Peripheral mechanisms II: The pharmacology of peripherally active antitussive drugs

Handbook of Experimental Pharmacology

Volumn 187, Issue , 2009, Pages 155-186

  Page, C P ^a   Spina, D ^b   McFadzean, I ^b   Bertram, F K R ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; 1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; ANTITUSSIVE AGENT; BRADYKININ ANTAGONIST; CANNABINOID 2 RECEPTOR; CANNABINOID DERIVATIVE; CAPSAZEPINE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; N ALLYLNORMETAZOCINE; N BENZYL N2 [4 HYDROXY 1 [(1 METHYL 1H INDOL 3 YL)CARBONYL]PROLYL] N METHYL 3 (2 NAPHTHYL)ALANINAMIDE; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROKININ 2 RECEPTOR ANTAGONIST; NEUROKININ 3 RECEPTOR ANTAGONIST; NKP 608; NOCICEPTIN RECEPTOR AGONIST; OPIATE AGONIST; OPIATE DERIVATIVE; OSANETANT; POLYCYSTIN; SAREDUTANT; SB 227122; SB 235375; SIGMA OPIATE RECEPTOR; SODIUM CHANNEL BLOCKING AGENT; SR 14167A; SR 49868; TACHYKININ RECEPTOR ANTAGONIST; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRK 851; UNCLASSIFIED DRUG; VANILLOID RECEPTOR;

ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; COUGHING; DRUG MECHANISM; FIBROSING ALVEOLITIS; HUMAN; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SENSORY NERVE; UNSPECIFIED SIDE EFFECT; UPPER RESPIRATORY TRACT INFECTION; ANIMAL; DRUG EFFECT; PERIPHERAL NERVOUS SYSTEM; PHYSIOLOGY; REFLEX; SENSORY NERVE CELL;

ANIMALS; ANTITUSSIVE AGENTS; COUGH; HUMANS; NEURONS, AFFERENT; PERIPHERAL NERVOUS SYSTEM; REFLEX;

EID: 56049098781     PISSN: 01712004     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-540-79842-2_8     Document Type: Review

References (241)

1. Adcock JJ, Schneider C, Smith TW (1988) Effects of codeine, morphine and a novel opioid pentapeptide BW443C, on cough, nociception and ventilation in the unanaesthetized guinea-pig. Br J Pharmacol 93:93-100.
2. Adcock JJ, Douglas GJ, Garabette M, Gascoigne M, Beatch G, Walker M, Page CP (2003) RSD931, a novel anti-tussive agent acting on airway sensory nerves. Br J Pharmacol 138: 407-416.
3. Advenier C, EmondsAlt X (1996) Tachykinin receptor antagonists and cough. Pulm Pharmacol 9:329-333.
4. Alexander SP, Mathie A, Peters JA (2007) Ion channels. Br J Pharmacol 150(Suppl 1):S96-S121.
5. Andresen MC, YangM(1995) Dynamics of sensory afferent synaptic transmission in aortic baroreceptor regions on nucleus tractus solitarius. J Neurophysiol 74:1518-1528.
6. Aversa C, Cazzola M, Clini V, Dal NR, Maiorano V, Tana F, Allegra L (1993) Clinical trial of the efficacy and safety of moguisteine in patients with cough associated with chronic respiratory diseases. Drugs Exp Clin Res 19:273-279.
7. Bailey CP, Maubach KA, Jones RS (2004) Neurokinin-1 receptors in the rat nucleus tractus solitarius: Pre- and postsynaptic modulation of glutamate and GABA release. Neuroscience 127: 467-479.
8. Barnabe R, Berni F, Clini V, Pirrelli M, Pisani CA, RobuschiM, Rossi M, Sestini P, Tana F, Vaghi A (1995) The efficacy and safety of moguisteine in comparison with codeine phosphate in patients with chronic cough. Monaldi Arch Chest Dis 50:93-97.
9. Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D (2007) The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 448:204-208.
10. Bisgaard H (2003) A randomized trial of montelukast in respiratory syncytial virus postbronchiolitis. Am J Respir Crit Care Med 167:379-383.
11. Bolser DC (1991) Fictive cough in the cat. J Appl Physiol 71:2325-2331.
12. Bolser DC (2006) Cough suppressant and pharmacologic protussive therapy: ACCP evidencebased clinical practice guidelines. Chest 129:238S-249S.
13. Bolser DC, DeGennaro FC, O'Reilly S, Chapman RW, Kreutner W, Egan RW, Hey JA (1994) Peripheral and central sites of action of GABA-B agonists to inhibit the cough reflex in the cat and guinea pig. Br J Pharmacol 113:1344-1348.
14. Bolser DC, DeGennaro FC, O'Reilly S, McLeod RL, Hey JA (1997) Central antitussive activity of the NK1 and NK2 tachykinin receptor antagonists, CP-99,994 and SR 48968, in the guinea-pig and cat. Br J Pharmacol 121:165-170.
15. Bonham AC, Chen CY, Mutoh T, Joad JP (2001) Lung C-fiber CNS reflex: Role in the respiratory consequences of extended environmental tobacco smoke exposure in young guinea pigs. Environ Health Perspect 109(Suppl 4):573-578.
16. Bonham AC, Sekizawa SI, Joad JP (2004) Plasticity of central mechanisms for cough. Pulm Pharmacol Ther 17:453-457.
17. Bonham AC, Chen CY, Sekizawa S, Joad JP (2006a) Plasticity in the nucleus tractus solitarius and its influence on lung and airway reflexes. J Appl Physiol 101:322-327.
18. Bonham AC, Sekizawa S, Chen CY, Joad JP (2006b) Plasticity of brainstem mechanisms of cough. Respir Physiol Neurobiol 152:312-319.
19. Braman SS (2006) Chronic cough due to chronic bronchitis: ACCP evidence-based clinical practice guidelines. Chest 129:104S-115S.
20. Brooks PA, Glaum SR, Miller RJ, Spyer KM (1992) The actions of baclofen on neurones and synaptic transmission in the nucleus tractus solitarii of the rat in vitro. J Physiol 457:115-129.
21. Brown C, Fezoui M, Selig WM, Schwartz CE, Ellis JL (2004) Antitussive activity of sigma-1 receptor agonists in the guinea-pig. Br J Pharmacol 141:233-240.
22. Buchan P, Adcock JJ (1992) Capsaicin-induced bronchoconstriction in the guinea-pig: Contribution of vagal cholinergic reflexes, local axon reflexes and their modulation by BW443C. Br J Pharmacol 105:448-452.
23. Calignano A, Katona I, Desarnaud F, Giuffrida A, La RG, Mackie K, Freund TF, Piomelli D (2000) Bidirectional control of airway responsiveness by endogenous cannabinoids. Nature 408: 96-101.
24. Canning BJ (2006) Anatomy and neurophysiology of the cough reflex: ACCP evidence-based clinical practice guidelines. Chest 129:33S-47S.
25. Canning BJ, Mazzone SB, Meeker SN, Mori N, Reynolds SM, Undem BJ (2004) Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs. J Physiol 557:543-558.
26. Canning BJ, Farmer DG, Mori N (2006) Mechanistic studies of acid-evoked coughing in anesthetized guinea pigs. Am J Physiol Regul Integr Comp Physiol 291:R454-R463.
27. Carr MJ, Hunter DD, Jacoby DB, Undem BJ (2002) Expression of tachykinins in nonnociceptive vagal afferent neurons during respiratory viral infection in guinea pigs. Am J Respir Crit Care Med 165:1071-1075.
28. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 389:816-824.
29. Caudle RM, Perez FM, Del Valle-Pinero AY, Iadarola MJ (2005) Spinal cord NR1 serine phosphorylation and NR2B subunit suppression following peripheral inflammation. Mol Pain 1:25.
30. Chang A,Marchant JM, McKean M, Morris P (2004) Inhaled cromones for prolonged non-specific cough in children. Cochrane Database Syst Rev CD004436.
31. Chang AB, Winter D, Acworth JP (2006) Leukotriene receptor antagonist for prolonged nonspecific cough in children. Cochrane Database Syst Rev CD005602.
32. Chapman RW, House A, Liu F, Celly C, Mei H, Hey JA (2004) Antitussive activity of the tachykinin NK1 receptor antagonist, CP-99994, in dogs. Eur J Pharmacol 485:329-332.
33. Chen CY, Horowitz JM, Bonham AC (1999) A presynaptic mechanism contributes to depression of autonomic signal transmission in NTS. Am J Physiol 277:H1350-H1360.
34. Chen CY, Bonham AC, Schelegle ES, Gershwin LJ, Plopper CG, Joad JP (2001) Extended allergen exposure in asthmatic monkeys induces neuroplasticity in nucleus tractus solitarius. J Allergy Clin Immunol 108:557-562.
35. Chen CY, Ling Eh EH, Horowitz JM, Bonham AC (2002) Synaptic transmission in nucleus tractus solitarius is depressed by group II and III but not group I presynaptic metabotropic glutamate receptors in rats. J Physiol 538:773-786.
36. Chen CY, Bonham AC, Plopper CG, Joad JP (2003) Neuroplasticity in nucleus tractus solitarius neurons after episodic ozone exposure in infant primates. J Appl Physiol 94:819-827.
37. Chong CF, Chen CC, Ma HP, Wu YC, Chen YC, Wang TL (2005) Comparison of lidocaine and bronchodilator inhalation treatments for cough suppression in patients with chronic obstructive pulmonary disease. Emerg Med J 22:429-432.
38. Choudry NB, Fuller RW, Pride NB (1989) Sensitivity of the human cough reflex: Effect of inflammatory mediators prostaglandin E2, bradykinin, and histamine. Am Rev Respir Dis 140: 137-141.
39. Choudry NB, Fuller RW, Anderson N, Karlsson JA (1990) Separation of cough and reflex bronchoconstriction by inhaled local anaesthetics. Eur Respir J 3:579-583.
40. Chuang HH, Prescott ED, Kong H, Shields S, Jordt SE, Basbaum AI, Chao MV, Julius D (2001) Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature 411:957-962.
41. Chung KF (2003) Current and future prospects for drugs to suppress cough. IDrugs 6:781-786.
42. Colin I, Blondeau C, Baude A (2002) Neurokinin release in the rat nucleus of the solitary tract via NMDA and AMPA receptors. Neuroscience 115:1023-1033.
43. Collier JG, Fuller RW(1984) Capsaicin inhalation in man and the effects of sodium cromoglycate. Br J Pharmacol 81:113-117.
44. Cook AJ,Woolf CJ,Wall PD, McMahon SB (1987) Dynamic receptive field plasticity in rat spinal cord dorsal horn following C-primary afferent input. Nature 325:151-153.
45. Corboz MR, Rivelli MA, Egan RW, Tulshian D, Matasi J, Fawzi AB, Benbow L, Smith-Torhan A, Zhang H, Hey JA (2000) Nociceptin inhibits capsaicin-induced bronchoconstriction in isolated guinea pig lung. Eur J Pharmacol 402:171-179.
46. Cullinan P (1992) Persistent cough and sputum: Prevalence and clinical characteristics in south east England. Respir Med 86:143-149.
47. da Costa JC, Olsen PC, de Azeredo SR, de FC, V, Serra MF, Alves LA, Faria RX, Xisto DG, Rocco PR, Cordeiro RS, Rodrigues E Silva PM, MartinsMA (2007) JMF2-1, a lidocaine derivative acting on airways spasm and lung allergic inflammation in rats. J Allergy Clin Immunol 119:219-225.
48. Danzon A, Lacroix J, Infante-Rivard C, Chicoine L (1988) A double-blind clinical trial on diphenhydramine in pertussis. Acta Paediatr Scand 77:614-615.
49. Daoui S, Cognon C, Naline E, Emonds-Alt X, Advenier C (1998) Involvement of tachykinin NK3 receptors in citric acid-induced cough and bronchial responses in guinea pigs. Am J Respir Crit Care Med 158:42-48.
50. Davenport PW, Bolser DC, Vickroy T, Berry RB, Martin AD, Hey JA, Danzig M (2007) The effect of codeine on the urge-to-cough response to inhaled capsaicin. Pulm Pharmacol Ther 20: 338-346.
51. Dicpinigaitis PV (1996) Use of baclofen to suppress cough induced by angiotensin- converting enzyme inhibitors. Ann Pharmacother 30:1242-1245.
52. Dicpinigaitis PV (2004) Potential new cough therapies. Pulm Pharmacol Ther 17:459-462.
53. Dicpinigaitis PV (2006a) Angiotensin-converting enzyme inhibitor-induced cough: ACCP evidence-based clinical practice guidelines. Chest 129:169S-173S.
54. Dicpinigaitis PV (2006b) Potential future therapies for the management of cough: ACCP evidencebased clinical practice guidelines. Chest 129:284S-286S.
55. Dicpinigaitis PV, Dobkin JB (1999) Effect of zafirlukast on cough reflex sensitivity in asthmatics. J Asthma 36:265-270.
56. Dicpinigaitis PV, Rauf K (1998) Treatment of chronic, refractory cough with baclofen. Respiration 65:86-88.
57. Dicpinigaitis PV, Dobkin JB, Rauf K, Aldrich TK (1998) Inhibition of capsaicin-induced cough by the gamma-aminobutyric acid agonist baclofen. J Clin Pharmacol 38:364-367.
58. Dicpinigaitis PV, Dobkin JB, Reichel J (2002) Antitussive effect of the leukotriene receptor antagonist zafirlukast in subjects with cough-variant asthma. J Asthma 39:291-297.
59. Dicpinigaitis PV, Gayle YE (2003a) Effect of guaifenesin on cough reflex sensitivity. Chest 124:2178-2181.
60. Dicpinigaitis PV, Gayle YE (2003b) Effect of the second-generation antihistamine, fexofenadine, on cough reflex sensitivity and pulmonary function. Br J Clin Pharmacol 56:501-504.
61. Doherty MJ, Mister R, Pearson MG, Calverley PM (2000) Capsaicin responsiveness and cough in asthma and chronic obstructive pulmonary disease. Thorax 55:643-649.
62. Drewe JA, Miles R, Kunze DL (1990) Excitatory amino acid receptors of guinea pig medial nucleus tractus solitarius neurons. Am J Physiol 259:H1389-H1395.
63. Duggan AW, Hope PJ, Jarrott B, Schaible HG, Fleetwood-Walker SM (1990) Release, spread and persistence of immunoreactive neurokinin A in the dorsal horn of the cat following noxious cutaneous stimulation. Studies with antibody microprobes. Neurosci 35:195-202.
64. Ebrahimi SA, Zareie MR, Rostami P, Mahmoudian M (2003) Interaction of noscapine with the bradykinin mediation of the cough response. Acta Physiol Hung 90:147-155.
65. Eccles R (1996) Codeine, cough and upper respiratory infection. Pulm Pharmacol 9:293-297.
66. El-Hashim AZ, Wyss D, Lewis C (2004) Effect of a novel NK1 receptor selective antagonist (NKP608) on citric acid induced cough and airway obstruction. Pulm Pharmacol Ther 17: 11-18.
67. Emmerson PJ, Miller RJ (1999) Pre- and postsynaptic actions of opioid and orphan opioid agonists in the rat arcuate nucleus and ventromedial hypothalamus in vitro. J Physiol 517(Part 2): 431-445.
68. Empey DW, Laitinen LA, Jacobs L, Gold WM, Nadel JA (1976) Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am Rev Respir Dis 113:131-139.
69. Empey DW, Laitinen LA, Young GA, Bye CE, Hughes DT (1979) Comparison of the antitussive effects of codeine phosphate 20 mg, dextromethorphan 30 mg and noscapine 30 mg using citric acid-induced cough in normal subjects. Eur J Clin Pharmacol 16:393-397.
70. Fahy JV, Wong HH, Geppetti P, Reis JM, Harris SC, Maclean DB, Nadel JA, Boushey HA (1995) Effect of an NK1 receptor antagonist (CP-99,994) on hypertonic saline-induced bronchoconstriction and cough in male asthmatic subjects. Am J Respir Crit Care Med 152:879-884.
71. Featherstone RL, Parry JE, Church MK (1996) The effects of a kinin antagonist on changes in lung function and plasma extravasation into the airways following challenge of sensitized guineapigs. Clin Exp Allergy 26:235-240.
72. Fischer A, Hoffmann B (1996) Nitric oxide synthase in neurons and nerve fibers of lower airways and in vagal sensory ganglia of man. Correlation with neuropeptides. Am J Respir Crit Care Med 154:209-216.
73. Fischer A, Forssmann WG, Undem BJ (1998) Nociceptin-induced inhibition of tachykinergic neurotransmission in guinea pig bronchus. J Pharmacol Exp Ther 285:902-907.
74. Foresi A, Cavigioli G, Pelucchi A,Mastropasqua B, Marazzini L (1996) Effect of acetazolamide on cough induced by low-chloride-ion solutions in normal subjects: Comparison with furosemide. J Allergy Clin Immunol 97:1093-1099.
75. Forsberg K, Karlsson JA, Theodorsson E, Lundberg JM, Persson CG (1988) Cough and bronchoconstriction mediated by capsaicin-sensitive sensory neurons in the guinea-pig. Pulm Pharmacol 1:33-39.
76. Fortin G, Champagnat J (1993) Spontaneous synaptic activities in rat nucleus tractus solitarius neurons in vitro: Evidence for re-excitatory processing. Brain Res 630:125-135.
77. Fox AJ, Barnes PJ, Venkatesan P, Belvisi MG (1997) Activation of large conductance potassium channels inhibits the afferent and efferent function of airway sensory nerves in the guinea pig. J Clin Invest 99:513-519.
78. Franklin PH, Murray TF (1992) High affinity [3H]dextrorphan binding in rat brain is localized to a noncompetitive antagonist site of the activated N-methyl-D-aspartate receptor-cation channel. Mol Pharmacol 41:134-146.
79. Freiman I, Szabo B (2005) Cannabinoids depress excitatory neurotransmission between the subthalamic nucleus and the globus pallidus. Neurosci 133:305-313.
80. French CL, Irwin RS, Curley FJ, Krikorian CJ (1998) Impact of chronic cough on quality of life. Arch Intern Med 158:1657-1661.
81. French CT, Fletcher KE, Irwin RS (2004) Gender differences in health-related quality of life in patients complaining of chronic cough. Chest 125:482-488.
82. French CT, Fletcher KE, Irwin RS (2005) A comparison of gender differences in health-related quality of life in acute and chronic coughers. Chest 127:1991-1998.
83. Fujimura M, Kamio Y, Hashimoto T, Matsuda T (1996) Effect of capsaicin inhalation on methacholine responsiveness in normal subjects. Clin Auton Res 6:45-48.
84. Fujimura M, Kamio Y, Myou S, Hashimoto T (2000) Effect of oral mexiletine on the cough response to capsaicin and tartaric acid. Thorax 55:126-128.
85. Fuller RW, Collier JG (1984) Sodium cromoglycate and atropine block the fall in FEV1 but not the cough induced by hypotonic mist. Thorax 39:766-770.
86. Fuller RW, Jackson DM (1990) Physiology and treatment of cough. Thorax 45:425-430.
87. Fuller RW, Karlsson JA, Choudry NB, Pride NB (1988) Effect of inhaled and systemic opiates on responses to inhaled capsaicin in humans. J Appl Physiol 65:1125-1130.
88. Gao X, Kim HK, Chung JM, Chung K (2005) Enhancement of NMDA receptor phosphorylation of the spinal dorsal horn and nucleus gracilis neurons in neuropathic rats. Pain 116:62-72.
89. Gastpar H, Criscuolo D, Dieterich HA (1984) Efficacy and tolerability of glaucine as an antitussive agent. Curr Med Res Opin 9:21-27.
90. Giardina GA, Sarau HM, Farina C, Medhurst AD, Grugni M, Foley JJ, Raveglia LF, Schmidt DB, Rigolio R, Vassallo M, Vecchietti V, Hay DW (1996) 2-Phenyl-4-quinolinecarboxamides: A novel class of potent and selective non-peptide competitive antagonists for the human neurokinin-3 receptor. J Med Chem 39:2281-2284.
91. Girard V, Naline E, Vilain P, Emonds-Alt X, Advenier C (1995) Effect of the two tachykinin antagonists, SR 48968 and SR 140333, on cough induced by citric acid in the unanaesthetized guinea pig. Eur Respir J 8:1110-1114.
92. Glatzer NR, Smith BN (2005) Modulation of synaptic transmission in the rat nucleus of the solitary tract by endomorphin-1. J Neurophysiol 93:2530-2540.
93. Gordon R, Gordon RJ, Sofia D (1976) Antitussive activity of some naturally occurring cannabinoids in anesthetized cats. Eur J Pharmacol 35:309-313.
94. Grattan TJ, Marshall AE, Higgins KS, Morice AH (1995) The effect of inhaled and oral dextromethorphan on citric acid induced cough in man. Br J Clin Pharmacol 39:261-263.
95. Groneberg DA, Niimi A, Dinh QT, Cosio B, Hew M, Fischer A, Chung KF (2004) Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough. Am J Respir Crit Care Med 170:1276-1280.
96. Gross PM, Wall KM, Pang JJ, Shaver SW, Wainman DS (1990) Microvascular specializations promoting rapid interstitial solute dispersion in nucleus tractus solitarius. Am J Physiol 259:R1131-R1138.
97. Guitart X, Codony X, Monroy X (2004) Sigma receptors: Biology and therapeutic potential. Psychopharmacology (Berl) 174:301-319.
98. Guo W, Zou S, Guan Y, Ikeda T, Tal M, Dubner R, Ren K (2002) Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord during the development and maintenance of inflammatory hyperalgesia. J Neurosci 22:6208-6217.
99. Hansson L, Midgren B, Karlsson JA (1994) Effects of inhaled lignocaine and adrenaline on capsaicin- induced cough in humans. Thorax 49:1166-1168.
100. Hargreaves MR, Benson MK (1995) Inhaled sodium cromoglycate in angiotensin-converting enzyme inhibitor cough. Lancet 345:13-16.
101. Hathaway TJ, Higenbottam TW, Morrison JF, Clelland CA, Wallwork J (1993) Effects of inhaled capsaicin in heart-lung transplant patients and asthmatic subjects. Am Rev Respir Dis 148:1233-1237.
102. Hay DW, Giardina GA, Griswold DE, Underwood DC, Kotzer CJ, Bush B, Potts W, Sandhu P, Lundberg D, Foley JJ, Schmidt DB, Martin LD, Kilian D, Legos JJ, Barone FC, LuttmannMA, Grugni M, Raveglia LF, Sarau HM (2002) Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs. J Pharmacol Exp Ther 300:314-323.
103. Herbert ME, Brewster GS (2000) Myth: Codeine is an effective cough suppressant for upper respiratory tract infections. West J Med 173:283.
104. Higenbottam TW (1987) Anticholinergics and cough. Postgrad Med J 63(Suppl 1):75-78.
105. Hill R (2000) NK1 (substance P) receptor antagonists - why are they not analgesic in humans? Trends Pharmacol Sci 21:244-246.
106. Holmes PW, Barter CE, Pierce RJ (1992) Chronic persistent cough: Use of ipratropium bromide in undiagnosed cases following upper respiratory tract infection. Respir Med 86:425-429.
107. Hope-Gill BD, Hilldrup S, Davies C, Newton RP, Harrison NK (2003) A study of the cough reflex in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 168:995-1002.
108. Huang SM, Bisogno T, Trevisani M, Al-Hayani A, De PL, Fezza F, Tognetto M, Petros TJ, Krey JF, Chu CJ, Miller JD, Davies SN, Geppetti P, Walker JM, Di Marzo V (2002) An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc Natl Acad Sci USA 99:8400-8405.
109. Hunter DD, Undem BJ (1999) Identification and substance P content of vagal afferent neurons innervating the epithelium of the guinea pig trachea. Am J Respir Crit CareMed 159: 1943-1948.
110. Hwang SW, Cho H, Kwak J, Lee SY, Kang CJ, Jung J, Cho S, Min KH, Suh YG, Kim D, Oh U (2000) Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances. Proc Natl Acad Sci USA 97:6155-6160.
111. Irwin RS (2006) Assessing cough severity and efficacy of therapy in clinical research: ACCP evidence-based clinical practice guidelines. Chest 129:232S-237S.
112. Ishiura Y, Fujimura M, Yamamori C, Nobata K, Myou S, Kurashima K, Michishita Y, Takegoshi T (2003) Effect of carbocysteine on cough reflex to capsaicin in asthmatic patients. Br J Clin Pharmacol 55:504-510.
113. Ji RR, Woolf CJ (2001) Neuronal plasticity and signal transduction in nociceptive neurons: Implications for the initiation and maintenance of pathological pain. Neurobiol Dis 8:1-10.
114. Ji RR, Baba H, Brenner GJ, Woolf CJ (1999) Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat Neurosci 2:1114-1119.
115. Ji RR, Kohno T, Moore KA, Woolf CJ (2003) Central sensitization and LTP: Do pain and memory share similar mechanisms? Trends Neurosci 26:696-705.
116. Jia Y,Wang X, Aponte SI, Rivelli MA, Yang R, Rizzo CA, Corboz MR, Priestley T, Hey JA (2002) Nociceptin/orphanin FQ inhibits capsaicin-induced guinea-pig airway contraction through an inward-rectifier potassium channel. Br J Pharmacol 135:764-770.
117. Joos GF, De Swert KO, Schelfhout V, Pauwels RA (2003) The role of neural inflammation in asthma and chronic obstructive pulmonary disease. Ann N Y Acad Sci 992:218-230.
118. Jordan D (2001) Central nervous pathways and control of the airways. Respir Physiol 125:67-81.
119. Kagaya M, Lamb J, Robbins J, Page CP, Spina D (2002) Characterization of the anandamide induced depolarization of guinea-pig isolated vagus nerve. Br J Pharmacol 137:39-48.
120. Kamei J (1996) Role of opioidergic and serotonergic mechanisms in cough and antitussives. Pulm Pharmacol 9:349-356.
121. Kamei J (2002) Delta-opioid receptor antagonists as a new concept for central acting antitussive drugs. Pulm Pharmacol Ther 15:235-240.
122. Karlsson JA (1996) The role of capsaicin-sensitive C-fibre afferent nerves in the cough reflex. Pulm Pharmacol 9:315-321.
123. Karlsson JA, Fuller RW(1999) Pharmacological regulation of the cough reflex-from experimental models to antitussive effects in Man. Pulm Pharmacol Ther 12:215-228.
124. Karlsson JA, Choudry NB, Zackrisson C, Fuller RW (1992) A comparison of the effect of inhaled diuretics on airway reflexes in humans and guinea pigs. J Appl Physiol 72:434-438.
125. Karttunen P, Tukiainen H, Silvasti M, Kolonen S (1987) Antitussive effect of dextromethorphan and dextromethorphan-salbutamol combination in healthy volunteers with artificially induced cough. Respiration 52:49-53.
126. Kato F, Shigetomi E (2001) Distinct modulation of evoked and spontaneous EPSCs by purinoceptors in the nucleus tractus solitarii of the rat. J Physiol 530:469-486.
127. Kohrogi H, Nadel JA, Malfroy B, Gorman C, Bridenbaugh R, Patton JS, Borson DB (1989) Recombinant human enkephalinase (neutral endopeptidase) prevents cough induced by tachykinins in awake guinea pigs. J Clin Invest 84:781-786.
128. KollarikM, Ru F, Undem BJ (2007) Acid-sensitive vagal sensory pathways and cough. Pulm Pharmacol Ther 20:402-411.
129. Kopriva F, Sobolova L, Szotkowska J, Zapalka M (2004) Treatment of chronic cough in children with montelukast,a leukotriene receptor antagonist. J Asthma 41:715-720.
130. Kvale PA (2006) Chronic cough due to lung tumors: ACCP evidence-based clinical practice guidelines. Chest 129:147S-153S.
131. Kwong K, Lee LY (2005) Prostaglandin E2 potentiates a TTX-resistant sodium current in rat capsaicin-sensitive vagal pulmonary sensory neurones. J Physiol 564:437-450.
132. Lai J, Porreca F, Hunter JC, Gold MS (2004) Voltage-gated sodium channels and hyperalgesia. Annu Rev Pharmacol Toxicol 44:371-397.
133. Lalloo UG, Fox AJ, BelvisiMG, Chung KF, Barnes PJ (1995) Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs. J Appl Physiol 79: 1082-1087.
134. Laude EA, Morice AH, Grattan TJ (1994) The antitussive effects of menthol, camphor and cineole in conscious guinea-pigs. Pulm Pharmacol 7:179-184.
135. Laursen LC, Lindqvist A, Hepburn T, Lloyd J, Perrett J, Sanders N, Rocchiccioli K (2003) The role of the novel D2/beta2-agonist, Viozan (sibenadet HCl), in the treatment of symptoms of chronic obstructive pulmonary disease: Results of a large-scale clinical investigation. Respir Med 97(Suppl A):S23-S33.
136. Lee PCL, Jawad MS, Eccles R (2000) Antitussive efficacy of dextromethorphan in cough associated with acute upper respiratory tract infection. J Pharm Pharmacol 52:1137-1142.
137. Lee J, Lee J, Szabo T, Gonzalez AF, Welter JD, Blumberg PM (2001) N-(3-acyloxy-2- benzylpropyl)-N'-dihydroxytetrahydrobenzazepine and tetrahydroisoquinoline thiourea analogues as vanilloid receptor ligands. Bioorg Med Chem 9:1713-1720.
138. Lee SY, Kim MK, Shin C, Shim JJ, Kim HK, Kang KH, Yoo SH, In KH (2003) Substance Pimmunoreactive nerves in endobronchial biopsies in cough-variant asthma and classic asthma. Respiration 70:49-53.
139. Lee J, Alrubaian J, Dores RM (2006) Are lungfish living fossils? Observation on the evolution of the opioid/orphanin gene family. Gen Comp Endocrinol 148:306-314.
140. Lewis CA, Ambrose C, Banner K, Battram C, Butler K, Giddings J, Mok J, Nasra J, Winny C, Poll C (2007) Animal models of cough: Literature review and presentation of a novel cigarette smoke-enhanced cough model in the guinea-pig. Pulm Pharmacol Ther 20:325-333.
141. Lilienfield LS, Rose JC, Princiotto JV (1976) Antitussive activity of diphenhydramine in chronic cough. Clin Pharmacol Ther 19:421-425.
142. Lowry R, Higenbottam T, Johnson T, Godden D (1987) Inhibition of artificially induced cough in man by bronchodilators. Br J Clin Pharmacol 24:503-510.
143. Lundberg JM, Hokfelt T, Martling CR, Saria A, Cuello C (1984) Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man. Cell Tissue Res 235:251-261.
144. Macpherson LJ, Dubin AE, Evans MJ, Marr F, Schultz PG, Cravatt BF, Patapoutian A (2007) Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445:541-545.
145. Mailleux P, Vanderhaeghen JJ (1992) Distribution of neuronal cannabinoid receptor in the adult rat brain: A comparative receptor binding radioautography and in situ hybridization histochemistry. Neuroscience 48:655-668.
146. Malcangio M, Lessmann V (2003) A common thread for pain and memory synapses? Brainderived neurotrophic factor and trkB receptors. Trends Pharmacol Sci 24:116-121.
147. Mazzone SB (2005) An overview of the sensory receptors regulating cough. Cough 1:2-11.
148. Mazzone SB, McGovern AE (2006) Na+-K+-2Cl- cotransporters and Cl- channels regulate citric acid cough in guinea pigs. J Appl Physiol 101:635-643.
149. Mazzone SB, McGovern AE (2007) Sensory neural targets for the treatment of cough. Clin Exp Pharmacol Physiol 34:955-962.
150. Mazzone SB, Mori N, Canning BJ (2005) Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs. J Physiol 569:559-573.
151. McAlexander MA, Myers AC, Undem BJ (1998) Inhibition of 5-lipoxygenase diminishes neurally evoked tachykinergic contraction of guinea pig isolated airway. J Pharmacol Exp Ther 285:602-607.
152. McGarvey LP, Morice AH (2006) Clinical cough and its mechanisms. Respir Physiol Neurobiol 152:363-371.
153. McKemy DD, Neuhausser WM, Julius D (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416:52-58.
154. McLeod RL, Bolser DC, Jia Y, Parra LE, Mutter JC, Wang X, Tulshian DB, Egan RW, Hey JA (2002) Antitussive effect of nociceptin/orphanin FQ in experimental cough models. Pulm Pharmacol Ther 15:213-216.
155. McLeod RL, Jia Y, Fernandez X, Parra LE, Wang X, Tulshian DB, Kiselgof EJ, Tan Z, Fawzi AB, Smith-Torhan A, Zhang H, Hey JA (2004) Antitussive profile of the NOP agonist Ro-64-6198 in the guinea pig. Pharmacology 71:143-149.
156. McLeod RL, Fernandez X, Correll CC, Phelps TP, Jia Y, Wang X, Hey JA (2006) TRPV1 antagonists attenuate antigen-provoked cough in ovalbumin sensitized guinea pigs. Cough 2:10.
157. Meis S, Pape HC (2001) Control of glutamate and GABA release by nociceptin/orphanin FQ in the rat lateral amygdala. J Physiol 532:701-712.
158. Melis M, Pistis M, Perra S, Muntoni AL, Pillolla G, Gessa GL (2004) Endocannabinoids mediate presynaptic inhibition of glutamatergic transmission in rat ventral tegmental area dopamine neurons through activation of CB1 receptors. J Neurosci 24:53-62.
159. Melzack R, Coderre TJ, Katz J, Vaccarino AL (2001) Central neuroplasticity and pathological pain. Ann N Y Acad Sci 933:157-174.
160. Meunier JC, Mollereau C, Toll L, Suaudeau C, Moisand C, Alvinerie P, Butour JL, Guillemot JC, Ferrara P, Monsarrat B,Mazarguil H, Vassart G, Parmentier M, Costentin J (1995) Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature 377:532-535.
161. Midgren B, Hansson L, Karlsson JA, Simonsson BG, Persson CG (1992) Capsaicin-induced cough in humans. Am Rev Respir Dis 146:347-351.
162. Mifflin SW, Felder RB (1990) Synaptic mechanisms regulating cardiovascular afferent inputs to solitary tract nucleus. Am J Physiol 259:H653-H661.
163. Mochizuki H, Shimizu T, Morikawa A, Kuroume T (1995) Inhaled diuretics attenuate acid-induced cough in children with asthma. Chest 107:413-417.
164. Monnet FP (2005) Sigma-1 receptor as regulator of neuronal intracellular Ca2+: Clinical and therapeutic relevance. Biol Cell 97:873-883.
165. Monteillet-Agius G, Fein J, Anton B, Evans CJ (1998) ORL-1 and mu opioid receptor antisera label different fibers in areas involved in pain processing. J Comp Neurol 399:373-383.
166. Mooraki A, Jenabi A, Jabbari M, Zolfaghari MI, Javanmardi SZ, Mahmoudian M, Bastani B (2005) Noscapine suppresses angiotensin converting enzyme inhibitors-induced cough. Nephrology (Carlton) 10:348-350.
167. Moreaux B, Nemmar A, Vincke G, Halloy D, Beerens D, Advenier C, Gustin P (2000) Role of substance P and tachykinin receptor antagonists in citric acid-induced cough in pigs. Eur J Pharmacol 408:305-312.
168. Morice AH, Geppetti P (2004) Cough. 5: The type 1 vanilloid receptor: a sensory receptor for cough. Thorax 59:257-258.
169. Morice AH, Lowry R, Brown MJ, Higenbottam T (1987) Angiotensin-converting enzyme and the cough reflex. Lancet 2:1116-1118.
170. Morice AH, Marshall AE, Higgins KS, Grattan TJ (1994) Effect of inhaled menthol on citric acid induced cough in normal subjects. Thorax 49:1024-1026.
171. Morice AH, Fontana GA, Sovijarvi AR, Pistolesi M, Chung KF, Widdicombe JG, O'Connell F, Geppetti P, Gronke L, De JJ, Belvisi M, Dicpinigaitis P, Fischer A, McGarvey L, Fokkens WJ, Kastelik J (2004) The diagnosis and management of chronic cough. Eur Respir J 24:481-492.
172. Morice AH, Menon MS, Mulrennan SA, Everett CF, Wright C, Jackson J, Thompson R (2007) Opiate therapy in chronic cough. Am J Respir Crit Care Med 175:312-315.
173. Mulrennan S, Wright C, Thompson R, Goustas P, Morice A (2004) Effect of salbutamol on smoking related cough. Pulm Pharmacol Ther 17:127-131.
174. Mutoh T, Bonham AC, Kott KS, Joad JP (1999) Chronic exposure to sidestream tobacco smoke augments lung C-fiber responsiveness in young guinea pigs. J Appl Physiol 87:757-768.
175. Mutoh T, Joad JP, Bonham AC (2000) Chronic passive cigarette smoke exposure augments bronchopulmonary C-fibre inputs to nucleus tractus solitarii neurones and reflex output in young guinea-pigs. J Physiol 523(Part 1):223-233.
176. Myers AC, Kajekar R, Undem BJ (2002) Allergic inflammation-induced neuropeptide production in rapidly adapting afferent nerves in guinea pig airways. Am J Physiol Lung Cell Mol Physiol 282:L775-L781.
177. Nakajima T, Nishimura Y, Nishiuma T, Kotani Y, Nakata H, Yokoyama M (2006) Cough sensitivity in pure cough variant asthma elicited using continuous capsaicin inhalation. Allergol Int 55:149-155.
178. Netzer R, Pflimlin P, Trube G (1993) Dextromethorphan blocks N-methyl-D-aspartate-induced currents and voltage-operated inward currents in cultured cortical neurons. Eur J Pharmacol 238:209-216.
179. Nichol GM, Alton EW, Nix A, Geddes DM, Chung KF, Barnes PJ (1990) Effect of inhaled furosemide on metabisulfite- and methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects. Am Rev Respir Dis 142:576-580.
180. Nilius B, Owsianik G, Voets T, Peters JA (2007) Transient receptor potential cation channels in disease. Physiol Rev 87:165-217.
181. O'Connell F, Thomas VE, Pride NB, Fuller RW(1994) Capsaicin cough sensitivity decreases with successful treatment of chronic cough. Am J Respir Crit Care Med 150:374-380.
182. O'Connell F, Springall DR, Moradoghli-Haftvani A, Krausz T, Price D, Fuller RW, Polak JM, Pride NB (1995) Abnormal intraepithelial airway nerves in persistent unexplained cough? Am J Respir Crit Care Med 152:2068-2075.
183. O'Connell F, Thomas VE, Studham JM, Pride NB, Fuller RW (1996) Capsaicin cough sensitivity increases during upper respiratory infection. Respir Med 90:279-286.
184. Pacher P, Batkai S, Kunos G (2006) The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 58:389-462.
185. Packman EW, Ciccone PE, Wilson J, Masurat T (1991) Antitussive effects of diphenhydramine on the citric acid aerosol-induced cough response in humans. Int J Clin Pharmacol Ther Toxicol 29:218-222.
186. Pantaleo T, Bongianni F, Mutolo D (2002) Central nervous mechanisms of cough. Pulm Pharmacol Ther 15:227-233.
187. Park KA, Vasko MR (2005) Lipid mediators of sensitivity in sensory neurons. Trends Pharmacol Sci 26:571-577.
188. Patel HJ, Birrell MA, Crispino N, Hele DJ, Venkatesan P, Barnes PJ, Yacoub MH, Belvisi MG (2003) Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation. Br J Pharmacol 140:261-268.
189. Pavord I, Hall I,Wahedna I, Cooper S, Tattersfield A (1994) Effect of 443c81, an inhaledmu-opioid receptor agonist in asthma. Clin Exp Allergy 24:144-148.
190. Pezet S, Spyropoulos A, Williams RJ, McMahon SB (2005) Activity-dependent phosphorylation of Akt/PKB in adult DRG neurons. Eur J Neurosci 21:1785-1797.
191. Pillay V, Swingler G (2003) Symptomatic treatment of the cough in whooping cough. Cochrane Database Syst Rev:CD003257.
192. Pounsford JC, Birch MJ, Saunders KB (1985) Effect of bronchodilators on the cough response to inhaled citric acid in normal and asthmatic subjects. Thorax 40:662-667.
193. Pratter MR (2006) Cough and the common cold: ACCP evidence-based clinical practice guidelines. Chest 129:72S-74S.
194. Pratter MR, Brightling CE, Boulet LP, Irwin RS (2006) An empiric integrative approach to the management of cough: ACCP evidence-based clinical practice guidelines. Chest 129: 222S-231S.
195. Rees PJ, Clark TJ (1983) Assessment of antitussive effects by citric acid threshold. Br J Dis Chest 77:94-97.
196. Reynolds SM, Mackenzie AJ, Spina D, Page CP (2004) The pharmacology of cough. Trends Pharmacol Sci 25:569-576.
197. Riccio MM, Myers AC, Undem BJ (1996) Immunomodulation of afferent neurones in guinea-pig isolated airways. J Physiol 491:499-509.
198. Ruhle KH, Criscuolo D, Dieterich HA, Kohler D, Riedel G (1984) Objective evaluation of dextromethorphan and glaucine as antitussive agents. Br J Clin Pharmacol 17:521-524.
199. Sant'Ambrogio FB, Sant'Ambrogio G, Anderson JW (1993) Effect of furosemide on the response of laryngeal receptors to low-chloride solutions. Eur Respir J 6:1151-1155.
200. Schroeder K, Fahey T (2002) Systematic review of randomised controlled trials of over the counter cough medicines for acute cough in adults. Br Med J 324:329-331.
201. Schroeder K, Fahey T (2004) Over-the-counter medications for acute cough in children and adults in ambulatory settings. Cochrane Database Syst Rev:CD001831.
202. Sekizawa K, Jia YX, Ebihara T, Hirose Y, Hirayama Y, Sasaki H (1996) Role of substance P in cough. Pulm Pharmacol 9:323-328.
203. Sekizawa S, Joad JP, Bonham AC (2003) Substance P presynaptically depresses the transmission of sensory input to bronchopulmonary neurons in the guinea pig nucleus tractus solitarii. J Physiol 552:547-559.
204. Shah S, Page CP, Spina D (1998) Nociceptin inhibits non-adrenergic non-cholinergic contraction in guinea-pig airway. Br J Pharmacol 125:510-516.
205. Shannon R, Baekey DM, Morris KF, Li Z, Lindsey BG (2000) Functional connectivity among ventrolateral medullary respiratory neurones and responses during fictive cough in the cat. J Physiol 525(Part 1):207-224.
206. Sheppard D, Rizk NW, Boushey HA, Bethel RA (1983) Mechanism of cough and bronchoconstriction induced by distilled water aerosol. Am Rev Respir Dis 127:691-694.
207. Shin J, Cho H, Hwang SW, Jung J, Shin CY, Lee SY, Kim SH, Lee MG, Choi YH, Kim J, Haber NA, Reichling DB, Khasar S, Levine JD, Oh U (2002) Bradykinin-12-lipoxygenase- VR1 signaling pathway for inflammatory hyperalgesia. Proc Natl Acad Sci USA 99:10150-10155.
208. Smart D, Gunthorpe MJ, Jerman JC, Nasir S, Gray J, Muir AI, Chambers JK, Randall AD, Davis JB (2000) The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1). Br J Pharmacol 129:227-230.
209. Smith CA, Adamson DL, Choudry NB, Fuller RW(1991) The effect of altering airway tone on the sensitivity of the cough reflex in normal volunteers. Eur Respir J 4:1078-1079.
210. Smith BN, Dou P, BarberWD, Dudek FE (1998) Vagally evoked synaptic currents in the immature rat nucleus tractus solitarii in an intact in vitro preparation. J Physiol 512(Part 1):149-162.
211. Soya A, Serino R, Fujihara H, Onaka T, Ozaki Y, Saito T, Nakamura J, Ueta Y (2005) Cannabinoids modulate synaptic activity in the rat supraoptic nucleus. J Neuroendocrinol 17:609-615.
212. Spina D, Page CP, Morley J. (1998). Sensory neuropeptides and bronchial hyperresponsiveness.In: Said SI (ed) ProInflammatory and antiinflammatory peptides. Marcel Deckker, New York, pp 89-146.
213. Stone RA, Barnes PJ, Chung KF (1993a) Effect of frusemide on cough responses to chloridedeficient solution in normal and mild asthmatic subjects. Eur Respir J 6:862-867.
214. Stone RA, Worsdell YM, Fuller RW, Barnes PJ (1993b) Effects of 5-hydroxytryptamine and 5- hydroxytryptophan infusion on the human cough reflex. J Appl Physiol 74:396-401.
215. Studham J, Fuller RW (1992) The effect of oral terfenadine on the sensitivity of the cough reflex in normal volunteers. Pulm Pharmacol 5:51-52.
216. Suzuki K, Sato M, Morishima Y, Nakanishi S (2005) Neuronal depolarization controls brainderived neurotrophic factor-induced upregulation of NR2C NMDA receptor via calcineurin signaling. J Neurosci 25:9535-9543.
217. Szallasi A, Blumberg PM (1999) Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol Rev 51:159-211.
218. Tashkin DP, Reiss S, Shapiro BJ, Calvarese B, Olsen JL, Lodge JW (1977) Bronchial effects of aerosolized delta 9-tetrahydrocannabinol in healthy and asthmatic subjects. Am Rev Respir Dis 115:57-65.
219. Tatar M, Webber SE, Widdicombe JG (1988) Lung C-fibre receptor activation and defensive reflexes in anaesthetized cats. J Physiol 402:411-420.
220. Tatar M, Sant'Ambrogio G, Sant'Ambrogio FB (1994) Laryngeal and tracheobronchial cough in anesthetized dogs. J Appl Physiol 76:2672-2679.
221. Trevisani M, Milan A, Gatti R, Zanasi A, Harrison S, Fontana G, Morice AH, Geppetti P (2004) Antitussive activity of iodo-resiniferatoxin in guinea pigs. Thorax 59:769-772.
222. Trochtenberg S (1994) Nebulized lidocaine in the treatment of refractory cough. Chest 105: 1592-1593.
223. Tucker RC, Kagaya M, Page CP, Spina D (2001) The endogenous cannabinoid agonist, anandamide stimulates sensory nerves in guinea-pig airways. Br J Pharmacol 132:1127-1135.
224. Undem BJ, Weinreich D (1993) Electrophysiological properties and chemosensitivity of guinea pig nodose ganglion neurons in vitro. J Auton Nerv Syst 44:17-33.
225. Undem BJ, Carr MJ, Kollarik M (2002) Physiology and plasticity of putative cough fibres in the Guinea pig. Pulm Pharmacol Ther 15:193-198.
226. Ventresca PG, Nichol GM, Barnes PJ, Chung KF (1990) Inhaled furosemide inhibits cough induced by low chloride content solutions but not by capsaicin. Am Rev Respir Dis 142:143-146.
227. Wang L, Bradley RM(1995) In vitro study of afferent synaptic transmission in the rostral gustatory zone of the rat nucleus of the solitary tract. Brain Res 702:188-198.
228. Watanabe N, Horie S, Michael GJ, Spina D, Page CP, Priestley JV (2005) Immunohistochemical localization of vanilloid receptor subtype 1 (TRPV1) in the guinea pig respiratory system. Pulm Pharmacol Ther 18:187-197.
229. Watanabe N, Horie S, Michael GJ, Keir S, Spina D, Page CP, Priestley JV (2006) Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system. Neuroscience 141:1533-1543.
230. Weinfeld D, Ternesten-Hasseus E, Lowhagen O, Millqvist E (2002) Capsaicin cough sensitivity in allergic asthmatic patients increases during the birch pollen season. Ann Allergy Asthma Immunol 89:419-424.
231. Widdicombe JG (1995) Neurophysiology of the cough reflex. Eur Respir J 8:1193-1202.
232. Widdicombe JG (2003) Overview of neural pathways in allergy and asthma. Pulm Pharmacol Ther 16:23-30/
233. Woolf CJ, King AE (1989) Subthreshold components of the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat lumbar spinal cord. J Neurophysiol 62:907-916.
234. Woolf CJ, King AE (1990) Dynamic alterations in the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat spinal cord. J Neurosci 10:2717-2726.
235. Woolf CJ, Salter MW (2000) Neuronal plasticity: Increasing the gain in pain. Science 288: 1765-1769.
236. Woolf CJ, Wall PD (1986) Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat. J Neurosci 6:1433-1442.
237. Yang L, Zhang FX, Huang F, Lu YJ, Li GD, Bao L, Xiao HS, Zhang X (2004) Peripheral nerve injury induces trans-synaptic modification of channels, receptors and signal pathways in rat dorsal spinal cord. Eur J Neurosci 19:871-883.
238. Yasumitsu R, Hirayama Y, Imai T,Miyayasu K, Hiroi J (1996) Effects of specific tachykinin receptor antagonists on citric acid-induced cough and bronchoconstriction in unanesthetized guinea pigs. Eur J Pharmacol 300:215-219.
239. Yukioka H, Yoshimoto N, Nishimura K, Fujimori M (1985) Intravenous lidocaine as a suppressant of coughing during tracheal intubation. Anesth Analg 64:1189-1192.
240. Zou X, Lin Q, Willis WD (2000) Enhanced phosphorylation of NMDA receptor 1 subunits in spinal cord dorsal horn and spinothalamic tract neurons after intradermal injection of capsaicin in rats. J Neurosci 20:6989-6997.
241. Zygmunt PM, Petersson J, Andersson DA, Chuang HH, Sorgard M, DiMarzo M, Julius V, Hogestatt ED (1999) Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400:452-457.