Menin interacts directly with the homeobox-containing protein pem

Biochemical and Biophysical Research Communications

Volumn 286, Issue 2, 2001, Pages 426-431

  Lemmens, Irma H ^a   Forsberg, Lars ^b   Pannett, Anna A J ^c   Meyen, Eva ^a   Piehl, Fredrik ^b   Turner, Jeremy J O ^c   Van de Ven, Wim J M ^a   Thakker, Rajesh V ^c   Larsson, Catharina ^b   Kas, Koen ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Endocrine; Homeobox; MEN1; Menin; Neoplasia; Pem; Spermatogenesis; Testis; Tumour suppressor; Yeast two hybrid

Indexed keywords

HOMEODOMAIN PROTEIN; METHIONINE;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CHO CELL; CHROMOSOME 11Q; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; IN SITU HYBRIDIZATION; MULTIPLE ENDOCRINE NEOPLASIA; NONHUMAN; NONSENSE MUTATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SPERMATOGENESIS; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

EID: 0034817095     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5405     Document Type: Article

References (22)

1. Multiple endocrine neoplasia type 1 (MEN1)
2. Positional cloning of the gene for multiple endocrine neoplasia-type 1
3. Identification of the multiple endocrine neoplasia type 1 (MEN1) gene
4. Menin, the product of the MEN1 gene, is a nuclear protein
5. Stable overexpression of MEN1 suppresses tumorigenicity of RAS
6. Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription
7. Menin, a gene product responsible for multiple endocrine neoplasia type 1, interacts with the putative tumor metastasis suppressor nm23
8. Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type β signaling
9. SIP1, a novel zinc finger/homeodomain repressor, interacts with smad proteins and binds to 5′-CACCT sequences in candidate target genes
10. Transforming yeast with DNA
11. Rearrangement of the human CDC5L gene by a t(6;19)(p21;q13.1) in a patient with multicystic renal dysplasia
12. Characterization of the mouse Men1 gene and its expression during development
13. Sensitive mRNA detection using unfixed tissue: Combined radioactive and non-radioactive in situ hybridization histochemistry
14. Restricted expression pattern of vegf-d in the adult and fetal mouse: High expression in the embryonic lung
15. TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation
16. Studies of the murine homolog of the multiple endocrine neoplasia type 1 (MEN1) gene, men1
17. A novel oncofetal gene is expressed in a stage-specific manner in murine embryonic development
18. The Pem homeobox gene. Androgen-dependent and -independent promoters and tissue-specific alternative RNA splicing
19. Forced expression of the homeobox-containing gene pem blocks differentiation of embryonic stem cells
20. Pem: A testosterone-and LH-regulated homeobox gene expressed in mouse Sertoli cells and epididymis
21. Homozygotes for the autosomal dominant neoplasia syndrome MEN1
22. Targeted disruption of the murine junD gene results in multiple defects in male reproductive function