Development of a 32P-postlabeling method for the detection of 1,N2-propanodeoxyguanosine adducts of trans-4-hydroxy-2-nonenal in vivo

Chemical Research in Toxicology

Volumn 13, Issue 11, 2000, Pages 1165-1173

  Wacker, M ^a   Schuler, D ^b   Wanek, P ^a   Eder, E ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b Madaus AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; BIOCHEMICAL MARKER; DEOXYGUANOSINE DERIVATIVE; NUCLEASE; PHOSPHATE; PHOSPHORUS 32; 1,N(2) PROPANODEOXYGUANOSINE; 1,N(2)-PROPANODEOXYGUANOSINE; 4-HYDROXY-2-NONENAL; ALDEHYDE; BIOLOGICAL MARKER; CROSS LINKING REAGENT; DEOXYGUANOSINE; DRUG DERIVATIVE; NUCLEASE S1; NUCLEOTIDE; PHOSPHORUS;

ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; DIASTEREOISOMER; DNA ADDUCT; HUMAN; HUMAN TISSUE; LIPID PEROXIDATION; MALE; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT; ADULT; ANIMAL; AUTORADIOGRAPHY; BRAIN; BRAIN LEVEL; CHEMISTRY; COLON; DRUG STABILITY; FEMALE; FISCHER 344 RAT; ISOTOPE LABELING; METABOLISM; METHODOLOGY; SENSITIVITY AND SPECIFICITY; STANDARD; THIN LAYER CHROMATOGRAPHY;

ANIMALIA;

ADULT; ALDEHYDES; ANIMALS; ASPERGILLUS NUCLEASE S1; AUTORADIOGRAPHY; BIOLOGICAL MARKERS; BRAIN; BRAIN CHEMISTRY; CHROMATOGRAPHY, THIN LAYER; COLON; CROSS-LINKING REAGENTS; DEOXYGUANOSINE; DNA ADDUCTS; DRUG STABILITY; FEMALE; HUMANS; ISOTOPE LABELING; LIPID PEROXIDATION; NUCLEOTIDES; PHOSPHORUS RADIOISOTOPES; RATS; RATS, INBRED F344; REFERENCE STANDARDS; SENSITIVITY AND SPECIFICITY;

EID: 0033623503     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx000058r     Document Type: Article

References (25)

1. 2+ in rat liver microsomes
2. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
3. Possible mutagens derived from lipids and lipid precursors
4. Cytotoxicity, DNA fragmentation and sister-chromatid exchange in Chinese hamster ovary cells exposed to the lipid peroxidation product 4-hydroxynonenal and homologous aldehydes
5. Structure-mutagenicity relationship in α,β-unsaturated carbonylic compounds and their corresponding allylic alcohols
6. Mutagenicity of β-alkyl substituted acrolein congeners in the Salmonella typhimurium strain TA 100 and genotoxicity testing in the SOS chromotest
7. Naturally occurring carbonyl compounds are mutagens in Salmonella tester strain TA104
8. 2,3-Epoxy-4-hydroxynonanal as a potential tumor-initiating agent of lipid peroxidation
9. Formation of cyclic adducts of deoxyguanosine with aldehydes trans-4-hydroxy-2-hexenal and trans-4-hydroxy-2-nonenal in vitro
10. Influence of an exocyclic guanine adduct on the thermal stability, conformation and melting thermodynamics of a DNA duplex
11. Genotoxicity and mutagenicity of the α,β-unsaturated carbonyl compound crotonaldehyde (butenal) on a plasmid shuttle vector
12. 1,N2-Ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal
13. High dietary ω-6 polyunsaturated fatty acids drastically increase the formation of etheno-DNA base adducts in white blood cells of female subjects
14. Lipid peroxidation-induced etheno-DNA adducts in the liver of patients with the genetic metal storage disorders Wilson's disease and primary hemochromatosis
15. Roles of etheno adducts in tumorigenesis of olefins
16. Vinyl halides, haloaldehydes and monoalkanes
17. Mercapturic acid conjugates as urinary end metabolites of lipid peroxidation product 4-hydroxynonenal in the rat
18. 1,4-Dihydroxynonene mercapturic acid, the major end metabolite of exogenous 4-hydroxy-2-nonenal, is a physiological component of rat and human urine
19. Fumaraldehyde monodimethyl acetal: An easily accessible and versatile intermediate
20. 3H]-4-hydroxy-2-trans-nonenal
21. Uber die wirkungen von aldehyden auf gesunde und maligne zellen
22. Identification and characterization of deoxyguanosine adducts of mutagenic β-alkyl substituted acrolein congeners
23. 2-(1,3-propano)-2'-deoxyguanosine 3'-phosphate adducts formed from 4-hydroxy-2-nonenal
24. 2-propanodeoxyguanosine adducts of 2-hexenal in vivo