Transcriptional regulation of lymphocyte development

Current Opinion in Genetics and Development

Volumn 18, Issue 5, 2008, Pages 441-448

  Dias, Sheila ^a   Xu, Wei ^a   McGregor, Stephanie ^a   Kee, Barbara ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IKAROS TRANSCRIPTION FACTOR; NOTCH1 RECEPTOR; STAT5 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR 7; TRANSCRIPTION FACTOR CBF BETA; TRANSCRIPTION FACTOR E2A; TRANSCRIPTION FACTOR EBF; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR GFI1; TRANSCRIPTION FACTOR LRF; TRANSCRIPTION FACTOR MI 2 BETA; TRANSCRIPTION FACTOR PAX5; TRANSCRIPTION FACTOR PU 1; UNCLASSIFIED DRUG;

B LYMPHOCYTE; CELL LINEAGE; CELL MATURATION; CELL SPECIFICITY; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; GENE; GENE EXPRESSION; GENE REPRESSION; HEMATOPOIETIC STEM CELL; LYMPHOCYTE; LYMPHOCYTE DIFFERENTIATION; MULTIPOTENT STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROGENY; REVIEW; T LYMPHOCYTE; THYMOCYTE; TRANSCRIPTION REGULATION;

CELL DIFFERENTIATION; CELL LINEAGE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEMATOPOIETIC STEM CELLS; LYMPHOCYTES; MODELS, GENETIC; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 56049099738     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gde.2008.07.015     Document Type: Review

References (46)

1. Kondo M., Weissman I.L., and Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91 (1997) 661-672
2. Akashi K., Traver D., Miyamoto T., and Weissman I.L. A clonogneic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404 (2000) 193-197
3. Miyamoto T., Iwasaki H., Reizis B., Ye M., Graf T., Weissman I.L., and Akashi K. Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment. Dev Cell 3 (2002) 137-147
4. Kioussis D., and Georgopoulos K. Epigenetic flexibility underlying lineage choices in the adaptive immune system. Science 317 (2007) 620-622
5. Buza-Vidas N., Luc S., and Jacobsen S.E. Delineation of the earliest lineage commitment steps of haematopoietic stem cells: new developments, controversies and major challenges. Curr Opin Hematol 14 (2007) 315-321
6. Adolfsson J., Mansson R., Buza-Vidas N., Hultquist A., Liuba K., Jensen C.T., Bryder D., Yang L., Borge O.J., Thoren L.A., et al. Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential: a revised road map for adult blood lineage commitment. Cell 121 (2005) 295-306
7. Arinobu Y., Mizuno S., Chong Y., Shigematsu H., Iino T., Iwasaki H., Graf T., Mayfield R., Chan S., Kastner P., et al. Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages. Cell Stem Cell 1 (2007) 416-427
8. Welner R.S., Pelayo R., and Kincade P.W. Evolving views on the genealogy of B cells. Nat Rev Immunol 8 (2008) 95-106
9. Mansson R., Hultquist A., Luc S., Yang L., Anderson K., Kharazi S., Al-Hashmi S., Liuba K., Thoren L., Adolfsson J., et al. Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors. Immunity 26 (2007) 407-419. Evidence is presented that differentiation from HSCs to MPPs and then LMPPs in the fetal liver and adult bone marrow involves the progressive downregulation of Mk/E-specific genes and priming of lymphoid genes.
10. Nichogiannopoulou A., Trevisan M., Neben S., Friedrich C., and Georgopoulos K. Defects in hemopoietic stem cell activity in Ikaros mutant mice. J Exp Med 190 (1999) 1201-1214
11. Zeng H., Yucel R., Kosan C., Klein-Hitpass L., and Moroy T. Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J 23 (2004) 4116-4125
12. Hock H., Hamblen M.J., Rooke H.M., Schindler J.W., Saleque S., Fujiwara Y., and Orkin S.H. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature 431 (2004) 1002-1007
13. -/- mice have increased G/M differentiation potential.
14. Attema J.L., Papathanasiou P., Forsberg E.C., Xu J., Smale S.T., and Weissman I.L. Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis. Proc Natl Acad Sci U S A 104 (2007) 12371-12376
15. Yoshida T., Hazan I., Zhang J., Ng S.Y., Naito T., Snippert H.J., Heller E.J., Qi X., Lawton L.N., Williams C.J., et al. The role of the chromatin remodeler Mi-2beta in hematopoietic stem cell self-renewal and multilineage differentiation. Genes Dev 22 (2008) 1174-1189. Conditional deletion of Mi-2beta in hematopoietic cells leads to proliferation and expansion of HSCs followed by exhaustion and loss of mature lymphoid and myeloid progeny. Mi-2beta-deficient HSCs lose expression of stem cell-associated genes and show premature lineage priming consistent with increased differentiation.
16. Qian H., Buza-Vidas N., Hyland C.D., Jensen C.T., Antonchuk J., Mansson R., Thoren L.A., Ekblom M., Alexander W.S., and Jacobsen S.E. Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. Cell Stem Cell 1 (2007) 671-684
17. Min I.M., Pietramaggiori G., Kim F.S., Passegue E., Stevenson K.E., and Wagers A.J. The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells. Cell Stem Cell 2 (2008) 380-391
18. Dykstra B., Kent D., Bowie M., McCaffrey L., Hamilton M., Lyons K., Lee S.J., Brinkman R., and Eaves C. Long-term propagation of distinct hematopoietic differentiation programs in vivo. Cell Stem Cell 1 (2007) 218-229. This large-scale study revealed two major patterns of reconstitution after in vivo transplantation of single LT-HSCs (1) myeloid skewed (alpha) and (2) myeloid/lymphoid balanced (beta). These fates appear to be intrinsically preset.
19. Sitnicka E., Buza-Vidas N., Ahlenius H., Cilio C.M., Gekas C., Nygren J.M., Mansson R., Cheng M., Jensen C.T., Svensson M., et al. Critical role of FLT3 ligand in IL-7 receptor independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors. Blood 110 (2007) 2955-2964
20. high cells but develop G/M lymphoid restricted progenitors, identifiable by the expression of a GFP reporter under the control of Ikaros regulatory elements. Therefore, Ikaros is dispensable for development of functionally defined LMPPs. However, it was found to be required for further lymphoid differentiation of LMPPs.
21. Singh H., Medina K., and Pongubala J.M. Contingent gene regulatory networks and B cell fate specification. Proc Natl Acad Sci 102 (2005) 4949-4953
22. Nutt S.L., and Kee B.L. The transcriptional regulation of B cell lineage commitment. Immunity 26 (2007) 715-725
23. Bhandoola A., von Boehmer H., Petrie H.T., and Zuniga-Pflucker J.C. Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from. Immunity 26 (2007) 678-689
24. Maeda T., Merghoub T., Hobbs R.M., Dong L., Maeda M., Zakrzewski J., van den Brink M.R., Zelent A., Shigematsu H., Akashi K., et al. Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science 316 (2007) 860-866. This paper demonstrates that LRF actively represses T cell differentiation in bone marrow progenitors by antagonizing Notch signaling.
25. Souabni A., Cobaleda C., Schebesta M., and Busslinger M. Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1. Immunity 17 (2002) 781-793
26. Mansson R., Zandi S., Andersson K., Martensson I.L., Jacobsen S.E., Bryder D., and Sigvardsson M. B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells. Blood 112 (2008) 1048-1055
27. Roessler S., Gyory I., Imhof S., Spivakov M., Williams R.R., Busslinger M., Fisher A.G., and Grosschedl R. Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5. Mol Cell Biol 27 (2007) 579-594. This paper provides an elegant molecular dissection of the transcription factors controlling expression of the Ebf1a and Ebf1b promoters. The analysis lends support to a novel model of B cell lineage specification and commitment involving progressive activation of E2A, EBF. and Pax5 combined with feed-back amplification loops that reinforce Ebf1, and consequently, Pax5 expression.
28. Cobaleda C., Jochum W., and Busslinger M. Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature 449 (2007) 473-477. Conditional deletion of Pax5 in peripheral mature B cells induces lymphoma and triggers reversion of differentiation, reacquisition of developmental plasticity, and T cell generation.
29. -/- pro-B-lymphocytes.
30. Boos M.D., Yokota Y., Eberl G., and Kee B.L. Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity. J Exp Med 204 (2007) 1119-1130
31. Rothenberg E.V. Negotiation of the T lineage fate decision by transcription-factor interplay and microenvironmental signals. Immunity 26 (2007) 690-702
32. Lai A.Y., and Kondo M. Identification of a bone marrow precursor of the earliest thymocytes in adult mouse. Proc Natl Acad Sci U S A 104 (2007) 6311-6316
33. Schwarz B.A., Sambandam A., Maillard I., Harman B.C., Love P.E., and Bhandoola A. Selective thymus settling regulated by cytokine and chemokine receptors. J Immunol 178 (2007) 2008-2017
34. Schwarz B.A., and Bhandoola A. Circulating hematopoietic progenitors with T lineage potential. Nat Immunol 5 (2004) 953-960
35. Wada H., Masuda K., Satoh R., Kakugawa K., Ikawa T., Katsura Y., and Kawamoto H. Adult T-cell progenitors retain myeloid potential. Nature 452 (2008) 768-772
36. ••], demonstrates at the clonal level that adult ETPs possess T and myeloid potential but not B cell potential. These observations lend support to the hypothesis that ETPs are the progeny of LMPPs or earlier progenitors rather than CLPs, which have already extinguished the myeloid differentiation option.
37. Sun X.H. Multitasking of helix-loop-helix proteins in lymphopoiesis. Adv Immunol 84 (2004) 43-77
38. -/- fetal T cell development in vitro.
39. Wang D., Claus C.L., Vaccarelli G., Braunstein M., Schmitt T.M., Zuniga-Pflucker J.C., Rothenberg E.V., and Anderson M.K. The basic helix-loop-helix transcription factor HEBAlt is expressed in pro-T-cells and enhances the generation of T cell precursors. J Immunol 177 (2006) 109-119
40. Taghon T.N., David E.S., Zuniga-Pflucker J.C., and Rothenberg E.V. Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling. Genes Dev 19 (2005) 965-978
41. Tydell C.C., David-Fung E.S., Moore J.E., Rowen L., Taghon T., and Rothenberg E.V. Molecular dissection of prethymic progenitor entry into the T lymphocyte developmental pathway. J Immunol 179 (2007) 421-438
42. Guo Y., Maillard I., Chakraborti S., Rothenberg E.V., and Speck N.A. Core binding factors are necessary for natural killer cell development, and cooperate with Notch signaling during T cell specification. Blood 112 (2008) 480-492
43. Anderson M.K., Hernandez-Hoyos G., Dionne C.J., Arias A.M., Chen D., and Rothenberg E.V. Definition of regulatory network elements for T cell development by perturbation analysis with PU.1 and GATA-3. Dev Biol 246 (2002) 103-121
44. Franco C.B., Scripture-Adams D.D., Proekt I., Taghon T., Weiss A.H., Yui M.A., Adams S.L., Diamond R.A., and Rothenberg E.V. Notch/Delta signaling constrains reengineering of pro-T-cells by PU.1. Proc Natl Acad Sci U S A 103 (2006) 11993-11998. PU.1 can divert the fate of specified pro-T-cells into myeloid lineages in the absence of Notch signaling, but the presence of Notch ligands prevents such transcriptional programs from emerging thus suppressing alternative lineage fates and ensuring commitment to the T cell lineage. PU.1 may divert cells in the absence of Notch signaling by inducing expression of the E2A antagonist Id2.
45. Laiosa C.V., Stadtfeld M., Xie H., de Andres-Aguayo L., and Graf T. Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors. Immunity 25 (2006) 731-744. Enforced expression of C/EBP alpha and PU.1 can induce pre-T-cells to transdifferentiate into cells resembling inflammatory macrophage and myeloid dendritic-like cells that contain TCR rearrangements. Evidence is presented that this reprogramming can be counteracted by activated Notch or Gata3.
46. Taghon T., Yui M.A., and Rothenberg E.V. Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3. Nat Immunol 8 (2007) 845-855. Overexpression of Gata3 inhibits normal T cell differentiation and cell growth but permits fetal thymocytes at the DN1 and DN2 stage to differentiate into mast cells in the absence of Notch signaling.