Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma

European Respiratory Journal

Volumn 10, Issue 12, 1997, Pages 2754-2760

  Ukena, D ^a   Harnest, U ^b   Sakalauskas, R ^b   Magyar, P ^c   Vetter, N ^d   Steffen, H ^b   Leichtl, S ^e   Rathgeb, F ^e   Keller, A ^e   Steinijans, V W ^e  

^a SAARLAND UNIVERSITY   (Germany)

^b Semmelweis University of Medicine ^*

^c SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^d Pulmologisches Zentrum   (Austria)

^e ALTANA PHARMA AG   (Germany)

Author keywords

Asthma; Beclomethasone; Inhaled steroid; Theophylline

Indexed keywords

BECLOMETASONE; BECLOMETASONE DIPROPIONATE; STEROID; THEOPHYLLINE;

ADULT; AGED; ARTICLE; ASTHMA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; INHALATIONAL DRUG ADMINISTRATION; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; THEOPHYLLINE BLOOD LEVEL;

EID: 6844254524     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.97.10122754     Document Type: Article

References (27)

1. Barnes PJ, Pauwels RA. Theophylline in the management of asthma: time for reappraisal? Eur Respir J 1994; 7: 579-591.
2. Kidney J, Dominguez M, Taylor PM, Rose M, Chung KF, Barnes PJ. Immunomodulation by theophylline in asthma: demonstration by withdrawal of therapy. Am J Respir Crit Care Med 1995; 151: 1907-1914.
3. Sullivan PJ, Bekir S, Jaffar Z, Page C, Jeffery P, Costello J. Anti-inflammatory effects of low-dose theophylline in atopic asthma. Lancet 1994; 343: 1006-1008.
4. International Consensus Report on Diagnosis and Management of Asthma. National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, March 1992. Publication No. 92-3091.
5. Woolcock A, Lundback B, Ringdahl N, Jacques LA. Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids. Am J Respir Crit Care Med 1996; 153: 1481-1488.
6. Greening AP, Ind PW, Northfield M, Shaw G. Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Lancet 1994; 344: 219-224.
7. American Thoracic Society report on chronic bronchitis, asthma, and pulmonary emphysema. Am Rev Respir Dis 1987; 136: 224-225.
8. Steinjans VW, Sauter R, Böhm A, Staudinger H. Pharmacokinetic profile of a new sustained-release theophylline pellet formulation for once-daily evening administration. Drug Research 1988; 38: 1241-1250.
9. Steinijans VW. Statistical evaluation of comparative clinical trials: what are the methods of choice. Henry-Stewart Conference on "Understanding Equivalence Testing for Inhaled Drugs", London, June 20, 1997. Conference report in preparation).
10. European Agency for the Evaluation of Medicinal Products. Human Medicines Evaluation Unit. Note for Guidance on Statistical Principles for Clinical Trials (CPMP/ ICH/363/96). ICH Topic E9, Statistical Principles for Clinical Trials, Step 3. January 17, 1997.
11. Elashoff JD. NQUERY Advisor User's Guide. Los Angeles, CA, Dixon Associates, 1995.
12. Holm S. A simple sequentially rejective multiple test procedure. Scand J Statist 1979; 6: 65-70.
13. Barnes PJ, Pedersen S. Efficacy and safety of inhaled corticosteroids in asthma. Am Rev Respir Dis 1993; 148: S1-S26.
14. Barnes PJ, Adcock I. Anti-inflammatory actions of steroids: molecular mechanisms. Trends Pharmacol Sci 1993; 14: 436-441.
15. Rabe KF, Magnussen H, Dent G. Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants. Eur Respir J 1995; 8: 637-642.
16. Banner KH, Page CP. Theophylline and selective phosphodiesterase inhibitors as anti-inflammatory drugs in the treatment of bronchial asthma. Eur Respir J 1995; 8: 996-1000.
17. Prowse K, Walters EH. Can theophylline reduce the need for oral corticosteroids? J Int Med Research 1979; 7: 101-105.
18. Nassif EG, Weinberger M, Thompson R, Huntley W. The value of theophylline in steroid-dependent asthma. N Engl J Med 1981; 304: 71-75.
19. Rivington RN, Boulet L-P, Cote J, et al. Efficacy of Uniphyl®, albutamol, and their combination in asthmatic patients on high-dose inhaled steroids. Am J Respir Crit Care Med 1995; 151: 325-332.
20. Pedersen S, O'Byrne P. A comparison of the efficacy and safety of inhaled corticosteroids in asthma. Allergy 1997; 52 (Suppl. 39): 1-34.
21. Busse W. Dose-related efficacy of Pulmicort® (BUD) Turbuhaler® in moderate to severe asthma. J Allergy Clin Immunol 1994; 93 (Suppl.): 186.
22. Dahl R, Lundbäck B, Malo JM, et al. A dose-ranging study of fluticasone propionate in adult patients with moderate asthma. Chest 1993; 104: 352-358.
23. Barnes PJ. Inhaled glucocorticoids for asthma. N Engl J Med 1995; 332: 868-875.
24. Geddes DM. Inhaled corticosteroids: benefits and risks. Thorax 1992; 47: 404-407.
25. Ryan G, Latimer KM, Dolovich J, Hargreave FE. Bronchial responsiveness to histamine. relationship to diurnal variation of peak flow rate, improvement after bronchodilator, and airway calibre. Thorax 1982; 37: 423-429.
26. Evans DJ, Taylor DA, Keller A, et al. Low dose inhaled steroid plus theophylline vs. high dose inhaled steroid in the control of asthma. Am J Respir Crit Care Med 1997; 155: A202.
27. Barnes PJ, Jonsson B, Klim JB. The cost of asthma. Eur Respir J 1996; 9: 636-642.