The stereochemistry of trans-4-hydroxynonenal-derived exocyclic 1,N 2-2′-deoxyguanosine adducts modulates formation of interstrand cross-links in the 5′-CpG-3′ sequence

Biochemistry

Volumn 47, Issue 44, 2008, Pages 11457-11472

  Huang, Hai ^a   Wang, Hao ^a   Qi, Nan ^a   Lloyd, R Stephen ^b   Rizzo, Carmelo J ^a   Stone, Michael P ^a  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; DIFFRACTIVE OPTICAL ELEMENTS; DNA; FORECASTING; GENES; MOLECULAR MECHANICS; NUCLEIC ACIDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; STEREOCHEMISTRY;

BASE PAIRS; DEOXYGUANOSINE; DIASTEREOMERIC; DNA DUPLEXES; DUPLEX DNAS; HEMIACETAL; HEMIACETALS; HYDROXYNONENAL; INTERCHAIN CROSS-LINKS; INTERSTRAND CROSS-LINKS; MINOR GROOVES; MOLECULAR MECHANICS CALCULATIONS; NEUTRAL PH; POTENTIAL ENERGY MINIMIZATIONS; REFINED STRUCTURES; STRUCTURAL BASES; STRUCTURAL PERTURBATIONS;

ALDEHYDES;

1,N2 2' DEOXYGUANOSINE; 4 HYDROXYNONENAL; ALDEHYDE; DEOXYGUANOSINE DERIVATIVE; DOUBLE STRANDED DNA; UNCLASSIFIED DRUG;

ARTICLE; CPG ISLAND; CROSS LINKING; DIASTEREOISOMER; DNA ADDUCT; DNA CROSS LINKING; DNA SEQUENCE; PRIORITY JOURNAL; STEREOCHEMISTRY;

ALDEHYDES; BASE SEQUENCE; CPG ISLANDS; CROSS-LINKING REAGENTS; DEOXYGUANOSINE; DNA ADDUCTS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEIC ACID CONFORMATION; STEREOISOMERISM; THERMODYNAMICS;

EID: 55249099774     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi8011143     Document Type: Article

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