Interleukin-15 and natural killer and NKT cells play a critical role in innate protection against genital herpes simplex virus type 2 infection

Journal of Virology

Volumn 77, Issue 18, 2003, Pages 10168-10171

  Ashkar, Ali A ^a,b   Rosenthal, Kenneth L ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 15; RAG2 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENITAL HERPES; HERPES SIMPLEX VIRUS 2; IMMUNE SYSTEM; INFECTION SENSITIVITY; LYMPHOID CELL; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; VAGINA SECRETION; VAGINITIS;

ANIMALS; DISEASE SUSCEPTIBILITY; DNA-BINDING PROTEINS; FEMALE; HERPES GENITALIS; IMMUNITY, NATURAL; INTERFERON TYPE II; INTERLEUKIN-15; KILLER CELLS, NATURAL; MICE; VAGINA;

EID: 0141569260     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.18.10168-10171.2003     Document Type: Article

References (26)

1. Ahmad, A., E. Sharif-Askari, L. Fawaz, and J. Menezes. 2000. Innate immune response of the human host to exposure with herpes simplex virus type 1: in vitro control of the virus infection by enhanced natural killer activity via interleukin-15 induction. J. Virol. 74:7196-7203.
2. Biron, C. A., and L. Brossay. 2001. NK cells and NKT cells in innate defense against viral infections. Curr. Opin. Immunol. 13:458-464.
3. Biron, C. A., K. B. Nguyen, G. C. Pien, L. P. Cousens, and T. P. Salazar-Mather. 1999. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu. Rev. Immunol. 17:189-220.
4. Blauvelt, A., H. Asada, V. Klaus-Kovtun, D. J. Altman, D. R. Lucey, and S. I. Katz. 1996. Interleukin-15 mRNA is expressed by human keratinocytes Langerhans cells, and blood-derived dendritic cells and is downregulated by ultraviolet B radiation. J. Investig. Dermatol. 106:1047-1052.
5. Fawaz, L. M., E. Sharif-Askari, and J. Menezes. 1999. Up-regulation of NK cytotoxic activity via IL-15 induction by different viruses: a comparative study. J. Immunol. 163:4473-4480.
6. Grubor-Bauk, B., A. Simmons, G. Mayrhofer, and P. G. Speck. 2003. Impaired clearance of herpes simplex virus type 1 from mice lacking CD1d or NKT cells expressing the semivariant V alpha 14-J alpha 281 TCR. J. Immunol. 170:1430-1434.
7. Jonuleit, H., K. Wiedemann, G. Muller, J. Degwert, U. Hoppe, J. Knop, and A. H. Enk. 1997. Induction of IL-15 messenger RNA and protein in human blood-derived dendritic cells: a role for IL-15 in attraction of T cells. J. Immunol. 158:2610-2615.
8. Kurago, Z. B., C. T. Lutz, K. D. Smith, and M. Colonna. 1998. NK cell natural cytotoxicity and IFN-gamma production are not always coordinately regulated: engagement of DX9 KIR+ NK cells by HLA-B7 variants and target cells. J. Immunol. 160:1573-1580.
9. Liu, T., H. Nishimura, T. Matsuguchi, and Y. Yoshikai. 2000. Differences in interleukin-12 and -15 production by dendritic cells at the early stage of Listeria monocytogenes infection between BALB/c and C57 BL/6 mice. Cell. Immunol. 202:31-40.
10. MacDonald, H. R. 2002. Development and selection of NKT cells. Curr. Opin. Immunol. 14:250-254.
11. Malmgaard, L., S. R. Paludan, S. C. Mogensen, and S. Ellermann-Eriksen. 2000. Herpes simplex virus type 2 induces secretion of IL-12 by macrophages through a mechanism involving NF-κB. J. Gen. Virol. 81:3011-3020.
12. McDermott, M. R., C. H. Goldsmith, K. L. Rosenthal, and L. J. Brais. 1989. T lymphocytes in genital lymph nodes protect mice from intravaginal infection with herpes simplex virus type 2. J. Infect. Dis. 159:460-466.
13. Milligan, G. N., and D. I. Bernstein. 1997. Interferon-gamma enhances resolution of herpes simplex virus type 2 infection of the murine genital tract. Virology 229:259-268.
14. Milligan, G. N., N. Bourne, and K. L. Dudley. 2001. Role of polymorphonuclear leukocytes in resolution of HSV-2 infection of the mouse vagina. J. Reprod. Immunol. 49:49-65.
15. Munder, M., M. Mallo, K. Eichmann, and M. Modolell. 1998. Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL)-12 and IL-18: a novel pathway of autocrine macrophage activation. J. Exp. Med. 187:2103-2108.
16. Ohteki, T. 2002. Critical role for IL-15 in innate immunity. Curr. Mol. Med. 2:371-380.
17. Parr, M. B., and E. L. Parr. 1999. The role of gamma interferon in immune resistance to vaginal infection by herpes simplex virus type 2 in mice. Virology 258:282-294.
18. Pereno, R., J. Giron-Michel, A. Gaggero, E. Cazes, R. Meazza, M. Monetti, E. Monaco, Z. Mishal, C. Jasmin, F. Indiveri, S. Ferrini, and B. Azzarone. 2000. IL-15/IL-15Rα intracellular trafficking in human melanoma cells and signal transduction through the IL-15Rα. Oncogene 19:5153-5162.
19. Puzanov, I. J., M. Bennett, and V. Kumar. 1996. IL-15 can substitute for the marrow microenvironment in the differentiation of natural killer cells. J. Immunol. 157:4282-4285.
20. Smith, X. G., E. M. Bolton, H. Ruchatz, X. Wei, F. Y. Liew, and J. A. Bradley. 2000. Selective blockade of IL-15 by soluble IL-15 receptor alpha-chain enhances cardiac allograft survival. J. Immunol. 165:3444-3450.
21. + T cells and natural killer cells is essential for the antimetastatic effect of alpha-galactosylceramide. Blood 99:1259-1266.
22. + T cells protect IL-2 receptor alphad-eficient mice from systemic infection with herpes simplex virus type 2. J. Immunol. 165:4552-4560.
23. Tsunobuchi, H., H. Nishimura, F. Goshima, T. Daikoku, H. Suzuki, I. Nakashima, Y. Nishiyama, and Y. Yoshikai. 2000. A protective role of interleukin-15 in a mouse model for systemic infection with herpes simplex virus. Virology 275:57-66.
24. Williams, N. S., J. Klem, I. J. Puzanov, P. V. Sivakumar, J. D. Schatzle, M. Bennett, and V. Kumar. 1998. Natural killer cell differentiation: insights from knockout and transgenic mouse models and in vitro systems. Immunol. Rev. 165:47-61.
25. Yeaman, G. R., J. E. Collins, J. K. Currie, P. M. Guyre, C. R. Wira, and M. W. Fanger. 1998. IFN-gamma is produced by polymorphonuclear neutrophils in human uterine endometrium and by cultured peripheral blood polymorphonuclear neutrophils. J. Immunol. 160:5145-5153.
26. Zhao, X., E. Deak, K. Soderberg, M. Linehan, D. Spezzano, J. Zhu, D. M. Knipe, and A. Iwasaki, 2003. Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2. J. Exp. Med. 197:153-162.