Inhibition of capsaicin-induced cough by the γ-aminobutyric acid agonist baclofen

Journal of Clinical Pharmacology

Volumn 38, Issue 4, 1998, Pages 364-367

  Dicpinigaitis, Peter V ^a,b   Dobkin, Jay B ^a   Rauf, Khalid ^a   Aldrich, Thomas K ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Albert Einstein Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; BACLOFEN; CAPSAICIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DOUBLE BLIND PROCEDURE; DRUG ACTIVITY; DRUG EFFECT; DRUG RESPONSE; DRUG SCREENING; HUMAN; ORAL DRUG ADMINISTRATION;

EID: 0031954634     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1552-4604.1998.tb04436.x     Document Type: Article

References (7)

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3. Bolser DC., DeGennaro FC, O'Reilly S, Chapman RW, Kreutner W, Egan RW, Hey JA: Peripheral and central sites of action of GABA-B agonists to inhibit the cough reflex in the cat and guinea pig. Br J Pharmacol 1994;113:1344-1348.
4. Dicpinigaitis PV, Dobkin JB: Antitussive effect of the GABA-agonist baclofen. Chest 1997;111:996-999.
5. Dicpinigaitis PV: Use of baclofen to suppress cough induced by angiotensin-converting enzyme inhibitors. Ann Pharmacother 1996;30:1242-1245.
6. Dicpinigaitis PV, Spungen AM, Bauman WA, Absgarten A, Almenoff PL: Inhibition of bronchial hyperresponsiveness by the GABA-agonist baclofen. Chest 1994;106:758-761.
7. Ray NJ, Jones AJ, Keen P: GABA-B receptor modulation of the release of substance P from capsaicin-sensitive neurones in the rat trachea in vitro. Br J Pharmacol 1991;102:801-804.