E2F6 negatively regulates ultraviolet-induced apoptosis via modulation of BRCA1

Cell Death and Differentiation

Volumn 14, Issue 4, 2007, Pages 807-817

  Yang, W W ^a,b   Wang, Z H ^a,b   Zhu, Y ^a   Yang, H T ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; MESSENGER RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR E2F6;

APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE OVEREXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RADIATION NECROSIS; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; ULTRAVIOLET RADIATION;

APOPTOSIS; BINDING SITES; BRCA1 PROTEIN; CELL LINE, TUMOR; DNA-BINDING PROTEINS; DOWN-REGULATION; E2F6 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BRCA1; HUMANS; KIDNEY; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; RNA, SMALL INTERFERING; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; ULTRAVIOLET RAYS;

EID: 33947359114     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4402062     Document Type: Article

References (39)

1. Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407: 770-776.
2. Trimarchi JM, Lees JA. Sibling rivalry in the E2F family. Nat Rev Mol Cell Biol 2002; 3: 11-20.
3. Kowalik TF, DeGregori J, Schwarz JK, Nevins JR. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J Virol 1995; 69: 2491-2500.
4. Harbour JW, Dean DC. Rb function in cell-cycle regulation and apoptosis. Nat Cell Biol 2000; 2: E65-E67.
5. Trimarchi JIM, Fairchild B, Verona R, Moberg K, Andon N, Lees JA. E2F-6, a member of the E2F family that can behave as a transcriptional repressor. Proc Natl Acad Sci USA 1998; 95: 2850-2855.
6. de Bruin A, Maiti B, Jakoi L, Timmers C, Buerki R, Leone G. Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation. J Biol Chem 2003; 278: 42041-42049.
7. Maiti B, Li J, de Bruin A, Gordon F, Timmers C, Opavsky R et al. Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation. J Biol Chem 2005; 280: 18211-18220.
8. Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C et al. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes Dev 1993; 7: 1850-1861.
9. Zhang Y, Chellappan SP. Cloning and characterization of human DP2, a novel dimerization partner of E2F. Oncogene 1995; 10: 2085-2093.
10. Takahashi Y, Rayman JB, Dynlacht BD. Analysis of promoter binding by the E2F and pRB families in vivo: Distinct E2F proteins mediate activation and repression. Genes Dev 2000; 14: 804-816.
11. DeGregori J, Leone G, Miron A, Jakoi L, Nevins JR. Distinct roles for E2F proteins in cell growth control and apoptosis. Proc Natl Acad Sci USA 1997; 94: 7245-7250.
12. Gaubatz S, Wood JG, Livingston DM. Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6. Proc Natl Acad Sci USA 1998; 95: 9190-9195.
13. Ogawa H, Ishiguro K, Gaubatz S, Livingston DM, Nakatani Y. A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science 2002; 296: 1132-1136.
14. Oberley MJ, Inman DR, Famham PJ. E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9. J Biol Chem 2003; 278: 42466-42476.
15. Chen Y, Farmer AA, Chen CF, Jones DC, Chen PL, Lee WH. BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner. Cancer Res 1996; 56: 3168-3172.
16. Cortez D, Wang Y, Qin J, Elledge SJ. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science 1999; 286: 1162-1166.
17. Moynahan ME, Chiu JW, Koller BH, Jasin M. Brca1 controls homology-directed DNA repair. Mol Cell 1999; 4: 511-518.
18. Hartman AR, Ford JM. BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair. Nat Genet 2002; 32: 180-184.
19. Shao N, Chai YL, Shyam E, Reddy P, Rao VN. Induction of apoptosis by the tumor suppressor protein BRCA1. Oncogene 1996; 13: 1-7.
20. Thangaraju M, Kaufmann SH, Couch FJ. BRCA1 facilitates stress-induced apoptosis in breast and ovarian cancer cell lines. J Biol Chem 2000; 275: 33487-33496.
21. Zhan Q, Jin S, Ng B, Plisket J, Shangary S, Rathi A et al. Caspase-3 mediated cleavage of BRCA1 during UV-induced apoptosis. Oncogene 2002; 21: 5335-5345.
22. Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J et al. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 1997; 88: 265-275.
23. Scully R, Chen J, Ochs RL, Keegan K, Hoekstra M, Feunteun J et al. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell 1997; 90: 425-435.
24. Scully R, Livingston DM. In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature 2000; 408: 429-432.
25. Lyons TE, Salih M, Tuana BS. The Activating E2Fs Mediate the Transcriptional Regulation of the Human E2F6 Repressor. Am J Physiol Cell Physiol 2006; 290: C189-c199.
26. Harkin DP, Bean JM, Miklos D, Song YH, Truong VB, Englert C et al. Induction of GADD45 and JNK/SAPK-dependent apoptoss following inducible expression of BRCA1. Cell 1999; 97: 575-586.
27. Fan S, Twu NF, Wang JA, Yuan RQ, Andres J, Goldberg ID et al. Down-regulation of BRCA1 and BRCA2 in human ovarian cancer cells exposed to adriamycin and ultraviolet radiation. Int J Cancer 1998; 77: 600-609.
28. Gowen LC, Avrutskaya AV, Latour AM, Koller BH, Leadon SA. BRCA1 required for transcription-coupled repair of oxidative DNA damage. Science 1998; 281: 1009-1012.
29. Hartman AR, Ford JM. BRCA1 and p53: Compensatory roles in DNA repair. J Mol Med 2003; 81: 700-707.
30. Zhong Q, Chen CF, Li S, Chen Y, Wang CC, Xiao J et al. Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. Science 1999; 285: 747-750.
31. Au WW, Henderson BR. The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci. J Biol Chem 2005; 280: 6993-7001.
32. Andres JL, Fan S, Turkel GJ, Wang JA, Twu NF, Yuan RQ et al. Regulation of BRCA1 and BRCA2 expression in human breast cancer cells by DNA-damaging agents. Oncogene 1998; 16: 2229-2241.
33. Fan Y, Wu D, Jin L, Yin Z. Human glutamylcysteine synthetase protects HEK293 cells against UV-induced cell death through inhibition of c-Jun NH2-terminal kinase. Cell Biol Int 2005; 29: 695-702.
34. Wu S, Loke HN, Rehemtulla A. Ultraviolet radiation-induced apoptosis is mediated by Daxx. Neoplasia 2002; 4: 486-492.
35. Wyllie AH, Morris RG. Hormone-induced cell death. Purification ad properties of thymocytes undergoing apoptosis after glucocorticoid treatment. Am J Pathol 1982; 109: 78-87.
36. Zhang FB, Li L, Fang B, Zhu DL, Yang HT, Gao PJ. Passage-restricted differentiation potential of mesenchymal stem cells into cardiomyocyte-like cells. Biochem Biophys Res Commun 2005; 336: 784-792.
37. Wu X, Yang Z, Liu Y, Zou Y. Preferential localization of hyperphosphorylated replication protein A to double strand break repair and checkpoint complexes upon DNA damage. Biochem J 2005; 391: 473-480.
38. Oberley MJ, Tsao J, Yau P, Farnham PJ. High-throughput screening of chromatin immunoprecipitates using CpG-island microarrays. Methods Enzymol 2004; 376: 315-334.
39. Rodriguez JA, Henderson BR. Identification of a functional nuclear export sequence in BRCA1. J Biol Chem 2000; 275: 38589-38596.