Mutational analysis of p27 (CDKN1B) and p18 (CDKN2C) in sporadic pancreatic endocrine tumors argues against tumor-suppressor function

Neoplasia

Volumn 9, Issue 7, 2007, Pages 533-535

  Lindberg, Daniel ^a   Åkerström, Göran ^a   Westin, Gunnar ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cyclin dependent kinase inhibitor; P18INK4C; P27Kip1; Sporadic pancreatic endocrine tumors; Tumor suppressor gene

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 2C; MENIN PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL ARTICLE; ENDOCRINE TUMOR; EXON; GASTRINOMA; GENE MUTATION; GENETIC POLYMORPHISM; GLUCAGONOMA; HUMAN; HUMAN TISSUE; INSULINOMA; MULTIPLE ENDOCRINE NEOPLASIA; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; PANCREAS TUMOR; PHENOTYPE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 34547235748     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.07328     Document Type: Article

References (17)

1. Skogseid B (2003). Multiple endocrine neoplasia type 1. Br J Surg 90, 383-385.
2. Öberg K and Eriksson B (2005). Endocrine tumours of the pancreas. Best Pract Res Clin Gastroenterol 19, 753-781.
3. House MG and Schulick RD (2006). Endocrine tumors of the pancreas. Curr Opin Oncol 18, 23-29.
4. Agarwal SK, Kennedy PA, Scacheri PC, Novotny EA, Hickman AB, Cerrato A, Rice TS, Moore JB, Rao S, Ji Y, et al. (2005). Menin molecular interactions: insights into normal functions and tumorigenesis. Horm Metab Res 37, 369-374.
5. Åkerström G, Hessman O, Hellman P, and Skogseid B (2005). Pancreatic tumours as part of the MEN-1 syndrome. Best Pract Res Clin Gastroenterol 19, 819-830.
6. Zhuang Z, Vortmeyer AO, Pack S, Huang S, Pham TA, Wang C, Park WS, Agarwal SK, Debelenko LV, Kester M, et al. (1997). Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas. Cancer Res 57, 4682-4686.
7. Hessman O, Lindberg D, Skogseid B, Carling T, Hellman P, Rastad J, Åkerström G, and Westin G (1998). Mutation of the multiple endocrine neoplasia type 1 gene in nonfamilial, malignant tumors of the endocrine pancreas. Cancer Res 58, 377-379.
8. Wan EH, Ebrahimi SA, Wu AY, Kashefi C, Passaro E Jr, and Sawicki MP (1998). Mutation of the MENIN gene in sporadic pancreatic endocrine tumors. Cancer Res 58, 4417-4420.
9. Pellegata NS, Quintanilla-Martinez L, Siggelkow H, Samson E, Bink K, Hofler H, Fend F, Graw J, and Atkinson MJ (2006). Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans. Proc Natl Acad Sci USA 103, 15558-15563.
10. Polyak K (2006). The p27Kip1 tumor suppressor gene: still a suspect or proven guilty? Cancer Cell 10, 352-354.
11. Franklin DS, Godfrey VL, O'Brien DA, Deng C, and Xiong Y (2000). Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity. Mol Cell Biol 20, 6147-6158.
12. Bai F, Pei XH, Nishikawa T, Smith MD, and Xiong Y (2007). p18INK4C, but not p27Kip1, collaborates with Men1 to suppress neuroendocrine organ tumors. Mol Cell Biol 27, 1495-1504.
13. Karnik SK, Hughes CM, Gu X, Rozenblatt-Rosen O, McLean GW, Xiong Y, Meyerson M, and Kim SK (2005). Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc Natl Acad Sci USA 102, 14659-14664.
14. Milne TA, Hughes CM, Lloyd R, Yang Z, Rozenblatt-Rosen O, Dou Y, Schnepp RW, Krankel C, Livolsi VA, Gibbs D, et al. (2005). Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc Natl Acad Sci USA 102, 749-754.
15. Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, et al. (2006). The consensus coding sequences of human breast and colorectal cancers. Science 314, 268-274.
16. Lindberg D, Åkerström G, and Westin G (2007). Mutational analyses of WNT7A and HDAC11 as candidate tumour suppressor genes in sporadic malignant pancreatic endocrine tumours. Clin Endocrinol (Oxf) 66, 110-114.
17. Ozawa A, Agarwal SK, Mateo CM, Burns AL, Rice TS, Kennedy PA, Quigley CM, Simonds WF, Weinstein LS, Chandrasekharappa SC, et al. (2007). The parathyroid/pituitary variant of MEN1 usuallyhas causes other than p27Kip1 mutations. J Clin Endocrinol Metab 92, 1948-1951.