E2F6 inhibits cobalt chloride-mimetic hypoxia-induced apoptosis through E2F1

Molecular Biology of the Cell

Volumn 19, Issue 9, 2008, Pages 3691-3700

  Yang, Wei Wei ^a   Shu, Bo ^a   Zhu, Yi ^a   Yang, Huang Tian ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COBALT CHLORIDE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR E2F6;

APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; GENE DELETION; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSACTIVATION;

ANOXIA; APOPTOSIS; BINDING SITES; CASPASE 3; CELL CYCLE; CELL LINE; E2F1 TRANSCRIPTION FACTOR; E2F6 TRANSCRIPTION FACTOR; GENE DELETION; GENE EXPRESSION REGULATION; HUMANS; IN SITU NICK-END LABELING; MUTATION; PROTEIN STRUCTURE, TERTIARY; RNA, SMALL INTERFERING;

EID: 55549125229     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E08-02-0171     Document Type: Article

References (41)

1. Cartwright, P., Muller, H., Wagener, C., Holm, K., and Helin, K. (1998). E2F-6, a novel member of the E2F family is an inhibitor of E2F-dependent transcription. Oncogene 17, 611-623.
2. Coquelle, A., Toledo, F., Stern, S., Bieth, A., and Debatisse, M. (1998). A new role for hypoxia in tumor progression: induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs. Mol. Cell 2, 259-265.
3. DeGregori, J. (2002). The genetics of the E2F family of transcription factors: shared functions and unique roles. Biochim. Biophys. Acta 1602, 131-150.
4. DeGregori, J., Leone, G., Miron, A., Jakoi, L., and Nevins, J. R. (1997). Distinct roles for E2F proteins in cell growth control and apoptosis. Proc. Natl. Acad. Sci. USA 94, 7245-7250.
5. Fan, Y., Wu, D., Jin, L., and Yin, Z. (2005). Human glutamylcysteine synthetase protects HEK293 cells against UV-induced cell death through inhibition of c-Jun NH2-terminal kinase. Cell Biol. Int. 29, 695-702.
6. Field, S. J., Tsai, F. Y., Kuo, F., Zubiaga, A. M., Kaelin, W. G., Jr., Livingston, D. M., Orkin, S. H., and Greenberg, M. E. (1996). E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85, 549-561.
7. Furukawa, Y., Nishimura, N., Furukawa, Y., Satoh, M., Endo, H., Iwase, S., Yamada, H., Matsuda, M., Kano, Y., and Nakamura, M. (2002). Apaf-1 is a mediator of E2F-1-induced apoptosis. J. Biol. Chem. 277, 39760-39768.
8. Gaubatz, S., Wood, J. G., and Livingston, D. M. (1998). Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6. Proc. Natl. Acad. Sci. USA 95, 9190-9195.
9. Gee, M. S. et al. (1999). Hypoxia-mediated apoptosis from angiogenesis inhibition underlies tumor control by recombinant interleukin 12. Cancer Res. 59, 4882-4889.
10. Guo, M., Song, L. P., Jiang, Y., Liu, W., Yu, Y., and Chen, G. Q. (2006). Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1alpha independent mechanisms. Apoptosis 11, 67-77.
11. Guy, C. T., Zhou, W., Kaufman, S., and Robinson, M. O. (1996). E2F-1 blocks terminal differentiation and causes proliferation in transgenic megakaryocytes. Mol. Cell Biol. 16, 685-693.
12. Harbour, J. W., and Dean, D. C. (2000). Rb function in cell-cycle regulation and apoptosis. Nat. Cell Biol. 2, E65-E67.
13. Harris, A. L. (2002). Hypoxia-a key regulatory factor in tumour growth. Nat. Rev. Cancer 2, 38-47.
14. Hauck, L., Hansmann, G., Dietz, R., and von Harsdorf, R. (2002). Inhibition of hypoxia-induced apoptosis by modulation of retinoblastoma protein-dependent signaling in cardiomyocytes. Circ. Res. 91, 782-789.
15. Holmberg, C., Helin, K., Sehested, M., and Karlstrom, O. (1998). E2F-1-induced p53-independent apoptosis in transgenic mice. Oncogene 17, 143-155.
16. Hsieh, J. K., Yap, D., O'Connor, D. J., Fogal, V., Fallis, L., Chan, F., Zhong, S., and Lu, X. (2002). Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage. Mol. Cell Biol. 22, 78-93.
17. Huang, L. E., Bindra, R. S., Glazer, P. M., and Harris, A. L. (2007). Hypoxia-induced genetic instability - a calculated mechanism underlying tumor progression. J. Mol. Med. 85, 139-148.
18. 2-induced apoptosis of rat PC12 cells. Neurosci. Lett. 371, 85-90.
19. Kherrouche, Z., Begue, A., Stehelin, D., and Monte, D. (2001). Molecular cloning and characterization of the mouse E2F6 gene. Biochem. Biophys. Res. Commun. 288, 22-33.
20. Kowalik, T. F., DeGregori, J., Leone, G., Jakoi, L., and Nevins, J. R. (1998). E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2. Cell Growth Differ. 9, 113-118.
21. Lyons, T. E., Salih, M., and Tuana, B. S. (2005). Activating E2Fs mediate the transcriptional regulation of the human E2F6 repressor. Am. J. Physiol. Cell Physiol. 290, C189-C199.
22. Ma, Y., Cress, W. D., and Haura, E. B. (2003). Flavopiridol-induced apoptosis is mediated through up-regulation of E2F1 and repression of Mcl-1. Mol. Cancer Ther. 2, 73-81.
23. Moroni, M. C., Hickman, E. S., Lazzerini, D. E., Caprara, G., Colli, E., Cecconi, F., Muller, H., and Helin, K. (2001). Apaf-1 is a transcriptional target for E2F and p53. Nat. Cell Biol. 3, 552-558.
24. Muller, H., Bracken, A. P., Vernell, R., Moroni, M. C., Christians, F., Grassilli, E., Prosperini, E., Vigo, E., Oliner, J. D., and Helin, K. (2001). E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev. 15, 267-285.
25. Nagarajah, N. S., Vigneswaran, N., and Zacharias, W. (2004). Hypoxia-mediated apoptosis in oral carcinoma cells occurs via two independent pathways. Mol. Cancer 3, 38.
26. Perou, C. M. et al. (2000). Molecular portraits of human breast tumours. Nature 406, 747-752.
27. Qin, X. Q., Livingston, D. M., Kaelin, W. G., Jr., and Adams, P. D. (1994). Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA 91, 10918-10922.
28. Rogoff, H. A., Pickering, M. T., Frame, F. M., Debatis, M. E., Sanchez, Y., Jones, S., and Kowalik, T. F. (2004). Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2. Mol. Cell Biol. 24, 2968-2977
29. Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., and Livingston, D. M. (1997). Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell 90, 425-435.
30. Slansky, J. E., Li, Y., Kaelin, W. G., and Farnham, P. J. (1993). A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter. Mol. Cell Biol. 13, 1610-1618.
31. Trimarchi, J. M., Fairchild, B., Verona, R., Moberg, K., Andon, N., and Lees, J. A. (1998). E2F-6, a member of the E2F family that can behave as a transcriptional repressor. Proc. Natl. Acad. Sci. USA 95, 2850-2855.
32. Trimarchi, J. M., Fairchild, B., Wen, J., and Lees, J. A. (2001). The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. Proc. Natl. Acad. Sci. USA 98, 1519-1524.
33. Trimarchi, J. M., and Lees, J. A. (2002). Sibling rivalry in the E2F family. Nat. Rev. Mol. Cell Biol. 3, 11-20.
34. Weinmann, M., Jendrossek, V., Handrick, R., Guner, D., Goecke, B., and Belka, C. (2004). Molecular ordering of hypoxia-induced apoptosis: critical involvement of the mitochondrial death pathway in a FADD/caspase-8 independent manner. Oncogene 23, 3757-3769.
35. Wu, X., Yang, Z., Liu, Y., and Zou, Y. (2005). Preferential localization of hyperphosphorylated replication protein A to double strand break repair and checkpoint complexes upon DNA damage. Biochem. J. 391, 473-480.
36. Wyllie, A. H., and Morris, R. G. (1982). Hormone-induced cell death. Purification ad properties of thymocytes undergoing apoptosis after glucocorticoid treatment. Am. J. Pathol. 109, 78-87.
37. Yang, H. L., Dong, Y. B., Elliott, M. J., Liu, T. J., and McMasters, K. M. (2000). Caspase activation and changes in Bcl-2 family member protein expression associated with E2F-1-mediated apoptosis in human esophageal cancer cells. Clin. Cancer Res. 6, 1579-1589.
38. Yang, W. W., Wang, Z. H., Zhu, Y., and Yang, H. T. (2007). E2F6 negatively regulates ultraviolet-induced apoptosis via modulation of BRCA1. Cell Death Differ. 14, 807-817.
39. Zhan, Q., Jin, S., Ng, B., Plisket, J., Shangary, S., Rathi, A., Brown, K. D., and Baskaran, R. (2002). Caspase-3 mediated cleavage of BRCA1 during UV-induced apoptosis. Oncogene 21, 5335-5345.
40. Zhang, F. B., Li, L., Fang, B., Zhu, D. L., Yang, H. T., and Gao, P. J. (2005). Passage-restricted differentiation potential of mesenchymal stem cells into cardiomyocyte-like cells. Biochem. Biophys. Res. Commun. 336, 784-792.
41. Zou, W., Zeng, J., Zhuo, M., Xu, W., Sun, L., Wang, J., and Liu, X. (2002). Involvement of caspase-3 and p38 mitogen-activated protein kinase in cobalt chloride-induced apoptosis in PC12 cells. J. Neurosci. Res. 67, 837-843.