clin Med 1991, 117:514-522.
20. Shute JK, Tenor H, Church MK, Holgate ST: Theophylline inhibits the release of eosinophil survival cytokines - is Raf-1 the protein kinase A target? Clin Exp Allergy 1998, 28(Suppl 3):47-52.
21. Yu SL, Chen HW, Yang PC, Peck K, Tsai MH, Chen JJ, Lin FY: Differential gene expression in gram-negative and gram-positive sepsis. Am J Respir Crit Care Med 2004, 169:1135-1143.
22. Chen HW, Yu SL, Chen JJ, Li HN, Lin YC, Yao PL, Chou HY, Chien CT, Chen WJ, Lee YT, Yang PC: Anti-invasive gene expression profile of curcumin in lung adenocarcinoma based on a high throughput microarray analysis. Mol Pharmacol 2004, 65:99-110.
23. Hancock A, Armstrong L, Gama R, Millar A: Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung. Am J Respir Cell Mol Biol 1998, 18:60-65.
24. Carre PC, Mortenson RL, King TE Jr, Noble PW, Sable CL, Riches DW: Increased expression of the interleukin-8 gene by alveolar macrophages in idiopathic pulmonary fibrosis. A potential mechanism for the recruitment and activation of neutrophils in lung fibrosis. J Clin Invest 1991, 88:1802-1810.
25. Ohta K, Fukuchi Y, Grouse L, Mizutani R, Rabe KF, Rennard SI, Zhong NS: A prospective clinical study of theophylline safety in 3810 elderly with asthma or COPD. Respir Med 2004, 98:1016-1024.
26. Chen JJ, Yao PL, Yuan A, Hong TM, Shun CT, Kuo ML, Lee YC, Yang PC: Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer. Clin Cancer Res 2003, 9:729-737.
27. Hiscott J, Grandvaux N, Sharma S, Tenoever BR, Servant MJ, Lin R: Convergence of the NF-kappaB and interferon signaling pathways in the regulation of antiviral defense and apoptosis. Ann N Y Acad Sci 2003, 1010:237-248.
28. Lu R, Pitha PM: Monocyte differentiation to macrophage requires interferon regulatory factor 7. J Biol Chem 2001, 276:45491-45496.
29. Huh HY, Pearce SF, Yesner LM, Schindler JL, Silverstein RL: Regulated expression of CD36 during monocyte-to-macrophage differentiation: potential role of CD36 in foam cell formation. Blood 1996, 87:2020-2028.
30. Yesner LM, Huh HY, Pearce SF, Silverstein RL: Regulation of monocyte CD36 and thrombospondin-1 expression by soluble mediators. Arterioscler Thromb Vasc Biol 1996, 16:1019-1025.
31. Kimura M, Okafuji I, Yoshida T: Theophylline suppresses IL-5 and IL-13 production, and lymphocyte proliferation upon stimulation with house dust mite in asthmatic children. Int Arch Allergy Immunol 2003, 131:189-194.
32. McKay A, Komai-Koma M, MacLeod KJ, Campbell CC, Kitson SM, Chaudhuri R, Thomson L, McSharry C, Liew FY, Thomson NC: Interleukin-18 levels in induced sputum are reduced in asthmatic and normal smokers. Clin Exp Allergy 2004, 34:904-910.
33. Patel HJ, Belvisi MG, Bishop-Bailey D, Yacoub MH, Mitchell JA: Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy. J Immunol 2003, 170:2663-2669.
34. Hershey GK: IL-13 receptors and signaling pathways: an evolving web. J Allergy Clin Immunol 2003, 111:677-690. quiz 691
35. Lee JH, Kaminski N, Dolganov G, Grunig G, Koth L, Solomon C, Erle DJ, Sheppard D: Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types. Am J Respir Cell Mol Biol 2001, 25:474-485.
36. Hancock A, Armstrong L, Gama R, Millar A: Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung. Am J Respir Cell Mol Biol 1998, 18:60-65.
37. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, Donaldson DD: Interleukin-13: central mediator of allergic asthma. Science 1998, 282:2258-2261.
38. Kotsimbos TC, Ernst P, Hamid QA: Interleukin-13 and interleukin-4 are coexpressed in atopic asthma. Proc Assoc Am Physicians 1996, 108:368-373.
39. Zhu Z, Ma B, Zheng T, Homer RJ, Lee CG, Charo IF, Noble P, Elias JA: IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol 2002, 168:2953-2962.
40. Hart PH, Bonder CS, Balogh J, Dickensheets HL, Vazquez N, Davies KV, Finlay-Jones JJ, Donnelly RP: Diminished responses to IL-13 by human monocytes differentiated in vitro: role of the IL-13Ralpha1 chain and STAT6. Eur J Immunol 1999, 29:2087-2097.
41. Grunig G: IL-13 and adenosine: partners in a molecular dance? J Clin Invest 2003, 112:329-331.
42. Chibana K, Ishii Y, Asakura T, Fukuda T: Up-regulation of cysteinyl leukotriene 1 receptor by IL-13 enables human lung fibroblasts to respond to leukotriene C4 and produce eotaxin. J Immunol 2003, 170:4290-4295.
43. Yoshida N, Shimizu Y, Kitaichi K, Hiramatsu K, Takeuchi M, Ito Y, Kume H, Yamaki K, Suzuki R, Shibata E, Hasegawa T, Takagi K: Differential effect of phosphodiesterase inhibitors on IL-13 release from peripheral blood mononuclear cells. Clin Exp Immunol 2001, 126:384-389.
44. Essayan DM, Kagey-Sobotka A, Lichtenstein LM, Huang SK: Regulation of interleukin-13 by type 4 cyclic nucleotide phosphodiesterase (PDE) inhibitors in allergen-specific human T lymphocyte clones. Biochem Pharmacol 1997, 53:1055-1060.
45. de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, Bos JL: Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 1998, 396:474-477.
46. Ye RD: Beta-Adrenergic agonists regulate NF-kappaB activation through multiple mechanisms. Am J Physiol Lung Cell Mol Physiol 2000, 279:L615-L617.
47. Lorentz A, Klopp I, Gebhardt T, Manns MP, Bischoff SC: Role of activator protein 1, nuclear factor-kappaB, and nuclear factor of activated T cells in IgE receptor-mediated cytokine expression in mature human mast cells. J Allergy Clin Immunol 2003, 111:1062-1068.