Menin regulates endocrine diseases by controlling histone modification and gene transcription

Annales d'Endocrinologie

Volumn 69, Issue 5, 2008, Pages 426-432

  Gao, S B ^a   Hua, X ^a,b   Jin, G H ^a  

^a XIAMEN UNIVERSITY   (China)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Diabetes; Endocrine disease; MEN1; Menin; Transcription

Indexed keywords

HISTONE; METHIONINE; NUCLEAR PROTEIN;

APOPTOSIS; CANCER INHIBITION; CELL PROLIFERATION; CHROMATIN STRUCTURE; DIABETES MELLITUS; DNA REPAIR; ENDOCRINE DISEASE; ENDOCRINE TUMOR; GENE; GENE LOCATION; GENE MUTATION; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; MEN1 GENE; MULTIPLE ENDOCRINE NEOPLASIA; NONHUMAN; REGULATORY MECHANISM; SHORT SURVEY; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL PROLIFERATION; DNA REPAIR; ENDOCRINE GLAND NEOPLASMS; ENDOCRINE SYSTEM DISEASES; HISTONES; HUMANS; MUTATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS; TRANSCRIPTION, GENETIC;

EID: 55049104466     PISSN: 00034266     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ando.2008.06.001     Document Type: Short Survey

References (60)

1. Lakhani V.T., You Y.N., and Wells S.A. The multiple endocrine neoplasia syndromes. Annu Rev Med 58 (2007) 253-265
2. Chandrasekharappa S.C., Guru S.C., Manickam P., Olufemi S.E., Collins F.S., Emmert-Buck M.R., et al. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 276 (1997) 404-407
3. Huang S.C., Zhuang Z., Weil R.J., Pack S., Wang C., Krutzsch H.C., et al. Nuclear/cytoplasmic localization of the multiple endocrine neoplasia type 1 gene product, menin. Lab Invest 79 (1999) 301-310
4. Tanaka C., Uchino S., Noguchi S., Nishioka T., Yamasaki H., Hashimoto K., et al. Biallelic inactivation by somatic mutations of the MEN1 gene in sporadic parathyroid tumors. Cancer Lett 175 (2002) 175-179
5. Lindberg D., Akerström G., and Westin G. Mutational analysis of p27 (CDKN1B) and p18 (CDKN2C) in sporadic pancreatic endocrine tumors argues against tumor-suppressor function. Neoplasia 9 (2007) 533-535
6. Hai N., Aoki N., Shimatsu A., Mori T., and Kosugi S. Clinical features of multiple endocrine neoplasia type 1 (MEN1) phenocopy without germline MEN1 gene mutations: analysis of 20 Japanese sporadic cases with MEN1. Clin Endocrinol (Oxf) 52 (2000) 509-518
7. Milne T.A., Hughes C.M., Lloyd R., Yang Z., Rozenblatt-Rosen O., Dou Y., et al. Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc Natl Acad Sci U S A 102 (2005) 749-754
8. Schnepp R.W., Chen Y.X., Wang H., Cash T., Silva A., Diehl J.A., et al. Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells. Cancer Res 66 (2006) 5707-5715
9. Schnepp R.W., Mao H., Sykes S.M., Zong W.X., Silva A., La P., et al. Menin induces apoptosis in murine embryonic fibroblasts. J Biol Chem 279 (2004) 10685-10691
10. La P., Yang Y., Karnik S.K., Silva A.C., Schnepp R.W., Kim S.K., et al. Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1. J Biol Chem 282 (2007) 31332-31340
11. Jin S., Mao H., Schnepp R.W., Sykes S.M., Silva A.C., D'Andrea A.D., et al. Menin associates with FANCD2, a protein involved in repair of DNA damage. Cancer Res 63 (2003) 4204-4210
12. Busygina V., Kottemann M.C., Scott K.L., Plon S.E., and Bale A.E. Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response. Cancer Res 66 (2006) 8397-8403
13. Marek L.R., Kottemann M.C., Glazer P.M., and Bale A.E. MEN1 and FANCD2 mediate distinct mechanisms of DNA crosslink repair. DNA Repair (Amst) 7 (2008) 476-486
14. Karnik S.K., Hughes C.M., Gu X., Rozenblatt-Rosen O., McLean G.W., Xiong Y., et al. Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc Natl Acad Sci U S A 102 (2005) 14659-14664
15. Guru S.C., Crabtree J.S., Brown K.D., Dunn K.J., Manickam P., Prasad N.B., et al. Isolation, genomic organization, and expression analysis of Men1, the murine homolog of the MEN1 gene. Mamm Genome 10 (1999) 592-596
16. Karges W., Maier S., Wissmann A., Dralle H., Dosch H.M., and Boehm B.O. Primary structure, gene expression and chromosomal mapping of rodent homologs of the MEN1 tumor suppressor gene. Biochim Biophys Acta 1446 (1999) 286-294
17. Khodaei S., O'Brien K.P., Dumanski J., Wong F.K., and Weber G. Characterization of the MEN1 ortholog in zebrafish. Biochem Biophys Res Commun 264 (1999) 404-408
18. Guru S.C., Prasad N.B., Shin E.J., Hemavathy K., Lu J., Ip Y.T., et al. Characterization of a MEN1 ortholog from Drosophila melanogaster. Gene 263 (2001) 31-38
19. Bertolino P., Radovanovic I., Casse H., Aguzzi A., Wang Z.Q., and Zhang C.X. Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs. Mech Dev 120 (2003) 549-560
20. Scacheri P.C., Crabtree J.S., Kennedy A.L., Swain G.P., Ward J.M., Marx S.J., et al. Homozygous loss of menin is well tolerated in liver, a tissue not affected in MEN1. Mamm Genome 15 (2004) 872-877
21. Crabtree J.S., Scacheri P.C., Ward J.M., McNally S.R., Swain G.P., Montagna C., et al. Of mice and MEN1: Insulinomas in a conditional mouse knockout. Mol Cell Biol 23 (2003) 6075-6085
22. Bertolino P., Tong W.M., Galendo D., Wang Z.Q., and Zhang C.X. Heterozygous Men1 mutant mice develop a range of endocrine tumors mimicking multiple endocrine neoplasia type 1. Mol Endocrinol 17 (2003) 1880-1892
23. Crabtree J.S., Scacheri P.C., Ward J.M., Garrett-Beal L., Emmert-Buck M.R., Edgemon K.A., et al. A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. Proc Natl Acad Sci U S A 98 (2001) 1118-1123
24. Lemos M.C., and Thakker R.V. Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene. Hum Mutat 29 (2008) 22-32
25. La P., Desmond A., Hou Z., Silva A.C., Schnepp R.W., and Hua X. Tumor suppressor menin: the essential role of nuclear localization signal domains in coordinating gene expression. Oncogene 25 (2006) 3537-3546
26. Agarwal S.K., Guru S.C., Heppner C., Erdos M.R., Collins R.M., Park S.Y., et al. Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Cell 96 (1999) 143-152
27. Lemmens I.H., Forsberg L., Pannett A.A., Meyen E., Piehl F., Turner J.J., et al. Menin interacts directly with the homeobox-containing protein Pem. Biochem Biophys Res Commun 286 (2001) 426-431
28. Heppner C., Bilimoria K.Y., Agarwal S.K., Kester M., Whitty L.J., Guru S.C., et al. The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation. Oncogene 20 (2001) 4917-4925
29. Kaji H., Canaff L., Lebrun J.J., Goltzman D., and Hendy G.N. Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling. Proc Natl Acad Sci U S A 98 (2001) 3837-3842
30. Sukhodolets K.E., Hickman A.B., Agarwal S.K., Sukhodolets M.V., Obungu V.H., Novotny E.A., et al. The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene. Mol Cell Biol 23 (2003) 493-509
31. Hughes C.M., Rozenblatt-Rosen O., Milne T.A., Copeland T.D., Levine S.S., Lee J.C., et al. Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol Cell 13 (2004) 587-597
32. Yokoyama A., Wang Z., Wysocka J., Sanyal M., Aufiero D.J., Kitabayashi I., et al. Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol Cell Biol 24 13 (2004) 5639-5649
33. Franklin D.S., Godfrey V.L., O'Brien D.A., Deng C., and Xiong Y. Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity. Mol Cell Biol 20 (2000) 6147-6158
34. Schnepp R.W., Hou Z., Wang H., Petersen C., Silva A., Masai H., et al. Functional interaction between tumor suppressor menin and activator of S-phase kinase. Cancer Res 64 (2004) 6791-6796
35. Jenuwein T., and Allis C.D. Translating the histone code. Science 293 (2001) 1074-1080
36. Karnik S.K., Hughes C.M., Gu X., Rozenblatt-Rosen O., McLean G.W., Xiong Y., et al. Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc Natl Acad Sci U S A. 102 (2005) 14659-14664
37. Spugnini E.P., Campioni M., D'Avino A., Caruso G., Citro G., and Baldi A. Cell-cycle molecules in mesothelioma: an overview. J Exp Clin Cancer Res 26 (2007) 443-449
38. Harada K., Toyooka S., Shivapurkar N., Maitra A., Reddy J.L., Matta H., et al. Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines. Cancer Res 62 (2002) 5897-5901
39. Hopkins-Donaldson S., Ziegler A., Kurtz S., Bigosch C., Kandioler D., Ludwig C., et al. Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation. Cell Death Differ 10 (2003) 356-364
40. Wei M.C., Zong W.X., Cheng E.H., Lindsten T., Panoutsakopoulou V., Ross A.J., et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292 (2001) 727-730
41. Farley SM, Chen G, Guo S, Wang MAJ, Lee F, Sawicki M. Menin localizes to chromatin through an ATR-CHK1 mediated pathway after UV-induced DNA damage. J Surg Res 2006; 133:29-37.
42. Vieyra D., Loewith R., Scott M., Bonnefin P., Boisvert F.M., Cheema P., et al. Human ING1 proteins differentially regulate histone acetylation. J Biol Chem 277 (2002) 29832-29839
43. Kim H., Lee J.E., Cho E.J., Liu J.O., and Youn H.D. Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex. Cancer Res 63 (2003) 6135-6139
44. Choy S.W., Wong Y.M., Ho S.H., and Chow K.L. C. elegans SIN-3 and its associated HDAC corepressor complex act as mediators of male sensory development. Biochem Biophys Res Commun 358 (2007) 802-807
45. Dannenberg J.H., David G., Zhong S., van der Torre J., Wong W.H., and Depinho R.A. mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival. Genes Dev 19 (2005) 1581-1595
46. Busygina V., Suphapeetiporn K., Marek L.R., Stowers R.S., Xu T., and Bale A.E. Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1. Hum Mol Genet 13 (2004) 2399-2408
47. Lin S.Y., and Elledge S.J. Multiple tumor suppressor pathways negatively regulate telomerase. Cell 113 (2003) 881-889
48. Brandi M.L., Gagel R.F., Angeli A., Bilezikian J.P., Beck-Peccoz P., Bordi C., et al. Guidelines for diagnosis and therapy of MEN type 1 and type 2. J Clin Endocrinol Metab 86 (2001) 5658-5671
49. Meyer G., Donner H., Herwig J., Böhles H., Usadel K.H., and Badenhoop K. Screening for an AIRE-1 mutation in patients with Addison's disease, type 1 diabetes, Graves' disease and Hashimoto's thyroiditis as well as in APECED syndrome. Clin Endocrinol (Oxf) 54 (2001) 335-338
50. Tsukada T., Yamaguchi K., and Kameya T. The MEN1 gene and associated diseases: an update. Endocr Pathol 12 (2001) 259-273
51. Wautot V., Vercherat C., Lespinasse J., Chambe B., Lenoir G.M., Zhang C.X., et al. Germline mutation profile of MEN1 in multiple endocrine neoplasia type 1: search for correlation between phenotype and the functional domains of the MEN1 protein. Hum Mutat 20 (2002) 35-47
52. Pannett A.A., and Thakker R.V. Somatic mutations in MEN type 1 tumors, consistent with the Knudson "two-hit" hypothesis. J Clin Endocrinol Metab 86 (2001) 4371-4374
53. Yaguchi H., Ohkura N., Takahashi M., Nagamura Y., Kitabayashi I., and Tsukada T. Menin missense mutants associated with multiple endocrine neoplasia type 1 are rapidly degraded via the ubiquitin-proteasome pathway. Mol Cell Biol 24 (2004) 6569-6580
54. Kouvaraki M.A., Lee J.E., Shapiro S.E., Gagel R.F., Sherman S.I., Sellin R.V., et al. Genotype-phenotype analysis in multiple endocrine neoplasia type 1. Arch Surg 137 (2002) 641-647
55. Fontanière S., Tost J., Wierinckx A., Lachuer J., Lu J., Hussein N., et al. Gene expression profiling in insulinomas of Men1 beta-cell mutant mice reveals early genetic and epigenetic events involved in pancreatic beta-cell tumorigenesis. Endocr Relat Cancer 13 4 (2006) 1223-1236
56. Lindberg D., Akerström G., and Westin G. Evaluation of CDKN2C/p18, CDKN1B/p27 and CDKN2B/p15 mRNA expression, and CpG methylation status in sporadic and MEN1-associated pancreatic endocrine tumours. Clin Endocrinol (Oxf) 68 (2008) 271-277
57. Johansson M., Mattsson G., Andersson A., Jansson L., and Carlsson P.O. Islet endothelial cells and pancreatic beta-cell proliferation: studies in vitro and during pregnancy in adult rats. Endocrinology 147 (2006) 2315-2324
58. Karnik S.K., Chen H., McLean G.W., Heit J.J., Gu X., Zhang A.Y., et al. Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus. Science 318 (2007) 806-809
59. Rulifson I.C., Karnik S.K., Heiser P.W., ten Berge D., Chen H., Gu X., et al. Wnt signaling regulates pancreatic beta cell proliferation. Proc Natl Acad Sci U S A 104 (2007) 6247-6252
60. Scacheri P.C., Davis S., Odom D.T., Crawford G.E., Perkins S., Halawi M.J., et al. Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis. PLoS Genet 2 (2006) e51